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Volumn 49, Issue 3, 2010, Pages 312-320

Beneficial effects of melatonin on cardiological alterations in a murine model of accelerated aging

Author keywords

aging; apoptosis; heart; inflammation; melatonin; oxidative stress

Indexed keywords

DRINKING WATER; ENDOTHELIAL NITRIC OXIDE SYNTHASE; HEME OXYGENASE 1; HEME OXYGENASE 2; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 1; INTERLEUKIN 10; MELATONIN; PROTEIN BAD; PROTEIN BAX; PROTEIN BCL 2; TUMOR NECROSIS FACTOR ALPHA;

EID: 77956337711     PISSN: 07423098     EISSN: 1600079X     Source Type: Journal    
DOI: 10.1111/j.1600-079X.2010.00800.x     Document Type: Article
Times cited : (51)

References (75)
  • 1
    • 0036051068 scopus 로고    scopus 로고
    • Cardiovascular ageing in health sets the stage for cardiovascular disease
    • Lakatta E. Cardiovascular ageing in health sets the stage for cardiovascular disease. Heart Lung Circ 2002 11 : 76 91.
    • (2002) Heart Lung Circ , vol.11 , pp. 76-91
    • Lakatta, E.1
  • 2
    • 22144452590 scopus 로고    scopus 로고
    • Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification
    • Li S, Du M, Dolence EK et al. Aging induces cardiac diastolic dysfunction, oxidative stress, accumulation of advanced glycation endproducts and protein modification. Aging Cell 2005 4 : 57 64.
    • (2005) Aging Cell , vol.4 , pp. 57-64
    • Li, S.1    Du, M.2    Dolence, E.K.3
  • 4
    • 0033982738 scopus 로고    scopus 로고
    • Age related endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxigenase products
    • Matz RL, Scott C, Stoclet C et al. Age related endothelial dysfunction with respect to nitric oxide, endothelium-derived hyperpolarizing factor and cyclooxigenase products. Physiol Res 2000 49 : 11 18.
    • (2000) Physiol Res , vol.49 , pp. 11-18
    • Matz, R.L.1    Scott, C.2    Stoclet, C.3
  • 5
    • 0037204539 scopus 로고    scopus 로고
    • Apoptosis and successful aging
    • Zhang Y, Herman B. Apoptosis and successful aging. Mech Ageing Dev 2002 123 : 563 565.
    • (2002) Mech Ageing Dev , vol.123 , pp. 563-565
    • Zhang, Y.1    Herman, B.2
  • 6
    • 0037112204 scopus 로고    scopus 로고
    • Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction
    • Chung HY, Kim HJ, Kim KW et al. Molecular inflammation hypothesis of aging based on the anti-aging mechanism of calorie restriction. Microsc Res Tech 2002 59 : 264 272.
    • (2002) Microsc Res Tech , vol.59 , pp. 264-272
    • Chung, H.Y.1    Kim, H.J.2    Kim, K.W.3
  • 7
    • 33845426239 scopus 로고    scopus 로고
    • Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice
    • Rodríguez MI, Carretero M, Escames G et al. Chronic melatonin treatment prevents age-dependent cardiac mitochondrial dysfunction in senescence-accelerated mice. Free Radic Res 2007 41 : 15 24.
    • (2007) Free Radic Res , vol.41 , pp. 15-24
    • Rodríguez, M.I.1    Carretero, M.2    Escames, G.3
  • 8
    • 67349135042 scopus 로고    scopus 로고
    • Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens
    • Baeza I, Alvarado C, Alvarez P et al. Improvement of leucocyte functions in ovariectomised aged rats after treatment with growth hormone, melatonin, oestrogens or phyto-oestrogens. J Reprod Immunol 2009 80 : 70 79.
    • (2009) J Reprod Immunol , vol.80 , pp. 70-79
    • Baeza, I.1    Alvarado, C.2    Alvarez, P.3
  • 9
    • 0022973346 scopus 로고
    • Human melatonin production decreases with age
    • Sack RL, Lewy AJ, Erb DL et al. Human melatonin production decreases with age. J Pineal Res 1986 3 : 379 388.
    • (1986) J Pineal Res , vol.3 , pp. 379-388
    • Sack, R.L.1    Lewy, A.J.2    Erb, D.L.3
  • 10
    • 0019209714 scopus 로고
    • Pineal melatonin rhythm: Reduction in aging Syrian hamsters
    • Reiter RJ, Richardson BA, Johnson LY et al. Pineal melatonin rhythm: reduction in aging Syrian hamsters. Science 1980 210 : 1372 1373.
    • (1980) Science , vol.210 , pp. 1372-1373
    • Reiter, R.J.1    Richardson, B.A.2    Johnson, L.Y.3
  • 11
    • 27744433573 scopus 로고    scopus 로고
    • Effects of ovariectomy and growth hormone administration on body composition and vascular function and structure in old female rats
    • Castillo C, Cruzado M, Ariznavarreta C et al. Effects of ovariectomy and growth hormone administration on body composition and vascular function and structure in old female rats. Biogerontology 2005 6 : 49 60.
    • (2005) Biogerontology , vol.6 , pp. 49-60
    • Castillo, C.1    Cruzado, M.2    Ariznavarreta, C.3
  • 12
    • 0035162008 scopus 로고    scopus 로고
    • Ageing and the free radical theory
    • Wickens AP. Ageing and the free radical theory. Respir Physiol 2001 128 : 379 391.
    • (2001) Respir Physiol , vol.128 , pp. 379-391
    • Wickens, A.P.1
  • 13
    • 53749095235 scopus 로고    scopus 로고
    • Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage
    • Kireev RA, Tresguerres AC, García C et al. Melatonin is able to prevent the liver of old castrated female rats from oxidative and pro-inflammatory damage. J Pineal Res 2008 45 : 394 402.
    • (2008) J Pineal Res , vol.45 , pp. 394-402
    • Kireev, R.A.1    Tresguerres, A.C.2    García, C.3
  • 14
    • 0036238915 scopus 로고    scopus 로고
    • The role of apoptosis in the normal aging brain, skeletal muscle, and heart
    • Pollack M, Phaneuf S, Dirks A et al. The role of apoptosis in the normal aging brain, skeletal muscle, and heart. Ann N Y Acad Sci 2002 959 : 93 107.
    • (2002) Ann N y Acad Sci , vol.959 , pp. 93-107
    • Pollack, M.1    Phaneuf, S.2    Dirks, A.3
  • 15
    • 77954814492 scopus 로고    scopus 로고
    • Cardiological aging in SAM model: Effect of chronic treatment with growth hormone
    • Forman K, Vara E, García C et al. Cardiological aging in SAM model: effect of chronic treatment with growth hormone. Biogerontology 2010 11 : 275 286.
    • (2010) Biogerontology , vol.11 , pp. 275-286
    • Forman, K.1    Vara, E.2    García, C.3
  • 17
    • 34548503618 scopus 로고    scopus 로고
    • Effect of chronic treatments with GH, melatonin, estrogens, and phytoestrogens on oxidative stress parameters in liver from aged female rats
    • Kireev RA, Tresguerres AF, Vara E et al. Effect of chronic treatments with GH, melatonin, estrogens, and phytoestrogens on oxidative stress parameters in liver from aged female rats. Biogerontology 2007 8 : 469 482.
    • (2007) Biogerontology , vol.8 , pp. 469-482
    • Kireev, R.A.1    Tresguerres, A.F.2    Vara, E.3
  • 18
    • 61849126736 scopus 로고    scopus 로고
    • Aging affects lipopolysaccharide-induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages
    • Ito Y, Betsuyaku T, Moriyama C et al. Aging affects lipopolysaccharide- induced upregulation of heme oxygenase-1 in the lungs and alveolar macrophages. Biogerontology 2009 10 : 173 180.
    • (2009) Biogerontology , vol.10 , pp. 173-180
    • Ito, Y.1    Betsuyaku, T.2    Moriyama, C.3
  • 19
    • 55449136486 scopus 로고    scopus 로고
    • Inflammation and endothelial dysfunction during aging: Role of NF-Kb
    • Csiszar A, Wang M, Lakatta E et al. Inflammation and endothelial dysfunction during aging: role of NF-Kb. J Appl Physiol 2008 105 : 1333 1341.
    • (2008) J Appl Physiol , vol.105 , pp. 1333-1341
    • Csiszar, A.1    Wang, M.2    Lakatta, E.3
  • 20
    • 9344256749 scopus 로고    scopus 로고
    • Mechanisms of aging-induced impairment of endothelium dependent relaxation: Role of tetrahydrobiopterin
    • Blackwell KA, Sorenson JP, Richardson DM et al. Mechanisms of aging-induced impairment of endothelium dependent relaxation: role of tetrahydrobiopterin. Am J Physiol Heart Circ Physiol 2004 287 : H2448 H2453.
    • (2004) Am J Physiol Heart Circ Physiol , vol.287
    • Blackwell, K.A.1    Sorenson, J.P.2    Richardson, D.M.3
  • 21
    • 0034634281 scopus 로고    scopus 로고
    • Endothelial dysfunction in cardiovascular diseases: The role of oxidant stress
    • Cai H, Harrison DG. Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress. Circ Res 2000 87 : 840 844.
    • (2000) Circ Res , vol.87 , pp. 840-844
    • Cai, H.1    Harrison, D.G.2
  • 22
  • 23
    • 0344392953 scopus 로고    scopus 로고
    • Apoptosis and oxidants in the heart
    • Kumar D, Jugdutt BI. Apoptosis and oxidants in the heart. J Lab Clin Med 2003 142 : 288 297.
    • (2003) J Lab Clin Med , vol.142 , pp. 288-297
    • Kumar, D.1    Jugdutt, B.I.2
  • 24
    • 59149092821 scopus 로고    scopus 로고
    • Microtubules modulate melatonin receptors involved in phase-shifting circadian activity rhythms: In vitro and in vivo evidence
    • Jarzynka MJ, Passey DK, Johnson DA et al. Microtubules modulate melatonin receptors involved in phase-shifting circadian activity rhythms: in vitro and in vivo evidence. J Pineal Res 2009 46 : 161 171.
    • (2009) J Pineal Res , vol.46 , pp. 161-171
    • Jarzynka, M.J.1    Passey, D.K.2    Johnson, D.A.3
  • 25
    • 68249099777 scopus 로고    scopus 로고
    • Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment
    • Simko F, Pechanova O. Potential roles of melatonin and chronotherapy among the new trends in hypertension treatment. J Pineal Res 2009 47 : 127 133.
    • (2009) J Pineal Res , vol.47 , pp. 127-133
    • Simko, F.1    Pechanova, O.2
  • 27
    • 33847607366 scopus 로고    scopus 로고
    • Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence-accelerated mice
    • Rodríguez MI, Escames G, López LC et al. Chronic melatonin treatment reduces the age-dependent inflammatory process in senescence- accelerated mice. J Pineal Res 2007 42 : 272 279.
    • (2007) J Pineal Res , vol.42 , pp. 272-279
    • Rodríguez, M.I.1    Escames, G.2    López, L.C.3
  • 28
    • 0032188888 scopus 로고    scopus 로고
    • Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells
    • Cos S, Fernández R, Güézmes A et al. Influence of melatonin on invasive and metastatic properties of MCF-7 human breast cancer cells. Cancer Res 1998 58 : 4383 4390.
    • (1998) Cancer Res , vol.58 , pp. 4383-4390
    • Cos, S.1    Fernández, R.2    Güézmes, A.3
  • 29
    • 51649122293 scopus 로고    scopus 로고
    • Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species
    • Peyrot F, Ducrocq C. Potential role of tryptophan derivatives in stress responses characterized by the generation of reactive oxygen and nitrogen species. J Pineal Res 2008 45 : 235 246.
    • (2008) J Pineal Res , vol.45 , pp. 235-246
    • Peyrot, F.1    Ducrocq, C.2
  • 30
    • 68249129060 scopus 로고    scopus 로고
    • Kynuramines, metabolites of melatonin and other indoles: The resurrection of an almost forgotten class of biogenic amines
    • Hardeland R, Tan DX, Reiter RJ. Kynuramines, metabolites of melatonin and other indoles: the resurrection of an almost forgotten class of biogenic amines. J Pineal Res 2009 47 : 109 126.
    • (2009) J Pineal Res , vol.47 , pp. 109-126
    • Hardeland, R.1    Tan, D.X.2    Reiter, R.J.3
  • 31
    • 0030930937 scopus 로고    scopus 로고
    • Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin
    • Pozo D, Reiter RJ, Calvo JR et al. Inhibition of cerebellar nitric oxide synthase and cyclic GMP production by melatonin via complex formation with calmodulin. J Cell Biochem 1997 65 : 430 442.
    • (1997) J Cell Biochem , vol.65 , pp. 430-442
    • Pozo, D.1    Reiter, R.J.2    Calvo, J.R.3
  • 32
    • 0032847560 scopus 로고    scopus 로고
    • Senescence-accelerated mouse (SAM): A biogerontological resource in aging research
    • Takeda T. Senescence-accelerated mouse (SAM): a biogerontological resource in aging research. Neurobiol Aging 1999 20 : 105 110.
    • (1999) Neurobiol Aging , vol.20 , pp. 105-110
    • Takeda, T.1
  • 33
    • 0032078031 scopus 로고    scopus 로고
    • Difference between senescence-accelerated prone and resistant mice in response to insulin in the heart
    • Kurokawa T, Osaki N, Ishibashi S. Difference between senescence- accelerated prone and resistant mice in response to insulin in the heart. Mech Ageing Dev 1998 102 : 25 32.
    • (1998) Mech Ageing Dev , vol.102 , pp. 25-32
    • Kurokawa, T.1    Osaki, N.2    Ishibashi, S.3
  • 34
    • 34147199638 scopus 로고    scopus 로고
    • Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8
    • Gutierrez-Cuesta J, Sureda FX, Romeu M et al. Chronic administration of melatonin reduces cerebral injury biomarkers in SAMP8. J Pineal Res 2007 42 : 394 402.
    • (2007) J Pineal Res , vol.42 , pp. 394-402
    • Gutierrez-Cuesta, J.1    Sureda, F.X.2    Romeu, M.3
  • 35
    • 26244456297 scopus 로고    scopus 로고
    • The senescence-accelerated prone mouse (SAMP8): A model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease
    • Butterfield DA, Poon HF. The senescence-accelerated prone mouse (SAMP8): a model of age-related cognitive decline with relevance to alterations of the gene expression and protein abnormalities in Alzheimer's disease. Exp Gerontol 2005 40 : 774 783.
    • (2005) Exp Gerontol , vol.40 , pp. 774-783
    • Butterfield, D.A.1    Poon, H.F.2
  • 36
    • 38449105499 scopus 로고    scopus 로고
    • The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging
    • Lloréns S, De Mera RM, Pascual A et al. The senescence-accelerated mouse (SAM-P8) as a model for the study of vascular functional alterations during aging. Biogerontology 2007 8 : 663 672.
    • (2007) Biogerontology , vol.8 , pp. 663-672
    • Lloréns, S.1    De Mera, R.M.2    Pascual, A.3
  • 37
    • 0026575905 scopus 로고
    • Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse
    • Flood JF, Morley JE. Early onset of age-related impairment of aversive and appetitive learning in the SAM-P/8 mouse. J Gerontol 1992 47 : B52 B59.
    • (1992) J Gerontol , vol.47
    • Flood, J.F.1    Morley, J.E.2
  • 38
    • 0027410175 scopus 로고
    • Age-related changes in the pharmacological improvement of retention in senescence accelerated mouse (SAM)
    • Flood JF, Morley JE, La Reginna M. Age-related changes in the pharmacological improvement of retention in senescence accelerated mouse (SAM). Neurobiol Aging 1993 14 : 159 166.
    • (1993) Neurobiol Aging , vol.14 , pp. 159-166
    • Flood, J.F.1    Morley, J.E.2    La Reginna, M.3
  • 39
    • 0023277545 scopus 로고
    • Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
    • Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987 162 : 156 159.
    • (1987) Anal Biochem , vol.162 , pp. 156-159
    • Chomczynski, P.1    Sacchi, N.2
  • 40
    • 0035710746 scopus 로고    scopus 로고
    • Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method
    • Livak KJ, Schmittgen TD. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods 2001 25 : 402 408.
    • (2001) Methods , vol.25 , pp. 402-408
    • Livak, K.J.1    Schmittgen, T.D.2
  • 41
    • 0036860219 scopus 로고    scopus 로고
    • A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice
    • Hosokawa M. A higher oxidative status accelerates senescence and aggravates age-dependent disorders in SAMP strains of mice. Mech Ageing Dev 2002 123 : 1553 1561.
    • (2002) Mech Ageing Dev , vol.123 , pp. 1553-1561
    • Hosokawa, M.1
  • 42
    • 60349124651 scopus 로고    scopus 로고
    • Endothelial ageing: Molecular mechanisms and functional significance
    • Brown MD. Endothelial ageing: molecular mechanisms and functional significance. Exp Physiol 2009 94 : 297 298.
    • (2009) Exp Physiol , vol.94 , pp. 297-298
    • Brown, M.D.1
  • 43
    • 0035082777 scopus 로고    scopus 로고
    • Characterization of aging-associated up-regulation of constitutive nuclear factor-kappa B binding activity
    • Helenius M, Kyrylenko S, Vehviläinen P et al. Characterization of aging-associated up-regulation of constitutive nuclear factor-kappa B binding activity. Antioxid Redox Signal 2001 3 : 147 156.
    • (2001) Antioxid Redox Signal , vol.3 , pp. 147-156
    • Helenius, M.1    Kyrylenko, S.2    Vehviläinen, P.3
  • 44
    • 0036211772 scopus 로고    scopus 로고
    • Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart
    • Hoppel CL, Moghaddas S, Lesnefsky EJ. Interfibrillar cardiac mitochondrial comples III defects in the aging rat heart. Biogerontology 2002 3 : 41 44.
    • (2002) Biogerontology , vol.3 , pp. 41-44
    • Hoppel, C.L.1    Moghaddas, S.2    Lesnefsky, E.J.3
  • 45
    • 34250823178 scopus 로고    scopus 로고
    • Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative response
    • Seta F, Bellner L, Rezzani R et al. Heme oxygenase-2 is a critical determinant for execution of an acute inflammatory and reparative response. Am J Pathol 2006 169 : 1612 1623.
    • (2006) Am J Pathol , vol.169 , pp. 1612-1623
    • Seta, F.1    Bellner, L.2    Rezzani, R.3
  • 46
    • 19544370917 scopus 로고    scopus 로고
    • Heme oxygenase and the cardiovascular-renal system
    • Abraham NG, Kappas A. Heme oxygenase and the cardiovascular-renal system. Free Radic Biol Med 2005 39 : 1 25.
    • (2005) Free Radic Biol Med , vol.39 , pp. 1-25
    • Abraham, N.G.1    Kappas, A.2
  • 47
    • 0035983247 scopus 로고    scopus 로고
    • Heme oxygenase-1: The "emerging molecule" has arrived
    • Morse D, Choi AM. Heme oxygenase-1: the "emerging molecule" has arrived. Am J Respir Cell Mol Biol 2002 27 : 8 16.
    • (2002) Am J Respir Cell Mol Biol , vol.27 , pp. 8-16
    • Morse, D.1    Choi, A.M.2
  • 48
    • 33645945014 scopus 로고    scopus 로고
    • Heme oxygenase-1/carbon monoxide: From basic science to therapeutic applications
    • Ryter SW, Alam J, Choi AM. Heme oxygenase-1/carbon monoxide: from basic science to therapeutic applications. Physiol Rev 2006 86 : 583 650.
    • (2006) Physiol Rev , vol.86 , pp. 583-650
    • Ryter, S.W.1    Alam, J.2    Choi, A.M.3
  • 49
    • 0032981357 scopus 로고    scopus 로고
    • The inducible nitric oxide synthase in vascular and cardiac tissue
    • Stoclet JC, Muller B, György K et al. The inducible nitric oxide synthase in vascular and cardiac tissue. Eur J Pharmacol 1999 375 : 139 155.
    • (1999) Eur J Pharmacol , vol.375 , pp. 139-155
    • Stoclet, J.C.1    Muller, B.2    György, K.3
  • 50
    • 33846392950 scopus 로고    scopus 로고
    • Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation
    • Mount PF, Kemp BE, Power DA. Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol 2007 42 : 271 279.
    • (2007) J Mol Cell Cardiol , vol.42 , pp. 271-279
    • Mount, P.F.1    Kemp, B.E.2    Power, D.A.3
  • 51
    • 33748288089 scopus 로고    scopus 로고
    • Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: Evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A
    • Smith AR, Visioli F, Frei B et al. Age-related changes in endothelial nitric oxide synthase phosphorylation and nitric oxide dependent vasodilation: evidence for a novel mechanism involving sphingomyelinase and ceramide-activated phosphatase 2A. Aging Cell 2006 5 : 391 400.
    • (2006) Aging Cell , vol.5 , pp. 391-400
    • Smith, A.R.1    Visioli, F.2    Frei, B.3
  • 52
    • 0024475227 scopus 로고
    • NF-kappa B: A pleiotropic mediator of inducible and tissue-specific gene control
    • Lenardo MJ, Baltimore D. NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell 1989 58 : 227 229.
    • (1989) Cell , vol.58 , pp. 227-229
    • Lenardo, M.J.1    Baltimore, D.2
  • 54
    • 0033947601 scopus 로고    scopus 로고
    • The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus
    • Kaltschmidt B, Kaltschmidt C, Hofmann TG et al. The pro- or anti-apoptotic function of NF-kappaB is determined by the nature of the apoptotic stimulus. Eur J Biochem 2000 267 : 3828 3835.
    • (2000) Eur J Biochem , vol.267 , pp. 3828-3835
    • Kaltschmidt, B.1    Kaltschmidt, C.2    Hofmann, T.G.3
  • 55
    • 0029670391 scopus 로고    scopus 로고
    • Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle
    • Helenius M, Hänninen M, Lehtinen SK et al. Aging-induced up-regulation of nuclear binding activities of oxidative stress responsive NF-kB transcription factor in mouse cardiac muscle. J Mol Cell Cardiol 1996 28 : 487 498.
    • (1996) J Mol Cell Cardiol , vol.28 , pp. 487-498
    • Helenius, M.1    Hänninen, M.2    Lehtinen, S.K.3
  • 56
    • 0029834145 scopus 로고    scopus 로고
    • Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kB
    • Helenius M, Hänninen M, Lehtinen SK et al. Changes associated with aging and replicative senescence in the regulation of transcription factor nuclear factor-kB. Biochem J 1996 318 : 603 608.
    • (1996) Biochem J , vol.318 , pp. 603-608
    • Helenius, M.1    Hänninen, M.2    Lehtinen, S.K.3
  • 57
    • 0030960606 scopus 로고    scopus 로고
    • Age-related changes in the regulation of transcription factor NF-kappa B in rat brain
    • Korhonen P, Helenius M, Salminen A. Age-related changes in the regulation of transcription factor NF-kappa B in rat brain. Neurosci Lett 1997 225 : 61 64.
    • (1997) Neurosci Lett , vol.225 , pp. 61-64
    • Korhonen, P.1    Helenius, M.2    Salminen, A.3
  • 58
    • 77950859629 scopus 로고    scopus 로고
    • Hormonal regulation of pro-inflammatory and lipid peroxidation processes in liver of old ovariectomized female rats
    • Kireev RA, Tresguerres AC, Garcia C et al. Hormonal regulation of pro-inflammatory and lipid peroxidation processes in liver of old ovariectomized female rats. Biogerontology 2010 11 : 229 243.
    • (2010) Biogerontology , vol.11 , pp. 229-243
    • Kireev, R.A.1    Tresguerres, A.C.2    Garcia, C.3
  • 59
    • 0034564998 scopus 로고    scopus 로고
    • Changes in expressions of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8
    • Tha KK, Okuma Y, Miyazaki H et al. Changes in expressions of proinflammatory cytokines IL-1beta, TNF-alpha and IL-6 in the brain of senescence accelerated mouse (SAM) P8. Brain Res 2000 885 : 25 31.
    • (2000) Brain Res , vol.885 , pp. 25-31
    • Tha, K.K.1    Okuma, Y.2    Miyazaki, H.3
  • 61
    • 0034668151 scopus 로고    scopus 로고
    • Apoptosis and nuclear factor-kB: A tale of association and dissociation
    • Aggarwal BB. Apoptosis and nuclear factor-kB: a tale of association and dissociation. Biochem Pharmacol 2000 60 : 1033 1039.
    • (2000) Biochem Pharmacol , vol.60 , pp. 1033-1039
    • Aggarwal, B.B.1
  • 63
    • 0033805442 scopus 로고    scopus 로고
    • Oxidative stress and apoptosis
    • Kannan K, Jain SK. Oxidative stress and apoptosis. Pathophysiology 2000 7 : 153 163.
    • (2000) Pathophysiology , vol.7 , pp. 153-163
    • Kannan, K.1    Jain, S.K.2
  • 64
    • 57149139867 scopus 로고    scopus 로고
    • Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice
    • Caballero B, Vega-Naredo I, Sierra V et al. Melatonin alters cell death processes in response to age-related oxidative stress in the brain of senescence-accelerated mice. J Pineal Res 2009 46 : 106 114.
    • (2009) J Pineal Res , vol.46 , pp. 106-114
    • Caballero, B.1    Vega-Naredo, I.2    Sierra, V.3
  • 65
    • 0037131586 scopus 로고    scopus 로고
    • Melatonin prevents focal rat cerebellum injury as assessed by induction of heat shock protein (HO-1) following subarachnoid injections of lysed blood
    • Martinez-Cruz F, Espinar A, Pozo D et al. Melatonin prevents focal rat cerebellum injury as assessed by induction of heat shock protein (HO-1) following subarachnoid injections of lysed blood. Neurosci Lett 2002 331 : 208 210.
    • (2002) Neurosci Lett , vol.331 , pp. 208-210
    • Martinez-Cruz, F.1    Espinar, A.2    Pozo, D.3
  • 66
    • 36849008650 scopus 로고    scopus 로고
    • Cardiovascular diseases: Protective effects of melatonin
    • Tengattini S, Reiter RJ, Tan DX et al. Cardiovascular diseases: protective effects of melatonin. J Pineal Res 2008 44 : 16 25.
    • (2008) J Pineal Res , vol.44 , pp. 16-25
    • Tengattini, S.1    Reiter, R.J.2    Tan, D.X.3
  • 67
    • 0034068733 scopus 로고    scopus 로고
    • Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats
    • Hoyos M, Guerreros JM, Perez-Cano R et al. Serum cholesterol and lipid peroxidation are decreased by melatonin in diet-induced hypercholesterolemic rats. J Pineal Res 2000 28 : 150 155.
    • (2000) J Pineal Res , vol.28 , pp. 150-155
    • Hoyos, M.1    Guerreros, J.M.2    Perez-Cano, R.3
  • 68
    • 1842854678 scopus 로고    scopus 로고
    • Blood pressure response to melatonin in type 1 diabetes
    • Cavallo A, Daniels SR, Dolan LM et al. Blood pressure response to melatonin in type 1 diabetes. Pediatr Diabetes 2004 5 : 26 31.
    • (2004) Pediatr Diabetes , vol.5 , pp. 26-31
    • Cavallo, A.1    Daniels, S.R.2    Dolan, L.M.3
  • 69
    • 0035123767 scopus 로고    scopus 로고
    • Effect of exogenous melatonin on vascular reactivity and nitric oxide in postmenopausal women: Role of hormone replacement therapy
    • Cagnacci A, Arangino S, Angiolucci M et al. Effect of exogenous melatonin on vascular reactivity and nitric oxide in postmenopausal women: role of hormone replacement therapy. Clin Endocrinol (Oxf) 2001 54 : 261 266.
    • (2001) Clin Endocrinol (Oxf) , vol.54 , pp. 261-266
    • Cagnacci, A.1    Arangino, S.2    Angiolucci, M.3
  • 70
    • 0346059342 scopus 로고    scopus 로고
    • Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats
    • Bruck R, Aeed H, Avni Y et al. Melatonin inhibits nuclear factor kappa B activation and oxidative stress and protects against thioacetamide induced liver damage in rats. J Hepatol 2004 40 : 86 93.
    • (2004) J Hepatol , vol.40 , pp. 86-93
    • Bruck, R.1    Aeed, H.2    Avni, Y.3
  • 71
    • 33746504821 scopus 로고    scopus 로고
    • Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells: Involvement of nuclear factor kappa B, Bax and Bcl-2
    • Chetsawang B, Putthaprasart C, Phansuwan-Pujito P et al. Melatonin protects against hydrogen peroxide-induced cell death signaling in SH-SY5Y cultured cells: involvement of nuclear factor kappa B, Bax and Bcl-2. J Pineal Res 2006 41 : 116 123.
    • (2006) J Pineal Res , vol.41 , pp. 116-123
    • Chetsawang, B.1    Putthaprasart, C.2    Phansuwan-Pujito, P.3
  • 72
    • 0034740584 scopus 로고    scopus 로고
    • Expression of the MT1 melatonin receptor subtype in human coronary arteries
    • Ekmekcioglu C, Haslmayer P, Philipp C et al. Expression of the MT1 melatonin receptor subtype in human coronary arteries. J Recept Signal Transduct Res 2001 21 : 85 91.
    • (2001) J Recept Signal Transduct Res , vol.21 , pp. 85-91
    • Ekmekcioglu, C.1    Haslmayer, P.2    Philipp, C.3
  • 73
    • 10744232166 scopus 로고    scopus 로고
    • The melatonin receptor subtype MT2 is present in the human cardiovascular system
    • Ekmekcioglu C, Thalhammer T, Humpeler S et al. The melatonin receptor subtype MT2 is present in the human cardiovascular system. J Pineal Res 2003 35 : 40 44.
    • (2003) J Pineal Res , vol.35 , pp. 40-44
    • Ekmekcioglu, C.1    Thalhammer, T.2    Humpeler, S.3
  • 74
    • 0036721503 scopus 로고    scopus 로고
    • MT(2) melatonin receptors are present and functional in rat caudal artery
    • Masana MI, Doolen S, Ersahin C et al. MT(2) melatonin receptors are present and functional in rat caudal artery. J Pharmacol Exp Ther 2002 302 : 1295 1302.
    • (2002) J Pharmacol Exp Ther , vol.302 , pp. 1295-1302
    • Masana, M.I.1    Doolen, S.2    Ersahin, C.3
  • 75
    • 0037192558 scopus 로고    scopus 로고
    • Constitutively active melatonin MT(1) receptors in male rat caudal arteries
    • Erşahin C, Masana MI, Dubocovich ML. Constitutively active melatonin MT(1) receptors in male rat caudal arteries. Eur J Pharmacol 2002 439 : 171 172.
    • (2002) Eur J Pharmacol , vol.439 , pp. 171-172
    • Erşahin, C.1    Masana, M.I.2    Dubocovich, M.L.3


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