Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats

Digestive Diseases and Sciences

Volumn 56, Issue 3, 2011, Pages 715-720

  Tahan, Gulgun ^a,b   Gramignoli, Roberto ^c   Marongiu, Fabio ^c   Aktolga, Serdal ^b   Cetinkaya, Ali ^d   Tahan, Veysel ^c   Dorko, Kenneth ^c  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b MARMARA UNIVERSITY   (Turkey)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d ISTANBUL UNIVERSITY   (Turkey)

Author keywords

Cytokine; Inflammatory bowel disease; Melatonin; Oxidative stress; Tumor necrosis factor; Ulcerative colitis

Indexed keywords

ACETIC ACID; GLUTATHIONE; INTERLEUKIN 1BETA; INTERLEUKIN 6; MALONALDEHYDE; MELATONIN; MYELOPEROXIDASE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICLE; COLON INJURY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME BLOOD LEVEL; FEMALE; HISTOPATHOLOGY; MALE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RAT; TISSUE HOMOGENATE; TREATMENT DURATION; ULCERATIVE COLITIS;

ACETIC ACID; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIOXIDANTS; COLITIS, ULCERATIVE; COLON; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; INTESTINAL MUCOSA; MALE; MELATONIN; RATS; RATS, WISTAR; TREATMENT OUTCOME;

EID: 79952446269     PISSN: 01632116     EISSN: None     Source Type: Journal    
DOI: 10.1007/s10620-010-1364-5     Document Type: Article

References (32)

1. L Lih-Brody SR Powell KP Collier GM Reddy R Cerchia E Kahn, et al. 1996 Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease Dig Dis Sci 41 2078 2086 1:CAS:528:DyaK28XntVSisLw%3D 10.1007/BF02093613 8888724 (Pubitemid 26366811)
2. A Cetinkaya E Bulbuloglu B Kantarceken H Ciralik EB Kurutas MA Buyukbese, et al. 2006 Effects of L-carnitine on oxidant/antioxidant status in acetic acid-induced colitis Dig Dis Sci 51 488 494 1:CAS:528:DC%2BD28XjsFyjtrk%3D 10.1007/s10620-006-3160-9 16614957
3. A Cetinkaya E Bulbuloglu EB Kurutas H Ciralik B Kantarceken MA Buyukbese 2005 Beneficial effects of N-acetylcysteineon acetic acid-induced colitis in rats Tohoku J Exp 206 131 139 1:CAS:528:DC%2BD2MXkvVemsrs%3D 10.1620/tjem.206.131 (Pubitemid 40895042)
4. TR Koch LX Yuan SJ Stryker P Ratliff GL Telford EC Opara 2000 Total antioxidant capacity of colon in patients with chronic ulcerative colitis Dig Dis Sci 45 1814 1819 1:CAS:528:DC%2BD3cXnvV2ls7k%3D 10.1023/A:1005517824877 11052325
5. GD Buffinton WF Doe 1995 Depleted mucosal antioxidant defenses in inflammatory bowel disease Free Radic Bio Med 19 911 918 1:CAS:528: DyaK2MXptVGjur8%3D 10.1016/0891-5849(95)94362-H
6. GW Burton A Joyce KU Ingold 1982 First proof that melatonin is major lipid-soluble, chain-breaking antioxidant in human blood plasma Lancet 2 327 1:CAS:528:DyaL3sXivFGm 10.1016/S0140-6736(82)90293-8 6124736 (Pubitemid 12089629)
7. V Tahan R Ozaras B Canbakan H Uzun S Aydin B Yildirim, et al. 2004 Melatonin reduces dimethylnitrosamine-induced liver fibrosis in rats J Pineal Res 37 78 84 1:CAS:528:DC%2BD2cXnt1WjsrY%3D 10.1111/j.1600-079X.2004.00137.x 15298665 (Pubitemid 39120210)
8. V Tahan O Atug H Akin F Eren G Tahan O Tarcin, et al. 2009 Melatonin ameliorates methionine choline deficient diet induced nonalcoholic steatohepatitis in rats J Pineal Res 46 401 407 1:CAS:528:DC%2BD1MXlsFSru7g%3D 10.1111/j.1600-079X.2009.00676.x 19552763
9. V Nosál'ová M Zeman S Cerná J Navarová M Zakálová 2007 Protective effect of melatonin in acetic acid induced colitis in rats J Pineal Res 42 364 370 10.1111/j.1600-079X.2007.00428.x 17439553 (Pubitemid 46581661)
10. GA Bubenik DE Blask GM Brown GJ Maestroni SF Pang RJ Reiter M Viswanathan N Zisapel 1998 Prospects of the clinical utilization of melatonin Biol Signals Recept 7 195 219 1:CAS:528:DyaK1cXmt1SnurY%3D 10.1159/000014545 9730580 (Pubitemid 28430162)
11. GA Bubenik S Dhanvantari 1989 Influence of serotonin and melatonin on some parameters of gastrointestinal motility J Pineal Res 7 333 344 1:CAS:528:DyaK3cXntVGntQ%3D%3D 10.1111/j.1600-079X.1989.tb00909.x 2600759 (Pubitemid 20089197)
12. J Jaworek T Brzozowski SJ Konturek 2005 Melatonin as an organoprotector in the stomach and the pancreas J Pineal Res 38 73 83 1:CAS:528: DC%2BD2MXhvFKnurY%3D 10.1111/j.1600-079X.2004.00179.x 15683461 (Pubitemid 40293231)
13. S Cuzzocrea JR Reiter 2001 Pharmacological action of melatonin in shock, inflammation and ischemia/reperfusion injury Eur J Pharmacol 426 1 10 1:CAS:528:DC%2BD3MXmt1Kktbc%3D 10.1016/S0014-2999(01)01175-X 11525764 (Pubitemid 32781781)
14. S Cuzzocrea JR Reiter 2002 Pharmacological action of melatonin in acute and chronic inflammation Curr Top Med Chem 2 153 165 1:CAS:528: DC%2BD38XhvVaqu7g%3D 10.2174/1568026023394425 11899098
15. PT Pentney GA Bubenik 1995 Melatonin reduces the severity of dextran-induced colitis in mice J Pineal Res 19 31 39 1:CAS:528: DyaK2MXpsFChsb8%3D 10.1111/j.1600-079X.1995.tb00168.x 8609593
16. GP Morris PL Beck MS Herridge WT Depew MR Szewczuk JL Wallace 1989 Hapten-induced model of chronic inflammation and ulceration in the rat colon Gastroenterology 96 795 803 1:STN:280:DyaL1M7itFeqtQ%3D%3D 2914642 (Pubitemid 19057602)
17. CB Appleyard JL Wallace 1995 Reactivation of hapten-induced colitis and its prevention by anti-inflammatory drugs Am J Physiol 269 119 125
18. JE Krawisz P Sharon WF Stenson 1984 Quantitative assay for acute intestinal inflammation based on myeloperoxidase activity. Assessment of inflammation in rat and hamster models Gastroenterology 87 1344 1350 1:CAS:528:DyaL2MXktVym 6092199 (Pubitemid 15201434)
19. K Yagi 1984 Assay for blood plasma or serum Methods Enzymol 105 328 331 1:CAS:528:DyaL2cXktlGnsLo%3D 10.1016/S0076-6879(84)05042-4 6727672 (Pubitemid 14165394)
20. AF Boyne GL Ellman 1972 A methodology for analysis of tissue sulfhydryl components Anal Biochem 46 639 653 1:CAS:528:DyaE38Xht1eluro%3D 10.1016/0003-2697(72)90335-1 4623507
21. I Fridovich 1983 Superoxide radical: an endogenous toxicant Annu Rev Pharmacol Toxicol 23 239 257 1:CAS:528:DyaL3sXktFOmsbw%3D 10.1146/annurev.pa.23. 040183.001323 6307121 (Pubitemid 13079375)
22. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with folin phenol reagent J Biol Chem 193 265 275 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
23. T Yoshikawa N Yoshida H Miyagawa T Takemura T Tanigawa T Sugino, et al. 1987 Role of lipid peroxidation, in gastric mucosal lesions induced by burn shock in rats J Clin Biochem Nutr 2 163 170 1:CAS:528:DyaL2sXltlWqt7g%3D
24. T Yoshikawa S Ueda Y Naito T Takahashi H Oyamada Y Mortita, et al. 1989 Role of oxygen-derived free radicals in gastric mucosal injury induced by ischemia or ischemia-reperfusion in rats Free Radic Res Commun 7 285 291 1:CAS:528:DyaK3cXjsVSlug%3D%3D 10.3109/10715768909087953 2583548 (Pubitemid 19281977)
25. Bitiren M, Karakilcik AZ, Zerin M, Ozardali I, Selek S, Nazligul Y, et al. Protective effects of selenium and melatonin combination on experimental colitis in blood plasma and colon of rats. Biol Trace Elem Res 2009; Sep 23. doi 10.1007/s12011-009-8518-3.
26. J Pravda 2005 Radical induction theory of ulcerative colitis World J Gastroenterol 11 2371 2384 1:CAS:528:DC%2BD2MXltVWisLs%3D 15832404 (Pubitemid 40667968)
27. E Ademoglu Y Erbil B Tam U Barbaros E Ilhan V Olgac, et al. 2004 Do melatonin and selenium have beneficial effects on trinitrobenzene sulfonic acid-induced experimental colitis Dig Dis Sci 49 102 108 1:CAS:528: DC%2BD2cXislegtg%3D%3D 10.1023/B:DDAS.0000011610.47179.0b 14992443 (Pubitemid 38183753)
28. MB Grisham T Yamada 1992 Neutrophils, nitrogen oxides, and inflammatory bowel disease Ann NY Acad Sci 664 103 115 1:CAS:528:DyaK3sXht1Wrur8%3D 10.1111/j.1749-6632.1992.tb39753.x 1456643 (Pubitemid 23022842)
29. SA Mirbagheri BG Nezami S Assa M Hajimahmoodi 2008 Rectal administration of d-alpha tocopherol for active ulcerative colitis: A preliminary report World J Gastroenterol 14 5990 5995 1:CAS:528:DC%2BD1MXitVWhtbY%3D 10.3748/wjg.14.5990 18932276
30. X Shan TY Aw DP Jones 1990 Glutathione-dependent protection against oxidative injury Aliment Pharmacol Ther 47 61 71 1:CAS:528:DyaK3cXkslGks7g%3D (Pubitemid 20183308)
31. S Cuzzocrea E Mazzon I Serraino V Lepore ML Terranova A Ciccolo, et al. 2001 Melatonin reduces dinitrobenzene sulfonic acid-induced colitis J Pineal Res 30 1 12 1:CAS:528:DC%2BD3MXktVyiuw%3D%3D 10.1034/j.1600-079X.2001.300101.x 11168901 (Pubitemid 32056605)
32. A Keshavarzian G Morgan S Sedgfi 1990 Role of reactive oxygen metabolites in experimental colitis Gut 31 786 790 1:CAS:528:DyaK3MXpvFeisg%3D%3D 10.1136/gut.31.7.786 2164491 (Pubitemid 20233945)