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Volumn 3, Issue , 2008, Pages 723-759

Manufacture of Recombinant Biopharmaceutical Proteins by Cultivated Mammalian Cells in Bioreactors

Author keywords

Bioreactors; Electroporation; Hygromycin; Jeopardizing; Linearization

Indexed keywords


EID: 84889979454     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9783527620982.ch31     Document Type: Chapter
Times cited : (13)

References (152)
  • 1
    • 84889994584 scopus 로고    scopus 로고
    • Scientific report at a cell culture conference in Cancun
    • Andersen, D. (2004) Scientific report at a cell culture conference in Cancun.
    • (2004)
    • Andersen, D.1
  • 2
    • 0014321756 scopus 로고
    • Genetics of somatic mammalian cells VII. Induction and isolation of nutritional mutants in Chinese hamster cells
    • Kao, F.-T., Puck, T.T. (1968) Genetics of somatic mammalian cells VII. Induction and isolation of nutritional mutants in Chinese hamster cells. Proc. Natl. Acad. Sci. USA 60:1275-1281.
    • (1968) Proc. Natl. Acad. Sci. USA , vol.60 , pp. 1275-1281
    • Kao, F.-T.1    Puck, T.T.2
  • 3
    • 1842285853 scopus 로고
    • Development of the Chinese hamster ovary (CHO) cell for use in somatic cell genetics
    • In: M.M. Gottesman (Ed), John Wiley & Sons, New York
    • Puck, T.T. (1985) Development of the Chinese hamster ovary (CHO) cell for use in somatic cell genetics. In: M.M. Gottesman (Ed) Molecular Cell Genetics, John Wiley & Sons, New York, pp. 37-64.
    • (1985) , pp. 37-64
    • Puck, T.T.1
  • 4
    • 0001127374 scopus 로고
    • Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity
    • Urlaub, G. and Chasin, L. A. (1980) Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity. Proc. Natl. Acad. Sci. USA 77:4216-4220.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 4216-4220
    • Urlaub, G.1    Chasin, L.A.2
  • 5
    • 0019863416 scopus 로고
    • Co-expression and amplification of dihydrofolate reductase cDNA and the Escherichia coli XGPRT gene in Chinese hamster ovary cells
    • Ringold, G., Dieckmann, B., and Lee, F. (1981) Co-expression and amplification of dihydrofolate reductase cDNA and the Escherichia coli XGPRT gene in Chinese hamster ovary cells. J. Mol. Appl. Genet. 1:165-175.
    • (1981) J. Mol. Appl. Genet. , vol.1 , pp. 165-175
    • Ringold, G.1    Dieckmann, B.2    Lee, F.3
  • 6
    • 0020400592 scopus 로고
    • Amplification and Expression of Sequences Cotransfected with a Modular Dihydrofolate Reductase Complementary DNA Gene
    • Kaufman, R. J. and Sharp, P. (1982) Amplification and Expression of Sequences Cotransfected with a Modular Dihydrofolate Reductase Complementary DNA Gene. J. Mol. Biol. 159:601-621.
    • (1982) J. Mol. Biol. , vol.159 , pp. 601-621
    • Kaufman, R.J.1    Sharp, P.2
  • 7
    • 0022100495 scopus 로고
    • Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase in Chinese hamster ovary cells
    • Kaufman, R. J., Wasley, L. C., Spiliotes, A. J., Gossels, S. D., Latt, S. A., Larsen, G.R., and Kay, R.M. (1985) Coamplification and coexpression of human tissue-type plasminogen activator and murine dihydrofolate reductase in Chinese hamster ovary cells. Mol. Cell. Biol. 5:1750-1759.
    • (1985) Mol. Cell. Biol. , vol.5 , pp. 1750-1759
    • Kaufman, R.J.1    Wasley, L.C.2    Spiliotes, A.J.3    Gossels, S.D.4    Latt, S.A.5    Larsen, G.R.6    Kay, R.M.7
  • 9
    • 84890010446 scopus 로고
    • Molecular Genetics
    • John Wiley & Sons, New York
    • Gottesman, M.M. (1985) Molecular Genetics. John Wiley & Sons, New York.
    • (1985)
    • Gottesman, M.M.1
  • 10
    • 0015847039 scopus 로고
    • A new technique for the assay of infectivity of human adenovirus 5 DNA
    • Graham, F. L. and van der Eb, A. J. (1973) A new technique for the assay of infectivity of human adenovirus 5 DNA. Virology 52:456-467.
    • (1973) Virology , vol.52 , pp. 456-467
    • Graham, F.L.1    Van der Eb, A.J.2
  • 11
    • 0017647917 scopus 로고
    • Transfer of purified Herpes Virus thymidine kinase gene to cultured cells
    • Wigler, M., Silverstein, S., Lee, L.-S., Pellicer, A., Cheng, Y.-C., and Axel, R. (1977) Transfer of purified Herpes Virus thymidine kinase gene to cultured cells. Cell 11:223-232.
    • (1977) Cell , vol.11 , pp. 223-232
    • Wigler, M.1    Silverstein, S.2    Lee, L.-S.3    Pellicer, A.4    Cheng, Y.-C.5    Axel, R.6
  • 12
    • 0017867182 scopus 로고
    • The transfer and stable integration of the HSV thymidine kinase gene into mouse cells
    • Pellicer, A., Wigler, M., and Axel, R. (1978) The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell 14:133-141.
    • (1978) Cell , vol.14 , pp. 133-141
    • Pellicer, A.1    Wigler, M.2    Axel, R.3
  • 13
    • 0019353199 scopus 로고
    • Transforming DNA integrates into the host chromosome
    • Robins, D.M., Ripley, S., Henderson, A., and Axel, R. (1981) Transforming DNA integrates into the host chromosome. Cell 23:29-39.
    • (1981) Cell , vol.23 , pp. 29-39
    • Robins, D.M.1    Ripley, S.2    Henderson, A.3    Axel, R.4
  • 14
    • 0023392945 scopus 로고
    • High efficiency transformation of mammalian cells by plasmid DNA
    • Chen, C. and Okayama, H. (1987) High efficiency transformation of mammalian cells by plasmid DNA. Mol. Cell. Biol. 7, 8:2745-2752.
    • (1987) Mol. Cell. Biol. , vol.7 , Issue.8 , pp. 2745-2752
    • Chen, C.1    Okayama, H.2
  • 15
    • 0029991350 scopus 로고    scopus 로고
    • Transfecting mammalian cells: optimization of critical parameters affecting calciumphosphate precipitate formation
    • Jordan, M., Schallhorn, A. and Wurm, F.M. (1996) Transfecting mammalian cells: optimization of critical parameters affecting calciumphosphate precipitate formation. Nucleic Acids Res. 24, 4:596-601.
    • (1996) Nucleic Acids Res. , vol.24 , Issue.4 , pp. 596-601
    • Jordan, M.1    Schallhorn, A.2    Wurm, F.M.3
  • 16
    • 0344307702 scopus 로고    scopus 로고
    • Principles of a scaleable transient transfection and expression technology for mammalian cells
    • In: M.J. Carrondo, B. Griffiths and J. P. Moreira (Eds)
    • Jordan M., Köhne, C. and Wurm, F.M. (1997) Principles of a scaleable transient transfection and expression technology for mammalian cells. In: M.J. Carrondo, B. Griffiths and J. P. Moreira (Eds) Animal Cell Technology-from Vaccines to Genetic Medicine, pp. 47-50. Kluwer Academic Publishers.
    • (1997) Animal Cell Technology-from Vaccines to Genetic Medicine , pp. 47-50
    • Jordan, M.1    Köhne, C.2    Wurm, F.M.3
  • 17
    • 0024434889 scopus 로고
    • Homologous plasmid recombination is elevated in immortally transformed cells
    • Finn, G. K., Kurz, B.W., Cheng, R. Z. and Shmookler, R. J. (1989) Homologous plasmid recombination is elevated in immortally transformed cells. Mol. Cell. Biol. 9:4009-4017.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 4009-4017
    • Finn, G.K.1    Kurz, B.W.2    Cheng, R.Z.3    Shmookler, R.J.4
  • 18
    • 0036426979 scopus 로고    scopus 로고
    • S-phase synchronized CHO cells show elevated transfection efficiency and expression using CaPi
    • Grosjean, F., Batard, P., Jordan, M. and Wurm, F.M. (2002) S-phase synchronized CHO cells show elevated transfection efficiency and expression using CaPi. Cytotechnology 38, 1/2:57-62.
    • (2002) Cytotechnology , vol.38 , Issue.1-2 , pp. 57-62
    • Grosjean, F.1    Batard, P.2    Jordan, M.3    Wurm, F.M.4
  • 19
    • 0024296027 scopus 로고
    • Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes
    • Mansour, S. L., Thomas, K. R., and Capecchi, M.R. (1988) Disruption of the proto-oncogene int-2 in mouse embryo-derived stem cells: a general strategy for targeting mutations to non-selectable genes. Nature 336:348-352.
    • (1988) Nature , vol.336 , pp. 348-352
    • Mansour, S.L.1    Thomas, K.R.2    Capecchi, M.R.3
  • 20
    • 0025327618 scopus 로고
    • Gene targeting in normal and amplified cell lines
    • Zheng, H. and Wilson, J.H. (1990) Gene targeting in normal and amplified cell lines. Nature 344:170-173.
    • (1990) Nature , vol.344 , pp. 170-173
    • Zheng, H.1    Wilson, J.H.2
  • 21
    • 0029885877 scopus 로고    scopus 로고
    • Gene transfer and amplification in CHO cells-efficient methods for maximising specific productivity and assessment of genetic consequences
    • Wurm, F. M., Johnson, A., Ryll, T., Köhne, C., Scherthan, H., Glaab, F., Lie, Y. S., Petropoulos, C. J. and Arathoon, W.R. (1996) Gene transfer and amplification in CHO cells-efficient methods for maximising specific productivity and assessment of genetic consequences. Ann. N.Y. Acad. Sci. 782:70-78.
    • (1996) Ann. N.Y. Acad. Sci. , vol.782 , pp. 70-78
    • Wurm, F.M.1    Johnson, A.2    Ryll, T.3    Köhne, C.4    Scherthan, H.5    Glaab, F.6    Lie, Y.S.7    Petropoulos, C.J.8    Arathoon, W.R.9
  • 22
    • 0019135289 scopus 로고
    • Genetic and physical linkage of exogenous sequences in transformed cells
    • Perucho, M., Hanahan, D., and Wigler, M. (1980) Genetic and physical linkage of exogenous sequences in transformed cells. Cell 22:309-317.
    • (1980) Cell , vol.22 , pp. 309-317
    • Perucho, M.1    Hanahan, D.2    Wigler, M.3
  • 23
    • 0024434889 scopus 로고
    • Homologous Plasmid Recombination is Elevated in Immortally Transformed Cells
    • Finn, G. K., Kurz, B.W., Cheng, R. Z., and Shmookler Reis, R. J. (1989) Homologous Plasmid Recombination is Elevated in Immortally Transformed Cells. Mol. Cell. Biol. 9, 9:4009-4017.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 4009-4017
    • Finn, G.K.1    Kurz, B.W.2    Cheng, R.Z.3    Shmookler Reis, R.J.4
  • 24
    • 0020396492 scopus 로고
    • Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid molecules
    • Folger, K. R., Wong, E. A., Wahl, G., and Capecchi, M.R. (1982) Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid molecules. Mol. Cell. Biol. 2, 11:1372-1387.
    • (1982) Mol. Cell. Biol. , vol.2 , Issue.11 , pp. 1372-1387
    • Folger, K.R.1    Wong, E.A.2    Wahl, G.3    Capecchi, M.R.4
  • 25
    • 36148950054 scopus 로고    scopus 로고
    • Co-transfer of multiple plasmids/viruses as an attractive method to introduce several genes in mammalian cells. Gene Transfer and Expression in Mammalian Cells
    • In: S. C. Makrides (Ed.)
    • Jordan, M. and Wurm, F.M. (2003) Co-transfer of multiple plasmids/viruses as an attractive method to introduce several genes in mammalian cells. In: S. C. Makrides (Ed.) Gene Transfer and Expression in Mammalian Cells. New Comprehensive Biochemistry, Volume 38, pp. 337-357.
    • (2003) New Comprehensive Biochemistry , vol.38 , pp. 337-357
    • Jordan, M.1    Wurm, F.M.2
  • 27
    • 8344271026 scopus 로고    scopus 로고
    • Production of recombinant protein therapeutics in cultivated mammalian cells
    • Wurm, F.M. (2004) Production of recombinant protein therapeutics in cultivated mammalian cells. Nature Biotechnology 22, 11:1393-1398.
    • (2004) Nature Biotechnology , vol.22 , Issue.11 , pp. 1393-1398
    • Wurm, F.M.1
  • 28
    • 8344231329 scopus 로고
    • Host Cell Derived Retroviral Sequences Enhance Transfection and Expression Efficiency in CHO Cells.
    • In: Spier, R. E., Griffiths, J. B., Mac-Donald, C. (Eds), Butterworth-Heinemann, Oxford, UK
    • Wurm, F. M., Johnson, A., Lie, Y. S., Etcheverry M.T., and Anderson, K. P. (1992) Host Cell Derived Retroviral Sequences Enhance Transfection and Expression Efficiency in CHO Cells. In: Spier, R. E., Griffiths, J. B., Mac-Donald, C. (Eds) Animal Cell Technology: Developments, Processes and Products. Butterworth-Heinemann, Oxford, UK, pp. 35-41.
    • (1992) , pp. 35-41
    • Wurm, F.M.1    Johnson, A.2    Lie, Y.S.3    Etcheverry, M.T.4    Anderson, K.P.5
  • 29
    • 0942265267 scopus 로고    scopus 로고
    • Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells
    • Barnes, L. M., Bentley, C. M., and Dickson, A. J. (2004) Molecular definition of predictive indicators of stable protein expression in recombinant NS0 myeloma cells. Biotechnol. Bioeng. 85:115-121.
    • (2004) Biotechnol. Bioeng. , vol.85 , pp. 115-121
    • Barnes, L.M.1    Bentley, C.M.2    Dickson, A.J.3
  • 31
    • 0023650538 scopus 로고
    • Electroporation for the efficient transfection of mammalian cells with DNA
    • Chu, G., Hayakawa, H., and Berg, P. (1987) Electroporation for the efficient transfection of mammalian cells with DNA. Nucleic Acids Res. 15:1311-1326.
    • (1987) Nucleic Acids Res. , vol.15 , pp. 1311-1326
    • Chu, G.1    Hayakawa, H.2    Berg, P.3
  • 32
    • 0025302843 scopus 로고
    • Introduction of stable high-copy-number DNA into Chinese hamster ovary cells by electroporation
    • Barsoum, J. (1990) Introduction of stable high-copy-number DNA into Chinese hamster ovary cells by electroporation. DNA Cell Biol. 9, 4:293-300.
    • (1990) DNA Cell Biol. , vol.9 , Issue.4 , pp. 293-300
    • Barsoum, J.1
  • 33
    • 0024978864 scopus 로고
    • Cationic liposome-mediated transfection
    • Felgner, P.L. and Ringold, G.M. (1989) Cationic liposome-mediated transfection. Nature 337:387-388.
    • (1989) Nature , vol.337 , pp. 387-388
    • Felgner, P.L.1    Ringold, G.M.2
  • 34
    • 0000893449 scopus 로고
    • Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA
    • Behr, J.-P., Demeneix, B., Loeffler, J.-P., and Perez-Mutul, J. (1989) Efficient gene transfer into mammalian primary endocrine cells with lipopolyamine-coated DNA. Proc. Natl. Acad. Sci. USA 86:6983-6986.
    • (1989) Proc. Natl. Acad. Sci. USA , vol.86 , pp. 6983-6986
    • Behr, J.-P.1    Demeneix, B.2    Loeffler, J.-P.3    Perez-Mutul, J.4
  • 35
    • 0025318771 scopus 로고
    • Efficient transfection and expression of heterologous genes in PC12 cells
    • Muller, S. R., Sullivan, P. D., Clegg, D.O., and Feinstein, S.C. (1990) Efficient transfection and expression of heterologous genes in PC12 cells. DNA Cell Biol. 9, 3:221-229.
    • (1990) DNA Cell Biol. , vol.9 , Issue.3 , pp. 221-229
    • Muller, S.R.1    Sullivan, P.D.2    Clegg, D.O.3    Feinstein, S.C.4
  • 36
    • 2342636360 scopus 로고    scopus 로고
    • Biolistic and diolistic transfection: using the gene gun to deliver DNA and lipophilic dyes into mammalian cells
    • O'Brien, J. and Lummis, S. C. R. (2004) Biolistic and diolistic transfection: using the gene gun to deliver DNA and lipophilic dyes into mammalian cells. Methods 33:121-125.
    • (2004) Methods , vol.33 , pp. 121-125
    • O'Brien, J.1    Lummis, S.C.R.2
  • 37
    • 1542467511 scopus 로고    scopus 로고
    • Peptide-and polymer-based gene delivery vehicles
    • Brokx, R. and Gariepy, J. (2004) Peptide-and polymer-based gene delivery vehicles. Methods Mol. Med. 90:139-160.
    • (2004) Methods Mol. Med. , vol.90 , pp. 139-160
    • Brokx, R.1    Gariepy, J.2
  • 38
    • 0035970032 scopus 로고    scopus 로고
    • Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini
    • Putnam, D., Gentry, C. A., Pack, D.W., and Langer, R. (2001) Polymer-based gene delivery with low cytotoxicity by a unique balance of side-chain termini. Proc. Natl. Acad. Sci. USA 98(3):1200-1205.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , Issue.3 , pp. 1200-1205
    • Putnam, D.1    Gentry, C.A.2    Pack, D.W.3    Langer, R.4
  • 39
    • 0024118441 scopus 로고
    • Homologous integration in mammalian cells without target gene selection
    • Jasin, M. and Berg, P. (1988) Homologous integration in mammalian cells without target gene selection. Genes Dev. 2:1353-1363.
    • (1988) Genes Dev. , vol.2 , pp. 1353-1363
    • Jasin, M.1    Berg, P.2
  • 40
    • 0022389290 scopus 로고
    • Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination
    • Smithies, O., Gregg, R. G., Boggs, S. S., Koralewski, M.A., and Kucherlapati, R.S. (1985) Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature 317:230-234.
    • (1985) Nature , vol.317 , pp. 230-234
    • Smithies, O.1    Gregg, R.G.2    Boggs, S.S.3    Koralewski, M.A.4    Kucherlapati, R.S.5
  • 43
    • 0035220172 scopus 로고    scopus 로고
    • The LoxP/CRE system and genome modification
    • Wilson, T.J. and Kola, I. (2001) The LoxP/CRE system and genome modification. Methods Mol. Biol. 158:83-94.
    • (2001) Methods Mol. Biol. , vol.158 , pp. 83-94
    • Wilson, T.J.1    Kola, I.2
  • 44
    • 0033571986 scopus 로고    scopus 로고
    • Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells
    • Gopalkrishnan, R.V., Christiansen, K. A., Goldstein, N. I., DePinho, R. A., and Fisher, P. B. (1999) Use of the human EF-1alpha promoter for expression can significantly increase success in establishing stable cell lines with consistent expression: a study using the tetracycline-inducible system in human cancer cells. Nucleic Acids Res. 27(24):4775-4782.
    • (1999) Nucleic Acids Res. , vol.27 , Issue.24 , pp. 4775-4782
    • Gopalkrishnan, R.V.1    Christiansen, K.A.2    Goldstein, N.I.3    DePinho, R.A.4    Fisher, P.B.5
  • 45
    • 0037074716 scopus 로고    scopus 로고
    • The human elongation factor 1 alpha (EF-1 alpha) first intron highly enhances expression of foreign genes from the murine cytomegalovirus promoter
    • Kim, S.Y., Lee, J. H., Shin, H.S., Kang, H.J., and Kim, Y. S. (2002) The human elongation factor 1 alpha (EF-1 alpha) first intron highly enhances expression of foreign genes from the murine cytomegalovirus promoter. J. Biotechnol. 93:183-187.
    • (2002) J. Biotechnol. , vol.93 , pp. 183-187
    • Kim, S.Y.1    Lee, J.H.2    Shin, H.S.3    Kang, H.J.4    Kim, Y.S.5
  • 46
    • 0020373190 scopus 로고
    • Somatic cells efficiently join unrelated DNA segments end to end
    • Wilson, J. H., Berget, P. B., and Pipas, J.M. (1982) Somatic cells efficiently join unrelated DNA segments end to end. Mol. Cell. Biol. 2:1258-1269.
    • (1982) Mol. Cell. Biol. , vol.2 , pp. 1258-1269
    • Wilson, J.H.1    Berget, P.B.2    Pipas, J.M.3
  • 47
    • 0023839206 scopus 로고
    • Characterisation of two differently processed forms of human recombinant factor IX synthesised in CHO cells transformed with a polycistronic vector
    • Balland, A., Faure, T., Carvallo, D., Cordier, P., Ulrich, P., Fournet, B., de la Salle, H., and Lecocq, J. P. (1988) Characterisation of two differently processed forms of human recombinant factor IX synthesised in CHO cells transformed with a polycistronic vector. Eur. J. Biochem. 172(3):565-572.
    • (1988) Eur. J. Biochem. , vol.172 , Issue.3 , pp. 565-572
    • Balland, A.1    Faure, T.2    Carvallo, D.3    Cordier, P.4    Ulrich, P.5    Fournet, B.6    De La Salle, H.7    Lecocq, J.P.8
  • 48
    • 0037144084 scopus 로고    scopus 로고
    • p 27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHODUKX adapted for growth in suspension and serum-free media
    • Meents, H., Enenkel, B., Werner, R.G. and Fussenegger, M. (2002) p 27Kip1-mediated controlled proliferation technology increases constitutive sICAM production in CHODUKX adapted for growth in suspension and serum-free media. Biotechnol. Bioeng. 79, 6:619-627.
    • (2002) Biotechnol. Bioeng. , vol.79 , Issue.6 , pp. 619-627
    • Meents, H.1    Enenkel, B.2    Werner, R.G.3    Fussenegger, M.4
  • 49
    • 8344240990 scopus 로고    scopus 로고
    • Metabolic engineering of mammalian cells for higher protein yield
    • In: S.C. Makrides (Ed), Elsevier Science B.V.
    • Kaufmann, H. and Fussenegger, M. (2003) Metabolic engineering of mammalian cells for higher protein yield. In: S.C. Makrides (Ed) Gene transfer and expression in mammalian cells. Elsevier Science B.V., pp. 547-569.
    • (2003) Gene transfer and expression in mammalian cells , pp. 547-569
    • Kaufmann, H.1    Fussenegger, M.2
  • 50
    • 0343148872 scopus 로고
    • Inducible overexpression of the mouse c-myc protein in mammalian cells
    • Wurm, F. M., Gwinn, K. A., and Kingston, R. E. (1986) Inducible overexpression of the mouse c-myc protein in mammalian cells. Proc. Natl. Acad. Sci. USA 83:5414-5418.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5414-5418
    • Wurm, F.M.1    Gwinn, K.A.2    Kingston, R.E.3
  • 52
    • 0037154972 scopus 로고    scopus 로고
    • Epigenetic codes for heterochromatin formation and silencing: rounding up of the usual suspects
    • Richards, E. J. and Elgin, S. C. (2002) Epigenetic codes for heterochromatin formation and silencing: rounding up of the usual suspects. Cell 108:489-500.
    • (2002) Cell , vol.108 , pp. 489-500
    • Richards, E.J.1    Elgin, S.C.2
  • 53
    • 36148937461 scopus 로고    scopus 로고
    • Use of scaffold/matrix-attachment regions for protein production
    • In: S. C. Makrides (Ed), Elsevier Science B.V.
    • Girod, P.-A. and Mermod, N. (2003) Use of scaffold/matrix-attachment regions for protein production. In: S. C. Makrides (Ed) Gene transfer and expression in mammalian cells. Elsevier Science B.V., pp. 359-379.
    • (2003) Gene transfer and expression in mammalian cells , pp. 359-379
    • Girod, P.-A.1    Mermod, N.2
  • 55
    • 0024948946 scopus 로고
    • A nuclear attachment element mediates elevated and position-independent gene activity
    • Stief, A., Winter, D. M., Stratling, W. H., and Sippel, A. E. (1989) A nuclear attachment element mediates elevated and position-independent gene activity. Nature 341:343-345.
    • (1989) Nature , vol.341 , pp. 343-345
    • Stief, A.1    Winter, D.M.2    Stratling, W.H.3    Sippel, A.E.4
  • 56
    • 0025272208 scopus 로고
    • The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes
    • Phi-Van, L., von Kries, J. P., Ostertag, W., and Stratling, W.H. (1990) The chicken lysozyme 5' matrix attachment region increases transcription from a heterologous promoter in heterologous cells and dampens position effects on the expression of transfected genes. Mol. Cell. Biol. 10:2302-2307.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 2302-2307
    • Phi-Van, L.1    Von Kries, J.P.2    Ostertag, W.3    Stratling, W.H.4
  • 57
    • 0036208002 scopus 로고    scopus 로고
    • Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes
    • Martens, J. H., Verlaan, M., Kalkhoven, E., Dorsman, J. C., and Zantema, A. (2002) Scaffold/matrix attachment region elements interact with a p300-scaffold attachment factor A complex and are bound by acetylated nucleosomes. Mol. Cell. Biol. 22:2598-2606.
    • (2002) Mol. Cell. Biol. , vol.22 , pp. 2598-2606
    • Martens, J.H.1    Verlaan, M.2    Kalkhoven, E.3    Dorsman, J.C.4    Zantema, A.5
  • 58
    • 0034750803 scopus 로고    scopus 로고
    • Matrix attachment region-dependent function of the immunoglobulin mu enhancer involves histone acetylation at a distance without changes in enhancer occupancy
    • Fernandez, L. A., Winkler, M., and Grosschell, R. (2001) Matrix attachment region-dependent function of the immunoglobulin mu enhancer involves histone acetylation at a distance without changes in enhancer occupancy. Mol. Cell. Biol. 21:196-208.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 196-208
    • Fernandez, L.A.1    Winkler, M.2    Grosschell, R.3
  • 59
    • 0035957848 scopus 로고    scopus 로고
    • Development of stable cell lines for production or regulated expression using matrix attachment regions
    • Zahn-Zabal, M., Kobr, M., Imhof, M.O., Chatellard, P., de Jesus, M., Wurm, F., and Mermod, N. (2001) Development of stable cell lines for production or regulated expression using matrix attachment regions. J. Biotechnol. 87:29-42.
    • (2001) J. Biotechnol. , vol.87 , pp. 29-42
    • Zahn-Zabal, M.1    Kobr, M.2    Imhof, M.O.3    Chatellard, P.4    De Jesus, M.5    Wurm, F.6    Mermod, N.7
  • 61
    • 0842307061 scopus 로고    scopus 로고
    • Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine
    • Mutskov, V. and Felsenfeld, G. (2004) Silencing of transgene transcription precedes methylation of promoter DNA and histone H3 lysine. EMBO J. 23:138-149.
    • (2004) EMBO J. , vol.23 , pp. 138-149
    • Mutskov, V.1    Felsenfeld, G.2
  • 62
    • 22144468761 scopus 로고    scopus 로고
    • The CELO Adenovirus Gam1 Protein Enhances Transient and Stable Recombinant Protein Expression in Chinese Hamster Ovary Cells
    • Hacker, D. L., Derow E. and Wurm, F.M. (2005) The CELO Adenovirus Gam1 Protein Enhances Transient and Stable Recombinant Protein Expression in Chinese Hamster Ovary Cells. J. Biotechnology 117:21-29.
    • (2005) J. Biotechnology , vol.117 , pp. 21-29
    • Hacker, D.L.1    Derow, E.2    Wurm, F.M.3
  • 63
    • 0021101284 scopus 로고
    • Expression of recombinant plasmids in mammalian cells is enhanced by sodium butyrate
    • Gorman, C. M., Howard, B. H., and Reeves, R. (1983) Expression of recombinant plasmids in mammalian cells is enhanced by sodium butyrate. Nucleic Acids Res. 11:7631-7648.
    • (1983) Nucleic Acids Res. , vol.11 , pp. 7631-7648
    • Gorman, C.M.1    Howard, B.H.2    Reeves, R.3
  • 64
    • 0017767153 scopus 로고
    • n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells
    • Riggs, M.G., Whittaker, R. G., Nuemann, J. R., and Ingram, V.M. (1977) n-Butyrate causes histone modification in HeLa and Friend erythroleukaemia cells. Nature 268:462-464.
    • (1977) Nature , vol.268 , pp. 462-464
    • Riggs, M.G.1    Whittaker, R.G.2    Nuemann, J.R.3    Ingram, V.M.4
  • 65
    • 0032577235 scopus 로고    scopus 로고
    • A protein phosphatase is involved in the inhibition of histone diacetylation by sodium butyrate
    • Cuisset, L., Tichonicky, L., and Delpech, M. (1998) A protein phosphatase is involved in the inhibition of histone diacetylation by sodium butyrate. Biochem. Biophys. Res. Commun. 246:760-764.
    • (1998) Biochem. Biophys. Res. Commun. , vol.246 , pp. 760-764
    • Cuisset, L.1    Tichonicky, L.2    Delpech, M.3
  • 66
    • 0033231184 scopus 로고    scopus 로고
    • Components of vectors for gene transfer and expression in mammalian cells
    • Makrides, S. C. (1999) Components of vectors for gene transfer and expression in mammalian cells. Protein Express. Purif. 17:183-202.
    • (1999) Protein Express. Purif. , vol.17 , pp. 183-202
    • Makrides, S.C.1
  • 68
    • 7144228446 scopus 로고    scopus 로고
    • Deregulated expression of cloned transcription factor E2F-1 in Chinese Hamster Ovary cells shifts protein patterns and activates growth in protein-free medium
    • In: Carrondo, M.J.T. et al. (Eds), Kluwer Academic Publishers
    • Lee, K. H., Guerini-Sburlati, A., Renner, W. A., and Bailey, J.E. (1997) Deregulated expression of cloned transcription factor E2F-1 in Chinese Hamster Ovary cells shifts protein patterns and activates growth in protein-free medium. In: Carrondo, M.J.T. et al. (Eds), Animal Cell Technology-from vaccines to genetic medicine. Kluwer Academic Publishers, pp. 621-623.
    • (1997) Animal Cell Technology-from vaccines to genetic medicine , pp. 621-623
    • Lee, K.H.1    Guerini-Sburlati, A.2    Renner, W.A.3    Bailey, J.E.4
  • 69
    • 0036016922 scopus 로고    scopus 로고
    • Role of vitamins in determining apoptosis and extent of suppression by bcl-2 during hybridoma cell culture
    • Ishaqe, A. and Al-Rubeai, M. (2002) Role of vitamins in determining apoptosis and extent of suppression by bcl-2 during hybridoma cell culture. Apoptosis 7:231-239.
    • (2002) Apoptosis , vol.7 , pp. 231-239
    • Ishaqe, A.1    Al-Rubeai, M.2
  • 70
    • 0030431008 scopus 로고    scopus 로고
    • Super CHO-a cell line capable of autocrine growth under fully defined protein-free conditions
    • Pak, S. C. O., Hunt, S.M.N., Bridges, M.W., Sleigh, M.J., and Gray, P.P. (1996) Super CHO-a cell line capable of autocrine growth under fully defined protein-free conditions. Cytotechnology 22:139-146.
    • (1996) Cytotechnology , vol.22 , pp. 139-146
    • Pak, S.C.O.1    Hunt, S.M.N.2    Bridges, M.W.3    Sleigh, M.J.4    Gray, P.P.5
  • 71
    • 0033587794 scopus 로고    scopus 로고
    • Bcl-2 overexpression reduces growth rate and prolongs G1 phase in continuous chemostat cultures of hybridoma cells
    • Simpson, N.H., Singh, R. P., Emery, A. and Al-Rubeai, M. (1999) Bcl-2 overexpression reduces growth rate and prolongs G1 phase in continuous chemostat cultures of hybridoma cells. Biotechnol. Bioeng. 64:174-186.
    • (1999) Biotechnol. Bioeng. , vol.64 , pp. 174-186
    • Simpson, N.H.1    Singh, R.P.2    Emery, A.3    Al-Rubeai, M.4
  • 72
    • 0034281735 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 and transferrin mediate growth and survival of Chinese hamster ovary cells
    • Sunstrom, N.-A., S., Gay, R. D., Wong, D.C., Kitchen, N. A., Deboer, L., Gray, P.P. (2000) Insulin-like growth factor-1 and transferrin mediate growth and survival of Chinese hamster ovary cells. Biotechnol. Prog. 16:698-702.
    • (2000) Biotechnol. Prog. , vol.16 , pp. 698-702
    • Sunstrom, N.-A.S.1    Gay, R.D.2    Wong, D.C.3    Kitchen, N.A.4    Deboer, L.5    Gray, P.P.6
  • 73
    • 0029347496 scopus 로고
    • Eppenberger Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium
    • Renner, W. A., Lee, K. H., Hstzimanikatis, V., Bailey, J. E., and Eppenberger (1995) Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium. Biotechnol. Bioeng. 47:476-482.
    • (1995) Biotechnol. Bioeng. , vol.47 , pp. 476-482
    • Renner, W.A.1    Lee, K.H.2    Hstzimanikatis, V.3    Bailey, J.E.4
  • 74
    • 8344291031 scopus 로고    scopus 로고
    • Cell engineering blocks cell stress and improves biotherapeutic production
    • Arden, N., Nivitchanyong, T., and Betenbaugh, M.J. (2004) Cell engineering blocks cell stress and improves biotherapeutic production. Bioprocess. J. 2:23-28.
    • (2004) Bioprocess. J. , vol.2 , pp. 23-28
    • Arden, N.1    Nivitchanyong, T.2    Betenbaugh, M.J.3
  • 75
    • 0033044588 scopus 로고    scopus 로고
    • Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity
    • Umaña, P., Jean-Mairet, J., Moudry, R., Amstutz, H., and Bailey, J.E. (1999) Engineered glycoforms of an antineuroblastoma IgG1 with optimized antibody-dependent cellular cytotoxic activity. Nature Biotechnol. 17:176-180.
    • (1999) Nature Biotechnol. , vol.17 , pp. 176-180
    • Umaña, P.1    Jean-Mairet, J.2    Moudry, R.3    Amstutz, H.4    Bailey, J.E.5
  • 76
    • 0026720075 scopus 로고
    • Tight control of gene expression in mammalian cells by tetracycline-responsive promoters
    • Gossen, M. and Bujard, H. (1992) Tight control of gene expression in mammalian cells by tetracycline-responsive promoters. Proc. Natl. Acad. Sci. USA 89:5547-5551.
    • (1992) Proc. Natl. Acad. Sci. USA , vol.89 , pp. 5547-5551
    • Gossen, M.1    Bujard, H.2
  • 78
    • 0032486578 scopus 로고    scopus 로고
    • In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by expression of the bcl-2 gene
    • Simpson, N.H., Singh, R. P., Perani, A., Goldenzon, C., and Al-Rubeai, M. (1999) In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by expression of the bcl-2 gene. Biotechnol. Bioeng. 59:90-98.
    • (1999) Biotechnol. Bioeng. , vol.59 , pp. 90-98
    • Simpson, N.H.1    Singh, R.P.2    Perani, A.3    Goldenzon, C.4    Al-Rubeai, M.5
  • 79
    • 0032170308 scopus 로고    scopus 로고
    • Higher productivity of growth-arrested Chinese hamster ovary cells expressing the cyclin-dependent kinase inhibitor p27
    • Mazur, X., Fussenegger, M., Renner, W. A., and Bailey, J.E. (1998) Higher productivity of growth-arrested Chinese hamster ovary cells expressing the cyclin-dependent kinase inhibitor p27. Biotechnol. Prog. 14:705-713.
    • (1998) Biotechnol. Prog. , vol.14 , pp. 705-713
    • Mazur, X.1    Fussenegger, M.2    Renner, W.A.3    Bailey, J.E.4
  • 81
    • 0034076307 scopus 로고    scopus 로고
    • Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets
    • Clynes, R. A., Towers, T. L., Presta, L. G., and Ravetch, J.V. (2000) Inhibitory Fc receptors modulate in vivo cytotoxicity against tumor targets. Nature Med. 6:443-446.
    • (2000) Nature Med. , vol.6 , pp. 443-446
    • Clynes, R.A.1    Towers, T.L.2    Presta, L.G.3    Ravetch, J.V.4
  • 82
    • 0031033895 scopus 로고    scopus 로고
    • Effect of glycosylation on antibody function: implications for genetic engineering
    • Wright, A. and Morrison, S.L. (1997) Effect of glycosylation on antibody function: implications for genetic engineering. Trends Biotechnol. 15:26-32.
    • (1997) Trends Biotechnol. , vol.15 , pp. 26-32
    • Wright, A.1    Morrison, S.L.2
  • 83
    • 0142073269 scopus 로고    scopus 로고
    • Highlevel expression of full-length antibodies using trans-complementing expression vectors
    • Bianchi, A. A. and McGrew, J.T. (2003) Highlevel expression of full-length antibodies using trans-complementing expression vectors. Biotechnol. Bioeng. 84:439-444.
    • (2003) Biotechnol. Bioeng. , vol.84 , pp. 439-444
    • Bianchi, A.A.1    McGrew, J.T.2
  • 84
    • 0033589372 scopus 로고    scopus 로고
    • GFP expressing mammalian cells for fast, accurate, non-invasive cell growth assessment in the kinetic mode
    • Hunt, L., M. De Jesus, M. Jordan, and F.M. Wurm (1999) GFP expressing mammalian cells for fast, accurate, non-invasive cell growth assessment in the kinetic mode. Biotechnol. Bioeng. 65:201-205.
    • (1999) Biotechnol. Bioeng. , vol.65 , pp. 201-205
    • Hunt, L.1    De Jesus, M.2    Jordan, M.3    Wurm, F.M.4
  • 85
    • 84889991679 scopus 로고    scopus 로고
    • unpublished observation
    • Wurm, F. M., unpublished observation.
    • Wurm, F.M.1
  • 88
    • 0029593442 scopus 로고
    • Amplification and expression of recombinant genes in serum-independent Chinese hamster ovary cells
    • Gandor, C., Leist, C., Fiechter, A., and Asselbergs, F. A. (1995) Amplification and expression of recombinant genes in serum-independent Chinese hamster ovary cells. FEBS Lett. 377:290-294.
    • (1995) FEBS Lett. , vol.377 , pp. 290-294
    • Gandor, C.1    Leist, C.2    Fiechter, A.3    Asselbergs, F.A.4
  • 89
    • 0017201739 scopus 로고
    • A novel chromosome abnormality in human neuroblastoma and antifolate-resistance Chinese hamster cell lines in culture
    • Biedler, J.L. and Spengler, B.A. (1976) A novel chromosome abnormality in human neuroblastoma and antifolate-resistance Chinese hamster cell lines in culture. J. Natl. Cancer Inst. 57, 3:683-689.
    • (1976) J. Natl. Cancer Inst. , vol.57 , Issue.3 , pp. 683-689
    • Biedler, J.L.1    Spengler, B.A.2
  • 90
    • 0343148872 scopus 로고
    • Inducible overexpression of the mouse c-myc protein in mammalian cells
    • Wurm, F. M., Gwinn, K. A., and Kingston, R. E. (1986) Inducible overexpression of the mouse c-myc protein in mammalian cells. Proc. Natl. Acad. Sci. USA 83:5414-5418.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 5414-5418
    • Wurm, F.M.1    Gwinn, K.A.2    Kingston, R.E.3
  • 91
    • 0030904279 scopus 로고    scopus 로고
    • Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to amplicons
    • Coquelle, A., Pipiras, E., Toledo, F., Buttin, G., and Debatisse, M. (1997) Expression of fragile sites triggers intrachromosomal mammalian gene amplification and sets boundaries to amplicons. Cell 89:215-225.
    • (1997) Cell , vol.89 , pp. 215-225
    • Coquelle, A.1    Pipiras, E.2    Toledo, F.3    Buttin, G.4    Debatisse, M.5
  • 92
    • 0024411328 scopus 로고
    • Recent progress in understanding mechanisms of mammalian DNA amplification
    • Stark, G. R., Debatisse, M., Giulotto, E., and Wahl, G.M. (1989) Recent progress in understanding mechanisms of mammalian DNA amplification. Cell 57:901-908.
    • (1989) Cell , vol.57 , pp. 901-908
    • Stark, G.R.1    Debatisse, M.2    Giulotto, E.3    Wahl, G.M.4
  • 93
    • 0024236101 scopus 로고
    • Isolation of overproducing recombinant mammalian cells by a fast and simple selection procedure
    • Zettlmeissl, G., Wirth, M., Hauser, H. J., and Küpper, H.A. (1988) Isolation of overproducing recombinant mammalian cells by a fast and simple selection procedure. Gene 73:419-426.
    • (1988) Gene , vol.73 , pp. 419-426
    • Zettlmeissl, G.1    Wirth, M.2    Hauser, H.J.3    Küpper, H.A.4
  • 94
    • 84890000978 scopus 로고    scopus 로고
    • unpublished observation
    • Wurm, F. M., unpublished observation.
    • Wurm, F.M.1
  • 95
    • 0024820602 scopus 로고
    • Enhanced Expression of an immunoglobulin based vector in myeloma cells mediated by coamplification with a mutant dihydrofolate reductase gene
    • Hendricks, M.B., Luchette, C. A., and Banker, M.J. (1989) Enhanced Expression of an immunoglobulin based vector in myeloma cells mediated by coamplification with a mutant dihydrofolate reductase gene. Biotechnology 7:1271-1274.
    • (1989) Biotechnology , vol.7 , pp. 1271-1274
    • Hendricks, M.B.1    Luchette, C.A.2    Banker, M.J.3
  • 96
    • 14744283551 scopus 로고
    • High level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker
    • Bebbington, C. R., Renner, G., Thomson, S., King, D., Abrams, D., and Yaranton, G.T. (1992) High level expression of a recombinant antibody from myeloma cells using a glutamine synthetase gene as an amplifiable selectable marker. Bio/Technology 10:169-175.
    • (1992) Bio/Technology , vol.10 , pp. 169-175
    • Bebbington, C.R.1    Renner, G.2    Thomson, S.3    King, D.4    Abrams, D.5    Yaranton, G.T.6
  • 97
    • 0034122420 scopus 로고    scopus 로고
    • Advances in animal cell recombinant protein production: GS-NS0 expression system
    • Barnes, L. M., Bentley, C.M. and Dickson, A. J. (2000) Advances in animal cell recombinant protein production: GS-NS0 expression system. Cytotechnology 32:109-123.
    • (2000) Cytotechnology , vol.32 , pp. 109-123
    • Barnes, L.M.1    Bentley, C.M.2    Dickson, A.J.3
  • 99
    • 0343252561 scopus 로고
    • Chromosomal evolution in cell populations
    • Hsu, T. C. (1961) Chromosomal evolution in cell populations. Int. Rev. Cytol. 12:69-121.
    • (1961) Int. Rev. Cytol. , vol.12 , pp. 69-121
    • Hsu, T.C.1
  • 100
    • 0018219028 scopus 로고
    • Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexateresistant Chinese hamster ovary cell line
    • Nunberg, J. H., Kaufman, R. J., Schimke, R.T., Urlaub, G., and Chasin, L. A. (1978) Amplified dihydrofolate reductase genes are localized to a homogeneously staining region of a single chromosome in a methotrexateresistant Chinese hamster ovary cell line. Proc. Natl. Acad. Sci. USA 75:5553-5556.
    • (1978) Proc. Natl. Acad. Sci. USA , vol.75 , pp. 5553-5556
    • Nunberg, J.H.1    Kaufman, R.J.2    Schimke, R.T.3    Urlaub, G.4    Chasin, L.A.5
  • 101
    • 0023931957 scopus 로고
    • Amplified expression constructs for human tissue-type plasminogen activator in Chinese hamster ovary cells: instability in the absence of selective pressure
    • Weidle, U. H., Buckel, P. and Wienberg, J. (1988) Amplified expression constructs for human tissue-type plasminogen activator in Chinese hamster ovary cells: instability in the absence of selective pressure. Gene 66:193-203.
    • (1988) Gene , vol.66 , pp. 193-203
    • Weidle, U.H.1    Buckel, P.2    Wienberg, J.3
  • 102
    • 0023613099 scopus 로고
    • Similarity in dynamics of single and double minute chromosomes incidence and number of chromosomal aberrations during long-term treatment of a human cell line with methotrexate
    • Vitek, J. A. (1987) Similarity in dynamics of single and double minute chromosomes incidence and number of chromosomal aberrations during long-term treatment of a human cell line with methotrexate. Neoplasma 34, 6:665-670.
    • (1987) Neoplasma , vol.34 , Issue.6 , pp. 665-670
    • Vitek, J.A.1
  • 103
    • 0022446922 scopus 로고
    • Cytogenetic analysis using quantitative, high sensitivity fluorescence hybridization
    • Pinkel, D., Straume, T., and Gray, J.W. (1986) Cytogenetic analysis using quantitative, high sensitivity fluorescence hybridization. Proc. Natl. Acad. Sci. USA 83:2934-2938.
    • (1986) Proc. Natl. Acad. Sci. USA , vol.83 , pp. 2934-2938
    • Pinkel, D.1    Straume, T.2    Gray, J.W.3
  • 104
    • 0025139423 scopus 로고
    • Effects of Methotrexate (MTX) on Transfected DNA Stability in Mammalian Cells
    • Pallavicini, M.G., DeTeresa, P. S., Rosette, C., Gray, J.W., and Wurm, F.M. (1990) Effects of Methotrexate (MTX) on Transfected DNA Stability in Mammalian Cells. Mol. Cell. Biol. 10:401-404.
    • (1990) Mol. Cell. Biol. , vol.10 , pp. 401-404
    • Pallavicini, M.G.1    DeTeresa, P.S.2    Rosette, C.3    Gray, J.W.4    Wurm, F.M.5
  • 105
    • 0026482796 scopus 로고
    • Integration and stability of CHO amplicons containing plasmid sequences
    • Wurm, F. M., Pallavicini, M.G., and Arathoon, R. (1992) Integration and stability of CHO amplicons containing plasmid sequences. Dev. Biol. Stand. 76:69-82.
    • (1992) Dev. Biol. Stand. , vol.76 , pp. 69-82
    • Wurm, F.M.1    Pallavicini, M.G.2    Arathoon, R.3
  • 106
    • 0344200036 scopus 로고    scopus 로고
    • Cytogenetic analysis of chimeric antibody-producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure
    • Kim, S. J. and Lee G.M. (1999) Cytogenetic analysis of chimeric antibody-producing CHO cells in the course of dihydrofolate reductase-mediated gene amplification and their stability in the absence of selective pressure. Biotechnol. Bioeng. 64, 6:741-749.
    • (1999) Biotechnol. Bioeng. , vol.64 , Issue.6 , pp. 741-749
    • Kim, S.J.1    Lee, G.M.2
  • 107
  • 109
    • 0033524362 scopus 로고    scopus 로고
    • Production of reovirus type-1 and type-3 from Vero cells grown on solid and macroporous microcarriers
    • Berry, J. M., Barnabe, N., Coombs, K. M., and Butler, M. (1999) Production of reovirus type-1 and type-3 from Vero cells grown on solid and macroporous microcarriers. Biotechnol. Bioeng. 62(1):12-19.
    • (1999) Biotechnol. Bioeng. , vol.62 , Issue.1 , pp. 12-19
    • Berry, J.M.1    Barnabe, N.2    Coombs, K.M.3    Butler, M.4
  • 111
    • 0031194199 scopus 로고    scopus 로고
    • The evolution of processes for the commercial exploitation of anchorage-dependent animal cells
    • Spier, R. and Kadouri, A. (1997) The evolution of processes for the commercial exploitation of anchorage-dependent animal cells. Enzyme Microb. Technol. 21:2-8.
    • (1997) Enzyme Microb. Technol. , vol.21 , pp. 2-8
    • Spier, R.1    Kadouri, A.2
  • 112
    • 84889966375 scopus 로고    scopus 로고
    • Wood Mackenzie, Horizons, Pharmaceuticals Issue 6 (January
    • Wood Mackenzie, Horizons, Pharmaceuticals Issue 6 (January 2003).
    • (2003)
  • 113
    • 0025579290 scopus 로고
    • Suspension culture of mammalian cells
    • In: A. S. Lubiniecki (Ed), Dekker Inc. N.Y.
    • Birch, J. R. and Arathoon, W. R. (1990) Suspension culture of mammalian cells. In: A. S. Lubiniecki (Ed) Large Scale Mammalian Cell Culture Technology. Dekker Inc. N.Y., pp. 251-270.
    • (1990) Large Scale Mammalian Cell Culture Technology , pp. 251-270
    • Birch, J.R.1    Arathoon, W.R.2
  • 114
    • 0038443201 scopus 로고    scopus 로고
    • Stable transfection of CHO cells with the c-myc gene results in increased proliferation rates, reduces serum dependency and induces anchorage independence
    • Afandi, V. and Al-Rubeai M. (2003) Stable transfection of CHO cells with the c-myc gene results in increased proliferation rates, reduces serum dependency and induces anchorage independence. Cytotechnology 41:1-10.
    • (2003) Cytotechnology , vol.41 , pp. 1-10
    • Afandi, V.1    Al-Rubeai, M.2
  • 115
    • 0002249378 scopus 로고
    • Production of recombinant Factor VIII from perfusion cultures: I. Large Scale Fermentation
    • In: Spier, R.E., Griffiths, J.B., Berthold, W. (Eds), Prospects for Tomorrow
    • Bödecker, B.G. D., Newcomb, R., Yuan, P., Braufman, A., and Kelsey, W. (1994) Production of recombinant Factor VIII from perfusion cultures: I. Large Scale Fermentation. In: Spier, R.E., Griffiths, J.B., Berthold, W. (Eds), Animal Cell Technology, Products of Today, Prospects for Tomorrow, pp. 580-590.
    • (1994) Animal Cell Technology, Products of Today , pp. 580-590
    • Bödecker, B.G.D.1    Newcomb, R.2    Yuan, P.3    Braufman, A.4    Kelsey, W.5
  • 116
    • 84889964591 scopus 로고    scopus 로고
    • Annual Report 1995, ARES-SERONO: Follicle Stimulating Hormone
    • Annual Report 1995, ARES-SERONO: Follicle Stimulating Hormone.
  • 117
    • 0003340755 scopus 로고
    • Mass culture of mouse and human hybridoma cells in hollow-fiber culture
    • In: S. Seaver (Ed), Dekker, New York
    • van Wedel, R. J. (1987) Mass culture of mouse and human hybridoma cells in hollow-fiber culture. In: S. Seaver (Ed) Commercial Production of Monoclonal Antibodies. Dekker, New York, pp. 159-173.
    • (1987) , pp. 159-173
    • van Wedel, R.J.1
  • 118
    • 4243611775 scopus 로고
    • Human therapeutic monoclonal Anti-D antibody produced in longterm hollow-fibre culture
    • In: Beuvery, E.C. et al. (Eds), Kluwer Academic Publishers
    • Davies, J. M., Lavender, C. M., Bowes, K. J., Hanak, J. A. J., Combridge B. S., and Kingsland, S. L. (1995) Human therapeutic monoclonal Anti-D antibody produced in longterm hollow-fibre culture. In: Beuvery, E.C. et al. (Eds) Animal Cell Technology: Developments towards the 21st century. Kluwer Academic Publishers, pp. 149-153.
    • (1995) , pp. 149-153
    • Davies, J.M.1    Lavender, C.M.2    Bowes, K.J.3    Hanak, J.A.J.4    Combridge, B.S.5    Kingsland, S.L.6
  • 119
    • 84889988883 scopus 로고    scopus 로고
    • Press Release of Cellex Biosciences: Cellex Biosciences perfusion equipment used for 1st injectable product produced in hollow fiber licensed by FDA
    • Heimbuch, S. (1996) Press Release of Cellex Biosciences: Cellex Biosciences perfusion equipment used for 1st injectable product produced in hollow fiber licensed by FDA. October 30, 1996.
    • (1996) October , vol.30 , pp. 1996
    • Heimbuch, S.1
  • 120
    • 84889989916 scopus 로고
    • Comparative study for the propagation of anchorage-dependent cells using different forms of macroporous carriers
    • In: Beuvery, E.C. et al. (Eds), Kluwer Academic Publishers
    • Preissmann, A., Bux, R., Schorn, P., and Noe, W. (1995) Comparative study for the propagation of anchorage-dependent cells using different forms of macroporous carriers. In: Beuvery, E.C. et al. (Eds) Animal Cell Technology: Developments towards the 21st century. Kluwer Academic Publishers, pp. 841-845.
    • (1995) Animal Cell Technology: Developments towards the 21st century , pp. 841-845
    • Preissmann, A.1    Bux, R.2    Schorn, P.3    Noe, W.4
  • 122
    • 0025731989 scopus 로고
    • Functional Properties of a Collection of Charged-to-Alanine Substitution Variants of Tissue-Type Plasminogen Activator
    • Bennett, W. F., Paoni, N., Botstein, D., Jones, A. J. S., Keyt, B., Presta, L., Wurm, F.M. and Zoller M. (1991) Functional Properties of a Collection of Charged-to-Alanine Substitution Variants of Tissue-Type Plasminogen Activator. J. Biol. Chem. 266, 8:5191-5201.
    • (1991) J. Biol. Chem. , vol.266 , Issue.8 , pp. 5191-5201
    • Bennett, W.F.1    Paoni, N.2    Botstein, D.3    Jones, A.J.S.4    Keyt, B.5    Presta, L.6    Wurm, F.M.7    Zoller, M.8
  • 124
    • 0001789834 scopus 로고
    • Transient Production of Proteins Using an Adenovirus Transformed Cell Line
    • Gorman, C. M., Gies, D.R., McCray, G. (1990) Transient Production of Proteins Using an Adenovirus Transformed Cell Line. DNA Protein Eng. Technol. 2:1-28.
    • (1990) DNA Protein Eng. Technol. , vol.2 , pp. 1-28
    • Gorman, C.M.1    Gies, D.R.2    McCray, G.3
  • 125
    • 0035922883 scopus 로고    scopus 로고
    • Transient Gene Expression: Recombinant Protein Production with Suspension-Adapted HEK-293EBNA Cells
    • Meissner, P., Kulangara, A., Pick, H., Chatellard, P. and Wurm, F.M. (2001) Transient Gene Expression: Recombinant Protein Production with Suspension-Adapted HEK-293EBNA Cells. Biotechnol. Bioeng. 75, 2:197-203.
    • (2001) Biotechnol. Bioeng. , vol.75 , Issue.2 , pp. 197-203
    • Meissner, P.1    Kulangara, A.2    Pick, H.3    Chatellard, P.4    Wurm, F.M.5
  • 126
  • 130
    • 0035689561 scopus 로고    scopus 로고
    • Transient gene expression from mammalian cells-a new chapter in animal cell technology?
    • Wurm, F.M. and Bernard, A. (2001) Transient gene expression from mammalian cells-a new chapter in animal cell technology? Cytotechnology 35:155-156.
    • (2001) Cytotechnology , vol.35 , pp. 155-156
    • Wurm, F.M.1    Bernard, A.2
  • 131
    • 84889974877 scopus 로고    scopus 로고
    • (Genentech), conference report
    • Reilly, D. (Genentech), conference report 2004.
    • (2004)
    • Reilly, D.1
  • 132
    • 0035972806 scopus 로고    scopus 로고
    • Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection
    • Batard, P., Jordan, M., Chatellard, P. and Wurm, F.M. (2001) Transfer of high copy number plasmid into mammalian cells by calcium phosphate transfection. Gene 270:61-68.
    • (2001) Gene , vol.270 , pp. 61-68
    • Batard, P.1    Jordan, M.2    Chatellard, P.3    Wurm, F.M.4
  • 133
    • 0344622606 scopus 로고
    • The serial cultivation of human diploid cell strains
    • Hayflick, L. and Moorhead, P. S. (1961) The serial cultivation of human diploid cell strains. Exp. Cell. Res. 25:585-621.
    • (1961) Exp. Cell. Res. , vol.25 , pp. 585-621
    • Hayflick, L.1    Moorhead, P.S.2
  • 134
    • 84890001005 scopus 로고    scopus 로고
    • SV 40 and Human Cancer, letter
    • Hayflick, L. (1997) SV 40 and Human Cancer, letter. Science 276:336-337.
    • (1997) Science , vol.276 , pp. 336-337
    • Hayflick, L.1
  • 135
    • 0003548166 scopus 로고
    • Points to Consider in the Characterization of Cell Lines Used to Produce Biologicals
    • revised Food and Drug Administration, Center for Biologics Evaluation and Research 1993
    • Food and Drug Administration, Center for Biologics Evaluation and Research (1987) Points to Consider in the Characterization of Cell Lines Used to Produce Biologicals, revised 1993.
    • (1987)
  • 137
    • 0030822582 scopus 로고    scopus 로고
    • Prion diseases and the BSE crisis
    • Prusiner, S.B. (1997) Prion diseases and the BSE crisis. Science 278:245-251.
    • (1997) Science , vol.278 , pp. 245-251
    • Prusiner, S.B.1
  • 138
    • 0842281643 scopus 로고    scopus 로고
    • Mammalian Prion Biology: One century of evolving concepts
    • Aguzzi, A. and Polymenidou, M. (2004) Mammalian Prion Biology: One century of evolving concepts. Cell 116:313-327.
    • (2004) Cell , vol.116 , pp. 313-327
    • Aguzzi, A.1    Polymenidou, M.2
  • 139
    • 84889988889 scopus 로고
    • Advances in Animal Cell Biology and Technology for Bioprocesses
    • In: Spier, R. E., Griffiths, J. B., Berthold, W. (Eds), Croy
    • Wiebe, M.E., Becker, F., Lazar, R., May, L., Casto, B., Semense, M., Fautz, C., Garnick, R., Miller, C., Masover, G., Bergman, D., and Lubiniecki, A. S. (1989) A multifaceted approach to assure that recombinant tPA is free of adventitious virus. In: Spier, R. E., Griffiths, J. B., Berthold, W. (Eds) Advances in Animal Cell Biology and Technology for Bioprocesses. Croy, pp. 68-71.
    • (1989) , pp. 68-71
    • Wiebe, M.E.1    Becker, F.2    Lazar, R.3    May, L.4    Casto, B.5    Semense, M.6    Fautz, C.7    Garnick, R.8    Miller, C.9    Masover, G.10    Bergman, D.11    Lubiniecki, A.S.12
  • 140
    • 0028724943 scopus 로고
    • Genetic Stability and Recombinant Product Consistency
    • In: Brown, F., Lubiniecki A. S. (Eds), Dev. Biol. Stand. Karger, Basel
    • O'Connor, J.V., Keck, R. G., Harris, R. J., and Field, M.J. (1994) In: Brown, F., Lubiniecki A. S. (Eds) Genetic Stability and Recombinant Product Consistency. Dev. Biol. Stand. Karger, Basel, pp. 165-173.
    • (1994) , pp. 165-173
    • O'Connor, J.V.1    Keck, R.G.2    Harris, R.J.3    Field, M.J.4
  • 141
    • 0027013264 scopus 로고
    • Peptide mapping for detecting variants in protein products
    • Garnick, R. L. (1992) Peptide mapping for detecting variants in protein products. Dev. Biol. Stand. 76:117-130.
    • (1992) Dev. Biol. Stand. , vol.76 , pp. 117-130
    • Garnick, R.L.1
  • 142
    • 0023733258 scopus 로고
    • Identification of unusual replacement of methionine by norleucine in recombinant interleukin-2 produced by E. coli.
    • Lu, H. S., Tsai, L. B., Kenney, W.C. and Lai, P.-H. (1988) Identification of unusual replacement of methionine by norleucine in recombinant interleukin-2 produced by E. coli. Biochem. Biophys. Res. Commun. 156:807-813.
    • (1988) Biochem. Biophys. Res. Commun. , vol.156 , pp. 807-813
    • Lu, H.S.1    Tsai, L.B.2    Kenney, W.C.3    Lai, P.-H.4
  • 143
    • 0024552682 scopus 로고
    • Study of the primary structure of recombinant tissue plasminogen activator by reversed-phase high-performance liquid chromatographic tryptic mapping
    • Chloupek, R. C., Harris, R. J., Leonard, C. K., Keck, R. G., Keyt, B. A., Spellman, M.W., Jones, A. J. S., and Hancock, W. S. (1989) Study of the primary structure of recombinant tissue plasminogen activator by reversed-phase high-performance liquid chromatographic tryptic mapping. J. Chromatogr. 463:375-396.
    • (1989) J. Chromatogr. , vol.463 , pp. 375-396
    • Chloupek, R.C.1    Harris, R.J.2    Leonard, C.K.3    Keck, R.G.4    Keyt, B.A.5    Spellman, M.W.6    Jones, A.J.S.7    Hancock, W.S.8
  • 144
    • 0027369036 scopus 로고
    • The use of peptide mapping for the detection of heterogeneity in recombinant DNA-derived proteins
    • O'Connor, J.V. (1993) The use of peptide mapping for the detection of heterogeneity in recombinant DNA-derived proteins. Biologicals 21:111-117.
    • (1993) Biologicals , vol.21 , pp. 111-117
    • O'Connor, J.V.1
  • 145
    • 0024516367 scopus 로고
    • Succinide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins
    • Stephenson, R. C. and Clarke, S. (1989) Succinide formation from aspartyl and asparaginyl peptides as a model for the spontaneous degradation of proteins. J. Biol. Chem. 264:6164-6170.
    • (1989) J. Biol. Chem. , vol.264 , pp. 6164-6170
    • Stephenson, R.C.1    Clarke, S.2
  • 146
    • 84875994076 scopus 로고
    • Analytical Considerations in the Development of Protein Purification Processes
    • In: R. Harrison (Ed), Marcel Dekker, Inc., New York
    • Anicetti, V. and Hancock, W. S. (1994) Analytical Considerations in the Development of Protein Purification Processes. In: R. Harrison (Ed) Protein Purification Process Engineering. Marcel Dekker, Inc., New York.
    • (1994) Protein Purification Process Engineering
    • Anicetti, V.1    Hancock, W.S.2
  • 147
    • 0010539031 scopus 로고
    • High mutation frequency in DNA transfected into mammalian cells
    • Calos, M., Lebkowski, J. S., and Botchan, M.R. (1983) High mutation frequency in DNA transfected into mammalian cells. Proc. Natl. Acad. Sci. USA 80:3015-3019.
    • (1983) Proc. Natl. Acad. Sci. USA , vol.80 , pp. 3015-3019
    • Calos, M.1    Lebkowski, J.S.2    Botchan, M.R.3
  • 148
    • 0025153689 scopus 로고
    • Stability of a gene recombinant: what does it mean and how to check for it
    • Galibert, F. (1990) Stability of a gene recombinant: what does it mean and how to check for it. Biologicals 18:221-224.
    • (1990) Biologicals , vol.18 , pp. 221-224
    • Galibert, F.1
  • 149
    • 0028693397 scopus 로고
    • Assessing genetic stability at the nucleic acid level
    • In: Brown, F., Lubiniecki, A. S. (Eds), Dev. Biol. Stand. Karger, Basel
    • Galibert, F. (1994) Assessing genetic stability at the nucleic acid level. In: Brown, F., Lubiniecki, A. S. (Eds) Genetic Stability and Recombinant Product Consistency. Dev. Biol. Stand. Karger, Basel, pp. 27-30.
    • (1994) Genetic Stability and Recombinant Product Consistency , pp. 27-30
    • Galibert, F.1
  • 151
    • 0026334738 scopus 로고
    • Spontaneous mutation
    • Drake, J.W. (1991) Spontaneous mutation. Annu. Rev. Genet. 25:125-146.
    • (1991) Annu. Rev. Genet. , vol.25 , pp. 125-146
    • Drake, J.W.1
  • 152
    • 0027445423 scopus 로고
    • Assessing genetic heterogeneity in production cell lines: Detection by peptide mapping of a low level Tyr to Gln sequence variant in a recombinant antibody
    • Harris, R. J., Murnane, A. A., Utter, S. L., Wagner, K. L., Cox, E.T., Polastri, G. D., Helder, J. C., and Sliwskowski, M.B. (1993) Assessing genetic heterogeneity in production cell lines: Detection by peptide mapping of a low level Tyr to Gln sequence variant in a recombinant antibody. Bio/Technology, pp. 1293-1297.
    • (1993) Bio/Technology , pp. 1293-1297
    • Harris, R.J.1    Murnane, A.A.2    Utter, S.L.3    Wagner, K.L.4    Cox, E.T.5    Polastri, G.D.6    Helder, J.C.7    Sliwskowski, M.B.8


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