메뉴 건너뛰기




Volumn 13, Issue 9, 2013, Pages 935-944

MicroRNAs as critical regulators involved in regulating epithelial-mesenchymal transition

Author keywords

Embryogenesis; EMT; Fibrosis; MET; Metastasis; MicroRNA

Indexed keywords

ACTIVIN; ALPHA CATENIN; BONE MORPHOGENETIC PROTEIN; DNA DIRECTED RNA POLYMERASE III; EPIDERMAL GROWTH FACTOR; EXPORTIN 5; GROWTH DIFFERENTIATION FACTOR; INHIBIN; MICRORNA; MICRORNA 141; MICRORNA 200; MICRORNA 31; MICRORNA 34A; NERVE CELL ADHESION MOLECULE; PLATELET DERIVED GROWTH FACTOR; RNA POLYMERASE II; SCATTER FACTOR; SMAD PROTEIN; SOMATOMEDIN C RECEPTOR; TRANSCRIPTION FACTOR ZEB1; TRANSFORMING GROWTH FACTOR BETA; TRANSFORMING GROWTH FACTOR BETA RECEPTOR; UVOMORULIN; VIMENTIN;

EID: 84890831249     PISSN: 15680096     EISSN: 18735576     Source Type: Journal    
DOI: 10.2174/15680096113136660099     Document Type: Review
Times cited : (27)

References (99)
  • 1
    • 44449144396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: At the crossroads of development and tumor metastasis
    • Yang, J.; Weinberg, R. A. Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. Dev. Cell 2008, 14(6), 818-829.
    • (2008) Dev. Cell , vol.14 , Issue.6 , pp. 818-829
    • Yang, J.1    Weinberg, R.A.2
  • 2
    • 0346724511 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition and its implications for fibrosis
    • Kalluri, R.; Neilson, E. G. Epithelial-mesenchymal transition and its implications for fibrosis. J. Clin. Invest. 2003, 112(12), 1776-1784.
    • (2003) J. Clin. Invest. , vol.112 , Issue.12 , pp. 1776-1784
    • Kalluri, R.1    Neilson, E.G.2
  • 3
    • 70450198396 scopus 로고    scopus 로고
    • Epithelialmesenchymal transitions in development and disease
    • Thiery, J. P.; Acloque, H.; Huang, R. Y; Nieto, M. A. Epithelialmesenchymal transitions in development and disease. Cell 2009, 139(5), 871-890.
    • (2009) Cell , vol.139 , Issue.5 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 4
    • 0029553183 scopus 로고
    • An overview of epithelio-mesenchymal transformation
    • Hay, E. D. An overview of epithelio-mesenchymal transformation. Acta Anat. (Basel) 1995, 154(1), 8-20.
    • (1995) Acta Anat. (Basel) , vol.154 , Issue.1 , pp. 8-20
    • Hay, E.D.1
  • 6
    • 67650999875 scopus 로고    scopus 로고
    • The basics of epithelial-mesenchymal transition
    • Kalluri, R.; Weinberg, R. A. The basics of epithelial-mesenchymal transition. J. Clin. Invest. 2009, 119(6), 1420-1428.
    • (2009) J. Clin. Invest. , vol.119 , Issue.6 , pp. 1420-1428
    • Kalluri, R.1    Weinberg, R.A.2
  • 7
    • 77951953778 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition: From molecular mechanisms, redox regulation to implications in human health and disease
    • Cannito, S.; Novo, E.; di Bonzo, L. V.; Busletta, C.; Colombatto, S.; Parola, M. Epithelial-mesenchymal transition: from molecular mechanisms, redox regulation to implications in human health and disease. Antioxid. Redox Signal. 2010, 12(12), 1383-1430.
    • (2010) Antioxid. Redox Signal. , vol.12 , Issue.12 , pp. 1383-1430
    • Cannito, S.1    Novo, E.2    di Bonzo, L.V.3    Busletta, C.4    Colombatto, S.5    Parola, M.6
  • 8
    • 34548175512 scopus 로고    scopus 로고
    • Signaling networks guiding epithelialmesenchymal transitions during embryogenesis and cancer progression
    • Moustakas, A.; Heldin, C. H. Signaling networks guiding epithelialmesenchymal transitions during embryogenesis and cancer progression. Cancer Sci. 2007, 98(10), 1512-1520.
    • (2007) Cancer Sci. , vol.98 , Issue.10 , pp. 1512-1520
    • Moustakas, A.1    Heldin, C.H.2
  • 9
    • 34249289041 scopus 로고    scopus 로고
    • Snail, Zeb and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • Peinado, H.; Olmeda, D.; Cano, A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat. Rev. Cancer 2007, 7(6), 415-428.
    • (2007) Nat. Rev. Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 10
    • 56749095797 scopus 로고    scopus 로고
    • Transcriptional regulation of cell polarity in EMT and cancer
    • Moreno-Bueno, G.; Portillo, F.; Cano, A. Transcriptional regulation of cell polarity in EMT and cancer. Oncogene 2008, 27(55), 6958-6969.
    • (2008) Oncogene , vol.27 , Issue.55 , pp. 6958-6969
    • Moreno-Bueno, G.1    Portillo, F.2    Cano, A.3
  • 11
    • 0029160437 scopus 로고
    • Morphogenetic roles of classic cadherins
    • Takeichi, M. Morphogenetic roles of classic cadherins. Curr. Opin. Cell Biol. 1995, 7(5), 619-627.
    • (1995) Curr. Opin. Cell Biol. , vol.7 , Issue.5 , pp. 619-627
    • Takeichi, M.1
  • 12
    • 75649151387 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition in cancer development and its clinical significance
    • Iwatsuki, M.; Mimori, K.; Yokobori, T.; Ishi, H.; Beppu, T.; Nakamori, S.; Baba, H.; Mori, M. Epithelial-mesenchymal transition in cancer development and its clinical significance. Cancer Sci. 2010, 101(2), 293-299.
    • (2010) Cancer Sci. , vol.101 , Issue.2 , pp. 293-299
    • Iwatsuki, M.1    Mimori, K.2    Yokobori, T.3    Ishi, H.4    Beppu, T.5    Nakamori, S.6    Baba, H.7    Mori, M.8
  • 13
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D. P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116(2), 281-297.
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 15
    • 6344281172 scopus 로고    scopus 로고
    • Identification of mammalian microRNA host genes and transcription units
    • Rodriguez, A.; Griffiths-Jones, S.; Ashurst, J. L.; Bradley, A. Identification of mammalian microRNA host genes and transcription units. Genome Res., 2004, 14(10A), 1902-1910.
    • (2004) Genome Res. , vol.14 , Issue.10 A , pp. 1902-1910
    • Rodriguez, A.1    Griffiths-Jones, S.2    Ashurst, J.L.3    Bradley, A.4
  • 16
    • 0037009364 scopus 로고    scopus 로고
    • MicroRNA maturation: Stepwise processing and subcellular localization
    • Lee, Y.; Jeon, K.; Lee, J. T.; Kim, S.; Kim, V. N. MicroRNA maturation: stepwise processing and subcellular localization. EMBO J. 2002, 21(17), 4663-4670.
    • (2002) EMBO J. , vol.21 , Issue.17 , pp. 4663-4670
    • Lee, Y.1    Jeon, K.2    Lee, J.T.3    Kim, S.4    Kim, V.N.5
  • 17
    • 1642499415 scopus 로고    scopus 로고
    • Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs
    • Bohnsack, M. T.; Czaplinski, K.; Gorlich, D. Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAs. RNA 2004, 10(2), 185-191.
    • (2004) RNA , vol.10 , Issue.2 , pp. 185-191
    • Bohnsack, M.T.1    Czaplinski, K.2    Gorlich, D.3
  • 18
    • 27744537851 scopus 로고    scopus 로고
    • Human RISC couples microRNA biogenesis and posttranscriptional gene silencing
    • Gregory, R. I.; Chendrimada, T. P.; Cooch, N.; Shiekhattar, R. Human RISC couples microRNA biogenesis and posttranscriptional gene silencing. Cell 2005, 123(4), 631-640.
    • (2005) Cell , vol.123 , Issue.4 , pp. 631-640
    • Gregory, R.I.1    Chendrimada, T.P.2    Cooch, N.3    Shiekhattar, R.4
  • 19
    • 77951972792 scopus 로고    scopus 로고
    • Regulation of MicroRNA biogenesis: A miRiad of mechanisms
    • Davis, B. N.; Hata, A. Regulation of MicroRNA biogenesis: A miRiad of mechanisms. Cell Commun. Signal. 2009, 7, 18.
    • (2009) Cell Commun. Signal. , vol.7 , pp. 18
    • Davis, B.N.1    Hata, A.2
  • 21
    • 78651293534 scopus 로고    scopus 로고
    • miRBase: Integrating microRNA annotation and deep-sequencing data
    • Database issue
    • Kozomara, A.; Griffiths-Jones, S. miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res. 2011, 39(Database issue), D152-D157.
    • (2011) Nucleic Acids Res. , vol.39
    • Kozomara, A.1    Griffiths-Jones, S.2
  • 22
    • 34249033020 scopus 로고    scopus 로고
    • MicroRNA detection and target prediction: Integration of computational and experimental approaches
    • Chaudhuri, K.; Chatterjee, R. MicroRNA detection and target prediction: integration of computational and experimental approaches. DNA Cell Biol. 2007, 26(5), 321-337.
    • (2007) DNA Cell Biol. , vol.26 , Issue.5 , pp. 321-337
    • Chaudhuri, K.1    Chatterjee, R.2
  • 23
    • 60149084560 scopus 로고    scopus 로고
    • MicroRNAs and cancer: Short RNAs go a long way
    • Ventura, A.; Jacks, T. MicroRNAs and cancer: short RNAs go a long way. Cell 2009, 136(4), 586-591.
    • (2009) Cell , vol.136 , Issue.4 , pp. 586-591
    • Ventura, A.1    Jacks, T.2
  • 24
    • 47549090432 scopus 로고    scopus 로고
    • TGFbeta in Cancer
    • Massague, J. TGFbeta in Cancer. Cell 2008, 134(2), 215-230.
    • (2008) Cell , vol.134 , Issue.2 , pp. 215-230
    • Massague, J.1
  • 25
    • 0036904895 scopus 로고    scopus 로고
    • Genetic analysis of the mammalian transforming growth factor-beta superfamily
    • Chang, H.; Brown, C. W.; Matzuk, M. M. Genetic analysis of the mammalian transforming growth factor-beta superfamily. Endocr. Rev. 2002, 23(6), 787-823.
    • (2002) Endocr. Rev. , vol.23 , Issue.6 , pp. 787-823
    • Chang, H.1    Brown, C.W.2    Matzuk, M.M.3
  • 26
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-to-mesenchymal transitions
    • Zavadil, J.; Bottinger, E. P. TGF-beta and epithelial-to-mesenchymal transitions. Oncogene 2005, 24(37), 5764-5774.
    • (2005) Oncogene , vol.24 , Issue.37 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 27
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu, J.; Lamouille, S.; Derynck, R. TGF-beta-induced epithelial to mesenchymal transition. Cell Res. 2009, 19(2), 156-172.
    • (2009) Cell Res. , vol.19 , Issue.2 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 28
    • 24644487312 scopus 로고    scopus 로고
    • TGF-beta and epithelial-tomesenchymal transitions
    • Zavadil, J.; Bottinger, E. P. TGF-beta and epithelial-tomesenchymal transitions. Oncogene 2005, 24(37), 5764-5774.
    • (2005) Oncogene , vol.24 , Issue.37 , pp. 5764-5774
    • Zavadil, J.1    Bottinger, E.P.2
  • 29
    • 77954956544 scopus 로고    scopus 로고
    • Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas
    • Braun, J.; Hoang-Vu, C.; Dralle, H.; Hüttelmaier, S. Downregulation of microRNAs directs the EMT and invasive potential of anaplastic thyroid carcinomas. Oncogene 2010, 29(29), 4237-4244.
    • (2010) Oncogene , vol.29 , Issue.29 , pp. 4237-4244
    • Braun, J.1    Hoang-Vu, C.2    Dralle, H.3    Hüttelmaier, S.4
  • 30
    • 77955171129 scopus 로고    scopus 로고
    • Targeting Smad4 links microRNA-146a to the TGFbeta pathway during retinoid acid induction in acute promyelocytic leukemia cell line
    • Zhong, H.; Wang, H. R.; Yang, S.; Zhong, J.H.; Wang, T.; Wang, C.; Chen, F.Y. Targeting Smad4 links microRNA-146a to the TGFbeta pathway during retinoid acid induction in acute promyelocytic leukemia cell line. Int. J. Hematol. 2010, 92(1), 129-135.
    • (2010) Int. J. Hematol. , vol.92 , Issue.1 , pp. 129-135
    • Zhong, H.1    Wang, H.R.2    Yang, S.3    Zhong, J.H.4    Wang, T.5    Wang, C.6    Chen, F.Y.7
  • 31
    • 68949169031 scopus 로고    scopus 로고
    • MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads
    • Rogler, C. E.; Levoci, L.; Ader, T. Massimi, A.; Tchaikovskaya, T.; Norel, R.; Rogler, L.E. MicroRNA-23b cluster microRNAs regulate transforming growth factor-beta/bone morphogenetic protein signaling and liver stem cell differentiation by targeting Smads. Hepatology 2009, 50(2), 575-584.
    • (2009) Hepatology , vol.50 , Issue.2 , pp. 575-584
    • Rogler, C.E.1    Levoci, L.2    Ader, T.3    Massimi, A.4    Tchaikovskaya, T.5    Norel, R.6    Rogler, L.E.7
  • 32
    • 67651111989 scopus 로고    scopus 로고
    • Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines
    • Shan, H.; Zhang, Y.; Lu, Y.; Zhang, Y.; Pan, Z.; Cai, B.; Wang, N.; Li, X.; Feng, T.; Hong, Y.; Yang, B. Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovasc. Res., 2009, 83(3), 465-472.
    • (2009) Cardiovasc. Res. , vol.83 , Issue.3 , pp. 465-472
    • Shan, H.1    Zhang, Y.2    Lu, Y.3    Zhang, Y.4    Pan, Z.5    Cai, B.6    Wang, N.7    Li, X.8    Feng, T.9    Hong, Y.10    Yang, B.11
  • 36
    • 69049120925 scopus 로고    scopus 로고
    • High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1
    • Qian, B.; Katsaros, D.; Lu, L.; Yu, H. High miR-21 expression in breast cancer associated with poor disease-free survival in early stage disease and high TGF-beta1. Breast Cancer Res. Treat. 2009, 117(1), 131-140.
    • (2009) Breast Cancer Res. Treat. , vol.117 , Issue.1 , pp. 131-140
    • Qian, B.1    Katsaros, D.2    Lu, L.3    Yu, H.4
  • 37
    • 73349117464 scopus 로고    scopus 로고
    • MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue
    • Kim, Y. J.; Hwang, S. J.; Bae, Y. C.; Jung, J. S. MiR-21 regulates adipogenic differentiation through the modulation of TGF-beta signaling in mesenchymal stem cells derived from human adipose tissue. Stem Cells 2009, 27(12), 3093-3102.
    • (2009) Stem Cells , vol.27 , Issue.12 , pp. 3093-3102
    • Kim, Y.J.1    Hwang, S.J.2    Bae, Y.C.3    Jung, J.S.4
  • 38
    • 77950242736 scopus 로고    scopus 로고
    • microRNA 21: Response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells
    • Pan, Q.; Luo, X.; Chegini, N. microRNA 21: response to hormonal therapies and regulatory function in leiomyoma, transformed leiomyoma and leiomyosarcoma cells. Mol. Hum. Reprod. 2010, 16(3), 215-227.
    • (2010) Mol. Hum. Reprod. , vol.16 , Issue.3 , pp. 215-227
    • Pan, Q.1    Luo, X.2    Chegini, N.3
  • 40
    • 46449128469 scopus 로고    scopus 로고
    • SMAD proteins control DROSHA-mediated microRNA maturation
    • Davis, B. N.; Hilyard, A. C.; Lagna, G.; Hata, A. SMAD proteins control DROSHA-mediated microRNA maturation. Nature 2008, 454(7200), 56-61.
    • (2008) Nature , vol.454 , Issue.7200 , pp. 56-61
    • Davis, B.N.1    Hilyard, A.C.2    Lagna, G.3    Hata, A.4
  • 41
    • 77955484492 scopus 로고    scopus 로고
    • Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha
    • Davis, B. N.; Hilyard, A. C.; Nguyen, P. H.; Lagna, G.; Hata, A. Smad proteins bind a conserved RNA sequence to promote microRNA maturation by Drosha. Mol. Cell 2010, 39(3), 373-384.
    • (2010) Mol. Cell , vol.39 , Issue.3 , pp. 373-384
    • Davis, B.N.1    Hilyard, A.C.2    Nguyen, P.H.3    Lagna, G.4    Hata, A.5
  • 42
    • 63049101157 scopus 로고    scopus 로고
    • The role of the ZEB family of transcription factors in development and disease
    • Vandewalle, C.; Van Roy, F.; Berx, G. The role of the ZEB family of transcription factors in development and disease. Cell. Mol. Life. Sci. 2009, 66(5), 773-787.
    • (2009) Cell. Mol. Life. Sci. , vol.66 , Issue.5 , pp. 773-787
    • Vandewalle, C.1    Van Roy, F.2    Berx, G.3
  • 43
    • 47249091921 scopus 로고    scopus 로고
    • The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2
    • Korpal, M.; Lee, E. S.; Hu, G.; Kang, Y. The miR-200 family inhibits epithelial-mesenchymal transition and cancer cell migration by direct targeting of E-cadherin transcriptional repressors ZEB1 and ZEB2. J. Biol. Chem. 2008, 283(22), 14910-14914.
    • (2008) J. Biol. Chem. , vol.283 , Issue.22 , pp. 14910-14914
    • Korpal, M.1    Lee, E.S.2    Hu, G.3    Kang, Y.4
  • 45
  • 46
    • 34548565806 scopus 로고    scopus 로고
    • Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of Ecadherin
    • Hurteau, G. J.; Carlson, J. A.; Spivack, S. D.; Brock G. J. Overexpression of the microRNA hsa-miR-200c leads to reduced expression of transcription factor 8 and increased expression of Ecadherin. Cancer Res. 2007, 67(17), 7972-7976.
    • (2007) Cancer Res. , vol.67 , Issue.17 , pp. 7972-7976
    • Hurteau, G.J.1    Carlson, J.A.2    Spivack, S.D.3    Brock, G.J.4
  • 48
  • 50
    • 54049084380 scopus 로고    scopus 로고
    • A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition
    • Bracken, C. P.; Gregory, P. A.; Kolesnikoff, N.; Bert, A. G.; Wang, J.; Shannon, M. F.; Goodall, G. J. A double-negative feedback loop between ZEB1-SIP1 and the microRNA-200 family regulates epithelial-mesenchymal transition. Cancer Res., 2008, 68(19), 7846-7854.
    • (2008) Cancer Res. , vol.68 , Issue.19 , pp. 7846-7854
    • Bracken, C.P.1    Gregory, P.A.2    Kolesnikoff, N.3    Bert, A.G.4    Wang, J.5    Shannon, M.F.6    Goodall, G.J.7
  • 51
    • 44649163918 scopus 로고    scopus 로고
    • A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells
    • Burk, U.; Schubert, J.; Wellner, U.; Schmalhofer, O.; Vincan, E.; Spaderna, S.; Brabletz, T. A reciprocal repression between ZEB1 and members of the miR-200 family promotes EMT and invasion in cancer cells. EMBO Rep. 2008, 9(6), 582-589.
    • (2008) EMBO Rep. , vol.9 , Issue.6 , pp. 582-589
    • Burk, U.1    Schubert, J.2    Wellner, U.3    Schmalhofer, O.4    Vincan, E.5    Spaderna, S.6    Brabletz, T.7
  • 52
    • 77956230322 scopus 로고    scopus 로고
    • The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer?
    • Brabletz, S.; Brabletz, T. The ZEB/miR-200 feedback loop--a motor of cellular plasticity in development and cancer? EMBO Rep. 2010, 11(9), 670-677.
    • (2010) EMBO Rep. , vol.11 , Issue.9 , pp. 670-677
    • Brabletz, S.1    Brabletz, T.2
  • 53
    • 84861802693 scopus 로고    scopus 로고
    • MicroRNAs: Critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression
    • Bullock, M. D.; Sayan, A. E.; Packham, G. K.; Mirnezami, A. H. MicroRNAs: critical regulators of epithelial to mesenchymal (EMT) and mesenchymal to epithelial transition (MET) in cancer progression. Biol. Cell 2012, 104(1), 3-12.
    • (2012) Biol. Cell , vol.104 , Issue.1 , pp. 3-12
    • Bullock, M.D.1    Sayan, A.E.2    Packham, G.K.3    Mirnezami, A.H.4
  • 54
    • 54049089608 scopus 로고    scopus 로고
    • MicroRNAs as regulators of epithelial-mesenchymal transition
    • Gregory, P. A.; Bracken, C. P.; Bert, A. G.; Goodall, G. J. MicroRNAs as regulators of epithelial-mesenchymal transition. Cell Cycle 2008, 7(20), 3112-3118.
    • (2008) Cell Cycle , vol.7 , Issue.20 , pp. 3112-3118
    • Gregory, P.A.1    Bracken, C.P.2    Bert, A.G.3    Goodall, G.J.4
  • 57
    • 84877928478 scopus 로고    scopus 로고
    • Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs
    • Lamouille, S.; Subramanyam, D.; Blelloch, R.; Derynck, R. Regulation of epithelial-mesenchymal and mesenchymal-epithelial transitions by microRNAs. Curr. Opin. Cell Biol. 2013, 25(2), 200-207.
    • (2013) Curr. Opin. Cell Biol. , vol.25 , Issue.2 , pp. 200-207
    • Lamouille, S.1    Subramanyam, D.2    Blelloch, R.3    Derynck, R.4
  • 59
    • 84857507248 scopus 로고    scopus 로고
    • MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer
    • Kumarswamy, R.; Mudduluru, G.; Ceppi, P.; Muppala, S.; Kozlowski, M.; Niklinski, J.; Papotti, M.; Allgayer, H. MicroRNA-30a inhibits epithelial-to-mesenchymal transition by targeting Snai1 and is downregulated in non-small cell lung cancer. Int. J. Cancer, 2012, 130(9), 2044-2053.
    • (2012) Int. J. Cancer , vol.130 , Issue.9 , pp. 2044-2053
    • Kumarswamy, R.1    Mudduluru, G.2    Ceppi, P.3    Muppala, S.4    Kozlowski, M.5    Niklinski, J.6    Papotti, M.7    Allgayer, H.8
  • 60
    • 77955466130 scopus 로고    scopus 로고
    • miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers
    • Vetter, G.; Saumet, A.; Moes, M.; Vallar, L.; Le Béchec, A.; Laurini, C.; Sabbah, M.; Arar, K.; Theillet, C.; Lecellier, C. H.; Friederich, E. miR-661 expression in SNAI1-induced epithelial to mesenchymal transition contributes to breast cancer cell invasion by targeting Nectin-1 and StarD10 messengers. Oncogene 2010, 29(31), 4436-4448.
    • (2010) Oncogene , vol.29 , Issue.31 , pp. 4436-4448
    • Vetter, G.1    Saumet, A.2    Moes, M.3    Vallar, L.4    Le Béchec, A.5    Laurini, C.6    Sabbah, M.7    Arar, K.8    Theillet, C.9    Lecellier, C.H.10    Friederich, E.11
  • 61
    • 84859720222 scopus 로고    scopus 로고
    • A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition
    • Moes, M.; Le Bechec, A.; Crespo, I.; Laurini, C.; Halavatyi, A.; Vetter, G.; Del Sol, A.; Friederich, E. A novel network integrating a miRNA-203/SNAI1 feedback loop which regulates epithelial to mesenchymal transition. PLoS One 2012, 7(4), e35440.
    • (2012) PLoS One , vol.7 , Issue.4
    • Moes, M.1    Le Bechec, A.2    Crespo, I.3    Laurini, C.4    Halavatyi, A.5    Vetter, G.6    Del Sol, A.7    Friederich, E.8
  • 63
    • 84862513160 scopus 로고    scopus 로고
    • Downregulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist
    • Li, B.; Han, Q.; Zhu, Y.; Yu, Y.; Wang, J.; Jiang, X. Downregulation of miR-214 contributes to intrahepatic cholangiocarcinoma metastasis by targeting Twist. FEBS J. 2012, 279(13), 2393-2398.
    • (2012) FEBS J. , vol.279 , Issue.13 , pp. 2393-2398
    • Li, B.1    Han, Q.2    Zhu, Y.3    Yu, Y.4    Wang, J.5    Jiang, X.6
  • 64
    • 35148886434 scopus 로고    scopus 로고
    • Tumour invasion and metastasis initiated by microRNA-10b in breast cancer
    • Ma, L.; Teruya-Feldstein, J.; Weinberg, R. A. Tumour invasion and metastasis initiated by microRNA-10b in breast cancer. Nature 2007, 449(7163), 682-688.
    • (2007) Nature , vol.449 , Issue.7163 , pp. 682-688
    • Ma, L.1    Teruya-Feldstein, J.2    Weinberg, R.A.3
  • 66
    • 0032510494 scopus 로고    scopus 로고
    • A causal role for E-cadherin in the transition from adenoma to carcinoma
    • Perl, A. K.; Wilgenbus, P.; Dahl, U.; Semb, H.; Christofori, G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature 1998, 392(6672), 190-193.
    • (1998) Nature , vol.392 , Issue.6672 , pp. 190-193
    • Perl, A.K.1    Wilgenbus, P.2    Dahl, U.3    Semb, H.4    Christofori, G.5
  • 67
    • 0033930954 scopus 로고    scopus 로고
    • E-cadherincatenin cell-cell adhesion complex and human cancer
    • Wijnhoven, B. P.; Dinjens, W. N.; Pignatelli, M. E-cadherincatenin cell-cell adhesion complex and human cancer. Br. J. Surg. 2000, 87(8), 992-1005.
    • (2000) Br. J. Surg. , vol.87 , Issue.8 , pp. 992-1005
    • Wijnhoven, B.P.1    Dinjens, W.N.2    Pignatelli, M.3
  • 68
    • 0344845003 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and pathologies
    • Thiery, J. P. Epithelial-mesenchymal transitions in development and pathologies. Curr. Opin. Cell Biol. 2003, 15(6), 740-746.
    • (2003) Curr. Opin. Cell Biol. , vol.15 , Issue.6 , pp. 740-746
    • Thiery, J.P.1
  • 71
    • 84866076859 scopus 로고    scopus 로고
    • MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis
    • Liu, Y.; Zhao, J.; Zhang, P. Y.; Zhang, Y.; Sun, S. Y.; Yu, S. Y.; Xi, Q. S. MicroRNA-10b targets E-cadherin and modulates breast cancer metastasis. Med. Sci. Monit. 2012, 18(8), R299-R308.
    • (2012) Med. Sci. Monit. , vol.18 , Issue.8
    • Liu, Y.1    Zhao, J.2    Zhang, P.Y.3    Zhang, Y.4    Sun, S.Y.5    Yu, S.Y.6    Xi, Q.S.7
  • 73
    • 78649588750 scopus 로고    scopus 로고
    • miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice
    • Meng, Z.; Fu, X.; Chen, X.; Zeng, S.; Tian, Y.; Jove, R.; Xu, R.; Huang, W. miR-194 is a marker of hepatic epithelial cells and suppresses metastasis of liver cancer cells in mice. Hepatology 2010, 52(6), 2148-2157.
    • (2010) Hepatology , vol.52 , Issue.6 , pp. 2148-2157
    • Meng, Z.1    Fu, X.2    Chen, X.3    Zeng, S.4    Tian, Y.5    Jove, R.6    Xu, R.7    Huang, W.8
  • 74
    • 67650996280 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions: The importance of changing cell state in development and disease
    • Acloque, H.; Adams, M. S.; Fishwick, K.; Bronner-Fraser, M.; Nieto, M. A. Epithelial-mesenchymal transitions: the importance of changing cell state in development and disease. J. Clin. Invest. 2009, 119(6), 1438-1449.
    • (2009) J. Clin. Invest. , vol.119 , Issue.6 , pp. 1438-1449
    • Acloque, H.1    Adams, M.S.2    Fishwick, K.3    Bronner-Fraser, M.4    Nieto, M.A.5
  • 75
    • 0027296534 scopus 로고
    • Epithelium-mesenchyme interconversion as example of epithelial plasticity
    • Boyer, B.; Thiery, J. P. Epithelium-mesenchyme interconversion as example of epithelial plasticity. APMIS 1993, 101(4), 257-268.
    • (1993) APMIS , vol.101 , Issue.4 , pp. 257-268
    • Boyer, B.1    Thiery, J.P.2
  • 76
    • 38149042783 scopus 로고    scopus 로고
    • Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells
    • Frankel, L. B.; Christoffersen, N. R.; Jacobsen, A.; Lindow M, Krogh A, Lund AH. Programmed cell death 4 (PDCD4) is an important functional target of the microRNA miR-21 in breast cancer cells. J. Biol. Chem. 2008, 283(2), 1026-1033.
    • (2008) J. Biol. Chem. , vol.283 , Issue.2 , pp. 1026-1033
    • Frankel, L.B.1    Christoffersen, N.R.2    Jacobsen, A.3    Lindow, M.4    Krogh, A.5    Lund, A.H.6
  • 77
    • 41749113108 scopus 로고    scopus 로고
    • MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer
    • Asangani, I. A.; Rasheed, S. A.; Nikolova, D. A.; Leupold, J. H.; Colburn, N. H.; Post, S.; Allgayer, H. MicroRNA-21 (miR-21) post-transcriptionally downregulates tumor suppressor Pdcd4 and stimulates invasion, intravasation and metastasis in colorectal cancer. Oncogene 2008, 27(15), 2128-2136.
    • (2008) Oncogene , vol.27 , Issue.15 , pp. 2128-2136
    • Asangani, I.A.1    Rasheed, S.A.2    Nikolova, D.A.3    Leupold, J.H.4    Colburn, N.H.5    Post, S.6    Allgayer, H.7
  • 78
    • 79955780736 scopus 로고    scopus 로고
    • Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells
    • Subramanyam, D.; Lamouille, S.; Judson, R. L.; Liu, J. Y.; Bucay, N.; Derynck, R.; Blelloch, R. Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells. Nat. Biotechnol. 2011, 29(5), 443-448.
    • (2011) Nat. Biotechnol. , vol.29 , Issue.5 , pp. 443-448
    • Subramanyam, D.1    Lamouille, S.2    Judson, R.L.3    Liu, J.Y.4    Bucay, N.5    Derynck, R.6    Blelloch, R.7
  • 79
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • Wynn, T. A. Cellular and molecular mechanisms of fibrosis. J. Pathol. 2008, 214(2), 199-210.
    • (2008) J. Pathol. , vol.214 , Issue.2 , pp. 199-210
    • Wynn, T.A.1
  • 80
    • 69949124749 scopus 로고    scopus 로고
    • Direct contribution of epithelium to organ fibrosis: Epithelial-mesenchymal transition
    • Guarino, M.; Tosoni, A.; Nebuloni, M. Direct contribution of epithelium to organ fibrosis: epithelial-mesenchymal transition. Hum. Pathol. 2009, 40(10), 1365-1376.
    • (2009) Hum. Pathol. , vol.40 , Issue.10 , pp. 1365-1376
    • Guarino, M.1    Tosoni, A.2    Nebuloni, M.3
  • 81
    • 84863183146 scopus 로고    scopus 로고
    • New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis
    • Lee, K.; Nelson, C. M. New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis. Int. Rev. Cell Mol. Biol. 2012, 294, 171-221.
    • (2012) Int. Rev. Cell Mol. Biol. , vol.294 , pp. 171-221
    • Lee, K.1    Nelson, C.M.2
  • 83
    • 84867740278 scopus 로고    scopus 로고
    • MicroRNAs involved in regulating epithelialmesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics
    • Xia, H.; Hui, K. M. MicroRNAs involved in regulating epithelialmesenchymal transition and cancer stem cells as molecular targets for cancer therapeutics. Cancer Gene Ther. 2012, 19(11), 723-730.
    • (2012) Cancer Gene Ther. , vol.19 , Issue.11 , pp. 723-730
    • Xia, H.1    Hui, K.M.2
  • 85
    • 84881551103 scopus 로고    scopus 로고
    • MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis
    • Hur, K.; Toiyama, Y.; Takahashi, M.; Balaguer, F.; Nagasaka, T.; Koike, J.; Hemmi, H.; Koi, M.; Boland, C.R.; Goel, A. MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis. Gut 2013, 62(9), 1315-1326.
    • (2013) Gut , vol.62 , Issue.9 , pp. 1315-1326
    • Hur, K.1    Toiyama, Y.2    Takahashi, M.3    Balaguer, F.4    Nagasaka, T.5    Koike, J.6    Hemmi, H.7    Koi, M.8    Boland, C.R.9    Goel, A.10
  • 86
    • 69249156944 scopus 로고    scopus 로고
    • miR-200 regulates PDGF-D-mediated epithelialmesenchymal transition, adhesion, and invasion of prostate cancer cells
    • Kong, D.; Li, Y.; Wang, Z.; Banerjee, S.; Ahmad, A.; Kim, H. R.; Sarkar, F. H. miR-200 regulates PDGF-D-mediated epithelialmesenchymal transition, adhesion, and invasion of prostate cancer cells. Stem Cells 2009, 27(8), 1712-1721.
    • (2009) Stem Cells , vol.27 , Issue.8 , pp. 1712-1721
    • Kong, D.1    Li, Y.2    Wang, Z.3    Banerjee, S.4    Ahmad, A.5    Kim, H.R.6    Sarkar, F.H.7
  • 87
    • 79955102595 scopus 로고    scopus 로고
    • Targets of miR-200c mediate suppression of cell motility and anoikis resistance
    • Howe, E. N.; Cochrane, D. R.; Richer, J. K. Targets of miR-200c mediate suppression of cell motility and anoikis resistance. Breast Cancer Res. 2011, 13(2), R45.
    • (2011) Breast Cancer Res. , vol.13 , Issue.2
    • Howe, E.N.1    Cochrane, D.R.2    Richer, J.K.3
  • 88
    • 84859911725 scopus 로고    scopus 로고
    • Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis
    • Davalos, V.; Moutinho, C.; Villanueva, A.; Boque R, Silva P, Carneiro F, Esteller M. Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene 2012, 31(16), 2062-2074.
    • (2012) Oncogene , vol.31 , Issue.16 , pp. 2062-2074
    • Davalos, V.1    Moutinho, C.2    Villanueva, A.3    Boque, R.4    Silva, P.5    Carneiro, F.6    Esteller, M.7
  • 89
    • 84875222626 scopus 로고    scopus 로고
    • MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulinlike growth factor-1 receptor
    • Zhao, X.; Dou, W.; He, L.; Liang, S.; Tie, J.; Liu, C.; Li, T.; Lu, Y.; Mo, P.; Shi, Y.; Wu, K.; Nie, Y.; Fan, D. MicroRNA-7 functions as an anti-metastatic microRNA in gastric cancer by targeting insulinlike growth factor-1 receptor. Oncogene 2013, 32(11), 1363-1372.
    • (2013) Oncogene , vol.32 , Issue.11 , pp. 1363-1372
    • Zhao, X.1    Dou, W.2    He, L.3    Liang, S.4    Tie, J.5    Liu, C.6    Li, T.7    Lu, Y.8    Mo, P.9    Shi, Y.10    Wu, K.11    Nie, Y.12    Fan, D.13
  • 90
    • 84875968686 scopus 로고    scopus 로고
    • MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of DeltaNP63alpha and promotes mesenchymal-toepithelial transition
    • Decastro, A. J.; Dunphy, K. A.; Hutchinson, J.; Balbani, A. L.; Cherukuri, P.; Jerry, D. J.; DiRenzo, J. MiR203 mediates subversion of stem cell properties during mammary epithelial differentiation via repression of DeltaNP63alpha and promotes mesenchymal-toepithelial transition. Cell Death Dis. 2013, 4, e514.
    • (2013) Cell Death Dis. , vol.4
    • Decastro, A.J.1    Dunphy, K.A.2    Hutchinson, J.3    Balbani, A.L.4    Cherukuri, P.5    Jerry, D.J.6    DiRenzo, J.7
  • 91
    • 84862909357 scopus 로고    scopus 로고
    • The miR-200 family regulates TGF-beta1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression
    • Xiong, M.; Jiang, L.; Zhou, Y.; Qiu, W.; Fang, L.; Tan, R.; Wen, P.; Yang, J. The miR-200 family regulates TGF-beta1-induced renal tubular epithelial to mesenchymal transition through Smad pathway by targeting ZEB1 and ZEB2 expression. Am. J. Physiol. Renal Physiol. 2012, 302(3), F369-F379.
    • (2012) Am. J. Physiol. Renal Physiol. , vol.302 , Issue.3
    • Xiong, M.1    Jiang, L.2    Zhou, Y.3    Qiu, W.4    Fang, L.5    Tan, R.6    Wen, P.7    Yang, J.8
  • 92
    • 84874157794 scopus 로고    scopus 로고
    • miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1
    • Bronnum, H.; Andersen, D. C.; Schneider, M.; Sandberg, M. B.; Eskildsen, T.; Sheikh, S. P.; Nielsen, S. B.; Kalluri, R. miR-21 promotes fibrogenic epithelial-to-mesenchymal transition of epicardial mesothelial cells involving Programmed Cell Death 4 and Sprouty-1. PLoS One 2013, 8(2), e56280.
    • (2013) PLoS One , vol.8 , Issue.2
    • Bronnum, H.1    Andersen, D.C.2    Schneider, M.3    Sandberg, M.B.4    Eskildsen, T.5    Sheikh, S.P.6    Nielsen, S.B.7    Kalluri, R.8
  • 93
    • 84875526984 scopus 로고    scopus 로고
    • Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells
    • Bronnum, H.; Andersen, D. C.; Schneider, M.; Nossent, A. Y.; Nielsen, S. B.; Sheikh, S. P. Islet-1 is a dual regulator of fibrogenic epithelial-to-mesenchymal transition in epicardial mesothelial cells. Exp. Cell Res. 2013, 319(4), 424-435.
    • (2013) Exp. Cell Res. , vol.319 , Issue.4 , pp. 424-435
    • Bronnum, H.1    Andersen, D.C.2    Schneider, M.3    Nossent, A.Y.4    Nielsen, S.B.5    Sheikh, S.P.6
  • 94
    • 84874708151 scopus 로고    scopus 로고
    • CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFbeta type II receptor with implications for nephropathic cell phenotypes
    • Faherty, N.; Curran, S. P.; O'Donovan, H.; Martin, F.; Godson, C.; Brazil, D. P.; Crean, J. K. CCN2/CTGF increases expression of miR-302 microRNAs, which target the TGFbeta type II receptor with implications for nephropathic cell phenotypes. J. Cell Sci. 2012, 125(Pt 23), 5621-5629.
    • (2012) J. Cell Sci. , vol.125 , Issue.Pt 23 , pp. 5621-5629
    • Faherty, N.1    Curran, S.P.2    O'Donovan, H.3    Martin, F.4    Godson, C.5    Brazil, D.P.6    Crean, J.K.7
  • 95
    • 84857147817 scopus 로고    scopus 로고
    • Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells
    • Du R.; Sun, W.; Xia, L.; Zhao, A.; Yu, Y.; Zhao, L.; Wang, H.; Huang, C.; Sun, S. Hypoxia-induced down-regulation of microRNA-34a promotes EMT by targeting the Notch signaling pathway in tubular epithelial cells. PLoS One 2012, 7(2), e30771.
    • (2012) PLoS One , vol.7 , Issue.2
    • Du, R.1    Sun, W.2    Xia, L.3    Zhao, A.4    Yu, Y.5    Zhao, L.6    Wang, H.7    Huang, C.8    Sun, S.9
  • 97
    • 84873365269 scopus 로고    scopus 로고
    • MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis
    • Cai, J.; Guan, H.; Fang, L.; Yang, Y.; Zhu, X.; Yuan, J.; Wu, J.; Li, M. MicroRNA-374a activates Wnt/beta-catenin signaling to promote breast cancer metastasis. J. Clin. Invest. 2013, 123(2), 566-579.
    • (2013) J. Clin. Invest. , vol.123 , Issue.2 , pp. 566-579
    • Cai, J.1    Guan, H.2    Fang, L.3    Yang, Y.4    Zhu, X.5    Yuan, J.6    Wu, J.7    Li, M.8
  • 98
    • 84874782064 scopus 로고    scopus 로고
    • Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer
    • Xu, Q.; Sun, Q.; Zhang, J.; Yu, J.; Chen, W.; Zhang, Z.L. Downregulation of miR-153 contributes to epithelial-mesenchymal transition and tumor metastasis in human epithelial cancer. Carcinogenesis 2013, 34(3), 539-549.
    • (2013) Carcinogenesis , vol.34 , Issue.3 , pp. 539-549
    • Xu, Q.1    Sun, Q.2    Zhang, J.3    Yu, J.4    Chen, W.5    Zhang, Z.L.6
  • 99
    • 84870360174 scopus 로고    scopus 로고
    • Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9
    • Lu, M. H.; Huang, C. C.; Pan, M. R.; Chen, H. H, Hung, W. C. Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9. Clin. Cancer Res. 2012, 18(23), 6416-6425.
    • (2012) Clin. Cancer Res. , vol.18 , Issue.23 , pp. 6416-6425
    • Lu, M.H.1    Huang, C.C.2    Pan, M.R.3    Chen, H.H.4    Hung, W.C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.