Perspectives of the relationship between IL-7 and autoimmune diseases

Clinical Rheumatology

Volumn 32, Issue 12, 2013, Pages 1703-1709

  Wang, Xiao Song ^a   Li, Bao Zhu ^a   Hu, Lin Feng ^a   Wen, Peng Fei ^a   Zhang, Min ^a   Pan, Hai Feng ^a   Ye, Dong Qing ^a  

^a ANHUI MEDICAL UNIVERSITY   (China)

Author keywords

Autoimmune diseases; Interleukin 7; Interleukin 7 receptor; MS; RA; SLE; T1D

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 15; INTERLEUKIN 15 RECEPTOR ALPHA; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 2 RECEPTOR BETA; INTERLEUKIN 23; INTERLEUKIN 4; INTERLEUKIN 7; INTERLEUKIN 7 RECEPTOR; INTERLEUKIN 9; JANUS KINASE; JANUS KINASE 2; JANUS KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE TYK2; PROTEIN TYROSINE KINASE; RECOMBINANT INTERLEUKIN 7; STAT PROTEIN; STAT5 PROTEIN; THYMIC STROMAL LYMPHOPOIETIN;

ALLERGIC ENCEPHALOMYELITIS; AUTOIMMUNE DISEASE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CELL MATURATION; CHRONIC ARTHRITIS; FIBROBLAST; HUMAN; IMMUNE COMPLEX DEPOSITION; IMMUNOSUPPRESSIVE TREATMENT; INSULIN DEPENDENT DIABETES MELLITUS; INTRACELLULAR SIGNALING; MACROPHAGE; MAJOR HISTOCOMPATIBILITY COMPLEX; MEMORY T LYMPHOCYTE; MULTIPLE SCLEROSIS; NATURAL KILLER T CELL; NONHUMAN; PRE B LYMPHOCYTE; PRIORITY JOURNAL; REVIEW; RHEUMATOID ARTHRITIS; SLEDAI; STROMA CELL; SYSTEMIC LUPUS ERYTHEMATOSUS; THYMOCYTE;

ANIMALS; ARTHRITIS, RHEUMATOID; AUTOIMMUNE DISEASES; AUTOIMMUNITY; CYTOKINES; DIABETES MELLITUS, TYPE 1; HUMANS; INTERLEUKIN-7; LUPUS ERYTHEMATOSUS, SYSTEMIC; MICE; MULTIPLE SCLEROSIS; RECEPTORS, INTERLEUKIN-7; SIGNAL TRANSDUCTION;

EID: 84890435744     PISSN: 07703198     EISSN: 14349949     Source Type: Journal    
DOI: 10.1007/s10067-013-2360-x     Document Type: Review

References (69)

1. Bikker A, Hack CE, Lafeber FP, van Roon JA (2012) Interleukin-7: a key mediator in T cell-driven autoimmunity, inflammation, and tissue destruction. Curr Pharm Des 18(16):2347-2356
2. van Roon JA, Verweij MC, Wijk MW et al (2005) Increased intraarticular interleukin-7 in rheumatoid arthritis patients stimulates cell contact-dependent activation of CD4(+) T cells and macrophages. Arthritis Rheum 52(6):1700-1710
3. Harrison C (2012) Autoimmune disease: targeting IL-7 reverses type 1 diabetes. Nat Rev Drug Discov 11(8):599
4. Liu X, Leung S, Wang C et al (2010) Crucial role of interleukin-7 in T helper type 17 survival and expansion in autoimmune disease. Nat Med 16(2):191-197
5. Gregory SG, Schmidt S, Seth P et al (2007) Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis. Nat Genet 39(9):1083-1091
6. Badot V, Luijten RK, van Roon JA et al (2013) Serum soluble interleukin 7 receptor is strongly associated with lupus nephritis in patients with systemic lupus erythematosus. Ann Rheum Dis 72(3):453-456
7. Lundström W, Highfill S, Walsh ST et al (2013) Soluble IL7Rα potentiates IL-7 bioactivity and promotes autoimmunity. Proc Natl Acad Sci U S A 110(19):E1761-E1770
8. Pillai M, Torok-Storb B, Iwata M (2004) Expression and function of IL-7 receptors in marrow stromal cells. Leuk Lymphoma 45(12):2403-2408
9. McElroy CA, Dohm JA, Walsh ST (2009) Structural and biophysical studies of the human IL-7/IL-7Ralpha complex. Structure 17(1):54-65
10. Ceredig R, Rolink AG (2012) The key role of IL-7 in lymphopoiesis. Semin Immunol 24(3):159-164
11. Hong C, Luckey MA, Park J-H (2012) Intrathymic IL-7: the where, when, and why of IL-7 signaling during T cell development. Semin Immunol 24(3):151-158
12. Jiang Q, Huang J, Li WQ et al (2007) Role of the intracellular domain of IL-7 receptor in T cell development. J Immunol 178(1):228-234
13. Mazzucchelli R, Durum SK (2007) Interleukin-7 receptor expression: intelligent design. Nat Rev Immunol 7(2):144-154
14. Rose T, Pillet AH, Lavergne V et al (2010) Interleukin-7 compartmentalizes its receptor signaling complex to initiate CD4 T lymphocyte response. J Biol Chem 285(20):14898-14908
15. Benbernou N, Muegge K, Durum SK (2000) Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha. J Biol Chem 275(10):7060-7065
16. Quintas-Cardama A, Verstovsek S (2013) Molecular pathways: Jak/STAT pathway: mutations, inhibitors, and resistance. Clin Cancer Res 19(8):1933-1940
17. Palmer MJ, Mahajan VS, Trajman LC et al (2008) Interleukin-7 receptor signaling network: an integrated systems perspective. Cell Mol Immunol 5(2):79-89
18. Jiang Q, Li WQ, Aiello FB et al (2005) Cell biology of IL-7, a key lymphotrophin. Cytokine Growth Factor Rev 16(4-5):513-533
19. Ivashkiv LB, Hu X (2004) Signaling by STATs. Arthritis Res Ther 6(4):159-168
20. Corfe SA, Paige CJ (2012) The many roles of IL-7 in B cell development; mediator of survival, proliferation and differentiation. Semin Immunol 24(3):198-208
21. Smyth CM, Ginn SL, Deakin CT et al (2007) Limiting {gamma}c expression differentially affects signaling via the interleukin IL-7 and IL-15 receptors. Blood 110(1):91-98
22. Carrette F, Surh CD (2012) IL-7 signaling and CD127 receptor regulation in the control of T cell homeostasis. Semin Immunol 24(3):209-217
23. Boyman O, Ramsey C, Kim DM, Sprent J et al (2008) IL-7/anti-IL-7 mAb complexes restore T cell development and induce homeostatic T Cell expansion without lymphopenia. J Immunol 180(11):7265-7275
24. El-Kassar N, Flomerfelt FA, Choudhury B et al (2012) High levels of IL-7 cause dysregulation of thymocyte development. Int Immunol 24(10):661-671
25. Milne CD, Paige CJ (2006) IL-7: a key regulator of B lymphopoiesis. Semin Immunol 18(1):20-30
26. Akashi K, Kondo M, von Freeden-Jeffry U et al (1997) Bcl-2 rescues T lymphopoiesis in interleukin-7 receptor-deficient mice. Cell 89(7):1033-1041
27. Malin S, McManus S, Busslinger M (2010) STAT5 in B cell development and leukemia. Curr Opin Immunol 22(2):168-176
28. Holm AM, Aukrust P, Damås JK, Müller F et al (2005) Abnormal interleukin-7 function in common variable immunodeficiency. Blood 105(7):2887-2890
29. Lundstrom W, Fewkes NM, Mackall CL (2012) IL-7 in human health and disease. Semin Immunol 24(3):218-224
30. Todd JA, Walker NM, Cooper JD et al (2007) Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 39(7):857-864
31. Firestein GS (2003) Evolving concepts of rheumatoid arthritis. Nature 423(6937):356-361
32. Bartok B, Firestein GS (2010) Fibroblast-like synoviocytes: key effector cells in rheumatoid arthritis. Immunol Rev 233(1):233-255
33. Fry TJ, Mackall CL (2002) Interleukin-7: from bench to clinic. Blood 99(11):3892-3904
34. van Amelsfort JM, van Roon JA, Noordegraaf M et al (2007) Proinflammatory mediator-induced reversal of CD4+, CD25+ regulatory T cell-mediated suppression in rheumatoid arthritis. Arthritis Rheum 56(3):732-742
35. Churchman SM, Ponchel F (2008) Interleukin-7 in rheumatoid arthritis. Rheumatology (Oxford) 47(6):753-759
36. Natsumeda M, Nishiya K, Ota Z (1993) Stimulation by interleukin-7 of mononuclear cells in peripheral blood, synovial fluid and synovial tissue from patients with rheumatoid arthritis. Acta Med Okayama 47(6):391-397
37. Sawa S, Kamimura D, Jin GH et al (2006) Autoimmune arthritis associated with mutated interleukin (IL)-6 receptor gp130 is driven by STAT3/IL-7-dependent homeostatic proliferation of CD4+ T cells. J Exp Med 203(6):1459-1470
38. Harada S, Yamamura M, Okamoto H et al (1999) Production of interleukin-7 and interleukin-15 by fibroblast-like synoviocytes from patients with rheumatoid arthritis. Arthritis Rheum 42(7):1508-1516
39. van Roon JA, Glaudemans KA, Bijlsma JW et al (2003) Interleukin 7 stimulates tumour necrosis factor alpha and Th1 cytokine production in joints of patients with rheumatoid arthritis. Ann Rheum Dis 62(2):113-119
40. Pickens SR, Chamberlain ND, Volin MV et al (2011) Characterization of interleukin-7 and interleukin-7 receptor in the pathogenesis of rheumatoid arthritis. Arthritis Rheum 63(10):2884-2893
41. Rekha P, Conaghan PG, Paul E et al (2012) Progression to rheumatoid arthritis in early inflammatory arthritis is associated with low IL-7 serum levels. Ann Rheum Dis 72(6):1032-1036
42. Makino T, Fukushima S, Wakasugi S et al (2009) Decreased serum IL-7 levels in patients with systemic sclerosis. Clin Exp Rheumatol 27(3 Suppl 54):68-69
43. Kader HA, Tchernev VT, Satyaraj E et al (2005) Protein microarray analysis of disease activity in pediatric inflammatory bowel disease demonstrates elevated serum PLGF, IL-7, TGF-beta1, and IL-12p40 levels in Crohn's disease and ulcerative colitis patients in remission versus active disease. Am J Gastroenterol 100(2):414-423
44. Lee LF, Logronio K, Tu GH et al (2012) Anti-IL-7 receptor-α reverses established type 1 diabetes in nonobese diabetic mice by modulating effector T-cell function. Proc Natl Acad Sci U S A 109(31):12674-12679
45. Maahs DM, West NA, Lawrence JM et al (2010) Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am 39(3):481-497
46. Anderson MS, Bluestone JA (2005) The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 23:447-485
47. Bluestone JA, Herold K, Eisenbarth G (2010) Genetics, pathogenesis and clinical interventions in type 1 diabetes. Nature 464(7293):1293-1300
48. Lee LF, Axtell R, Tu GH et al (2011) IL-7 promotes T(H)1 development and serum IL-7 predicts clinical response to interferon-β in multiple sclerosis. Sci Transl Med 3(93):93ra68
49. Penaranda C, Kuswanto W, Hofmann J et al (2012) IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells. Proc Natl Acad Sci U S A 109(31):12668-12673
50. Keir ME, Liang SC, Guleria I et al (2006) Tissue expression of PD-L1 mediates peripheral T cell tolerance. J Exp Med 203(4):883-895
51. Hafler DA (2004) Multiple sclerosis. J Clin Invest 113(6):788-794
52. McFarlin DE, McFarland HF (1982) Multiple sclerosis (first of two parts). N Engl J Med 307(19):1183-1188
53. McFarlin DE, McFarland HF (1982) Multiple sclerosis (second of two parts). N Engl J Med 307(20):1246-1251
54. Fernald GH, Yeh RF, Hauser SL et al (2005) Mapping gene activity in complex disorders: Integration of expression and genomic scans for multiple sclerosis. J Neuroimmunol 167(1-2):157-169
55. Sospedra M, Martin R (2005) Immunology of multiple sclerosis. Annu Rev Immunol 23:683-747
56. Kreft KL, Verbraak E, Wierenga-Wolf AF et al (2012) Decreased systemic IL-7 and soluble IL-7Rα in multiple sclerosis patients. Genes Immun 13(7):587-592
57. Walline CC, Kanakasabai S, Bright JJ (2011) IL-7Rα confers susceptibility to experimental autoimmune encephalomyelitis. Genes Immun 12(1):1-14
58. Lock C, Hermans G, Pedotti R et al (2002) Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med 8(5):500-508
59. McGeachy MJ, Chen Y, Tato CM et al (2009) The interleukin 23 receptor is essential for the terminal differentiation of interleukin 17-producing effector T helper cells in vivo. Nat Immunol 10(3):314-324
60. Chen Y, Langrish CL, McKenzie B et al (2006) Anti-IL-23 therapy inhibits multiple inflammatory pathways and ameliorates autoimmune encephalomyelitis. J Clin Invest 116(5):1317-1326
61. Tiffin N, Adeyemo A, Okpechi I (2013) A diverse array of genetic factors contribute to the pathogenesis of systemic lupus erythematosus. Orphanet J Rare Dis 8(1):2
62. Tsokos GC (2011) Systemic lupus erythematosus. N Engl J Med 365(22):2110-2121
63. Pons-Estel GJ, Alarcón GS, Scofield L et al (2010) Understanding the epidemiology and progression of systemic lupus erythematosus. Semin Arthritis Rheum 39(4):257-268
64. Pan HF, Ye DQ, Li XP (2008) Type 17 T-helper cells might be a promising therapeutic target for systemic lupus erythematosus. Nat Clin Pract Rheumatol 4(7):352-353
65. Ohl K, Tenbrock K (2011) Inflammatory cytokines in systemic lupus erythematosus. J Biomed Biotechnol 2011:432595
66. Ambrosi A, Espinosa A, Wahren-Herlenius M (2012) IL-17: a new actor in IFN-driven systemic autoimmune diseases. Eur J Immunol 42(9):2274-2284
67. Yang Y, Xiao X, Li F et al (2012) Increased IL-7 expression in Vogt-Koyanagi-Harada disease. Invest Ophthalmol Vis Sci 53(2):1012-1017
68. Bikker A, Moret FM, Kruize AA et al (2012) IL-7 drives Th1 and Th17 cytokine production in patients with primary SS despite an increase in CD4 T cells lacking the IL-7Rα. Rheumatology (Oxford) 51(6):996-1005
69. Ben-David H, Sharabi A, Parameswaran R et al (2009) A tolerogenic peptide down-regulates mature B cells in bone marrow of lupus-afflicted mice by inhibition of interleukin-7, leading to apoptosis. Immunology 128(2):245-252