Abnormal interleukin-7 function in common variable immunodeficiency

Blood

Volumn 105, Issue 7, 2005, Pages 2887-2890

  Holm, Are Martin ^a   Aukrust, Pål ^b   Damås, Jan Kristian ^b   Müller, Fredrik ^b   Halvorsen, Bente ^b   Frøland, Stig S ^b  

^a OSLO UNIVERSITY HOSPITAL   (Norway)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CD8 ANTIGEN; CHEMOKINE RECEPTOR CCR7; GAMMA INTERFERON; IMMUNOGLOBULIN; INTERLEUKIN 7; TRANSFORMING GROWTH FACTOR BETA;

ADULT; AGED; APOPTOSIS; ARTICLE; BLOOD LEVEL; CELL PROLIFERATION; CLINICAL ARTICLE; COMMON VARIABLE IMMUNODEFICIENCY; CONTROLLED STUDY; CYTOKINE RELEASE; DISEASE SEVERITY; EFFECTOR CELL; FEMALE; GENE MUTATION; HOMEOSTASIS; HUMAN; HUMAN CELL; IMMUNE DEFICIENCY; IMMUNE RESPONSE; IN VITRO STUDY; LYMPHOCYTE; LYMPHOCYTOPENIA; MALE; MEMORY CELL; PRIORITY JOURNAL; RESPIRATORY TRACT INFECTION; T LYMPHOCYTE;

EID: 15944428532     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood-2004-06-2423     Document Type: Article

References (20)

1. Rosen FS, Eibl MM, Roifman CM, et al. Primary immunodeficiency diseases: report of an IUIS Scientific Committee: International Union of Immunological Societies. Clin Exp Immunol. 1999;118(suppl 1):1-28.
2. Cunningham-Rundles C, Bodian C. Common variable immunodeficiency: clinical and immunological features of 248 patients. Clin Immunol. 1999;92:34-48.
3. Fry TJ, Mackall CL. Interleukin-7: from bench to clinic. Blood. 2002;99:3892-3904.
4. Napolitano LA, Grant RM, Deeks SG, et al. Increased production of IL-7 accompanies HIV-1-mediated T-cell depletion: implications for T-cell homeostasis. Nat Med. 2001;7:73-79.
5. Bolotin E, Annett G, Parkman R, Weinberg K. Serum levels of IL-7 in bone marrow transplant recipients: relationship to clinical characteristics and lymphocyte count. Bone Marrow Transplant. 1999;23:783-788.
6. Fry TJ, Connick E, Falloon J, et al. A potential role for interleukin-7 in T-cell homeostasis. Blood. 2001;97:2983-2990.
7. Storek J, Gillespy T III, Lu H, et al. Interleukin-7 improves CD4 T-cell reconstitution after autologous CD34 cell transplantation in monkeys. Blood. 2003;101:4209-4218.
8. Roifman CM, Zhang J, Chitayat D, Sharfe N. A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. Blood. 2000;96:2803-2807.
9. Aandahl EM, Aukrust P, Skalhegg BS, et al. Protein kinase A type I antagonist restores immune responses of T cells from HIV-infected patients. FASEB J. 1998;12:855-862.
10. Holm AM, Aukrust P, Aandahl EM, et al. Impaired secretion of IL-10 by T cells from patients with common variable immunodeficiency-involvement of protein kinase a type I. J Immunol. 2003;170:5772-5777.
11. Holm AM, Sivertsen EA, Tunheim SH, et al. Gene expression analysis of peripheral T cells in a subgroup of common variable immunodeficiency shows predominance of CCR7 effector-memory T cells. Clin Exp Immunol. 2004;138:278-289.
12. Sallusto F, Lenig D, Forster R, Lipp M, Lanzavecchia A. Two subsets of memory T lymphocytes with distinct homing potentials and effector functions. Nature. 1999;401:708-712.
13. Tang J, Nuccie BL, Ritterman I, et al. TGF-beta down-regulates stromal IL-7 secretion and inhibits proliferation of human B cell precursors. J Immunol. 1997;159:117-125.
14. Fry TJ, Mackall CL Interleukin-7: master regulator of peripheral T-cell homeostasis? Trends Immunol. 2001;22:564-571.
15. Jaffe JS, Strober W, Sneller MC. Functional abnormalities of CD8+ T cells define a unique subset of patients with common variable immunodeficiency. Blood. 1993;82:192-201.
16. Grimbacher B, Hutloff A, Schlesier M, et al. Homozygous loss of ICOS is associated with adultonset common variable immunodeficiency. Nat Immunol. 2003;4:261-268.
17. North ME, Webster AD, Farrant J. Primary defect in CD8+ lymphocytes in the antibody deficiency disease (common variable immunodeficiency): abnormalities in intracellular production of interferon-gamma (IFN-gamma) in CD28+ ('cytotoxic') and CD28- ('suppressor') CD8+ subsets. Clin Exp Immunol. 1998;111:70-75.
18. Serrano D, Becker K, Cunningham-Rundles C, Mayer L. Characterization of the T cell receptor repertoire in patients with common variable immunodeficiency: oligocional expansion of CD8(+) T cells. Clin Immunol. 2000;97:248-258.
19. Bayry J, Lacroix-Desmazes S, Kazatchkine MD, et al. Common variable immunodeficiency is associated with defective functions of dendritic cells. Blood. 2004;104:2441-2443.
20. Scott-Taylor TH, Green MR, Eren E, Webster AD. Monocyte derived dendritic cell responses in common variable immunodeficiency. Clin Exp Immunol. 2004;138:484-490.