Repression of E-cadherin by SNAIL, ZEB1, and TWIST in invasive ductal carcinomas of the breast: A cooperative effort?

Human Pathology

Volumn 42, Issue 1, 2011, Pages 103-110

  Montserrat, Núria ^a,c   Gallardo, Alberto ^a   Escuin, Daniel ^a   Catasus, Lluís ^a   Prat, Jaime ^a   Gutiérrez Avignó, Francisco José ^b   Peiró, Gloria ^b   Barnadas, Agustí ^a   Lerma, Enrique ^a  

^a UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^b HOSPITAL GENERAL UNIVERSITARIO DE ALICANTE   (Spain)

^c Center for Regenerative Medicine of Barcelona   (Spain)

Author keywords

E cadherin; Invasive ductal carcinoma; SNAIL; TWIST; ZEB 1

Indexed keywords

MESSENGER RNA; PROTEIN ZEB1; REGULATOR PROTEIN; TRANSCRIPTION FACTOR SNAIL; TRANSCRIPTION FACTOR TWIST; UNCLASSIFIED DRUG; UVOMORULIN;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER GRADING; CANCER SURVIVAL; CORRELATION ANALYSIS; DISEASE FREE SURVIVAL; DOWN REGULATION; GENE EXPRESSION; HUMAN; HUMAN TISSUE; INVASIVE DUCTAL BREAST CARCINOMA; LYMPH NODE METASTASIS; OVERALL SURVIVAL; PROTEIN EXPRESSION; UPREGULATION;

ADULT; AGED; AGED, 80 AND OVER; BREAST NEOPLASMS; CADHERINS; CARCINOMA, DUCTAL, BREAST; DISEASE-FREE SURVIVAL; FEMALE; HOMEODOMAIN PROTEINS; HUMANS; MIDDLE AGED; NUCLEAR PROTEINS; REPRESSOR PROTEINS; RNA, MESSENGER; TRANSCRIPTION FACTORS; TWIST TRANSCRIPTION FACTOR; UP-REGULATION;

EID: 78649987980     PISSN: 00468177     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.humpath.2010.05.019     Document Type: Article

References (30)

1. Gupta G.P., and Massague J. Cancer metastasis: building a framework Cell 127 2006 679 695
2. Thiery J.P., and Sleeman J.P. Complex networks orchestrate epithelial-mesenchymal transitions Nat Rev Mol Cell Biol 7 2006 131 142
3. Thiery J.P. Epithelial-mesenchymal transitions in tumour progression Nat Rev Cancer 2 2002 442 454
4. Berx G., and Van Roy F. The E-cadherin/catenin complex: an important gatekeeper in breast cancer tumorigenesis and malignant progression Breast Cancer Res 3 2001 289 293
5. Schmalhofer O., Brabletz S., and Brabletz T. E-cadherin, beta-catenin, and ZEB1 in malignant progression of cancer Cancer Metastasis Rev 28 2009 151 166
6. Asgeirsson K.S., Jonasson J.G., and Tryggvadottir L. Altered expression of E-cadherin in breast cancer. patterns, mechanisms and clinical significance Eur J Cancer 36 2000 1098 1106
7. Rakha E.A., Abd El Rehim D., Pinder S.E., Lewis S.A., and Ellis I.O. E-cadherin expression in invasive non-lobular carcinoma of the breast and its prognostic significance Histopathology 46 2005 685 693
8. Batlle E., Sancho E., and Franci C. The transcription factor snail is a repressor of E-cadherin gene expression in epithelial tumour cells Nat Cell Biol 2 2000 84 89
9. Cano A., Perez-Moreno M.A., and Rodrigo I. The transcription factor snail controls epithelial-mesenchymal transitions by repressing E-cadherin expression Nat Cell Biol 2 2000 76 83
10. Yang J., Mani S.A., and Donaher J.L. Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis Cell 117 2004 927 939
11. Peinado H., Olmeda D., and Cano A. Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype Nat Rev Cancer 7 2007 415 428
12. Cardamone M.D., Bardella C., and Gutierrez A. ERalpha as ligand-independent activator of CDH-1 regulates determination and maintenance of epithelial morphology in breast cancer cells Proc Natl Acad Sci U S A 106 2009 7420 7425
13. Fujita N., Jaye D.L., and Kajita M. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer Cell 113 2003 207 219
14. Mironchik Y., Winnard P.T. Jr., and Vesuna F. Twist overexpression induces in vivo angiogenesis and correlates with chromosomal instability in breast cancer Cancer Res 65 2005 10801 10809
15. Martin T.A., Goyal A., Watkins G., and Jiang W.G. Expression of the transcription factors snail, slug, and twist and their clinical significance in human breast cancer Ann Surg Oncol 12 2005 488 496
16. Elston C.W., and Ellis I.O. Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: experience from a large study with long-term follow-up Histopathology 19 1991 403 410
17. Peiro G., Benlloch S., and Sanchez-Tejada L. Low activation of insulin-like growth factor 1-receptor (IGF1R) is associated with local recurrence in early breast carcinoma Breast Cancer Res Treat 2008
18. Sarrio D., Rodriguez-Pinilla S.M., and Hardisson D. Epithelial- mesenchymal transition in breast cancer relates to the basal-like phenotype Cancer Res 68 2008 989 997
19. Dumont N., Wilson M.B., and Crawford Y.G. Sustained induction of epithelial to mesenchymal transition activates DNA methylation of genes silenced in basal-like breast cancers Proc Natl Acad Sci U S A 105 2008 14867 14872
20. Kowalski P.J., Rubin M.A., and Kleer C.G. E-cadherin expression in primary carcinomas of the breast and its distant metastases Breast Cancer Res 5 2003 R217 R222
21. Come C., Magnino F., and Bibeau F. Snail and slug play distinct roles during breast carcinoma progression Clin Cancer Res 12 2006 5395 5402
22. Moody S.E., Perez D., and Pan T.C. The transcriptional repressor Snail promotes mammary tumor recurrence Cancer Cell 8 2005 197 209
23. Eger A., Aigner K., and Sonderegger S. DeltaEF1 is a transcriptional repressor of E-cadherin and regulates epithelial plasticity in breast cancer cells Oncogene 24 2005 2375 2385
24. Aigner K., Dampier B., and Descovich L. The transcription factor ZEB1 (deltaEF1) promotes tumour cell dedifferentiation by repressing master regulators of epithelial polarity Oncogene 26 2007 6979 6988
25. Anose B.M., LaGoo L., and Schwendinger J. Characterization of androgen regulation of ZEB-1 and PSA in 22RV1 prostate cancer cells Adv Exp Med Biol 617 2008 541 546
26. Alexander N.R., Tran N.L., and Rekapally H. N-cadherin gene expression in prostate carcinoma is modulated by integrin-dependent nuclear translocation of Twist1 Cancer Res 66 2006 3365 3369
27. Maeda M., Johnson K.R., and Wheelock M.J. Cadherin switching: essential for behavioral but not morphological changes during an epithelium-to-mesenchyme transition J Cell Sci 118 2005 873 887
28. Kokkinos M.I., Wafai R., and Wong M.K. Vimentin and epithelial- mesenchymal transition in human breast cancer-observations in vitro and in vivo Cells Tissues Organs 185 2007 191 203
29. Reis-Filho J.S., and Re: Korsching The origin of vimentin expression in invasive breast cancer: epithelial-mesenchymal transition, myoepithelial histogenesis or histogenesis from progenitor cells with bilinear differentiation potential? J Pathol 206 2005 451 457 [J Pathol 2005; 207:367-9; author reply 70-1]
30. Rodriguez-Pinilla S.M., Sarrio D., and Honrado E. Vimentin and laminin expression is associated with basal-like phenotype in both sporadic and BRCA1-associated breast carcinomas J Clin Pathol 60 2007 1006 1012