In hybridoma cultures, deprivation of any single amino acid leads to apoptotic death, which is suppressed by the expression of the bcl-2 gene

Biotechnology and Bioengineering

Volumn 59, Issue 1, 1998, Pages 90-98

  Simpson, N H ^a   Singh, R P ^a   Perani, A ^a   Goldenzon, C ^a   Al Rubeai, M ^a  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

Author keywords

Amino acids; Apoptosis; Bcl 2; Cell culture; Cell death; Hybridoma; Necrosis

Indexed keywords

AMINO ACIDS; GENES;

APOPTOSIS; CELL DEATH; LYSINE; METHIONINE; MURINE HYBRIDOMA; NECROSIS;

BATCH CELL CULTURE;

AMINO ACID;

AMINO ACID DEFICIENCY; ANIMAL CELL; APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL GROWTH; CELL VIABILITY; CONTROLLED STUDY; CULTURE MEDIUM; GENE CONTROL; GENE EXPRESSION; GENE REPRESSION; HYBRIDOMA; NONHUMAN; NUTRITIONAL REQUIREMENT; RAT; SUPPRESSOR GENE;

AMINO ACIDS; ANIMALS; ANTIBODIES, MONOCLONAL; APOPTOSIS; CELL CULTURE TECHNIQUES; CULTURE MEDIA; GENES, BCL-2; HUMANS; HYBRIDOMAS; IMMUNOGLOBULIN FC FRAGMENTS; IMMUNOGLOBULIN G; KINETICS; MICE; PROTO-ONCOGENE PROTEINS C-BCL-2; RECOMBINANT PROTEINS; TRANSFECTION;

ANIMALIA; MURINAE;

EID: 0032486578     PISSN: 00063592     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-0290(19980705)59:1<90::AID-BIT12>3.0.CO;2-6     Document Type: Article

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