Pharmacological inhibition of nicotinamide phosphoribosyltransferase (NAMPT), an enzyme essential for NAD+ biosynthesis, in human cancer cells: Metabolic basis and potential clinical implications

Journal of Biological Chemistry

Volumn 288, Issue 5, 2013, Pages 3500-3511

  Tan, Bo ^a   Young, Debra A ^a   Lu, Zhao Hai ^a   Wang, Tao ^a   Meier, Timothy I ^a   Shepard, Robert L ^a   Roth, Kenneth ^a   Zhai, Yan ^a   Huss, Karen ^a   Kuo, Ming Shang ^a   Gillig, James ^a   Parthasarathy, Saravanan ^a   Burkholder, Timothy P ^a   Smith, Michele C ^a   Geeganage, Sandaruwan ^a   Zhao, Genshi ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATP DEPLETION; CANCER CELLS; CARBON FLOW; CELLULAR METABOLISM; CELLULAR PROCESS; CLINICAL TRIAL; DNA REPAIR; ENERGY PRODUCTIONS; GLYCOLYTIC INTERMEDIATE; HUMAN CANCER CELLS; INTERMEDIATE LEVEL; LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY; METABOLITE LEVEL; NON-OXIDATIVE BRANCH; PENTOSE PHOSPHATE PATHWAY; PHARMACOLOGICAL INHIBITION; PHOSPHORIBOSYLTRANSFERASE; RATE-LIMITING STEPS; SMALL MOLECULE INHIBITOR; TCA CYCLE; TRICARBOXYLIC ACIDS; TUMOR GROWTH; TUMOR XENOGRAFTS;

AMIDES; AMINO ACIDS; BIOCHEMISTRY; BIOSYNTHESIS; CARBON; CELLS; METABOLISM; PATHOLOGY; TUMORS;

ENZYME INHIBITION;

2 OXOGLUTARIC ACID; ADENOSINE TRIPHOSPHATE; DAPORINAD; GLYCERALDEHYDE 3 PHOSPHATE DEHYDROGENASE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PYRUVIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SERINE; SUCCINIC ACID;

AMINO ACID SYNTHESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CANCER INHIBITION; CITRIC ACID CYCLE; CONTROLLED STUDY; FEMALE; GLYCOLYSIS; HUMAN; HUMAN CELL; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PENTOSE PHOSPHATE CYCLE; PRIORITY JOURNAL; SOLID TUMOR; TUMOR XENOGRAFT;

ACRYLAMIDES; ADENOSINE TRIPHOSPHATE; ANIMALS; CARBON ISOTOPES; CELL DEATH; CELL LINE, TUMOR; CITRIC ACID CYCLE; ENZYME INHIBITORS; FEMALE; GLYCOLYSIS; HUMANS; ISOTOPE LABELING; MICE; MICE, SCID; NAD; NEOPLASMS; NICOTINAMIDE PHOSPHORIBOSYLTRANSFERASE; PENTOSE PHOSPHATE PATHWAY; PIPERIDINES; SERINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84873291018     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.394510     Document Type: Article

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