메뉴 건너뛰기




Volumn 51, Issue 1, 2011, Pages 44-60

New paradigms in chronic intestinal inflammation and colon cancer: Role of melatonin

Author keywords

autophagy; chronic inflammation; colitis; colon cancer; inflammatory bowel disease; melatonin; sirtuins

Indexed keywords

2 METHYLACYL COENZYME A RACEMASE; ACETYLSALICYLIC ACID; ADENOSINE PHOSPHATE; AUTOPHAGY PROTEIN 5; BECLIN 1; BETA CATENIN; CYCLOOXYGENASE 2; CYCLOSPORIN A; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; I KAPPA B; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 23; INTERLEUKIN 6; LIPID; MELATONIN; MITOCHONDRIAL DNA; MITOGEN ACTIVATED PROTEIN KINASE KINASE 4; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; PROTEIN BCL 2; PROTEIN KINASE; PROTEIN P53; REACTIVE OXYGEN METABOLITE; SIRTUIN 1; SMALL INTERFERING RNA; SULINDAC; TOLL LIKE RECEPTOR; UNINDEXED DRUG;

EID: 79960354764     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2011.00915.x     Document Type: Review
Times cited : (111)

References (205)
  • 1
    • 78649506169 scopus 로고    scopus 로고
    • News from the '5th International Meeting on Inflammatory Bowel Diseases' CAPRI 2010
    • Latella G, Fiocchi C, Caprili R,. News from the '5th International Meeting on Inflammatory Bowel Diseases' CAPRI 2010. J Crohns Colitis 2010; 4: 690-702.
    • (2010) J Crohns Colitis , vol.4 , pp. 690-702
    • Latella, G.1    Fiocchi, C.2    Caprili, R.3
  • 2
    • 30344445931 scopus 로고    scopus 로고
    • Inflammatory bowel disease: Epidemiology, pathogenesis, and therapeutic opportunities
    • DOI 10.1097/01.MIB.0000195385.19268.68, PII 0005472520060100100002
    • Hanauer SB,. Inflammatory bowel disease: epidemiology, pathogenesis, and therapeutic opportunities. Inflamm Bowel Dis 2006; 12: S3-S9. (Pubitemid 43068428)
    • (2006) Inflammatory Bowel Diseases , vol.12 , Issue.SUPPL. 1
    • Hanauer, S.B.1
  • 3
    • 0037043658 scopus 로고    scopus 로고
    • Inflammatory bowel disease
    • DOI 10.1056/NEJMra020831
    • Podolsky DK,. Inflammatory bowel disease. N Engl J Med 2002; 347: 417-429. (Pubitemid 34851835)
    • (2002) New England Journal of Medicine , vol.347 , Issue.6 , pp. 417-429
    • Podolsky, D.K.1
  • 4
    • 0036886760 scopus 로고    scopus 로고
    • The pathogenesis of inflammatory bowel disease: Translational implications for clinicians
    • Abreu MT,. The pathogenesis of inflammatory bowel disease: translational implications for clinicians. Curr Gastroenterol Rep 2002; 4: 481-489.
    • (2002) Curr Gastroenterol Rep , vol.4 , pp. 481-489
    • Abreu, M.T.1
  • 6
    • 0036088432 scopus 로고    scopus 로고
    • Epidemiology of inflammatory bowel disease
    • DOI 10.1097/00001574-200207000-00004
    • Montgomery SM, Ekbom A,. Epidemiology of inflammatory bowel disease. Curr Opin Gastroenterol 2002; 18: 416-420. (Pubitemid 34665099)
    • (2002) Current Opinion in Gastroenterology , vol.18 , Issue.4 , pp. 416-420
    • Montgomery, S.M.1    Ekbom, A.2
  • 7
    • 33748096092 scopus 로고    scopus 로고
    • Molecular Biology of Dysplasia and Cancer in Inflammatory Bowel Disease
    • DOI 10.1016/j.gtc.2006.07.002, PII S0889855306000367
    • Itzkowitz SH,. Molecular biology of dysplasia and cancer in inflammatory bowel disease. Gastroenterol Clin North Am 2006; 35: 553-571. (Pubitemid 44307575)
    • (2006) Gastroenterology Clinics of North America , vol.35 , Issue.3 , pp. 553-571
    • Itzkowitz, S.H.1
  • 9
    • 77954422428 scopus 로고    scopus 로고
    • Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases
    • Sarra M, Monteleone I, Stolfi C, et al., Interferon-gamma-expressing cells are a major source of interleukin-21 in inflammatory bowel diseases. Inflamm Bowel Dis 2010; 16: 1332-1339.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1332-1339
    • Sarra, M.1    Monteleone, I.2    Stolfi, C.3
  • 10
    • 79955563439 scopus 로고    scopus 로고
    • Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases
    • Strober W, Fuss IJ,. Proinflammatory cytokines in the pathogenesis of inflammatory bowel diseases. Gastroenterology 2011; 140: 1756-1767.
    • (2011) Gastroenterology , vol.140 , pp. 1756-1767
    • Strober, W.1    Fuss, I.J.2
  • 11
    • 79954510825 scopus 로고    scopus 로고
    • Crohn disease: A current perspective on genetics, autophagy and immunity
    • [Epub ahead of print].
    • Stappenbeck TS, Rioux JD, Mizoguchi A, et al., Crohn disease: a current perspective on genetics, autophagy and immunity. Autophagy 2010. [Epub ahead of print].
    • (2010) Autophagy
    • Stappenbeck, T.S.1    Rioux, J.D.2    Mizoguchi, A.3
  • 12
    • 68649126866 scopus 로고    scopus 로고
    • Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals
    • Martin B, Hirota K, Cua DJ, et al., Interleukin-17-producing gammadelta T cells selectively expand in response to pathogen products and environmental signals. Immunity 2009; 31: 321-330.
    • (2009) Immunity , vol.31 , pp. 321-330
    • Martin, B.1    Hirota, K.2    Cua, D.J.3
  • 13
    • 55749096587 scopus 로고    scopus 로고
    • Innate immune signalling at intestinal mucosal surfaces: A fine line between host protection and destruction
    • Cario E,. Innate immune signalling at intestinal mucosal surfaces: a fine line between host protection and destruction. Curr Opin Gastroenterol 2008; 24: 725-732.
    • (2008) Curr Opin Gastroenterol , vol.24 , pp. 725-732
    • Cario, E.1
  • 14
    • 79956118584 scopus 로고    scopus 로고
    • Autophagy signaling through reactive oxygen species
    • Huang J, Lam GY, Brumell JH,. Autophagy signaling through reactive oxygen species. Antioxid Redox Signal 2011; 14: 2215-2231.
    • (2011) Antioxid Redox Signal , vol.14 , pp. 2215-2231
    • Huang, J.1    Lam, G.Y.2    Brumell, J.H.3
  • 15
    • 2442530958 scopus 로고    scopus 로고
    • Inflammatory bowel disease gene hunting by linkage analysis: Rationale, methodology, and present status of the field
    • DOI 10.1097/00054725-200405000-00019
    • Brant SR, Shugart YY,. Inflammatory bowel disease gene hunting by linkage analysis: rationale, methodology, and present status of the field. Inflamm Bowel Dis 2004; 10: 300-311. (Pubitemid 38618262)
    • (2004) Inflammatory Bowel Diseases , vol.10 , Issue.3 , pp. 300-311
    • Brant, S.R.1    Shugart, Y.Y.2
  • 18
    • 33745151999 scopus 로고    scopus 로고
    • Cellular and molecular immunopathogenesis of ulcerative colitis
    • Zhang S, Zhao X, Zhang D,. Cellular and molecular immunopathogenesis of ulcerative colitis. Cell Mol Immunol 2006; 3: 35-40.
    • (2006) Cell Mol Immunol , vol.3 , pp. 35-40
    • Zhang, S.1    Zhao, X.2    Zhang, D.3
  • 19
    • 0742324857 scopus 로고    scopus 로고
    • Toll-like receptors and acquired immunity
    • DOI 10.1016/j.smim.2003.10.006
    • Pasare C, Medzhitov R,. Toll-like receptors and acquired immunity. Semin Immunol 2004; 16: 23-26. (Pubitemid 38147430)
    • (2004) Seminars in Immunology , vol.16 , Issue.1 , pp. 23-26
    • Pasare, C.1    Medzhitov, R.2
  • 20
    • 33645068615 scopus 로고    scopus 로고
    • Intestinal epithelial cell signalling and host- derived negative regulators under chronic inflammation: To be or not to be activated determines the balance towards commensal bacteria
    • Haller D,. Intestinal epithelial cell signalling and host- derived negative regulators under chronic inflammation: to be or not to be activated determines the balance towards commensal bacteria. Neurogastroenterol Motil 2006; 18: 184-199.
    • (2006) Neurogastroenterol Motil , vol.18 , pp. 184-199
    • Haller, D.1
  • 23
    • 71649089949 scopus 로고    scopus 로고
    • Role of NF-kappaB activation in intestinal immune homeostasis
    • Wullaert A,. Role of NF-kappaB activation in intestinal immune homeostasis. Int J Med Microbiol 2010; 300: 49-56.
    • (2010) Int J Med Microbiol , vol.300 , pp. 49-56
    • Wullaert, A.1
  • 26
    • 73849121209 scopus 로고    scopus 로고
    • Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry
    • Travassos LH, Carneiro LA, Ramjeet M, et al., Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat Immunol 2010; 11: 55-62.
    • (2010) Nat Immunol , vol.11 , pp. 55-62
    • Travassos, L.H.1    Carneiro, L.A.2    Ramjeet, M.3
  • 27
    • 73849151394 scopus 로고    scopus 로고
    • NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation
    • Cooney R, Baker J, Brain O, et al., NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat Med 2010; 16: 90-97.
    • (2010) Nat Med , vol.16 , pp. 90-97
    • Cooney, R.1    Baker, J.2    Brain, O.3
  • 28
    • 33745775434 scopus 로고    scopus 로고
    • Mechanisms of disease: Pathogenesis of Crohn's disease and ulcerative colitis
    • DOI 10.1038/ncpgasthep0528, PII NCPGASTHEP0528
    • Sartor RB,. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat Clin Pract Gastroenterol Hepatol 2006; 3: 390-407. (Pubitemid 44018812)
    • (2006) Nature Clinical Practice Gastroenterology and Hepatology , vol.3 , Issue.7 , pp. 390-407
    • Sartor, R.B.1
  • 30
    • 70350513270 scopus 로고    scopus 로고
    • Regulation of tissue homeostasis by NF-kappaB signalling: Implications for inflammatory diseases
    • Pasparakis M,. Regulation of tissue homeostasis by NF-kappaB signalling: implications for inflammatory diseases. Nat Rev Immunol 2009; 9: 778-788.
    • (2009) Nat Rev Immunol , vol.9 , pp. 778-788
    • Pasparakis, M.1
  • 31
    • 33745342580 scopus 로고    scopus 로고
    • NFκB pathway: A good signaling paradigm and therapeutic target
    • DOI 10.1016/j.biocel.2006.03.023, PII S1357272506001245
    • Tergaonkar V,. NFkappaB pathway: a good signaling paradigm and therapeutic target. Int J Biochem Cell Biol 2006; 38: 1647-1653. (Pubitemid 43947652)
    • (2006) International Journal of Biochemistry and Cell Biology , vol.38 , Issue.10 , pp. 1647-1653
    • Tergaonkar, V.1
  • 32
    • 70350764831 scopus 로고    scopus 로고
    • NF-kappaB signaling pathway, inflammation and colorectal cancer
    • Wang S, Liu Z, Wang L, et al., NF-kappaB signaling pathway, inflammation and colorectal cancer. Cell Mol Immunol 2009; 6: 327-334.
    • (2009) Cell Mol Immunol , vol.6 , pp. 327-334
    • Wang, S.1    Liu, Z.2    Wang, L.3
  • 33
    • 27644543662 scopus 로고    scopus 로고
    • Proinflammatory cytokines and signaling pathways in intestinal innate immune cells
    • In:, Mestecky J., Moldoveanu Z., Russell M.L. eds, Elsevier, Philadelphia,; pp.
    • Sartor RB, Hoentjen F,. Proinflammatory cytokines and signaling pathways in intestinal innate immune cells. In: Mucosal Immunology, Mestecky J, Moldoveanu Z, Russell ML, eds, Elsevier, Philadelphia, 2005; pp. 681-701.
    • (2005) Mucosal Immunology , pp. 681-701
    • Sartor, R.B.1    Hoentjen, F.2
  • 34
    • 70349113042 scopus 로고    scopus 로고
    • Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components
    • Martin H,. Role of PPAR-gamma in inflammation. Prospects for therapeutic intervention by food components. Mutat Res 2009; 669: 1-7.
    • (2009) Mutat Res , vol.669 , pp. 1-7
    • Martin, H.1
  • 35
    • 77953248869 scopus 로고    scopus 로고
    • The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease
    • Guri AJ, Mohapatra SK, Horne WT, et al., The role of T cell PPAR gamma in mice with experimental inflammatory bowel disease. BMC Gastroenterol 2010; 10: 60.
    • (2010) BMC Gastroenterol , vol.10 , pp. 60
    • Guri, A.J.1    Mohapatra, S.K.2    Horne, W.T.3
  • 36
    • 33744937585 scopus 로고    scopus 로고
    • CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD
    • DOI 10.1016/j.clnu.2005.12.008, PII S0261561406000021
    • Bassaganya-Riera J, Hontecillas R,. CLA and n-3 PUFA differentially modulate clinical activity and colonic PPAR-responsive gene expression in a pig model of experimental IBD. Clin Nutr 2006; 25: 454-465. (Pubitemid 43843028)
    • (2006) Clinical Nutrition , vol.25 , Issue.3 , pp. 454-465
    • Bassaganya-Riera, J.1    Hontecillas, R.2
  • 39
    • 79957689114 scopus 로고    scopus 로고
    • ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells
    • Lee JW, Kim WH, Yeo J, et al., ER stress is implicated in mitochondrial dysfunction-induced apoptosis of pancreatic beta cells. Mol Cells 2010; 30: 545-549.
    • (2010) Mol Cells , vol.30 , pp. 545-549
    • Lee, J.W.1    Kim, W.H.2    Yeo, J.3
  • 41
    • 79956220325 scopus 로고    scopus 로고
    • Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum
    • Takemoto K, Miyata S, Takamura H, et al., Mitochondrial TRAP1 regulates the unfolded protein response in the endoplasmic reticulum. Neurochem Int 2011; 58: 880-887.
    • (2011) Neurochem Int , vol.58 , pp. 880-887
    • Takemoto, K.1    Miyata, S.2    Takamura, H.3
  • 42
    • 77954144700 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress: Implications for inflammatory bowel disease pathogenesis
    • Kaser A, Martínez-Naves E, Blumberg RS,. Endoplasmic reticulum stress: implications for inflammatory bowel disease pathogenesis. Curr Opin Gastroenterol 2010; 26: 318-326.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 318-326
    • Kaser, A.1    Martínez-Naves, E.2    Blumberg, R.S.3
  • 43
    • 33745820796 scopus 로고    scopus 로고
    • Cytoplasmic IRE1α-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress
    • DOI 10.1074/jbc.M602030200
    • Back SH, Lee K, Vink E, et al., Cytoplasmic IRE1alpha-mediated XBP1 mRNA splicing in the absence of nuclear processing and endoplasmic reticulum stress. J Biol Chem 2006; 281: 18691-18706. (Pubitemid 44035530)
    • (2006) Journal of Biological Chemistry , vol.281 , Issue.27 , pp. 18691-18706
    • Sung, H.B.1    Lee, K.2    Vink, E.3    Kaufman, R.J.4
  • 44
    • 77249150521 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress and intestinal inflammation
    • Kaser A, Blumberg RS,. Endoplasmic reticulum stress and intestinal inflammation. Mucosal Immunol 2010; 3: 11-16.
    • (2010) Mucosal Immunol , vol.3 , pp. 11-16
    • Kaser, A.1    Blumberg, R.S.2
  • 45
    • 75749108288 scopus 로고    scopus 로고
    • Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis
    • Nakamura T, Furuhashi M, Li P, et al., Double-stranded RNA-dependent protein kinase links pathogen sensing with stress and metabolic homeostasis. Cell 2010; 140: 338-348.
    • (2010) Cell , vol.140 , pp. 338-348
    • Nakamura, T.1    Furuhashi, M.2    Li, P.3
  • 46
    • 0013958811 scopus 로고
    • Risk of malignant change in ulcerative colitis
    • Hinton JM,. Risk of malignant change in ulcerative colitis. Gut 1966; 7: 427-432.
    • (1966) Gut , vol.7 , pp. 427-432
    • Hinton, J.M.1
  • 47
    • 3042599473 scopus 로고    scopus 로고
    • Inflammation and cancer - IV. Colorectal cancer in inflammatory bowel disease: The role of inflammation
    • DOI 10.1152/ajpgi.00079.2004
    • Itzkowitz SH, Yio X,. Inflammation and cancer IV. Colorectal cancer in inflammatory bowel disease: the role of inflammation. Am J Physiol Gastrointest Liver Physiol 2004; 287: G7-G17. (Pubitemid 38802113)
    • (2004) American Journal of Physiology - Gastrointestinal and Liver Physiology , vol.287 , Issue.1
    • Itzkowitz, S.H.1    Yio, X.2
  • 48
    • 0034181587 scopus 로고    scopus 로고
    • Cancer in inflammatory bowel disease
    • Grenstein AJ,. Cancer in inflammatory bowel disease. Mt Sinai J Med 2000; 67: 227-240.
    • (2000) Mt Sinai J Med , vol.67 , pp. 227-240
    • Grenstein, A.J.1
  • 49
    • 77955279767 scopus 로고    scopus 로고
    • Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease
    • O'connor PM, Lapointe TK, Beck PL, et al., Mechanisms by which inflammation may increase intestinal cancer risk in inflammatory bowel disease. Inflamm Bowel Dis 2010; 16: 1411-1420.
    • (2010) Inflamm Bowel Dis , vol.16 , pp. 1411-1420
    • O'Connor, P.M.1    Lapointe, T.K.2    Beck, P.L.3
  • 50
    • 77957279353 scopus 로고    scopus 로고
    • Recently identified and potential targets for colon cancer treatment
    • Lea MA,. Recently identified and potential targets for colon cancer treatment. Future Oncol 2010; 6: 993-1002.
    • (2010) Future Oncol , vol.6 , pp. 993-1002
    • Lea, M.A.1
  • 51
    • 79551526537 scopus 로고    scopus 로고
    • Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis
    • Talero E, Sánchez-Fidalgo S, Villegas I, et al., Role of different inflammatory and tumor biomarkers in the development of ulcerative colitis-associated carcinogenesis. Inflamm Bowel Dis 2011; 17: 696-710.
    • (2011) Inflamm Bowel Dis , vol.17 , pp. 696-710
    • Talero, E.1    Sánchez-Fidalgo, S.2    Villegas, I.3
  • 52
    • 0021017589 scopus 로고
    • Dysplasia in inflammatory bowel disease: Standardized classification with provisional clinical application
    • Riddle RH, Goldman H, Ransohof DF, et al., Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical application. Human Pathol 1983; 14: 931-968.
    • (1983) Human Pathol , vol.14 , pp. 931-968
    • Riddle, R.H.1    Goldman, H.2    Ransohof, D.F.3
  • 53
    • 0027938828 scopus 로고
    • Dysplasia and early carcinoma in inflammatory bowel disease and colorectal adenomas
    • DOI 10.1016/0046-8177(94)90032-9
    • Pascal RR,. Dysplasia and early carcinoma in inflammatory bowel disease and colorectal carcinomas. Human Pathol 1994; 25: 1160-1171. (Pubitemid 24351499)
    • (1994) Human Pathology , vol.25 , Issue.11 , pp. 1160-1171
    • Pascal, R.R.1
  • 54
    • 0034653351 scopus 로고    scopus 로고
    • The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer
    • DOI 10.1016/S0378-4274(99)00261-1, PII S0378427499002611
    • Bird PR, Good CK,. The significance of aberrant crypt foci in understanding the pathogenesis of colon cancer. Toxicol Lett 2000; 112-113: 395-402. (Pubitemid 30138150)
    • (2000) Toxicology Letters , vol.112-113 , pp. 395-402
    • Bird, R.P.1    Good, C.K.2
  • 55
    • 0034052970 scopus 로고    scopus 로고
    • Dysplasia and cancer in the dextran sulfate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: A study of histopathology, B-catenin and p53 expression and the role of inflammation
    • Cooper HS, Murthy S, Kido K, et al., Dysplasia and cancer in the dextran sulphate sodium mouse colitis model. Relevance to colitis-associated neoplasia in the human: a study of histopathology, β-catenin and expression and the role of inflammation. Carcinogenesis 2000; 21: 757-768. (Pubitemid 30214034)
    • (2000) Carcinogenesis , vol.21 , Issue.4 , pp. 757-768
    • Cooper, H.S.1    Murthy, S.2    Kido, K.3    Yoshitake, H.4    Flanigan, A.5
  • 57
    • 58949094558 scopus 로고    scopus 로고
    • Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death
    • Sun Y, Chen J, Rigas B,. Chemopreventive agents induce oxidative stress in cancer cells leading to COX-2 overexpression and COX-2-independent cell death. Carcinogenesis 2009; 30: 93-100.
    • (2009) Carcinogenesis , vol.30 , pp. 93-100
    • Sun, Y.1    Chen, J.2    Rigas, B.3
  • 59
    • 33750497844 scopus 로고    scopus 로고
    • Inflammation and cancer: How hot is the link?
    • DOI 10.1016/j.bcp.2006.06.029, PII S0006295206003893, Cell Signalling, Transcription and Translation as Therapeutic Tergets
    • Aggarwal BB, Shishodia S, Sandur SK, et al., Inflammation and cancer: how hot is the link? Biochem Pharmacol 2006; 72: 1605-1621. (Pubitemid 44666739)
    • (2006) Biochemical Pharmacology , vol.72 , Issue.11 , pp. 1605-1621
    • Aggarwal, B.B.1    Shishodia, S.2    Sandur, S.K.3    Pandey, M.K.4    Sethi, G.5
  • 60
    • 26444605834 scopus 로고    scopus 로고
    • IKK/NF-κB signaling: Balancing life and death - A new approach to cancer therapy
    • DOI 10.1172/JCI26322
    • Luo JL, Kamata H, Karin M,. IKK/NF-kappaB signaling: balancing life and death-a new approach to cancer therapy. J Clin Invest 2005; 115: 2625-2632. (Pubitemid 41434385)
    • (2005) Journal of Clinical Investigation , vol.115 , Issue.10 , pp. 2625-2632
    • Luo, J.-L.1    Kamata, H.2    Karin, M.3
  • 61
    • 0036717195 scopus 로고    scopus 로고
    • NF-κB, chemokine gene transcription and tumour growth
    • DOI 10.1038/nri887
    • Richmond A,. Nf-kappa B, chemokine gene transcription and tumour growth. Nat Rev Immunol 2002; 2: 664-674. (Pubitemid 37328724)
    • (2002) Nature Reviews Immunology , vol.2 , Issue.9 , pp. 664-674
    • Richmond, A.1
  • 62
    • 0036964816 scopus 로고    scopus 로고
    • Chemopreventive agents induce suppression of nuclear factor-κB leading to chemosensitization
    • Bharti AC, Aggarwal BB,. Chemopreventive agents induce suppression of nuclear factor-kappaB leading to chemosensitization. Ann N Y Acad Sci 2002; 973: 392-395. (Pubitemid 36125041)
    • (2002) Annals of the New York Academy of Sciences , vol.973 , pp. 392-395
    • Bharti, A.C.1    Aggarwal, B.B.2
  • 63
    • 64549164046 scopus 로고    scopus 로고
    • Chemosensitization and immunosensitization of resistant cancer cells to apoptosis and inhibition of metastasis by the specific NF-kappaB inhibitor DHMEQ
    • Katsman A, Umezawa K, Bonavida B,. Chemosensitization and immunosensitization of resistant cancer cells to apoptosis and inhibition of metastasis by the specific NF-kappaB inhibitor DHMEQ. Curr Pharm Des 2009; 15: 792-808.
    • (2009) Curr Pharm des , vol.15 , pp. 792-808
    • Katsman, A.1    Umezawa, K.2    Bonavida, B.3
  • 64
    • 53049107046 scopus 로고    scopus 로고
    • Terpenoids: Natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential
    • Salminen A, Lehtonen M, Suuronen T, et al., Terpenoids: natural inhibitors of NF-kappaB signaling with anti-inflammatory and anticancer potential. Cell Mol Life Sci 2008; 65: 2979-2999.
    • (2008) Cell Mol Life Sci , vol.65 , pp. 2979-2999
    • Salminen, A.1    Lehtonen, M.2    Suuronen, T.3
  • 65
    • 78650286735 scopus 로고    scopus 로고
    • The nuclear hormone receptor PPARÎ as a therapeutic target in major diseases
    • Schmidt MV, Brüne B, Von Knethen A,. The nuclear hormone receptor PPARÎ as a therapeutic target in major diseases. Sci World J 2010; 10: 2181-2197.
    • (2010) Sci World J , vol.10 , pp. 2181-2197
    • Schmidt, M.V.1    Brüne, B.2    Von Knethen, A.3
  • 66
    • 77955270210 scopus 로고    scopus 로고
    • Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac
    • Kaur J, Sanyal SN,. Modulation of inflammatory changes in early stages of colon cancer through activation of PPARgamma by diclofenac. Eur J Cancer Prev 2010; 19: 319-327.
    • (2010) Eur J Cancer Prev , vol.19 , pp. 319-327
    • Kaur, J.1    Sanyal, S.N.2
  • 67
    • 77955920757 scopus 로고    scopus 로고
    • Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease
    • Bassaganya-Riera J, Hontecillas R,. Dietary conjugated linoleic acid and n-3 polyunsaturated fatty acids in inflammatory bowel disease. Curr Opin Clin Nutr Metab Care 2010; 13: 569-573.
    • (2010) Curr Opin Clin Nutr Metab Care , vol.13 , pp. 569-573
    • Bassaganya-Riera, J.1    Hontecillas, R.2
  • 69
    • 0034932886 scopus 로고    scopus 로고
    • New issues about nitric oxide and its effects on the gastrointestinal tract
    • DOI 10.2174/1381612013397645
    • Martín MJ, Jiménez MD, Motilva V,. New issues about nitric oxide and its effects on the gastrointestinal tract. Curr Pharm Des 2001; 7: 881-908. (Pubitemid 32624436)
    • (2001) Current Pharmaceutical Design , vol.7 , Issue.10 , pp. 881-908
    • Martin, M.J.1    Jimenez, M.D.2    Motilva, V.3
  • 70
    • 34248396797 scopus 로고    scopus 로고
    • Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis
    • DOI 10.1002/mc.20282
    • Seril DN, Liao J, Yang GY,. Colorectal carcinoma development in inducible nitric oxide synthase-deficient mice with dextran sulfate sodium-induced ulcerative colitis. Mol Carcinog 2007; 46: 341-353. (Pubitemid 46744454)
    • (2007) Molecular Carcinogenesis , vol.46 , Issue.5 , pp. 341-353
    • Seril, D.N.1    Liao, J.2    Yang, G.-Y.3
  • 71
    • 60749108379 scopus 로고    scopus 로고
    • Regulation of autophagy by reactive oxygen species (ROS): Implications for cancer progression and treatment
    • Azad MB, Chen Y, Gibson SB,. Regulation of autophagy by reactive oxygen species (ROS): implications for cancer progression and treatment. Antioxid Redox Signal 2009; 11: 777-790.
    • (2009) Antioxid Redox Signal , vol.11 , pp. 777-790
    • Azad, M.B.1    Chen, Y.2    Gibson, S.B.3
  • 72
    • 77954096426 scopus 로고    scopus 로고
    • A systems biology viewpoint on autophagy in health and disease
    • Huett A, Goel G, Xavier RJ,. A systems biology viewpoint on autophagy in health and disease. Curr Opin Gastroenterol 2010; 26: 302-309.
    • (2010) Curr Opin Gastroenterol , vol.26 , pp. 302-309
    • Huett, A.1    Goel, G.2    Xavier, R.J.3
  • 73
    • 78649636176 scopus 로고    scopus 로고
    • Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria
    • Wirawan E, Vande Walle L, Kersse K, et al., Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria. Cell Death Dis 2010; 1: e18.
    • (2010) Cell Death Dis , vol.1
    • Wirawan, E.1    Vande Walle, L.2    Kersse, K.3
  • 78
    • 78649833334 scopus 로고    scopus 로고
    • P53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation
    • Scherz-Shouval R, Weidberg H, Gonen C, et al., p53-dependent regulation of autophagy protein LC3 supports cancer cell survival under prolonged starvation. Proc Natl Acad Sci U S A 2010; 107: 18511-18516.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , pp. 18511-18516
    • Scherz-Shouval, R.1    Weidberg, H.2    Gonen, C.3
  • 79
    • 0035881870 scopus 로고    scopus 로고
    • Autophagy delays sulindac sulfide-induced apoptosis in the human intestinal colon cancer cell line HT-29
    • DOI 10.1006/excr.2001.5285
    • Bauvy C, Gane P, Arico S, et al., Autophagy delays sulindac sulphide-induced apoptosis in the human intestinal colon cancer cell line HT-29. Exp Cell Res 2001; 268: 139-149. (Pubitemid 32744645)
    • (2001) Experimental Cell Research , vol.268 , Issue.2 , pp. 139-149
    • Bauvy, C.1    Gane, P.2    Arico, S.3    Codogno, P.4    Ogier-Denis, E.5
  • 80
    • 50349098812 scopus 로고    scopus 로고
    • Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells
    • Han J, Hou W, Goldstein LA, et al., Involvement of protective autophagy in TRAIL resistance of apoptosis-defective tumor cells. J Biol Chem 2008; 283: 19665-19677.
    • (2008) J Biol Chem , vol.283 , pp. 19665-19677
    • Han, J.1    Hou, W.2    Goldstein, L.A.3
  • 81
  • 82
    • 77149128638 scopus 로고    scopus 로고
    • Inhibition of autophagy potentiates sulphorane-induced apoptosis in human colon cancer cells
    • Nishikawa T, Tsuno NH, Okaji Y, et al., Inhibition of autophagy potentiates sulphorane-induced apoptosis in human colon cancer cells. Ann Surg Oncol 2010; 17: 592-602.
    • (2010) Ann Surg Oncol , vol.17 , pp. 592-602
    • Nishikawa, T.1    Tsuno, N.H.2    Okaji, Y.3
  • 83
    • 77953289524 scopus 로고    scopus 로고
    • Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model
    • Li J, Hou N, Faried A, et al., Inhibition of autophagy augments 5-fluorouracil chemotherapy in human colon cancer in vitro and in vivo model. Eur J Cancer 2010; 46: 1900-1909.
    • (2010) Eur J Cancer , vol.46 , pp. 1900-1909
    • Li, J.1    Hou, N.2    Faried, A.3
  • 84
    • 77953288455 scopus 로고    scopus 로고
    • Regulation of yeast sirtuins by NAD+ metabolism and calorie restriction
    • Lu SP, Lin SJ,. Regulation of yeast sirtuins by NAD+ metabolism and calorie restriction. Biochim Biophys Acta 2010; 1804: 1567-1575.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1567-1575
    • Lu, S.P.1    Lin, S.J.2
  • 85
    • 77953290752 scopus 로고    scopus 로고
    • SIRT1-dependent regulation of chromatin and transcription: Linking NAD+ metabolism and signalling to the control of cellular functions
    • Zhang T, Kraus WL,. SIRT1-dependent regulation of chromatin and transcription: linking NAD+ metabolism and signalling to the control of cellular functions. Biochim Biophys Acta 2010; 1804: 1666-1675.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1666-1675
    • Zhang, T.1    Kraus, W.L.2
  • 86
    • 77953292242 scopus 로고    scopus 로고
    • Nutrient-dependent regulation of PGC-1α's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5
    • Dominy JE, Lee Y, Gerhart-Hines Z, et al., Nutrient-dependent regulation of PGC-1α's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5. Biochim Biophys Acta 2010; 1804: 1676-1683.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1676-1683
    • Dominy, J.E.1    Lee, Y.2    Gerhart-Hines, Z.3
  • 87
    • 77953290430 scopus 로고    scopus 로고
    • 'Clocks' in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging
    • Imai SI,. 'Clocks' in the NAD world: NAD as a metabolic oscillator for the regulation of metabolism and aging. Biochim Biophys Acta 2010; 1804: 1584-1590.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1584-1590
    • Imai, S.I.1
  • 88
    • 71549154751 scopus 로고    scopus 로고
    • Sirtuins, melatonin and circadian rhythms: Building a bridge between aging and cancer
    • Jung-Hynes B, Reiter RJ, Ahmad N,. Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. J Pineal Res 2010; 48: 9-19.
    • (2010) J Pineal Res , vol.48 , pp. 9-19
    • Jung-Hynes, B.1    Reiter, R.J.2    Ahmad, N.3
  • 89
    • 78650537866 scopus 로고    scopus 로고
    • Sleep disturbances and inflammatory bowel disease: A potential trigger for disease flare?
    • Swanson GR, Burgess HJ, Keshavarzian A,. Sleep disturbances and inflammatory bowel disease: a potential trigger for disease flare? Expert Rev Clin Immunol 2011; 7: 29-36.
    • (2011) Expert Rev Clin Immunol , vol.7 , pp. 29-36
    • Swanson, G.R.1    Burgess, H.J.2    Keshavarzian, A.3
  • 90
    • 77249089947 scopus 로고    scopus 로고
    • Resveratrol (trans-3,5,4′-trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulphate sodium-induced colitis
    • Singh UP, Singh NP, Balwan S, et al., Resveratrol (trans-3,5,4′- trihydroxystilbene) induces silent mating type information regulation-1 and down-regulates nuclear transcription factor-kappaB activation to abrogate dextran sulphate sodium-induced colitis. J Pharmacol Exp Ther 2009; 332: 829-839.
    • (2009) J Pharmacol Exp Ther , vol.332 , pp. 829-839
    • Singh, U.P.1    Singh, N.P.2    Balwan, S.3
  • 91
    • 77950820267 scopus 로고    scopus 로고
    • Resveratrol suppresses colitis and colon cancer associated with colitis
    • Cui X, Jin Y, Hofseth AB, et al., Resveratrol suppresses colitis and colon cancer associated with colitis. Cancer Prev Res 2010; 3: 549-559.
    • (2010) Cancer Prev Res , vol.3 , pp. 549-559
    • Cui, X.1    Jin, Y.2    Hofseth, A.B.3
  • 92
    • 78049510453 scopus 로고    scopus 로고
    • Taming the beast within: Resveratrol suppresses colitis and prevents colon cancer
    • Hofseth LJ, Singh UP, Singh NP, et al., Taming the beast within: resveratrol suppresses colitis and prevents colon cancer. Aging 2010; 2: 183-184.
    • (2010) Aging , vol.2 , pp. 183-184
    • Hofseth, L.J.1    Singh, U.P.2    Singh, N.P.3
  • 93
    • 3242719545 scopus 로고    scopus 로고
    • Modulation of NF-κB-dependent transcription and cell survival by the SIRT1 deacetylase
    • DOI 10.1038/sj.emboj.7600244
    • Yeung F, Hoberg JE, Ramsey CS, et al., Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO J 2004; 23: 2369-2380. (Pubitemid 38954844)
    • (2004) EMBO Journal , vol.23 , Issue.12 , pp. 2369-2380
    • Yeung, F.1    Hoberg, J.E.2    Ramsey, C.S.3    Keller, M.D.4    Jones, D.R.5    Frye, R.A.6    Mayo, M.W.7
  • 94
    • 28544444366 scopus 로고    scopus 로고
    • Cancer-specific functions of SIRT1 enable human epithelial cancer cell growth and survival
    • DOI 10.1158/0008-5472.CAN-05-1923
    • Ford J, Jiang M, Milner J,. Cancer-specific functions of SIRT1 enables human epithelial cancer cell growth and survival. Cancer Res 2005; 65: 10457-10463. (Pubitemid 41743740)
    • (2005) Cancer Research , vol.65 , Issue.22 , pp. 10457-10463
    • Ford, J.1    Jiang, M.2    Milner, J.3
  • 96
    • 67650691722 scopus 로고    scopus 로고
    • SIRT1 histonedeacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer
    • Nosho K, Shima K, Irahara N, et al., SIRT1 histonedeacetylase expression is associated with microsatellite instability and CpG island methylator phenotype in colorectal cancer. Mod Pathol 2009; 22: 922-932.
    • (2009) Mod Pathol , vol.22 , pp. 922-932
    • Nosho, K.1    Shima, K.2    Irahara, N.3
  • 97
    • 44849096876 scopus 로고    scopus 로고
    • The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth
    • Firestein R, Blander G, Michan S, et al., The SIRT1 deacetylase suppresses intestinal tumorigenesis and colon cancer growth. PLoS ONE 2008; 3: e2020.
    • (2008) PLoS ONE , vol.3
    • Firestein, R.1    Blander, G.2    Michan, S.3
  • 98
    • 0033119801 scopus 로고    scopus 로고
    • β-catenin regulates expression of cyclin D1 in colon carcinoma cells
    • DOI 10.1038/18884
    • Tetsu O, Mccormick F,. β-catenin regulates expression of cyclin D1 in colon carcinoma cells. Nature 1999; 398: 422-426. (Pubitemid 29180374)
    • (1999) Nature , vol.398 , Issue.6726 , pp. 422-426
    • Tetsu, O.1    McCormick, F.2
  • 99
    • 63049111216 scopus 로고    scopus 로고
    • PCAF acetylates β-catenin and improves its stability
    • Ge X, Jin Q, Zhang F, et al., PCAF acetylates β-catenin and improves its stability. Mol Biol Cell 2009; 20: 419-427.
    • (2009) Mol Biol Cell , vol.20 , pp. 419-427
    • Ge, X.1    Jin, Q.2    Zhang, F.3
  • 100
    • 0033895709 scopus 로고    scopus 로고
    • Wnt signalling and cancer
    • Polakis P,. Wnt signalling and cancer. Genes Dev 2000; 14: 1837-1851.
    • (2000) Genes Dev , vol.14 , pp. 1837-1851
    • Polakis, P.1
  • 101
    • 77952714326 scopus 로고    scopus 로고
    • SIRT1 regulates Dishevalled proteins and promotes transient and constitutive Wnt signalling
    • Holloway KR, Calhoun TN, Saxena M, et al., SIRT1 regulates Dishevalled proteins and promotes transient and constitutive Wnt signalling. Proc Natl Acad Sci USA 2010; 107: 9216-9221.
    • (2010) Proc Natl Acad Sci USA , vol.107 , pp. 9216-9221
    • Holloway, K.R.1    Calhoun, T.N.2    Saxena, M.3
  • 102
    • 67650563916 scopus 로고    scopus 로고
    • SirT1 is an inhibitor of proliferation and tumor formation in colon cancer
    • Kabra N, Li Z, Chen L, et al., SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem 2009; 284: 18210-18217.
    • (2009) J Biol Chem , vol.284 , pp. 18210-18217
    • Kabra, N.1    Li, Z.2    Chen, L.3
  • 104
    • 67650439330 scopus 로고    scopus 로고
    • Caloric restriction delays disease onset and mortality in Rhesus monkeys
    • Colman RJ, Anderson RM, Johnson ST, et al., Caloric restriction delays disease onset and mortality in Rhesus monkeys. Science 2009; 325: 201-204.
    • (2009) Science , vol.325 , pp. 201-204
    • Colman, R.J.1    Anderson, R.M.2    Johnson, S.T.3
  • 105
    • 67650944993 scopus 로고    scopus 로고
    • Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
    • Harrison DE, Strong R, Sharp ZD, et al., Rapamycin fed late in life extends lifespan in genetically heterogeneous mice. Nature 2009; 460: 392-395.
    • (2009) Nature , vol.460 , pp. 392-395
    • Harrison, D.E.1    Strong, R.2    Sharp, Z.D.3
  • 106
    • 66149173551 scopus 로고    scopus 로고
    • Aging and cancer cell biology
    • Campisi J, Yaswen P,. Aging and cancer cell biology. Aging Cell 2009; 8: 221-225.
    • (2009) Aging Cell , vol.8 , pp. 221-225
    • Campisi, J.1    Yaswen, P.2
  • 108
    • 67349276169 scopus 로고    scopus 로고
    • AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
    • Cantõ C, Gerhart-Hines Z, Feige JN, et al., AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009; 458: 1056-1060.
    • (2009) Nature , vol.458 , pp. 1056-1060
    • Cantõ, C.1    Gerhart-Hines, Z.2    Feige, J.N.3
  • 110
    • 75149128169 scopus 로고    scopus 로고
    • The life span-prolonging effect of sirtuin-1 is mediated by autophagy
    • Morselli E, Maiuri MC, Markaki M, et al., The life span-prolonging effect of sirtuin-1 is mediated by autophagy. Autophagy 2010; 6: 1-3.
    • (2010) Autophagy , vol.6 , pp. 1-3
    • Morselli, E.1    Maiuri, M.C.2    Markaki, M.3
  • 111
    • 51449101022 scopus 로고    scopus 로고
    • Thirty four years since the discovery of gastrointestinal melatonin
    • Bubenik GA,. Thirty four years since the discovery of gastrointestinal melatonin. J Physiol Pharmacol 2008; 59: 33-51.
    • (2008) J Physiol Pharmacol , vol.59 , pp. 33-51
    • Bubenik, G.A.1
  • 113
    • 71549120441 scopus 로고    scopus 로고
    • Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes
    • Jou MJ, Peng TI, Hsu LF, et al., Visualization of melatonin's multiple mitochondrial levels of protection against mitochondrial Ca(2+)-mediated permeability transition and beyond in rat brain astrocytes. J Pineal Res 2010; 48: 20-38.
    • (2010) J Pineal Res , vol.48 , pp. 20-38
    • Jou, M.J.1    Peng, T.I.2    Hsu, L.F.3
  • 114
    • 77950663581 scopus 로고    scopus 로고
    • Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease
    • Paradies G, Petrosillo G, Paradies V, et al., Melatonin, cardiolipin and mitochondrial bioenergetics in health and disease. J Pineal Res 2010; 48: 297-310.
    • (2010) J Pineal Res , vol.48 , pp. 297-310
    • Paradies, G.1    Petrosillo, G.2    Paradies, V.3
  • 115
    • 57149136499 scopus 로고    scopus 로고
    • Melatonin attenuates lipopolysaccharide-induced acute lung inflammation in sleep-deprived mice
    • Lee YD, Kim JY, Lee KH, et al., Melatonin attenuates lipopolysaccharide- induced acute lung inflammation in sleep-deprived mice. J Pineal Res 2009; 46: 53-57.
    • (2009) J Pineal Res , vol.46 , pp. 53-57
    • Lee, Y.D.1    Kim, J.Y.2    Lee, K.H.3
  • 116
    • 59149099772 scopus 로고    scopus 로고
    • Melatonin protects against experimental reflux esophagitis
    • Lahiri S, Singh P, Singh S, et al., Melatonin protects against experimental reflux esophagitis. J Pineal Res 2009; 46: 207-213.
    • (2009) J Pineal Res , vol.46 , pp. 207-213
    • Lahiri, S.1    Singh, P.2    Singh, S.3
  • 117
    • 77749310344 scopus 로고    scopus 로고
    • Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats
    • Jung KH, Hong SW, Zheng HM, et al., Melatonin ameliorates cerulein-induced pancreatitis by the modulation of nuclear erythroid 2-related factor 2 and nuclear factor-kappaB in rats. J Pineal Res 2010; 48: 239-250.
    • (2010) J Pineal Res , vol.48 , pp. 239-250
    • Jung, K.H.1    Hong, S.W.2    Zheng, H.M.3
  • 118
    • 14344250929 scopus 로고    scopus 로고
    • Melatonin as an organoprotector in the stomach and the pancreas
    • DOI 10.1111/j.1600-079X.2004.00179.x
    • Jaworek J, Brzozowski T, Konturek SJ,. Melatonin as an organoprotector in the stomach and the pancreas. J Pineal Res 2005; 38: 73-83. (Pubitemid 40293231)
    • (2005) Journal of Pineal Research , vol.38 , Issue.2 , pp. 73-83
    • Jaworek, J.1    Brzozowski, T.2    Konturek, S.J.3
  • 119
    • 78049451374 scopus 로고    scopus 로고
    • Melatonin: A pleiotropic molecule regulating inflammation
    • Radogna F, Diederich M, Ghibelli L,. Melatonin: a pleiotropic molecule regulating inflammation. Biochem Pharmacol 2010; 80: 1844-1852.
    • (2010) Biochem Pharmacol , vol.80 , pp. 1844-1852
    • Radogna, F.1    Diederich, M.2    Ghibelli, L.3
  • 120
  • 121
    • 0004608585 scopus 로고    scopus 로고
    • Melatonin: Lowering the High Price of Free Radicals
    • Reiter RJ,. Melatonin: lowering the High Price of Free Radicals. News Physiol Sci 2000; 15: 246-250.
    • (2000) News Physiol Sci , vol.15 , pp. 246-250
    • Reiter, R.J.1
  • 122
    • 70349577367 scopus 로고    scopus 로고
    • Reducing oxidative/nitrosative stress: A newly-discovered genre for melatonin
    • Reiter RJ, Paredes SD, Manchester LC, et al., Reducing oxidative/nitrosative stress: a newly-discovered genre for melatonin. Crit Rev Biochem Mol Biol 2009; 44: 175-200.
    • (2009) Crit Rev Biochem Mol Biol , vol.44 , pp. 175-200
    • Reiter, R.J.1    Paredes, S.D.2    Manchester, L.C.3
  • 123
    • 78149411295 scopus 로고    scopus 로고
    • Melatonin: Action as antioxidant and potential applications in human disease and aging
    • Bonnefont-Rousselot D, Collin F,. Melatonin: action as antioxidant and potential applications in human disease and aging. Toxicology 2010; 278: 55-67.
    • (2010) Toxicology , vol.278 , pp. 55-67
    • Bonnefont-Rousselot, D.1    Collin, F.2
  • 124
    • 77954378907 scopus 로고    scopus 로고
    • Melatonin as a therapeutic tool in ophthalmology: Implications for glaucoma and uveitis
    • Rosenstein RE, Pandi-Perumal SR, Srinivasan V, et al., Melatonin as a therapeutic tool in ophthalmology: implications for glaucoma and uveitis. J Pineal Res 2010; 49: 1-13.
    • (2010) J Pineal Res , vol.49 , pp. 1-13
    • Rosenstein, R.E.1    Pandi-Perumal, S.R.2    Srinivasan, V.3
  • 126
    • 0029349171 scopus 로고
    • Melatonin reduces the severity of dextran-induced colitis in mice
    • Pentney PT, Bubenik GA,. Melatonin reduces the severity of dextran-induced colitis in mice. J Pineal Res 1995; 19: 31-39.
    • (1995) J Pineal Res , vol.19 , pp. 31-39
    • Pentney, P.T.1    Bubenik, G.A.2
  • 127
    • 77955159826 scopus 로고    scopus 로고
    • Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: Role of matrix metalloproteinase-2
    • Ganguly K, Sharma AV, Reiter RJ, Swarnakar S,. Melatonin promotes angiogenesis during protection and healing of indomethacin-induced gastric ulcer: role of matrix metalloproteinase-2. J Pineal Res 2010; 49: 130-140.
    • (2010) J Pineal Res , vol.49 , pp. 130-140
    • Ganguly, K.1    Sharma, A.V.2    Reiter, R.J.3    Swarnakar, S.4
  • 129
    • 27144513254 scopus 로고    scopus 로고
    • Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro
    • DOI 10.1136/pgmj.2004.030817
    • Mei Q, Xu JM, Xiang L, et al., Change of nitric oxide in experimental colitis and its inhibition by melatonin in vivo and in vitro. Postgrad Med J 2005; 81: 667-672. (Pubitemid 41498476)
    • (2005) Postgraduate Medical Journal , vol.81 , Issue.960 , pp. 667-672
    • Mei, Q.1    Xu, J.-M.2    Xiang, L.3    Hu, Y.-M.4    Hu, X.-P.5    Xu, Z.-W.6
  • 131
    • 49549087478 scopus 로고    scopus 로고
    • Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis
    • Esposito E, Mazzon E, Riccardi L, et al., Matrix metalloproteinase-9 and metalloproteinase-2 activity and expression is reduced by melatonin during experimental colitis. J Pineal Res 2008; 45: 166-173.
    • (2008) J Pineal Res , vol.45 , pp. 166-173
    • Esposito, E.1    Mazzon, E.2    Riccardi, L.3
  • 132
    • 79952446269 scopus 로고    scopus 로고
    • Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats
    • Tahan G, Gramignoli R, Marongiu F, et al., Melatonin expresses powerful anti-inflammatory and antioxidant activities resulting in complete improvement of acetic-acid-induced colitis in rats. Dig Dis Sci 2011; 56: 715-720.
    • (2011) Dig Dis Sci , vol.56 , pp. 715-720
    • Tahan, G.1    Gramignoli, R.2    Marongiu, F.3
  • 133
    • 0032545762 scopus 로고    scopus 로고
    • Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP- ribose) synthase in a carrageenan-induced model of local inflammation
    • DOI 10.1016/S0014-2999(97)01417-9, PII S0014299997014179
    • Cuzzocrea S, Zingarelli B, Gilad E, et al., Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation. Eur J Pharmacol 1998; 342: 67-76. (Pubitemid 28131347)
    • (1998) European Journal of Pharmacology , vol.342 , Issue.1 , pp. 67-76
    • Cuzzocrea, S.1    Zingarelli, B.2    Gilad, E.3    Hake, P.4    Salzman, A.L.5    Szabo, C.6
  • 134
    • 0029032902 scopus 로고
    • Melatonin stimulates brain glutathione peroxidase activity
    • Barlow-Walden LR, Reiter RJ, Abe M, et al., Melatonin stimulates brain glutathione peroxidase activity. Neurochem Int 1995; 26: 497-502.
    • (1995) Neurochem Int , vol.26 , pp. 497-502
    • Barlow-Walden, L.R.1    Reiter, R.J.2    Abe, M.3
  • 135
    • 0029385216 scopus 로고
    • Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks
    • Pablos MI, Agapito MT, Gutierrez R, et al., Melatonin stimulates the activity of the detoxifying enzyme glutathione peroxidase in several tissues of chicks. J Pineal Res 1995; 19: 111-115.
    • (1995) J Pineal Res , vol.19 , pp. 111-115
    • Pablos, M.I.1    Agapito, M.T.2    Gutierrez, R.3
  • 137
    • 34147219227 scopus 로고    scopus 로고
    • Protective effect of melatonin in acetic acid induced colitis in rats
    • DOI 10.1111/j.1600-079X.2007.00428.x
    • Nosál'ová V, Zeman M, Cerná S, et al., Protective effect of melatonin in acetic acid induced colitis in rats. J Pineal Res 2007; 42: 364-370. (Pubitemid 46581661)
    • (2007) Journal of Pineal Research , vol.42 , Issue.4 , pp. 364-370
    • Nosal'ova, V.1    Zeman, M.2    Cerna, S.3    Navarova, J.4    Zakalova, M.5
  • 139
    • 0036790693 scopus 로고    scopus 로고
    • Melatonin reduces colon immunological injury in rats by regulating activity of macrophages
    • Mei Q, Yu JP, Xu JM, et al., Melatonin reduces colon immunological injury in rats by regulating activity of macrophages. Acta Pharmacol Sin 2002; 23: 882-886.
    • (2002) Acta Pharmacol Sin , vol.23 , pp. 882-886
    • Mei, Q.1    Yu, J.P.2    Xu, J.M.3
  • 140
    • 25644449484 scopus 로고    scopus 로고
    • Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis
    • Li JH, Yu JP, Yu HG, et al., Melatonin reduces inflammatory injury through inhibiting NF-kappaB activation in rats with colitis. Mediators Inflamm 2005; 2005: 185-193.
    • (2005) Mediators Inflamm , vol.2005 , pp. 185-193
    • Li, J.H.1    Yu, J.P.2    Yu, H.G.3
  • 142
    • 33644890227 scopus 로고    scopus 로고
    • Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis
    • Marquez E, Sánchez-Fidalgo S, Calvo JR, et al., Acutely administered melatonin is beneficial while chronic melatonin treatment aggravates the evolution of TNBS-induced colitis. J Pineal Res 2006; 40: 48-55.
    • (2006) J Pineal Res , vol.40 , pp. 48-55
    • Marquez, E.1    Sánchez-Fidalgo, S.2    Calvo, J.R.3
  • 144
    • 0030272628 scopus 로고    scopus 로고
    • Effect of melatonin on NF-κB DNA-binding activity in the rat spleen
    • DOI 10.1006/cbir.1996.0091
    • Chuang JI, Mohan N, Meltz ML, et al., Effect of melatonin on NF-kappa-B DNA-binding activity in the rat spleen. Cell Biol Int 1996; 20: 687-692. (Pubitemid 26402163)
    • (1996) Cell Biology International , vol.20 , Issue.10 , pp. 687-692
    • Chuang, J.-I.1    Mohan, N.2    Meltz, M.L.3    Reiter, R.J.4
  • 145
    • 0037254010 scopus 로고    scopus 로고
    • Melatonin for ulcerative colitis?
    • Mann S,. Melatonin for ulcerative colitis? Am J Gastroenterol 2003; 98: 232-233.
    • (2003) Am J Gastroenterol , vol.98 , pp. 232-233
    • Mann, S.1
  • 147
    • 51649109708 scopus 로고    scopus 로고
    • Melatonin usage in ulcerative colitis: A case report
    • Maldonado MD, Calvo JR,. Melatonin usage in ulcerative colitis: a case report. J Pineal Res 2008; 45: 339-340.
    • (2008) J Pineal Res , vol.45 , pp. 339-340
    • Maldonado, M.D.1    Calvo, J.R.2
  • 148
    • 27644466592 scopus 로고    scopus 로고
    • A review of the multiple actions of melatonin on the immune system
    • DOI 10.1385/ENDO:27:2:189
    • Carrillo-Vico A, Guerrero JM, Lardone PJ, et al., A review of the multiple actions of melatonin on the immune system. Endocrine 2005; 27: 189-200. (Pubitemid 41558451)
    • (2005) Endocrine , vol.27 , Issue.2 , pp. 189-200
    • Carrillo-Vico, A.1    Guerrero, J.M.2    Lardone, P.J.3    Reiter, R.J.4
  • 150
    • 53749085741 scopus 로고    scopus 로고
    • Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line
    • Martín-Renedo J, Mauriz JL, Jorquera F, et al., Melatonin induces cell cycle arrest and apoptosis in hepatocarcinoma HepG2 cell line. J Pineal Res 2008; 45: 532-540.
    • (2008) J Pineal Res , vol.45 , pp. 532-540
    • Martín-Renedo, J.1    Mauriz, J.L.2    Jorquera, F.3
  • 151
    • 77954323682 scopus 로고    scopus 로고
    • Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells
    • Cabrera J, Negrín G, Estévez F, et al., Melatonin decreases cell proliferation and induces melanogenesis in human melanoma SK-MEL-1 cells. J Pineal Res 2010; 49: 45-54.
    • (2010) J Pineal Res , vol.49 , pp. 45-54
    • Cabrera, J.1    Negrín, G.2    Estévez, F.3
  • 152
    • 77954322791 scopus 로고    scopus 로고
    • Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells
    • Jung-Hynes B, Huang W, Reiter RJ, et al., Melatonin resynchronizes dysregulated circadian rhythm circuitry in human prostate cancer cells. J Pineal Res 2010; 49: 60-68.
    • (2010) J Pineal Res , vol.49 , pp. 60-68
    • Jung-Hynes, B.1    Huang, W.2    Reiter, R.J.3
  • 153
    • 77956330076 scopus 로고    scopus 로고
    • Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer
    • Padillo FJ, Ruiz-Rabelo JF, Cruz A, et al., Melatonin and celecoxib improve the outcomes in hamsters with experimental pancreatic cancer. J Pineal Res 2010; 49: 264-270.
    • (2010) J Pineal Res , vol.49 , pp. 264-270
    • Padillo, F.J.1    Ruiz-Rabelo, J.F.2    Cruz, A.3
  • 154
    • 78650672113 scopus 로고    scopus 로고
    • Basic mechanisms involved in the anti-cancer effects of melatonin
    • Mediavilla MD, Sanchez-Barcelo EJ, Tan DX, et al., Basic mechanisms involved in the anti-cancer effects of melatonin. Curr Med Chem 2010; 17: 4462-4481.
    • (2010) Curr Med Chem , vol.17 , pp. 4462-4481
    • Mediavilla, M.D.1    Sanchez-Barcelo, E.J.2    Tan, D.X.3
  • 156
    • 33645333682 scopus 로고    scopus 로고
    • The role of melatonin in immuno-enhancement: Potential application in cancer
    • Miller SC, Pandi-Perumal SR, Esquifino AI, et al., The role of melatonin in immuno-enhancement: potential application in cancer. Int J Exp Pathol 2006; 87: 81-87.
    • (2006) Int J Exp Pathol , vol.87 , pp. 81-87
    • Miller, S.C.1    Pandi-Perumal, S.R.2    Esquifino, A.I.3
  • 157
    • 33846935284 scopus 로고    scopus 로고
    • Antiproliferative effects of melatonin on the growth of rat pituitary prolactin-secreting tumor cells in vitro
    • Yang QH, Xu JN, Xu RK, et al., Antiproliferative effects of melatonin on the growth of rat pituitary prolactin-secreting tumor cells in vitro. J Pineal Res 2007; 42: 172-179.
    • (2007) J Pineal Res , vol.42 , pp. 172-179
    • Yang, Q.H.1    Xu, J.N.2    Xu, R.K.3
  • 158
    • 0029670379 scopus 로고    scopus 로고
    • Melatonin and 2[125I]iodomelatonin binding sites in the human colon
    • Poon AM, Mak AS, Luk HT,. Melatonin and 2[125I]iodomelatonin binding sites in the human colon. Endocr Res 1996; 22: 77-94.
    • (1996) Endocr Res , vol.22 , pp. 77-94
    • Poon, A.M.1    Mak, A.S.2    Luk, H.T.3
  • 161
    • 59849088009 scopus 로고    scopus 로고
    • A generalized theory of carcinogenesis due to chronodisruption
    • Erren TC, Reiter RJ,. A generalized theory of carcinogenesis due to chronodisruption. Neuro Endocrinol Lett 2008; 29: 815-821.
    • (2008) Neuro Endocrinol Lett , vol.29 , pp. 815-821
    • Erren, T.C.1    Reiter, R.J.2
  • 162
    • 0031756038 scopus 로고    scopus 로고
    • Antiproliferative effects of melatonin and CGP 52608 on the murine Colon 38 adenocarcinoma in vitro and in vivo
    • Karasek M, Winczyk K, Kunert-Radek J, et al., Antiproliferative effects of melatonin and CGP 52608 on the murine colon 38 adenocarcinoma in vitro and in vivo. Neuro Endocrinol Lett 1998; 19: 71-78. (Pubitemid 28438269)
    • (1998) Neuroendocrinology Letters , vol.19 , Issue.2 , pp. 71-78
    • Karasek, M.1    Winczyk, K.2    Kunert-Radek, J.3    Wiesenberg, I.4    Pawlikowski, M.5
  • 163
    • 0033027891 scopus 로고    scopus 로고
    • Antiproliferative effects of melatonin and CGP 52608
    • Karasek M, Pawlikowski M,. Antiproliferative effects of melatonin and CGP 52608. Biol Signals Recept 1999; 8: 75-78. (Pubitemid 29132386)
    • (1999) Biological Signals and Receptors , vol.8 , Issue.1-2 , pp. 75-78
    • Karasek, M.1    Pawlikowski, M.2
  • 165
    • 0344417047 scopus 로고    scopus 로고
    • Melatonin blocks the activation of estrogen receptor for DNA binding
    • Rato AG, Pedrero JG, Martinez MA, et al., Melatonin blocks the activation of estrogen receptor for DNA binding. FASEB J 1999; 13: 857-868.
    • (1999) FASEB J , vol.13 , pp. 857-868
    • Rato, A.G.1    Pedrero, J.G.2    Martinez, M.A.3
  • 168
    • 0033859912 scopus 로고    scopus 로고
    • Melatonin inhibits apoptosis during early B-cell development in mouse bone marrow
    • Yu Q, Miller SC, Osmond DG,. Melatonin inhibits apoptosis during early B-cell development in mouse bone marrow. J Pineal Res 2000; 29: 86-93.
    • (2000) J Pineal Res , vol.29 , pp. 86-93
    • Yu, Q.1    Miller, S.C.2    Osmond, D.G.3
  • 169
    • 75149124310 scopus 로고    scopus 로고
    • The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors
    • Das A, Mcdowell M, Pava MJ, et al., The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-alpha toxicity involves membrane melatonin receptors. J Pineal Res 2010; 48: 157-169.
    • (2010) J Pineal Res , vol.48 , pp. 157-169
    • Das, A.1    McDowell, M.2    Pava, M.J.3
  • 170
    • 77956301403 scopus 로고    scopus 로고
    • Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1)
    • Leja-Szpak A, Jaworek J, Pierzchalski P, et al., Melatonin induces pro-apoptotic signaling pathway in human pancreatic carcinoma cells (PANC-1). J Pineal Res 2010; 49: 248-255.
    • (2010) J Pineal Res , vol.49 , pp. 248-255
    • Leja-Szpak, A.1    Jaworek, J.2    Pierzchalski, P.3
  • 171
    • 0031761543 scopus 로고    scopus 로고
    • Somatostatin analogue octreotide and melatonin inhibit bromodeoxyuridine incorporation into cell nuclei and enhance apoptosis in the transplantable murine Colon 38 cancer
    • MeÅen-Mucha G, Winczyk K, Pawlikowski M,. Somatostatin analogue octreotide and melatonin inhibit bromodeoxyuridine incorporation into cell nuclei and enhance apoptosis in the transplantable murine Colon 38 cancer. Anticancer Res 1998; 18: 3615-3619. (Pubitemid 28546499)
    • (1998) Anticancer Research , vol.18 , Issue.5 , pp. 3615-3619
    • Melen-Mucha, G.1    Winczyk, K.2    Pawlikowski, M.3
  • 172
    • 0034894104 scopus 로고    scopus 로고
    • Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer
    • DOI 10.1034/j.1600-079X.2001.310213.x
    • Winczyk K, Pawlikowski M, Karasek M,. Melatonin and RZR/ROR receptor ligand CGP 52608 induce apoptosis in the murine colonic cancer. J Pineal Res 2001; 31: 179-182. (Pubitemid 32778168)
    • (2001) Journal of Pineal Research , vol.31 , Issue.2 , pp. 179-182
    • Winczyk, K.1    Pawlikowski, M.2    Karasek, M.3
  • 173
    • 0036925663 scopus 로고    scopus 로고
    • Possible involvement of the nuclear RZR/ROR-alpha receptor in the
    • DOI 10.1159/000068569
    • Winczyk K, Pawlikowski M, Guerrero JM, et al., Possible involvement of the nuclear RZR/ROR-alpha receptor in the antitumor action of melatonin on murine Colon 38 cancer. Tumour Biol 2002; 23: 298-302. (Pubitemid 36302487)
    • (2002) Tumor Biology , vol.23 , Issue.5 , pp. 298-302
    • Winczyk, K.1    Pawlikowski, M.2    Guerrero, J.M.3    Karasek, M.4
  • 174
    • 22044458158 scopus 로고    scopus 로고
    • Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products
    • DOI 10.1002/ijc.20837
    • Wenzel U, Nickel A, Daniel H,. Melatonin potentiates flavone-induced apoptosis in human colon cancer cells by increasing the level of glycolytic end products. Int J Cancer 2005; 116: 236-242. (Pubitemid 40967260)
    • (2005) International Journal of Cancer , vol.116 , Issue.2 , pp. 236-242
    • Wenzel, U.1    Nickel, A.2    Daniel, H.3
  • 176
    • 0031428105 scopus 로고    scopus 로고
    • Melatonin and colon carcinogenesis: I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2-dimethylhydrazine in rats
    • DOI 10.1093/carcin/18.8.1549
    • Anisimov VN, Popovich IG, Zabezhinski MA,. Melatonin and colon carcinogenesis: I. Inhibitory effect of melatonin on development of intestinal tumors induced by 1,2 dimethylhydrazine in rats. Carcinogenesis 1997; 18: 1549-1553. (Pubitemid 28134778)
    • (1997) Carcinogenesis , vol.18 , Issue.8 , pp. 1549-1553
    • Anisimov, V.N.1    Popovich, I.G.2    Zabezhinski, M.A.3
  • 178
    • 0034320122 scopus 로고    scopus 로고
    • Melatonin and colon carcinogenesis. IV. Effect of melatonin on proliferative activity and expression of apoptosis-related proteins in the spleen of rats exposed to 1,2-dimethylhydrazine
    • Kossoy G, Ben-Hur H, Popovich I, et al., Melatonin and colon carcinogenesis. IV. Effect of melatonin on proliferative activity and expression of apoptosis-related proteins in the spleen of rats exposed to 1,2-dimethylhydrazine. Oncol Rep 2000; 7: 1401-1405.
    • (2000) Oncol Rep , vol.7 , pp. 1401-1405
    • Kossoy, G.1    Ben-Hur, H.2    Popovich, I.3
  • 179
    • 57649225896 scopus 로고    scopus 로고
    • Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats
    • Tanaka T, Yasui Y, Tanaka M, et al., Melatonin suppresses AOM/DSS-induced large bowel oncogenesis in rats. Chem Biol Interact 2009; 177: 128-136.
    • (2009) Chem Biol Interact , vol.177 , pp. 128-136
    • Tanaka, T.1    Yasui, Y.2    Tanaka, M.3
  • 180
    • 0442323561 scopus 로고    scopus 로고
    • Autophagy: In sickness and in health
    • DOI 10.1016/j.tcb.2003.12.002
    • Cuervo AM,. Autophagy: in sickness and in health. Trends Cell Biol 2004; 14: 70-77. (Pubitemid 38186640)
    • (2004) Trends in Cell Biology , vol.14 , Issue.2 , pp. 70-77
    • Cuervo, A.M.1
  • 181
    • 77953292238 scopus 로고    scopus 로고
    • SIRT1 and p53, effect on cancer, senescence and beyond
    • Yi J, Luo J,. SIRT1 and p53, effect on cancer, senescence and beyond. Biochim Biophys Acta 2010; 1804: 1684-1689.
    • (2010) Biochim Biophys Acta , vol.1804 , pp. 1684-1689
    • Yi, J.1    Luo, J.2
  • 182
    • 71849083952 scopus 로고    scopus 로고
    • Autophagy upregulation and loss of NF-kappaB in oxidative stress-related immunodeficient SAMP8 mice
    • Caballero B, Vega-Naredo I, Sierra V, et al., Autophagy upregulation and loss of NF-kappaB in oxidative stress-related immunodeficient SAMP8 mice. Mech Ageing Dev 2009; 130: 722-730.
    • (2009) Mech Ageing Dev , vol.130 , pp. 722-730
    • Caballero, B.1    Vega-Naredo, I.2    Sierra, V.3
  • 183
    • 77149160042 scopus 로고    scopus 로고
    • Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement
    • Guo Y, Wang J, Wang Z, et al., Melatonin protects N2a against ischemia/reperfusion injury through autophagy enhancement. J Huazhong Univ Sci Technolog Med Sci 2010; 30: 1-7.
    • (2010) J Huazhong Univ Sci Technolog Med Sci , vol.30 , pp. 1-7
    • Guo, Y.1    Wang, J.2    Wang, Z.3
  • 184
    • 33645923392 scopus 로고    scopus 로고
    • Could melatonin unbalance the equilibrium between autophagy and invasive processes?
    • Coto-Montes A, Tomas-Zapico C,. Could melatonin unbalance the equilibrium between autophagy and invasive processes? Autophagy 2006; 2: 126-128.
    • (2006) Autophagy , vol.2 , pp. 126-128
    • Coto-Montes, A.1    Tomas-Zapico, C.2
  • 185
    • 33644903543 scopus 로고    scopus 로고
    • Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis
    • Esrefoglu M, Güi M, Ates B, et al., Ultrastructural clues for the protective effect of melatonin against oxidative damage in cerulein-induced pancreatitis J Pineal Res 2006; 40: 92-97.
    • (2006) J Pineal Res , vol.40 , pp. 92-97
    • Esrefoglu, M.1    Güi, M.2    Ates, B.3
  • 186
    • 42249099251 scopus 로고    scopus 로고
    • Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signaling pathways in H4IIE hepatoma cells through inhibition of Ras
    • DOI 10.1111/j.1600-079X.2007.00539.x
    • Kimball SR, Abbas A, Jefferson LS,. Melatonin represses oxidative stress-induced activation of the MAP kinase and mTOR signalling pathways in H4IIE hepatoma cells through inhibition of Ras. J Pineal Res 2008; 44: 379-386. (Pubitemid 351545739)
    • (2008) Journal of Pineal Research , vol.44 , Issue.4 , pp. 379-386
    • Kimball, S.R.1    Abbas, A.2    Jefferson, L.S.3
  • 187
    • 50849106068 scopus 로고    scopus 로고
    • Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway
    • Koh PO,. Melatonin prevents ischemic brain injury through activation of the mTOR/p70S6 kinase signaling pathway. Neurosci Lett 2008; 444: 74-78.
    • (2008) Neurosci Lett , vol.444 , pp. 74-78
    • Koh, P.O.1
  • 188
    • 59149091414 scopus 로고    scopus 로고
    • Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells
    • Kongsuphol P, Mukda S, Nopparat C, et al., Melatonin attenuates methamphetamine-induced deactivation of the mammalian target of rapamycin signaling to induce autophagy in SK-N-SH cells. J Pineal Res 2009; 46: 199-206.
    • (2009) J Pineal Res , vol.46 , pp. 199-206
    • Kongsuphol, P.1    Mukda, S.2    Nopparat, C.3
  • 189
    • 78349253806 scopus 로고    scopus 로고
    • The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy
    • Nopparat C, Porter JE, Ebadi M, et al., The mechanism for the neuroprotective effect of melatonin against methamphetamine-induced autophagy. J Pineal Res 2010; 49: 382-389.
    • (2010) J Pineal Res , vol.49 , pp. 382-389
    • Nopparat, C.1    Porter, J.E.2    Ebadi, M.3
  • 190
    • 77749336538 scopus 로고    scopus 로고
    • Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells
    • Yoo YM, Jeung EB,. Melatonin suppresses cyclosporine A-induced autophagy in rat pituitary GH3 cells. J Pineal Res 2010; 48: 204-211.
    • (2010) J Pineal Res , vol.48 , pp. 204-211
    • Yoo, Y.M.1    Jeung, E.B.2
  • 191
    • 70450239457 scopus 로고    scopus 로고
    • Metabolism and cancer: The circadian clock connection
    • Sahar S, Sassone-Corsi P,. Metabolism and cancer: the circadian clock connection. Nat Rev Cancer 2009; 9: 886-896.
    • (2009) Nat Rev Cancer , vol.9 , pp. 886-896
    • Sahar, S.1    Sassone-Corsi, P.2
  • 192
    • 56449122777 scopus 로고    scopus 로고
    • Period 2 mutation accelerates ApcMin/+ tumorigenesis
    • Wood PA, Yang X, Taber A, et al., Period 2 mutation accelerates ApcMin/+ tumorigenesis. Mol Cancer Res 2008; 6: 1786-1793.
    • (2008) Mol Cancer Res , vol.6 , pp. 1786-1793
    • Wood, P.A.1    Yang, X.2    Taber, A.3
  • 193
    • 70349323610 scopus 로고    scopus 로고
    • SIRT1 controls circadian clock circuitry and promotes cell survival: A connection with age-related neoplasms
    • Jung-Hynes B, Ahmad N,. SIRT1 controls circadian clock circuitry and promotes cell survival: a connection with age-related neoplasms. FASEB J 2009; 23: 2803-2809.
    • (2009) FASEB J , vol.23 , pp. 2803-2809
    • Jung-Hynes, B.1    Ahmad, N.2
  • 194
    • 0034466534 scopus 로고    scopus 로고
    • Melatonin in cancer patients and in tumor-bearing animals
    • Bartsch C, Bartsch H,. Melatonin in cancer patients and in tumor-bearing animals. Adv Exp Med Biol 1999; 467: 247-264.
    • (1999) Adv Exp Med Biol , vol.467 , pp. 247-264
    • Bartsch, C.1    Bartsch, H.2
  • 196
    • 79952113404 scopus 로고    scopus 로고
    • Neuroendocrine changes in patients with inflammatory diseases and colonic cancer
    • Rakhimova O, Paizullaeva ZK, Aleksandrov VB,. Neuroendocrine changes in patients with inflammatory diseases and colonic cancer. Klin Med (Mosk) 2010; 88: 56-60.
    • (2010) Klin Med (Mosk) , vol.88 , pp. 56-60
    • Rakhimova, O.1    Paizullaeva, Z.K.2    Aleksandrov, V.B.3
  • 197
    • 0344754096 scopus 로고    scopus 로고
    • Melatonin: A clock-output, a clock-input
    • DOI 10.1046/j.1365-2826.2003.01001.x
    • Stehle JH, Von Gall C, Korf HW,. Melatonin: a clock-output, a clock-input. J Neuroendocrinol 2003; 15: 383-389. (Pubitemid 36395236)
    • (2003) Journal of Neuroendocrinology , vol.15 , Issue.4 , pp. 383-389
    • Stehle, J.H.1    Von Gall, C.2    Korf, H.-W.3
  • 200
    • 84857041134 scopus 로고    scopus 로고
    • Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis
    • [Epub ahead of print].
    • Bang JB, Chang HW, Jung HR, et al., Melatonin attenuates clock gene Cryptochrome1, which may aggravates mouse anti-type II collagen antibody-induced arthritis. Rheumatol Int 2010 [Epub ahead of print].
    • (2010) Rheumatol Int
    • Bang, J.B.1    Chang, H.W.2    Jung, H.R.3
  • 201
    • 79951632056 scopus 로고    scopus 로고
    • Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model
    • Jung-Hynes B, Schmit TL, Reagan-Shaw SR, et al., Melatonin, a novel Sirt1 inhibitor, imparts antiproliferative effects against prostate cancer in vitro in culture and in vivo in TRAMP model. J Pineal Res 2011; 50: 140-149.
    • (2011) J Pineal Res , vol.50 , pp. 140-149
    • Jung-Hynes, B.1    Schmit, T.L.2    Reagan-Shaw, S.R.3
  • 202
    • 69949114938 scopus 로고    scopus 로고
    • Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats
    • Chang HM, Wu UI, Lan CT,. Melatonin preserves longevity protein (sirtuin 1) expression in the hippocampus of total sleep-deprived rats. J Pineal Res 2009; 47: 211-220.
    • (2009) J Pineal Res , vol.47 , pp. 211-220
    • Chang, H.M.1    Wu, U.I.2    Lan, C.T.3
  • 203
    • 53849094099 scopus 로고    scopus 로고
    • Evaluation of potencial pro-survival pathways regulated by melatonin in a murine senescente model
    • Gutierrez-Cuesta J, Tajes M, Jimenez A, et al., Evaluation of potencial pro-survival pathways regulated by melatonin in a murine senescente model. J Pineal Res 2008; 45: 497-505.
    • (2008) J Pineal Res , vol.45 , pp. 497-505
    • Gutierrez-Cuesta, J.1    Tajes, M.2    Jimenez, A.3
  • 204
    • 69949114091 scopus 로고    scopus 로고
    • Anti-aging properties of melatonin in an in Vitro murine senescente model: Involvement of the sirtuin 1 pathway
    • Tajes M, Gutierrez-Cuesta J, Ortuño-Sahagun D, et al., Anti-aging properties of melatonin in an in Vitro murine senescente model: involvement of the sirtuin 1 pathway. J Pineal Res 2009; 47: 228-237.
    • (2009) J Pineal Res , vol.47 , pp. 228-237
    • Tajes, M.1    Gutierrez-Cuesta, J.2    Ortuño-Sahagun, D.3
  • 205
    • 76549104638 scopus 로고    scopus 로고
    • Resveratrol and rapamycin: Are they anti-aging drugs?
    • Kaeberlein M,. Resveratrol and rapamycin: are they anti-aging drugs? Bioessays 2010; 32: 96-99.
    • (2010) Bioessays , vol.32 , pp. 96-99
    • Kaeberlein, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.