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Volumn 744, Issue 2, 2012, Pages 172-183

Dextran sulfate sodium-induced ulcerative colitis leads to increased hematopoiesis and induces both local as well as systemic genotoxicity in mice

Author keywords

Cell proliferation; Dextran sulfate sodium; Genotoxicity; Inflammation; Mice

Indexed keywords

8 HYDROXYDEOXYGUANOSINE; BIOLOGICAL MARKER; CYCLINE; DEXTRAN SULFATE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; PROSTAGLANDIN E2; TUMOR NECROSIS FACTOR ALPHA;

EID: 84859165038     PISSN: 13835718     EISSN: 18793592     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2012.03.001     Document Type: Article
Times cited : (29)

References (52)
  • 1
    • 33745775434 scopus 로고    scopus 로고
    • Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis
    • Sartor R.B. Mechanisms of disease: pathogenesis of Crohn's disease and ulcerative colitis. Nat. Clin. Pract. Gastroenterol. Hepatol. 2006, 3:390-407.
    • (2006) Nat. Clin. Pract. Gastroenterol. Hepatol. , vol.3 , pp. 390-407
    • Sartor, R.B.1
  • 2
    • 77952367628 scopus 로고    scopus 로고
    • The Economic Costs of Crohn's Disease and Ulcerative Colitis
    • available from: (cited 09.06.2007).
    • The Economic Costs of Crohn's Disease and Ulcerative Colitis, 2007, available from: (cited 09.06.2007). http://www.accesseconomics.com.au/publicationsreports.
    • (2007)
  • 4
    • 34249801765 scopus 로고    scopus 로고
    • G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice
    • Eijkelkamp N., Heijnen C.J., Lucas A., Premont R.T., Elsenbruch S., Schedlowski M., Kavelaars A. G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. Gut 2007, 56:847-854.
    • (2007) Gut , vol.56 , pp. 847-854
    • Eijkelkamp, N.1    Heijnen, C.J.2    Lucas, A.3    Premont, R.T.4    Elsenbruch, S.5    Schedlowski, M.6    Kavelaars, A.7
  • 5
    • 70949107842 scopus 로고    scopus 로고
    • Mechanisms of disease: inflammatory bowel disease
    • Abraham C., Cho J. Mechanisms of disease: inflammatory bowel disease. N. Engl. J. Med. 2009, 361:2066-2078.
    • (2009) N. Engl. J. Med. , vol.361 , pp. 2066-2078
    • Abraham, C.1    Cho, J.2
  • 6
    • 78650624793 scopus 로고    scopus 로고
    • Innate immune mechanisms of colitis and colitis-associated colorectal cancer
    • Saleh M., Trinchieri G. Innate immune mechanisms of colitis and colitis-associated colorectal cancer. Nat. Rev. Immunol. 2011, 11:9-20.
    • (2011) Nat. Rev. Immunol. , vol.11 , pp. 9-20
    • Saleh, M.1    Trinchieri, G.2
  • 7
    • 33646254148 scopus 로고    scopus 로고
    • Propionibacterium freudenreichii component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing
    • Okada Y., Tsuzuki Y., Miyazaki J., Matsuzaki K., Hokari R., Komoto S., Kato S., Kawaguchi A., Nagao S., Itoh K., Watanabe T., Miura S. Propionibacterium freudenreichii component 1.4-dihydroxy-2-naphthoic acid (DHNA) attenuates dextran sodium sulphate induced colitis by modulation of bacterial flora and lymphocyte homing. Gut 2006, 55:681-688.
    • (2006) Gut , vol.55 , pp. 681-688
    • Okada, Y.1    Tsuzuki, Y.2    Miyazaki, J.3    Matsuzaki, K.4    Hokari, R.5    Komoto, S.6    Kato, S.7    Kawaguchi, A.8    Nagao, S.9    Itoh, K.10    Watanabe, T.11    Miura, S.12
  • 8
    • 66349107334 scopus 로고    scopus 로고
    • Intestinal mucosal inflammation leads to systemic genotoxicity in mice
    • Westbrook A.M., Wei B., Braun J., Schiestl R.H. Intestinal mucosal inflammation leads to systemic genotoxicity in mice. Cancer Res. 2009, 69:4827-4834.
    • (2009) Cancer Res. , vol.69 , pp. 4827-4834
    • Westbrook, A.M.1    Wei, B.2    Braun, J.3    Schiestl, R.H.4
  • 9
    • 69249209950 scopus 로고    scopus 로고
    • More damaging than we think: systemic effects of intestinal inflammation
    • Westbrook A.M., Wei B., Braun J., Schiestl R.H. More damaging than we think: systemic effects of intestinal inflammation. Cell Cycle 2009, 8:2482-2483.
    • (2009) Cell Cycle , vol.8 , pp. 2482-2483
    • Westbrook, A.M.1    Wei, B.2    Braun, J.3    Schiestl, R.H.4
  • 10
    • 78649294424 scopus 로고    scopus 로고
    • Asian dust and titanium dioxide particles-induced inflammation and oxidative DNA damage in C57BL/6 mice
    • Hwang Y.J., Jeung Y.S., Seo M.H., Yoon J.Y., Kim D.Y., Park J.W., Han J.H., Jeong S.H. Asian dust and titanium dioxide particles-induced inflammation and oxidative DNA damage in C57BL/6 mice. Inhal. Toxicol. 2010, 22:1127-1133.
    • (2010) Inhal. Toxicol. , vol.22 , pp. 1127-1133
    • Hwang, Y.J.1    Jeung, Y.S.2    Seo, M.H.3    Yoon, J.Y.4    Kim, D.Y.5    Park, J.W.6    Han, J.H.7    Jeong, S.H.8
  • 11
    • 38349107062 scopus 로고    scopus 로고
    • Total antioxidant status and 8-hydroxy-2'-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients
    • Konopka T., Krol K., Kopec W., Gerber H. Total antioxidant status and 8-hydroxy-2'-deoxyguanosine levels in gingival and peripheral blood of periodontitis patients. Arch. Immunol. Ther. Exp. (Warsz.) 2007, 55:417-422.
    • (2007) Arch. Immunol. Ther. Exp. (Warsz.) , vol.55 , pp. 417-422
    • Konopka, T.1    Krol, K.2    Kopec, W.3    Gerber, H.4
  • 14
    • 0019926141 scopus 로고
    • Erythropoietin production in response to anemia or hypoxia in the newborn rat
    • Caro J., Erslev A.J., Silver R., Miller O., Birgegard G. Erythropoietin production in response to anemia or hypoxia in the newborn rat. Blood 1982, 60:984-988.
    • (1982) Blood , vol.60 , pp. 984-988
    • Caro, J.1    Erslev, A.J.2    Silver, R.3    Miller, O.4    Birgegard, G.5
  • 15
    • 36249023751 scopus 로고    scopus 로고
    • The effect of bleeding on hematopoietic stem cell cycling and self-renewal
    • Cheshier S.H., Prohaska S.S., Weissman I.L. The effect of bleeding on hematopoietic stem cell cycling and self-renewal. Stem Cells Dev. 2007, 16:707-717.
    • (2007) Stem Cells Dev. , vol.16 , pp. 707-717
    • Cheshier, S.H.1    Prohaska, S.S.2    Weissman, I.L.3
  • 16
    • 0021885136 scopus 로고
    • Evaluation of nongenotoxic and genotoxic factors modulating the frequency of micronucleated erythrocytes in the peripheral blood of mice
    • Steinheider G., Neth R., Marquardt H. Evaluation of nongenotoxic and genotoxic factors modulating the frequency of micronucleated erythrocytes in the peripheral blood of mice. Cell Biol. Toxicol. 1986, 2:197-211.
    • (1986) Cell Biol. Toxicol. , vol.2 , pp. 197-211
    • Steinheider, G.1    Neth, R.2    Marquardt, H.3
  • 17
    • 0027215247 scopus 로고
    • Induction of micronucleated erythrocytes by recombinant human erythropoietin
    • Yajima N., Kurata Y., Sawai T., Takeshita Y. Induction of micronucleated erythrocytes by recombinant human erythropoietin. Mutagenesis 1993, 8:221-229.
    • (1993) Mutagenesis , vol.8 , pp. 221-229
    • Yajima, N.1    Kurata, Y.2    Sawai, T.3    Takeshita, Y.4
  • 18
    • 0027848672 scopus 로고
    • DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis
    • Ames B.N., Shigenaga M.K., Gold L.S. DNA lesions, inducible DNA repair, and cell division: three key factors in mutagenesis and carcinogenesis. Environ. Health Perspect. 1993, 101(Suppl. 5):35-44.
    • (1993) Environ. Health Perspect. , vol.101 , Issue.SUPPL. 5 , pp. 35-44
    • Ames, B.N.1    Shigenaga, M.K.2    Gold, L.S.3
  • 19
    • 36048934956 scopus 로고    scopus 로고
    • Evaluation of streptozotocin genotoxicity in rats from different ages using the micronucleus assay
    • Vikram A., Tripathi D.N., Ramarao P., Jena G.B. Evaluation of streptozotocin genotoxicity in rats from different ages using the micronucleus assay. Regul. Toxicol. Pharmacol. 2007, 49:238-244.
    • (2007) Regul. Toxicol. Pharmacol. , vol.49 , pp. 238-244
    • Vikram, A.1    Tripathi, D.N.2    Ramarao, P.3    Jena, G.B.4
  • 21
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • Ohkawa H., Ohishi N., Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Anal. Biochem. 1979, 95:351-358.
    • (1979) Anal. Biochem. , vol.95 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 22
    • 0018327389 scopus 로고
    • Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver
    • Moron M.S., Depierre J.W., Mannervik B. Levels of glutathione, glutathione reductase and glutathione S-transferase activities in rat lung and liver. Biochim. Biophys. Acta 1979, 582:67-78.
    • (1979) Biochim. Biophys. Acta , vol.582 , pp. 67-78
    • Moron, M.S.1    Depierre, J.W.2    Mannervik, B.3
  • 25
    • 36849078901 scopus 로고    scopus 로고
    • Intervention of d-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat
    • Vikram A., Tripathi D.N., Ramarao P., Jena G.B. Intervention of d-glucose ameliorates the toxicity of streptozotocin in accessory sex organs of rat. Toxicol. Appl. Pharmacol. 2008, 226:84-93.
    • (2008) Toxicol. Appl. Pharmacol. , vol.226 , pp. 84-93
    • Vikram, A.1    Tripathi, D.N.2    Ramarao, P.3    Jena, G.B.4
  • 26
    • 33144485558 scopus 로고    scopus 로고
    • Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice
    • Yoshihara K., Yajima T., Kubo C., Yoshikai Y. Role of interleukin 15 in colitis induced by dextran sulphate sodium in mice. Gut 2006, 55:334-341.
    • (2006) Gut , vol.55 , pp. 334-341
    • Yoshihara, K.1    Yajima, T.2    Kubo, C.3    Yoshikai, Y.4
  • 27
    • 71549114179 scopus 로고    scopus 로고
    • Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: a study in rat intestine
    • Dadhania V.P., Tripathi D.N., Vikram A., Ramarao P., Jena G.B. Intervention of alpha-lipoic acid ameliorates methotrexate-induced oxidative stress and genotoxicity: a study in rat intestine. Chem. Biol. Interact. 2010, 183:85-97.
    • (2010) Chem. Biol. Interact. , vol.183 , pp. 85-97
    • Dadhania, V.P.1    Tripathi, D.N.2    Vikram, A.3    Ramarao, P.4    Jena, G.B.5
  • 28
    • 0030002162 scopus 로고    scopus 로고
    • Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay
    • Kasamatsu T., Kohda K., Kawazoe Y. Comparison of chemically induced DNA breakage in cellular and subcellular systems using the comet assay. Mutat. Res. 1996, 369:1-6.
    • (1996) Mutat. Res. , vol.369 , pp. 1-6
    • Kasamatsu, T.1    Kohda, K.2    Kawazoe, Y.3
  • 29
    • 0032604577 scopus 로고    scopus 로고
    • The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair
    • Speit G., Hartmann A. The comet assay (single-cell gel test). A sensitive genotoxicity test for the detection of DNA damage and repair. Methods Mol. Biol. 1999, 113:203-212.
    • (1999) Methods Mol. Biol. , vol.113 , pp. 203-212
    • Speit, G.1    Hartmann, A.2
  • 30
    • 0027375157 scopus 로고
    • Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA
    • Collins A.R., Duthie S.J., Dobson V.L. Direct enzymic detection of endogenous oxidative base damage in human lymphocyte DNA. Carcinogenesis 1993, 14:1733-1735.
    • (1993) Carcinogenesis , vol.14 , pp. 1733-1735
    • Collins, A.R.1    Duthie, S.J.2    Dobson, V.L.3
  • 31
  • 32
    • 0030913564 scopus 로고    scopus 로고
    • A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay
    • Holden H.E., Majeska J.B., Studwell D. A direct comparison of mouse and rat bone marrow and blood as target tissues in the micronucleus assay. Mutat. Res. 1997, 391:87-89.
    • (1997) Mutat. Res. , vol.391 , pp. 87-89
    • Holden, H.E.1    Majeska, J.B.2    Studwell, D.3
  • 34
    • 15444376847 scopus 로고    scopus 로고
    • Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis
    • Andresen L., Jorgensen V.L., Perner A., Hansen A., Eugen-Olsen J., Rask-Madsen J. Activation of nuclear factor kappaB in colonic mucosa from patients with collagenous and ulcerative colitis. Gut 2005, 54:503-509.
    • (2005) Gut , vol.54 , pp. 503-509
    • Andresen, L.1    Jorgensen, V.L.2    Perner, A.3    Hansen, A.4    Eugen-Olsen, J.5    Rask-Madsen, J.6
  • 35
    • 0034610759 scopus 로고    scopus 로고
    • Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase
    • Rossi A., Kapahi P., Natoli G., Takahashi T., Chen Y., Karin M., Santoro M.G. Anti-inflammatory cyclopentenone prostaglandins are direct inhibitors of IkappaB kinase. Nature 2000, 403:103-108.
    • (2000) Nature , vol.403 , pp. 103-108
    • Rossi, A.1    Kapahi, P.2    Natoli, G.3    Takahashi, T.4    Chen, Y.5    Karin, M.6    Santoro, M.G.7
  • 36
    • 77955267142 scopus 로고    scopus 로고
    • Chronic inflammation and mutagenesis
    • Ferguson L.R. Chronic inflammation and mutagenesis. Mutat. Res. 2011, 690:3-11.
    • (2011) Mutat. Res. , vol.690 , pp. 3-11
    • Ferguson, L.R.1
  • 40
    • 0032446105 scopus 로고    scopus 로고
    • Dextran sulfate enhances the level of an oxidative DNA damage biomarker 8-oxo-7,8-dihydro-2'-deoxyguanosine, in rat colonic mucosa
    • Tardieu D., Jaeg J.P., Cadet J., Embvani E., Corpet D.E., Petit C. Dextran sulfate enhances the level of an oxidative DNA damage biomarker 8-oxo-7,8-dihydro-2'-deoxyguanosine, in rat colonic mucosa. Cancer Lett. 1998, 134:1-5.
    • (1998) Cancer Lett. , vol.134 , pp. 1-5
    • Tardieu, D.1    Jaeg, J.P.2    Cadet, J.3    Embvani, E.4    Corpet, D.E.5    Petit, C.6
  • 43
    • 0033969322 scopus 로고    scopus 로고
    • Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism
    • Jaiswal M., LaRusso N.F., Burgart L.J., Gores G.J. Inflammatory cytokines induce DNA damage and inhibit DNA repair in cholangiocarcinoma cells by a nitric oxide-dependent mechanism. Cancer Res. 2000, 60:184-190.
    • (2000) Cancer Res. , vol.60 , pp. 184-190
    • Jaiswal, M.1    LaRusso, N.F.2    Burgart, L.J.3    Gores, G.J.4
  • 44
    • 34249066085 scopus 로고    scopus 로고
    • PCNA, the maestro of the replication fork
    • Moldovan G.L., Pfander B., Jentsch S. PCNA, the maestro of the replication fork. Cell 2007, 129:665-679.
    • (2007) Cell , vol.129 , pp. 665-679
    • Moldovan, G.L.1    Pfander, B.2    Jentsch, S.3
  • 46
    • 0028172389 scopus 로고
    • Effects of prostaglandin E2 on the micronucleus formation in mouse bone marrow cells by various mutagens
    • Suzuki Y., Shimizu H., Ishikawa T., Sakaba H., Fukumoto M., Okonogi H., Kadokura M. Effects of prostaglandin E2 on the micronucleus formation in mouse bone marrow cells by various mutagens. Mutat. Res. 1994, 311:287-293.
    • (1994) Mutat. Res. , vol.311 , pp. 287-293
    • Suzuki, Y.1    Shimizu, H.2    Ishikawa, T.3    Sakaba, H.4    Fukumoto, M.5    Okonogi, H.6    Kadokura, M.7
  • 47
    • 0015111538 scopus 로고
    • Stimulation of erythropoiesis by cyclic adenosine monophosphate
    • Gidari A.S., Zanjani E.D., Gordon A.S. Stimulation of erythropoiesis by cyclic adenosine monophosphate. Life Sci. II 1971, 10:895-900.
    • (1971) Life Sci. II , vol.10 , pp. 895-900
    • Gidari, A.S.1    Zanjani, E.D.2    Gordon, A.S.3
  • 48
    • 0016589936 scopus 로고
    • Inhibition of prostaglandin E2-induced cyclic amp accumulation in the rat anterior pituitary by 11-deoxyprostaglandin E analogs (9-ketoprostynoic acids)
    • Lippmann W. Inhibition of prostaglandin E2-induced cyclic amp accumulation in the rat anterior pituitary by 11-deoxyprostaglandin E analogs (9-ketoprostynoic acids). Prostaglandins 1975, 10:479-491.
    • (1975) Prostaglandins , vol.10 , pp. 479-491
    • Lippmann, W.1
  • 49
    • 0035080498 scopus 로고    scopus 로고
    • Prostaglandin E(2) increases cyclic AMP and inhibits endothelin-1 production/secretion by guinea-pig tracheal epithelial cells through EP(4) receptors
    • Pelletier S., Dube J., Villeneuve A., Gobeil F., Yang Q., Battistini B., Guillemette G., Sirois P. Prostaglandin E(2) increases cyclic AMP and inhibits endothelin-1 production/secretion by guinea-pig tracheal epithelial cells through EP(4) receptors. Br. J. Pharmacol. 2001, 132:999-1008.
    • (2001) Br. J. Pharmacol. , vol.132 , pp. 999-1008
    • Pelletier, S.1    Dube, J.2    Villeneuve, A.3    Gobeil, F.4    Yang, Q.5    Battistini, B.6    Guillemette, G.7    Sirois, P.8
  • 50
    • 58149293536 scopus 로고    scopus 로고
    • The micronucleus test and erythropoiesis: effects of cyclic adenosine monophosphate (cAMP) on micronucleus formation
    • Suzuki Y., Takagi R., Kawasaki I., Matsudaira T., Yanagisawa H., Shimizu H. The micronucleus test and erythropoiesis: effects of cyclic adenosine monophosphate (cAMP) on micronucleus formation. Mutat. Res. 2008, 655:47-51.
    • (2008) Mutat. Res. , vol.655 , pp. 47-51
    • Suzuki, Y.1    Takagi, R.2    Kawasaki, I.3    Matsudaira, T.4    Yanagisawa, H.5    Shimizu, H.6
  • 51
    • 0019932614 scopus 로고
    • Extrarenal erythropoietin production by macrophages
    • Rich I.N., Heit W., Kubanek B. Extrarenal erythropoietin production by macrophages. Blood 1982, 60:1007-1018.
    • (1982) Blood , vol.60 , pp. 1007-1018
    • Rich, I.N.1    Heit, W.2    Kubanek, B.3
  • 52
    • 47749155653 scopus 로고    scopus 로고
    • Cancer related inflammation: the macrophage connection
    • Sica A., Allavena P., Mantovani A. Cancer related inflammation: the macrophage connection. Cancer Lett. 2008, 267:204-215.
    • (2008) Cancer Lett. , vol.267 , pp. 204-215
    • Sica, A.1    Allavena, P.2    Mantovani, A.3


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