Downregulation of nuclear factor-kappa B (NF-κB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensis

Life Sciences

Volumn 86, Issue 23-24, 2010, Pages 880-886

  Bannwart, Camila Ferreira ^a   Nakaira Takahagi, Erika ^a   Golim, Marjorie Assis ^a   de Medeiros, Leonardo Teixeira Lopes ^a   Romão, Mariana ^a   Weel, Ingrid Cristina ^a   Serrão Peraçoli, Maria Terezinha ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Monocytes; NF B; Paracoccidioides brasiliensis; Silibinin; TNF

Indexed keywords

GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; NITRIC OXIDE; NITRITE; PROSTAGLANDIN E2; SILIBININ; TRANSFORMING GROWTH FACTOR BETA1; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CELL COUNT; CELL CULTURE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENZYME LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; FUNGICIDAL ACTIVITY; GENE ACTIVATION; HUMAN; HUMAN CELL; IN VITRO STUDY; MONOCYTE; NORMAL HUMAN; PARACOCCIDIOIDES BRASILIENSIS; PROTEIN EXPRESSION; PROTEIN SYNTHESIS;

ADULT; ANTI-INFLAMMATORY AGENTS; CELLS, CULTURED; DINOPROSTONE; DOWN-REGULATION; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLOW CYTOMETRY; HUMANS; INTERLEUKIN-10; MIDDLE AGED; MONOCYTES; NF-KAPPA B; NITRIC OXIDE; PARACOCCIDIOIDES; PARACOCCIDIOIDOMYCOSIS; SIGNAL TRANSDUCTION; SILYMARIN; TUMOR NECROSIS FACTOR-ALPHA; YOUNG ADULT;

PARACOCCIDIOIDES BRASILIENSIS;

EID: 77953023898     PISSN: 00243205     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lfs.2010.04.005     Document Type: Article

References (40)

1. Arruda C., Franco M.F., Kashino S.S., Nascimento F.R., Fazioli Rdos A., Vaz C.A., Russo M., Calich V.L. Interleukin-12 protects mice against disseminated infection caused by Paracoccidioides brasiliensis but enhances pulmonary inflammation. Clinical Immunology 2002, 103(2):185-195.
2. Bannwart C.F., Peraçoli J.C., Nakaira-Takahagi E., Peraçoli M.T.S. Inhibitory effect of silibinin on tumor necrosis factor-alpha and hydrogen peroxide production by human monocytes. Natural Products Research 2010, 24(18).
3. Benard G., Romano C.C., Cacere C.R., Juvenale M., Mendes-Gianini M.J., Duarte A.J. Imbalance of IL-2, IFN-gamma and IL-10 secretion in the immunosuppression associated with human paracoccidioidomycosis. Cytokine 2001, 13:248-252.
4. Bordon A.P., Dias-Melicio L.A., Acorci M.J., Calvi S.A., Serrão Peraçoli M.T., Victoriano de Campos Soares A.M. Prostaglandin E2 inhibits Paracoccidioides brasiliensis killing by human monocytes. Microbes Infection 2007, 9(6):744-747.
5. Bozzi A., Reis B.S., Goulart M.I., Pereira M.C.N., Pedroso E.P., Goes A.M. Analysis of memory T cells in the human paracoccidioidomycosis before and during chemotherapy treatment. Immunology Letters 2007, 114(1):23-30.
6. Calich V.L., Kashino S.S. Cytokines produced by susceptible and resistant mice in the course of Paracoccidioides brasiliensis infection. Brazilian Journal of Medical and Biological Research 1998, 31(5):615-623.
7. Calvi S.A., Peraçoli M.T., Mendes R.P., Marcondes-Machado J., Fecchio D., Marques A.S. Effect of cytokines on the in vitro fungicidal activity of monocytes from paracoccidioidomycosis patients. Microbes and Infection 2003, 5(15):107-113.
8. 2-dependent mechanism. Medical Mycology 2006, 44:363-368.
9. Comelli M.C., Mengs U., Schneider C., Prosdocimi M. Toward the definition of the mechanism of action of silymarin, activities related to cellular protection from toxic damage induced by chemotherapy. Integrative Cancer Therapies 2007, 6:120-129.
10. De Waal Malefyt R., Abrams J., Bennett B., Figdor C.G., De Vries J.E. Interlukin-10 (IL-10) inhibits cytokine synthesis by human monocytes: na autoregulatory role of IL-10 produced by monocytes. Journal of Experimental Medicine 1991, 174:1209-1220.
11. Dehmlow C., Murawski N., Groot H. Scavening of reactive oxygen species and inhibition of arachidonic acid metabolism by silibinin in human cells. Life Sciences 1996, 58(18):1591-1600.
12. Dixit N., Baboota S., Kohli K., Ahmad S., Ali J. Silymarin: a review of pharmacological aspects and bioavailability enhancement approaches. Indian Journal of Pharmacology 2007, 39(4):172-179.
13. Eigler A., Moeller J., Endres S. Exogenous and endogenous nitric oxide attenuates tumor necrosis factor synthesis in the murine macrophage cell line RAW 264.7. Journal of Immunology 1995, 154(8):4048-4054.
14. Fornari M.C., Bava A.J., Guereño M.T., Berardi V.E., Silaf M.R., Negroni R., Diez R.A. High serum interleukin-10 and tumor necrosis factor alpha levels in chronic paracoccidioidomycosis. Clinical and Diagnostic Laboratory Immunology 2001, 8(5):1036-1038.
15. Foulds S. Novel flow cytometric method for quantifying nuclear binding of the transcription factor nuclear kappa B in unseparated human monocytes and polymorphonuclear cells. Cytometry 1997, 29:182-186.
16. Franco L., Najvar L., Gomez B.L., Restrepo S., Graybill J.R., Restrepo A. Experimental pulmonary fibrosis induced by Paracoccidioides brasiliensis conidia, measurement of local host responses. American Journal of Tropical Medicine and Hygiene 1998, 58:424-430.
17. Jeong D.H., Lee G.P., Jeong W.I., Do S.H., Yang H.J., Yuan D.W., Park H.Y., Kim K.J., Jeong K.S. Alterations of mast cells and TGF-beta1 on the silymarin treatment for CCl4-induced hepatic fibrosis. World Journal of Gastroenterology 2005, 11(8):1141-1148.
18. Kang J.S., Jeon Y.J., Kim H.M., Han S.H., Yang K.H. Inhibition of inducible nitric-oxide synthase expression by silymarin in lipopolysaccharide-stimulated macrophages. Journal of Pharmacology and Experimental Therapeutics 2002, 302:138-144.
19. Kohno T., Daa T., Otani H., Shimokawa I., Yokoyama S., Matsuyama T. Aberrant expression of BAFF receptor, a member of the tumor necrosis factor receptor family, in malignant cells of nonhematopoietic origins. Genes to Cells 2008, 13(10):1061-1073.
20. Kurokawa C.S., Peraçoli M.T., Araujo J.P., Calvi S.A., Sugizaki M.F., Soares A.M. Pro and anti-inflamatory cytokines produced by human monocytes challenged in vitro with Paracoccidioides brasiliensis. Microbiology and Immunology 2007, 51(4):421-428.
21. Lappas M., Permezel M., Georgiou H.M., Rice G.E. Nuclear factor kappa B regulation of proinflammatory cytokines in human gestational tissues in vitro. Biology of Reproduction 2002, 67(2):668-673.
22. Lin W.W., Karin M. A cytokine-mediated link between innate immunity, inflammation, and cancer. Journal of Clinical Investigation 2007, 117(5):1175-1183.
23. Lowry O.H., Rosebrough N.J., Farr A.L., Randall R.J. Protein measurement with the Folin phenol reagent. Journal of Biological Chemistry 1951, 193:265-275.
24. Maeda S., Hsu L.C., Liu H., Bankston L.A., Iimura M., Kagnoff M.F., Eckmann L., Karin M. Nod2 mutation in Crohn's disease potentiates NF-kappaB activity and IL-1beta processing. Science 2005, 307:734-738. Erratum in: Science 308, 633.
25. Manna S.K., Mukhopadhyay A., Van N.T., Aggarwal B.B. Silymarin suppress TNF-induced activation of NF-κB, c-Jun N-terminal kinase, and apoptosis. Journal of Immunology 1999, 163(12):6800-6809.
26. Mazzeo D., Panina-Bordignon P., Recalde H., Sinigaglia F., D'Ambrosio D. Decreased IL-12 production and Th1 cell development by acetyl salicylic acid-mediated inhibition of NF-kappaB. European Journal of Immunology 1998, 28(10):3205-3213.
27. McEwen J.G., Restrepo B.I., Salazar M.E., Restrepo A. Nuclear staining of Paracoccidioides brasiliensis conidia. Journal of Medical and Veterinary Mycology 1987, 25(5):343-345.
28. Mendes R.P. The gamut of clinical manifestations. Paracoccidioidomycosis 1994, 233-258. CRC Press, Boca Raton, Florida. M. Franco, C.S. Lacaz, A. Restrepo-Moreno, G. Del Negro (Eds.).
29. 2 and NO effector mechanisms. Mycopathologia 2008, 166(1):17-23.
30. Nascimento M.P., Soares A.M., Dias-Melicio L.A., Parise-Fortes M.R., Martins R.A., Nakaira E.T., Peraçoli M.T. Fungicidal activity of human monocyte-derived multinucleated giant cells induced in vitro by Paracoccidioides brasiliensis antigen. Mycopathologia 2008, 166(1):25-33.
31. Niho Y., Niiro H., Tanaka Y., Nakashima H., Otsuka T. Role of IL-10 in the crossregulation of prostaglandins and cytokines in monocytes. Acta Haematologica 1998, 99:165-170.
32. Parise-Fortes M.R., Silva M.F., Sugizaki M.F., Defaveri J., Montenegro M.R., Soares A.M., Peraçoli M.T. Experimental paracoccidioidomycosis of the Syrian hamster, fungicidal activity and production of inflammatory cytokines by macrophages. Medical Mycology 2000, 38(1):51-60.
33. Parise-Fortes M.R., Marques S.A., Soares A.M., Kurokawa C.S., Marques M.E., Peraçoli M.T. Cytokines released from blood monocytes and expressed in mucocutaneous lesions of patients with paracoccidioidomycosis evaluated before and during trimethoprim-sulfametoxazole treatment. British Journal of Dermatology 2006, 154(4):643-650.
34. Peraçoli M.T., Sugizaki M.F., Mendes R.P., Naiff R., Montenegro M.R. Paracoccidioides brasiliensis isolated from armadillos is virulent to Syrian hamsters. Mycopathologia 1999, 148(3):123-130.
35. Peraçoli M.T., Kurokawa C.S., Calvi S.A., Mendes R.P., Pereira P.C.M., Marques S.A., Soares A.M. Production of pro- and anti-inflammatory cytokines by monocytes from patients with paracoccidioidomycosis. Microbes and Infection 2003, 5(5):413-418.
36. Redpath S., Ghazal P., Gascoigne N.R. Hijacking and exploitation of IL-10 by intracellular pathogens. Trends in Microbiology 2001, 9(2):86-92.
37. Siqueira K.Z., Campos Soares A.M., Dias-Melicio L.A., Calvi S.A., Peraçoli M.T. Interleukin-6 treatment enhances human monocyte permissiveness for Paracoccidioides brasiliensis growth by modulating cytokine production. Medical Mycology 2009, 47(3):259-267.
38. Soares A.M., Calvi S.A., Peraçoli M.T.S., Fernadez A.C., Dias L.A., Dos Anjos A.R. Modulatory effect of prostaglandins on human monocyte activation for killing of high-and low-virulence strains of Paracoccidioides brasiliensis. Immunology 2001, 102:480-485.
39. Wanke B., Londero A.T. Epidemiology and paracoccidioidomycosis infection. Paracoccidioidomycosis 1994, 109-120. CRC Press, Boca Raton, Florida. M. Franco, C.S. Lacaz, A. Restrepo-Moreno, G. Del Negro (Eds.).
40. Zhang J.P., Hu Z.L., Feng Z.H., Lin W., Yu X.B., Qian D.H. Effect of silymarin on mouse liver damage, production and activity of tumor necrosis factor. Yao Xue Xue Bao 1996, 31(8):577-580.