IL-7 receptor blockade reverses autoimmune diabetes by promoting inhibition of effector/memory T cells

Proceedings of the National Academy of Sciences of the United States of America

Volumn 109, Issue 31, 2012, Pages 12668-12673

  Penaranda, Cristina ^a   Kuswanto, Wilson ^a   Hofmann, Jerry ^a   Kenefeck, Rupert ^b   Narendran, Parth ^b   Walker, Lucy S K ^b   Bluestone, Jeffrey A ^a   Abbas, Abul K ^a   Dooms, Hans ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b UNIVERSITY DEPARTMENT OF MEDICINE   (United Kingdom)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Cytokines; Immune regulation; Type 1 diabetes

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 7 RECEPTOR ALPHA; MONOCLONAL ANTIBODY; PROGRAMMED DEATH 1 RECEPTOR;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOIMMUNE DISEASE; CELL CYCLE REGULATION; CONTROLLED STUDY; DIABETES MELLITUS; EFFECTOR CELL; FEMALE; GENE REPRESSION; GROWTH INHIBITION; IN VITRO STUDY; MEMORY T LYMPHOCYTE; MOUSE; NONHUMAN; NONOBESE DIABETIC MOUSE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BLOCKING; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE ACTIVATION;

ADOPTIVE TRANSFER; ANIMALS; ANTIGENS, DIFFERENTIATION; DIABETES MELLITUS, TYPE 1; FEMALE; IMMUNE TOLERANCE; IMMUNOLOGIC MEMORY; INTERFERON-GAMMA; INTERLEUKIN-7; LYMPHOCYTE ACTIVATION; MICE; MICE, INBRED NOD; RECEPTORS, INTERLEUKIN-7; SIGNAL TRANSDUCTION; T-LYMPHOCYTES;

ANIMALIA; MUS;

EID: 84864510487     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1203692109     Document Type: Article

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