메뉴 건너뛰기




Volumn 30, Issue 43, 2011, Pages 4410-4427

HAb18G/CD147 promotes epithelial-mesenchymal transition through TGF-β signaling and is transcriptionally regulated by Slug

Author keywords

CD147; epithelial mesenchymal transition; hepatocarcinogenesis; hepatocellular carcinoma; PI3K Akt; TGF b

Indexed keywords

AQUAPORIN; CD147 ANTIGEN; GLYCOGEN SYNTHASE KINASE 3BETA; LUCIFERASE; NERVE CELL ADHESION MOLECULE; PROTEIN KINASE B; TRANSCRIPTION FACTOR SLUG; TRANSFORMING GROWTH FACTOR BETA; UVOMORULIN; VIMENTIN;

EID: 80055051887     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2011.149     Document Type: Article
Times cited : (148)

References (40)
  • 1
    • 0034711307 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase function is required for transforming growth factor β-mediated epithelial to mesenchymal transition and cell migration
    • DOI 10.1074/jbc.M005912200
    • Bakin AV, Tomlinson AK, Bhowmick NA, Moses HL, Arteaga CL. (2000). Phosphatidylinositol 3-kinase function is required for transforming growth factor beta-mediated epithelial to mesenchymal transition and cell migration. J Biol Chem 275: 36803-36810. (Pubitemid 32002090)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.47 , pp. 36803-36810
    • Bakin, A.V.1    Tomlinson, A.K.2    Bhowmick, N.A.3    Moses, H.L.4    Arteaga, C.L.5
  • 2
    • 84864283714 scopus 로고    scopus 로고
    • Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition
    • Battaglia S, Benzoubir N, Nobilet S, Charneau P, Samuel D, Zignego AL et al. (2009). Liver cancer-derived hepatitis C virus core proteins shift TGF-beta responses from tumor suppression to epithelial-mesenchymal transition. PLoS One 4: e4355.
    • (2009) PLoS One , vol.4
    • Battaglia, S.1    Benzoubir, N.2    Nobilet, S.3    Charneau, P.4    Samuel, D.5    Zignego, A.L.6
  • 3
    • 0028959114 scopus 로고
    • Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers
    • Bedossa P, Peltier E, Terris B, Franco D, Poynard T. (1995). Transforming growth factor-beta 1 (TGF-beta 1) and TGF-beta 1 receptors in normal, cirrhotic, and neoplastic human livers. Hepatology 21: 760-766.
    • (1995) Hepatology , vol.21 , pp. 760-766
    • Bedossa, P.1    Peltier, E.2    Terris, B.3    Franco, D.4    Poynard, T.5
  • 4
    • 49649091622 scopus 로고    scopus 로고
    • Basigin-2 is a cell surface receptor for soluble basigin ligand
    • Belton Jr RJ, Chen L, Mesquita FS, Nowak RA. (2008). Basigin-2 is a cell surface receptor for soluble basigin ligand. J Biol Chem 283: 17805-17814.
    • (2008) J Biol Chem , vol.283 , pp. 17805-17814
    • Belton Jr., R.J.1    Chen, L.2    Mesquita, F.S.3    Nowak, R.A.4
  • 5
    • 33646251826 scopus 로고    scopus 로고
    • Targeting radioimmunotherapy of hepatocellular carcinoma with iodine ((131)I) metuximab injection: Clinical phase I/II trials
    • Chen ZN, Mi L, Xu J, Song F, Zhang Q, Zhang Z et al. (2006). Targeting radioimmunotherapy of hepatocellular carcinoma with iodine ((131)I) metuximab injection: clinical phase I/II trials. Int J Radiat Oncol Biol Phys 65: 435-444.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 435-444
    • Chen, Z.N.1    Mi, L.2    Xu, J.3    Song, F.4    Zhang, Q.5    Zhang, Z.6
  • 6
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-κB and the hepatic inflammation-fibrosis-cancer axis
    • DOI 10.1002/hep.21802
    • Elsharkawy AM, Mann DA. (2007). Nuclear factor-kappaB and the hepatic inflammation-fibrosis-cancer axis. Hepatology 46: 590-597. (Pubitemid 47344795)
    • (2007) Hepatology , vol.46 , Issue.2 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 7
    • 43949140575 scopus 로고    scopus 로고
    • Blocking transforming growth factor-beta up-regulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells
    • DOI 10.1002/hep.22201
    • Fransvea E, Angelotti U, Antonaci S, Giannelli G. (2008). Blocking transforming growth factor-beta upregulates E-cadherin and reduces migration and invasion of hepatocellular carcinoma cells. Hepatology 47: 1557-1566. (Pubitemid 351702739)
    • (2008) Hepatology , vol.47 , Issue.5 , pp. 1557-1566
    • Fransvea, E.1    Angelotti, U.2    Antonaci, S.3    Giannelli, G.4
  • 8
    • 19944414923 scopus 로고    scopus 로고
    • Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: Role in epithelio-stromal interactions and matrix metalloproteinase induction
    • Gabison EE, Mourah S, Steinfels E, Yan L, Hoang-Xuan T, Watsky MA et al. (2005). Differential expression of extracellular matrix metalloproteinase inducer (CD147) in normal and ulcerated corneas: role in epithelio-stromal interactions and matrix metalloproteinase induction. Am J Pathol 166: 209-219. (Pubitemid 40051673)
    • (2005) American Journal of Pathology , vol.166 , Issue.1 , pp. 209-219
    • Gabison, E.E.1    Mourah, S.2    Steinfels, E.3    Yan, L.4    Hoang-Xuan, T.5    Watsky, M.A.6    De Wever, B.7    Calvo, F.8    Mauviel, A.9    Menashi, S.10
  • 9
    • 27744527762 scopus 로고    scopus 로고
    • Laminin-5 with transforming growth factor-β1 induces epithelial to mesenchymal transition in hepatocellular carcinoma
    • DOI 10.1053/j.gastro.2005.09.055, PII S0016508505019980
    • Giannelli G, Bergamini C, Fransvea E, Sgarra C, Antonaci S. (2005). Laminin-5 with transforming growth factor-beta1 induces epithelial to mesenchymal transition in hepatocellular carcinoma. Gastroenterology 129: 1375-1383. (Pubitemid 41597379)
    • (2005) Gastroenterology , vol.129 , Issue.5 , pp. 1375-1383
    • Giannelli, G.1    Bergamini, C.2    Fransvea, E.3    Sgarra, C.4    Antonaci, S.5
  • 10
    • 65349164160 scopus 로고    scopus 로고
    • HAb18G/ CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 downregulation
    • Gou X, Ru Q, Zhang H, Chen Y, Li L, Yang H et al. (2009). HAb18G/ CD147 inhibits starvation-induced autophagy in human hepatoma cell SMMC7721 with an involvement of Beclin 1 downregulation. Cancer Sci 100: 837-843.
    • (2009) Cancer Sci , vol.100 , pp. 837-843
    • Gou, X.1    Ru, Q.2    Zhang, H.3    Chen, Y.4    Li, L.5    Yang, H.6
  • 11
    • 42049113189 scopus 로고    scopus 로고
    • Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing α-smooth muscle actin expression and collagen gel contraction: Implications in tissue remodeling
    • DOI 10.1096/fj.07-8748com
    • Huet E, Vallé e B, Szul D, Verrecchia F, Mourah S, Jester JV et al. (2008). Extracellular matrix metalloproteinase inducer/CD147 promotes myofibroblast differentiation by inducing alpha-smooth muscle actin expression and collagen gel contraction: implications in tissue remodeling. FASEB J 22: 1144-1154. (Pubitemid 351519969)
    • (2008) FASEB Journal , vol.22 , Issue.4 , pp. 1144-1154
    • Huet, E.1    Vallee, B.2    Szul, D.3    Verrecchia, F.4    Mourah, S.5    Jester, J.V.6    Hoang-Xuan, T.7    Menashi, S.8    Gabison, E.E.9
  • 12
    • 36048958229 scopus 로고    scopus 로고
    • CD147 immunoglobulin superfamily receptor function and role in pathology
    • DOI 10.1016/j.yexmp.2007.08.014, PII S0014480007001116
    • Iacono KT, Brown AL, Greene MI, Saouaf SJ. (2007). CD147 immunoglobulin superfamily receptor function and role in pathology. Exp Mol Pathol 83: 283-295. (Pubitemid 350087035)
    • (2007) Experimental and Molecular Pathology , vol.83 , Issue.3 , pp. 283-295
    • Iacono, K.T.1    Brown, A.L.2    Greene, M.I.3    Saouaf, S.J.4
  • 13
    • 0035861597 scopus 로고    scopus 로고
    • The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells
    • Jiang JL, Zhou Q, Yu MK, Ho LS, Chen ZN, Chan HC. (2001). The involvement of HAb18G/CD147 in regulation of store-operated calcium entry and metastasis of human hepatoma cells. J Biol Chem 276: 46870-46877.
    • (2001) J Biol Chem , vol.276 , pp. 46870-46877
    • Jiang, J.L.1    Zhou, Q.2    Yu, M.K.3    Ho, L.S.4    Chen, Z.N.5    Chan, H.C.6
  • 14
    • 33846456632 scopus 로고    scopus 로고
    • Transcriptional cooperation between the transforming growth factor-β and Wnt pathways in mammary and intestinal tumorigenesis
    • DOI 10.1158/0008-5472.CAN-06-2559
    • Labbé E, Lock L, Letamendia A, Gorska AE, Gryfe R, Gallinger S et al. (2007). Transcriptional cooperation between the transforming growth factor-beta and Wnt pathways in mammary and intestinal tumorigenesis. Cancer Res 67: 75-84. (Pubitemid 46142761)
    • (2007) Cancer Research , vol.67 , Issue.1 , pp. 75-84
    • Labbe, E.1    Lock, L.2    Letamendia, A.3    Gorska, A.E.4    Gryfe, R.5    Gallinger, S.6    Moses, H.L.7    Attisano, L.8
  • 15
    • 63849191286 scopus 로고    scopus 로고
    • Modulation of TGF-beta signaling during progression of chronic liver diseases
    • Matsuzaki K. (2009). Modulation of TGF-beta signaling during progression of chronic liver diseases. Front Biosci 14: 2923-2934.
    • (2009) Front Biosci , vol.14 , pp. 2923-2934
    • Matsuzaki, K.1
  • 16
    • 65449159717 scopus 로고    scopus 로고
    • Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B
    • Murata M, Matsuzaki K, Yoshida K, Sekimoto G, Tahashi Y, Mori S et al. (2009). Hepatitis B virus X protein shifts human hepatic transforming growth factor (TGF)-beta signaling from tumor suppression to oncogenesis in early chronic hepatitis B. Hepatology 49: 1203-1217.
    • (2009) Hepatology , vol.49 , pp. 1203-1217
    • Murata, M.1    Matsuzaki, K.2    Yoshida, K.3    Sekimoto, G.4    Tahashi, Y.5    Mori, S.6
  • 17
    • 65349118157 scopus 로고    scopus 로고
    • HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection
    • Li Y, Xu J, Chen L, Zhong WD, Zhang Z, Mi L et al. (2009). HAb18G (CD147), a cancer-associated biomarker and its role in cancer detection. Histopathology 54: 677-687.
    • (2009) Histopathology , vol.54 , pp. 677-687
    • Li, Y.1    Xu, J.2    Chen, L.3    Zhong, W.D.4    Zhang, Z.5    Mi, L.6
  • 18
    • 78649327037 scopus 로고    scopus 로고
    • Expression of HAb18G is associated with tumor progression and prognosis of breast carcinoma
    • Liu F, Cui L, Zhang Y, Chen L, Wang Y, Fan Y et al. (2010). Expression of HAb18G is associated with tumor progression and prognosis of breast carcinoma. Breast Cancer Res Treat 124: 677-688.
    • (2010) Breast Cancer Res Treat , vol.124 , pp. 677-688
    • Liu, F.1    Cui, L.2    Zhang, Y.3    Chen, L.4    Wang, Y.5    Fan, Y.6
  • 19
    • 51349133312 scopus 로고    scopus 로고
    • Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways
    • Nitta T, Kim JS, Mohuczy D, Behrns KE. (2008). Murine cirrhosis induces hepatocyte epithelial mesenchymal transition and alterations in survival signaling pathways. Hepatology 48: 909-919.
    • (2008) Hepatology , vol.48 , pp. 909-919
    • Nitta, T.1    Kim, J.S.2    Mohuczy, D.3    Behrns, K.E.4
  • 20
    • 34249289041 scopus 로고    scopus 로고
    • Snail, ZEB and bHLH factors in tumour progression: An alliance against the epithelial phenotype?
    • DOI 10.1038/nrc2131, PII NRC2131
    • Peinado H, Olmeda D, Cano A. (2007). Snail1, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype? Nat Rev Cancer 7: 415-428. (Pubitemid 46809165)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.6 , pp. 415-428
    • Peinado, H.1    Olmeda, D.2    Cano, A.3
  • 21
    • 77954951632 scopus 로고    scopus 로고
    • EMMPRIN regulates the canonical Wnt/betacatenin signaling pathway, a potential role in accelerating lung tumorigenesis
    • Sidhu SS, Nawroth R, Retz M, Lemjabbar-Alaoui H, Dasari V, Basbaum C. (2010). EMMPRIN regulates the canonical Wnt/betacatenin signaling pathway, a potential role in accelerating lung tumorigenesis. Oncogene 29: 4145-4156.
    • (2010) Oncogene , vol.29 , pp. 4145-4156
    • Sidhu, S.S.1    Nawroth, R.2    Retz, M.3    Lemjabbar-Alaoui, H.4    Dasari, V.5    Basbaum, C.6
  • 23
    • 72849130207 scopus 로고    scopus 로고
    • The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells
    • Song LB, Li J, Liao WT, Feng Y, Yu CP, Hu LJ et al. (2009). The polycomb group protein Bmi-1 represses the tumor suppressor PTEN and induces epithelial-mesenchymal transition in human nasopharyngeal epithelial cells. J Clin Invest 119: 3626-3636.
    • (2009) J Clin Invest , vol.119 , pp. 3626-3636
    • Song, L.B.1    Li, J.2    Liao, W.T.3    Feng, Y.4    Yu, C.P.5    Hu, L.J.6
  • 24
    • 52549106580 scopus 로고    scopus 로고
    • Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways
    • Tang J, Wu YM, Zhao P, Yang XM, Jiang JL, Chen ZN. (2008). Overexpression of HAb18G/CD147 promotes invasion and metastasis via alpha3beta1 integrin mediated FAK-paxillin and FAK-PI3K-Ca2+ pathways. Cell Mol Life Sci 65: 2933-2942.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2933-2942
    • Tang, J.1    Wu, Y.M.2    Zhao, P.3    Yang, X.M.4    Jiang, J.L.5    Chen, Z.N.6
  • 26
    • 70450198396 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transitions in development and disease
    • Thiery JP, Acloque H, Huang RY, (2009). Epithelial-mesenchymal transitions in development and disease. Cell 139: 871-890.
    • (2009) Cell , vol.139 , pp. 871-890
    • Thiery, J.P.1    Acloque, H.2    Huang, R.Y.3    Nieto, M.A.4
  • 27
    • 57749114754 scopus 로고    scopus 로고
    • HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition
    • Thuault S, Tan EJ, Peinado H, Cano A, Heldin CH, Moustakas A. (2008). HMGA2 and Smads co-regulate SNAIL1 expression during induction of epithelial-to-mesenchymal transition. J Biol Chem 283: 33437-33446.
    • (2008) J Biol Chem , vol.283 , pp. 33437-33446
    • Thuault, S.1    Tan, E.J.2    Peinado, H.3    Cano, A.4    Heldin, C.H.5    Moustakas, A.6
  • 28
    • 0030961335 scopus 로고    scopus 로고
    • Elevated urinary transforming growth factor-β1 level as a tumour marker and predictor of poor survival in cirrhotic hepatocellular carcinoma
    • Tsai JF, Jeng JE, Chuang LY, Yang ML, Ho MS, Chang WY et al. (1997). Elevated urinary transforming growth factor-beta1 level as a tumour marker and predictor of poor survival in cirrhotic hepatocellular carcinoma. Br J Cancer 76: 244-250. (Pubitemid 27279666)
    • (1997) British Journal of Cancer , vol.76 , Issue.2 , pp. 244-250
    • Tsai, J.F.1    Jeng, J.E.2    Chuang, L.Y.3    Yang, M.L.4    Ho, M.S.5    Chang, W.Y.6    Hsieh, M.Y.7    Lin, Z.Y.8    Tsai, J.H.9
  • 29
    • 0344406127 scopus 로고    scopus 로고
    • The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor beta in fetal rat hepatocytes
    • Valdé s F, Alvarez AM, Locascio A, Vega S, Herrera B, Ferná ndez M et al. (2002). The epithelial mesenchymal transition confers resistance to the apoptotic effects of transforming growth factor beta in fetal rat hepatocytes. Mol Cancer Res 1: 68-78.
    • (2002) Mol Cancer Res , vol.1 , pp. 68-78
    • Valdé, S.F.1    Alvarez, A.M.2    Locascio, A.3    Vega, S.4    Herrera, B.5    Ferná Ndez, M.6
  • 32
    • 68249092353 scopus 로고    scopus 로고
    • A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition
    • Vincent T, Neve EP, Johnson JR, Kukalev A, Rojo F, Albanell J et al. (2009). A SNAIL1-SMAD3/4 transcriptional repressor complex promotes TGF-beta mediated epithelial-mesenchymal transition. Nat Cell Biol 11: 943-950.
    • (2009) Nat Cell Biol , vol.11 , pp. 943-950
    • Vincent, T.1    Neve, E.P.2    Johnson, J.R.3    Kukalev, A.4    Rojo, F.5    Albanell, J.6
  • 33
    • 59449090107 scopus 로고    scopus 로고
    • TGF-beta-induced epithelial to mesenchymal transition
    • Xu J, Lamouille S, Derynck R. (2009). TGF-beta-induced epithelial to mesenchymal transition. Cell Res 19: 156-172.
    • (2009) Cell Res , vol.19 , pp. 156-172
    • Xu, J.1    Lamouille, S.2    Derynck, R.3
  • 36
    • 35548929009 scopus 로고    scopus 로고
    • Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes
    • DOI 10.1002/ajh.21030
    • Yan L, Han Y, Wang J, Liu J, Hong L, Fan D. (2007). Peripheral blood monocytes from patients with HBV related decompensated liver cirrhosis can differentiate into functional hepatocytes. Am J Hematol 82: 949-954. (Pubitemid 350004384)
    • (2007) American Journal of Hematology , vol.82 , Issue.11 , pp. 949-954
    • Yan, L.1    Han, Y.2    Wang, J.3    Liu, J.4    Hong, L.5    Fan, D.6
  • 38
    • 33744801153 scopus 로고    scopus 로고
    • Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2
    • DOI 10.1016/j.ccr.2006.04.025, PII S1535610806001486
    • Yang YA, Zhang GM, Feigenbaum L, Zhang YE. (2006). Smad3 reduces susceptibility to hepatocarcinoma by sensitizing hepatocytes to apoptosis through downregulation of Bcl-2. Cancer Cell 9: 445-457. (Pubitemid 43832193)
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 445-457
    • Yang, Y.-A.1    Zhang, G.-M.2    Feigenbaum, L.3    Zhang, Y.E.4
  • 39
    • 15444372825 scopus 로고    scopus 로고
    • Type I transforming growth factor β receptor binds to and activates phosphatidylinositol 3-kinase
    • DOI 10.1074/jbc.M413223200
    • Yi JY, Shin I, Arteaga CL. (2005). Type I transforming growth factor beta receptor binds to and activates phosphatidylinositol 3-kinase. J Biol Chem 280: 10870-10876. (Pubitemid 40395952)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.11 , pp. 10870-10876
    • Jae, Y.Y.1    Shin, I.2    Arteaga, C.L.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.