-
1
-
-
34248136828
-
Inflammatory bowel disease: Cause and immunobiology
-
Baumgart DC, Carding SR,. Inflammatory bowel disease: cause and immunobiology. Lancet. 2007; 369: 1627-1640.
-
(2007)
Lancet.
, vol.369
, pp. 1627-1640
-
-
Baumgart, D.C.1
Carding, S.R.2
-
2
-
-
77957238924
-
Inflammatory bowel disease: Established and evolving considerations on its etiopathogenesis and therapy
-
Schirbel A, Fiocchi C,. Inflammatory bowel disease: established and evolving considerations on its etiopathogenesis and therapy. J Dig Dis. 2010; 11: 266-276.
-
(2010)
J Dig Dis.
, vol.11
, pp. 266-276
-
-
Schirbel, A.1
Fiocchi, C.2
-
3
-
-
34249933089
-
Altered permeability in inflammatory bowel disease: Pathophysiology and clinical implications
-
Mankertz J, Schulzke JD,. Altered permeability in inflammatory bowel disease: pathophysiology and clinical implications. Curr Opin Gastroenterol. 2007; 23: 379-383.
-
(2007)
Curr Opin Gastroenterol.
, vol.23
, pp. 379-383
-
-
Mankertz, J.1
Schulzke, J.D.2
-
4
-
-
0032958705
-
Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis
-
Schmitz H, Barmeyer C, Fromm M, et al. Altered tight junction structure contributes to the impaired epithelial barrier function in ulcerative colitis. Gastroenterology. 1999; 116: 301-309.
-
(1999)
Gastroenterology
, vol.116
, pp. 301-309
-
-
Schmitz, H.1
Barmeyer, C.2
Fromm, M.3
-
5
-
-
67649784378
-
Intestinal fibrosis in inflammatory bowel disease: Progress in basic and clinical science
-
Rieder F, Fiocchi C,. Intestinal fibrosis in inflammatory bowel disease: progress in basic and clinical science. Curr Opin Gastroenterol. 2008; 24: 462-468.
-
(2008)
Curr Opin Gastroenterol.
, vol.24
, pp. 462-468
-
-
Rieder, F.1
Fiocchi, C.2
-
6
-
-
28844473957
-
Infliximab for induction and maintenance therapy for ulcerative colitis
-
Rutgeerts P, Sandborn WJ, Feagan BG, et al. Infliximab for induction and maintenance therapy for ulcerative colitis. N Engl J Med. 2005; 353: 2462-2476.
-
(2005)
N Engl J Med.
, vol.353
, pp. 2462-2476
-
-
Rutgeerts, P.1
Sandborn, W.J.2
Feagan, B.G.3
-
7
-
-
73949159228
-
Importance of mucosal healing in ulcerative colitis
-
Lichtenstein GR, Rutgeerts P,. Importance of mucosal healing in ulcerative colitis. Inflamm Bowel Dis. 2010; 16: 338-346.
-
(2010)
Inflamm Bowel Dis.
, vol.16
, pp. 338-346
-
-
Lichtenstein, G.R.1
Rutgeerts, P.2
-
8
-
-
0036229932
-
Binding and functional comparisons of two types of tumor necrosis factor antagonists
-
Scallon B, Cai A, Solowski N, et al. Binding and functional comparisons of two types of tumor necrosis factor antagonists. J Pharmacol Exp Ther. 2002: 301: 418-426.
-
(2002)
J Pharmacol Exp Ther.
, vol.301
, pp. 418-426
-
-
Scallon, B.1
Cai, A.2
Solowski, N.3
-
9
-
-
0036151047
-
Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease
-
ten Hove T, van Montfrans C, Peppelenbosch MP, et al. Infliximab treatment induces apoptosis of lamina propria T lymphocytes in Crohn's disease. Gut. 2002; 50: 206-211.
-
(2002)
Gut.
, vol.50
, pp. 206-211
-
-
Ten Hove, T.1
Van Montfrans, C.2
Peppelenbosch, M.P.3
-
10
-
-
0032848210
-
Review article: Targeting TNFα as a key cytokine in the inflammatory processes of Crohn's diseasethe mechanisms of action of infliximab
-
van Deventer SJ,. Review article: targeting TNFα as a key cytokine in the inflammatory processes of Crohn's diseasethe mechanisms of action of infliximab. Aliment Pharmacol Ther. 1999; 13: 3-8.
-
(1999)
Aliment Pharmacol Ther.
, vol.13
, pp. 3-8
-
-
Van Deventer, S.J.1
-
11
-
-
79960041812
-
Gene expression profiling and response signatures associated with differential responses to infliximab treatment in ulcerative colitis
-
Toedter G, Li K, Marano C, et al. Gene expression profiling and response signatures associated with differential responses to infliximab treatment in ulcerative colitis. Am J Gastroenterol. 2011; 106: 1272-1280.
-
(2011)
Am J Gastroenterol.
, vol.106
, pp. 1272-1280
-
-
Toedter, G.1
Li, K.2
Marano, C.3
-
12
-
-
0036678630
-
Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease
-
Suenaert P, Bulteel V, Lemmens L, et al. Anti-tumor necrosis factor treatment restores the gut barrier in Crohn's disease. Am J Gastroenterol. 2002; 97: 2000-2004.
-
(2002)
Am J Gastroenterol.
, vol.97
, pp. 2000-2004
-
-
Suenaert, P.1
Bulteel, V.2
Lemmens, L.3
-
13
-
-
0037336331
-
Open source software for the analysis of microarray data
-
Dudoit S, Gentleman RC, Quackenbush J,. Open source software for the analysis of microarray data. Biotechniques. 2003;(Suppl): 45-51.
-
(2003)
Biotechniques.
, Issue.SUPPL.
, pp. 45-51
-
-
Dudoit, S.1
Gentleman, R.C.2
Quackenbush, J.3
-
14
-
-
63549094179
-
Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo
-
Smith JJ, Kenney RD, Gagne DJ, et al. Small molecule activators of SIRT1 replicate signaling pathways triggered by calorie restriction in vivo. BMC Sys Biol. 2009; 3: 31.
-
(2009)
BMC Sys Biol.
, vol.3
, pp. 31
-
-
Smith, J.J.1
Kenney, R.D.2
Gagne, D.J.3
-
15
-
-
77954181353
-
Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693
-
Kumar R, Blakemore SJ, Ellis CE, et al. Causal reasoning identifies mechanisms of sensitivity for a novel AKT kinase inhibitor, GSK690693. BMC Genomics. 2010; 11: 419.
-
(2010)
BMC Genomics.
, vol.11
, pp. 419
-
-
Kumar, R.1
Blakemore, S.J.2
Ellis, C.E.3
-
16
-
-
67249152713
-
Epithelial tight junctions in intestinal inflammation
-
Schulzke JD, Ploeger S, Amasheh M, et al. Epithelial tight junctions in intestinal inflammation. Ann N Y Acad Sci. 2009; 1165: 294-300.
-
(2009)
Ann N y Acad Sci.
, vol.1165
, pp. 294-300
-
-
Schulzke, J.D.1
Ploeger, S.2
Amasheh, M.3
-
17
-
-
40049097843
-
Role of the intestinal barrier in inflammatory bowel disease
-
Laukoetter MG, Nava P, Nusrat A,. Role of the intestinal barrier in inflammatory bowel disease. World J Gastroenterol. 2008; 14: 401-407.
-
(2008)
World J Gastroenterol.
, vol.14
, pp. 401-407
-
-
Laukoetter, M.G.1
Nava, P.2
Nusrat, A.3
-
18
-
-
2142813761
-
A porous defense: The leaky epithelial barrier in intestinal disease
-
Clayburgh DR, Shen L, Turner JR,. A porous defense: the leaky epithelial barrier in intestinal disease. Lab Invest. 2004; 84: 282-291.
-
(2004)
Lab Invest.
, vol.84
, pp. 282-291
-
-
Clayburgh, D.R.1
Shen, L.2
Turner, J.R.3
-
19
-
-
53049091561
-
A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease
-
Sandborn WJ, Feagan BG, Fedorak RN, et al. A randomized trial of Ustekinumab, a human interleukin-12/23 monoclonal antibody, in patients with moderate-to-severe Crohn's disease. Gastroenterology. 2008; 135: 1130-1141.
-
(2008)
Gastroenterology
, vol.135
, pp. 1130-1141
-
-
Sandborn, W.J.1
Feagan, B.G.2
Fedorak, R.N.3
-
20
-
-
82955248086
-
A Crohn's disease patient who does not respond to infliximab: What is next?
-
[Epub ahead of print]
-
Maharshak N, Plevy SE,. A Crohn's disease patient who does not respond to infliximab: what is next? Clin Gastroenterol Hepatol. 2011 [Epub ahead of print].
-
(2011)
Clin Gastroenterol Hepatol.
-
-
Maharshak, N.1
Plevy, S.E.2
-
21
-
-
0037115724
-
Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells
-
Amasheh S, Meiri N, Gitter AH, et al. Claudin-2 expression induces cation-selective channels in tight junctions of epithelial cells. J Cell Sci. 2002; 115: 4969-4976.
-
(2002)
J Cell Sci.
, vol.115
, pp. 4969-4976
-
-
Amasheh, S.1
Meiri, N.2
Gitter, A.H.3
-
22
-
-
52649123158
-
Claudin-1 and claudin-2 expression are elevated in inflammatory bowel disease and may contribute to early neoplastic transformation
-
Weber CR, Nalle SC, Tretiakova M, et al. Claudin-1 and claudin-2 expression are elevated in inflammatory bowel disease and may contribute to early neoplastic transformation Lab Invest. 2008; 88: 1110-1120.
-
(2008)
Lab Invest.
, vol.88
, pp. 1110-1120
-
-
Weber, C.R.1
Nalle, S.C.2
Tretiakova, M.3
-
23
-
-
33845995125
-
Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease
-
Zeissig S, Burgel N, Gunzel D, et al. Changes in expression and distribution of claudin 2, 5 and 8 lead to discontinuous tight junctions and barrier dysfunction in active Crohn's disease. Gut. 2007; 56: 61-72.
-
(2007)
Gut.
, vol.56
, pp. 61-72
-
-
Zeissig, S.1
Burgel, N.2
Gunzel, D.3
-
24
-
-
0031454617
-
Endostatin: An endogenous inhibitor of angiogenesis and tumor growth
-
O'Reilly MS, Boehm T, Shing Y, et al. Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell. 1997; 88: 277-285.
-
(1997)
Cell.
, vol.88
, pp. 277-285
-
-
O'Reilly, M.S.1
Boehm, T.2
Shing, Y.3
-
25
-
-
33749058959
-
Altered angiogenic balance in ulcerative colitis: A key to impaired healing?
-
Sandor Z, Deng XM, Khomenko T, et al. Altered angiogenic balance in ulcerative colitis: a key to impaired healing? Biochem Biophys Res Commun. 2006; 350: 147-150.
-
(2006)
Biochem Biophys Res Commun.
, vol.350
, pp. 147-150
-
-
Sandor, Z.1
Deng, X.M.2
Khomenko, T.3
-
26
-
-
71449091695
-
Correlation of plasma MMP-1 and TIMP-1 levels and the colonic mucosa expressions in patients with ulcerative colitis
-
Wang YD, Tan XY, Zhang K,. Correlation of plasma MMP-1 and TIMP-1 levels and the colonic mucosa expressions in patients with ulcerative colitis. Mediators Inflamm. 2009; 2009: 275072.
-
(2009)
Mediators Inflamm.
, vol.2009
, pp. 275072
-
-
Wang, Y.D.1
Tan, X.Y.2
Zhang, K.3
-
27
-
-
0033933804
-
Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease
-
von Lampe B, Barthel B, Coupland SE, et al. Differential expression of matrix metalloproteinases and their tissue inhibitors in colon mucosa of patients with inflammatory bowel disease. Gut. 2000; 47: 63-73.
-
(2000)
Gut.
, vol.47
, pp. 63-73
-
-
Von Lampe, B.1
Barthel, B.2
Coupland, S.E.3
-
28
-
-
13244287807
-
Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase
-
Wang FQ, So J, Reierstad S, et al. Matrilysin (MMP-7) promotes invasion of ovarian cancer cells by activation of progelatinase. Int J Cancer. 2005; 114: 19-31.
-
(2005)
Int J Cancer.
, vol.114
, pp. 19-31
-
-
Wang, F.Q.1
So, J.2
Reierstad, S.3
-
29
-
-
0032079433
-
Activation of gelatinase-tissue-inhibitors-of-metalloproteinase complexes by matrilysin
-
von Bredow DC, Cress AE, Howard EW, et al. Activation of gelatinase-tissue-inhibitors-of-metalloproteinase complexes by matrilysin. Biochem J. 1998; 331 (Pt 3): 965-972.
-
(1998)
Biochem J.
, vol.331
, Issue.PART 3
, pp. 965-972
-
-
Von Bredow, D.C.1
Cress, A.E.2
Howard, E.W.3
-
30
-
-
8844222024
-
Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing
-
Salmela MT, Pender SL, Karjalainen-Lindsberg ML, et al. Collagenase-1 (MMP-1), matrilysin-1 (MMP-7), and stromelysin-2 (MMP-10) are expressed by migrating enterocytes during intestinal wound healing. Scand J Gastroenterol. 2004; 39: 1095-1104.
-
(2004)
Scand J Gastroenterol.
, vol.39
, pp. 1095-1104
-
-
Salmela, M.T.1
Pender, S.L.2
Karjalainen-Lindsberg, M.L.3
-
31
-
-
0038529391
-
The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis
-
Matsuno K, Adachi Y, Yamamoto H, et al. The expression of matrix metalloproteinase matrilysin indicates the degree of inflammation in ulcerative colitis. J Gastroenterol. 2003; 38: 348-354.
-
(2003)
J Gastroenterol.
, vol.38
, pp. 348-354
-
-
Matsuno, K.1
Adachi, Y.2
Yamamoto, H.3
-
32
-
-
0035971090
-
Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury
-
Lohi J, Wilson CL, Roby JD, et al. Epilysin, a novel human matrix metalloproteinase (MMP-28) expressed in testis and keratinocytes and in response to injury. J Biol Chem. 2001; 276: 10134-10144.
-
(2001)
J Biol Chem.
, vol.276
, pp. 10134-10144
-
-
Lohi, J.1
Wilson, C.L.2
Roby, J.D.3
-
33
-
-
0036424303
-
Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair
-
Saarialho-Kere U, Kerkela E, Jahkola T, et al. Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. J Invest Dermatol. 2002; 119: 14-21.
-
(2002)
J Invest Dermatol.
, vol.119
, pp. 14-21
-
-
Saarialho-Kere, U.1
Kerkela, E.2
Jahkola, T.3
-
34
-
-
54049130859
-
Epilysin (MMP-28) structure, expression and potential functions
-
Illman SA, Lohi J, Keski-Oja J,. Epilysin (MMP-28) structure, expression and potential functions. Exp Dermatol. 2008; 17: 897-907.
-
(2008)
Exp Dermatol.
, vol.17
, pp. 897-907
-
-
Illman, S.A.1
Lohi, J.2
Keski-Oja, J.3
-
35
-
-
49249139476
-
Autoregulation of Th1-mediated inflammation by twist1
-
Niesner U, Albrecht I, Janke M, et al. Autoregulation of Th1-mediated inflammation by twist1. J Exp Med. 2008; 205: 1889-1901.
-
(2008)
J Exp Med.
, vol.205
, pp. 1889-1901
-
-
Niesner, U.1
Albrecht, I.2
Janke, M.3
-
36
-
-
33644981348
-
Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier
-
Ye D, Ma I, Ma TY,. Molecular mechanism of tumor necrosis factor-alpha modulation of intestinal epithelial tight junction barrier. Am J Physiol Gastrointest Liver Physiol. 2006; 290: G496-G504.
-
(2006)
Am J Physiol Gastrointest Liver Physiol.
, vol.290
-
-
Ye, D.1
Ma, I.2
Ma, T.Y.3
-
37
-
-
23244455992
-
Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution
-
Heller F, Florian P, Bojarski C, et al. Interleukin-13 is the key effector Th2 cytokine in ulcerative colitis that affects epithelial tight junctions, apoptosis, and cell restitution. Gastroenterology. 2005; 129: 550-564.
-
(2005)
Gastroenterology
, vol.129
, pp. 550-564
-
-
Heller, F.1
Florian, P.2
Bojarski, C.3
-
38
-
-
0024553788
-
Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers
-
Madara JL, Stafford J,. Interferon-γ directly affects barrier function of cultured intestinal epithelial monolayers. J Clin Invest. 1989; 83: 724-727.
-
(1989)
J Clin Invest.
, vol.83
, pp. 724-727
-
-
Madara, J.L.1
Stafford, J.2
-
39
-
-
0037018761
-
Maintenance infliximab for Crohn's disease: The ACCENT i randomized trial
-
Hanauer SB, Feagan BG, Lichtenstein GR, et al. Maintenance infliximab for Crohn's disease: the ACCENT I randomized trial. Lancet. 2002; 359: 1541-1549.
-
(2002)
Lancet.
, vol.359
, pp. 1541-1549
-
-
Hanauer, S.B.1
Feagan, B.G.2
Lichtenstein, G.R.3
|