-
2
-
-
0033678688
-
Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion
-
Boyd RA, Stern RH, Stewart BH, Wu X, Reyner EL, Zegarac EA, Randinitis EJ, Whitfield L. Atorvastatin coadministration may increase digoxin concentrations by inhibition of intestinal P-glycoprotein-mediated secretion. J Clin Pharmacol 2000;40:91-8.
-
(2000)
J Clin Pharmacol
, vol.40
, pp. 91-98
-
-
Boyd, R.A.1
Stern, R.H.2
Stewart, B.H.3
Wu, X.4
Reyner, E.L.5
Zegarac, E.A.6
Randinitis, E.J.7
Whitfield, L.8
-
3
-
-
0000006828
-
Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)
-
Johne A, Brockmoller J, Bauer S, Maurer A, Langheinrich M, Roots I. Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum). Clin Pharmacol Ther 1999;66:338-45.
-
(1999)
Clin Pharmacol Ther
, vol.66
, pp. 338-345
-
-
Johne, A.1
Brockmoller, J.2
Bauer, S.3
Maurer, A.4
Langheinrich, M.5
Roots, I.6
-
4
-
-
3242785620
-
Importance of P-glycoprotein at blood-tissue barriers
-
Fromm MF. Importance of P-glycoprotein at blood-tissue barriers. Trends in Pharmacol Sci 2004;25:423-9.
-
(2004)
Trends in Pharmacol Sci
, vol.25
, pp. 423-429
-
-
Fromm, M.F.1
-
5
-
-
0038670226
-
Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump
-
Yu EW, McDermott G, Zgurskaya HI, Nikaido H, Koshland DE Jr. Structural basis of multiple drug-binding capacity of the AcrB multidrug efflux pump. Science 2003;300:976-80.
-
(2003)
Science
, vol.300
, pp. 976-980
-
-
Yu, E.W.1
McDermott, G.2
Zgurskaya, H.I.3
Nikaido, H.4
Koshland Jr., D.E.5
-
6
-
-
33645830172
-
A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants
-
Juliano RL, Ling V. A surface glycoprotein modulating drug permeability in Chinese hamster ovary cell mutants. Biochim Biophys Acta 1976;455:152-62.
-
(1976)
Biochim Biophys Acta
, vol.455
, pp. 152-162
-
-
Juliano, R.L.1
Ling, V.2
-
7
-
-
0027218689
-
Biochemistry of multidrug resistance mediated by multidrug transporter
-
Gottesman MM, Pastan I. Biochemistry of multidrug resistance mediated by multidrug transporter. An Rev Biochem 1993;62:385-427.
-
(1993)
An Rev Biochem
, vol.62
, pp. 385-427
-
-
Gottesman, M.M.1
Pastan, I.2
-
8
-
-
0019430432
-
Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity on vincristine and vinblastine by verapamil
-
Tsuruo T, Iida H, Tsukagoshi S, Sakurai Y. Overcoming of vincristine resistance in P388 leukemia in vivo and in vitro through enhanced cytotoxicity on vincristine and vinblastine by verapamil. Cancer Res 1981;41:1967-72.
-
(1981)
Cancer Res
, vol.41
, pp. 1967-1972
-
-
Tsuruo, T.1
Iida, H.2
Tsukagoshi, S.3
Sakurai, Y.4
-
10
-
-
33644775686
-
Targeting multidrug resistance in cancer
-
Szakacs G, Paterson JK, Ludwig JA, Booth-Genthe C, Gottesman MM. Targeting multidrug resistance in cancer. Nat Rev Drug Discov 2006;5:219-34.
-
(2006)
Nat Rev Drug Discov
, vol.5
, pp. 219-234
-
-
Szakacs, G.1
Paterson, J.K.2
Ludwig, J.A.3
Booth-Genthe, C.4
Gottesman, M.M.5
-
11
-
-
33644692007
-
P-glycoprotein recognition of substrates and circumvention through rational drug design
-
Raub TJ. P-glycoprotein recognition of substrates and circumvention through rational drug design. Mol Pharm 2006;1:3-25.
-
(2006)
Mol Pharm
, vol.1
, pp. 3-25
-
-
Raub, T.J.1
-
12
-
-
14544287387
-
Inhibitors of P-glycoprotein-Lead identification and optimisation
-
Pleban K, Ecker GF. Inhibitors of P-glycoprotein-Lead identification and optimisation. Minirev Med Chem 2005;5:153-63.
-
(2005)
Minirev Med Chem
, vol.5
, pp. 153-163
-
-
Pleban, K.1
Ecker, G.F.2
-
13
-
-
0035047222
-
Structure-activity relationships of multidrug resistance revers-ers
-
Wiese M, Pajeva IK. Structure-activity relationships of multidrug resistance revers-ers. Curr Med Chem 2001;8:685-713.
-
(2001)
Curr Med Chem
, vol.8
, pp. 685-713
-
-
Wiese, M.1
Pajeva, I.K.2
-
14
-
-
0031822348
-
A combined Hansch/free-Wilson approach as predictive tool in QSAR studies on propafenone-type modulators of multidrug resistance
-
Tmej C, Chiba P, Huber M, Richter E, Hitzler M, Schaper KJ, Ecker G. A combined Hansch/free-Wilson approach as predictive tool in QSAR studies on propafenone-type modulators of multidrug resistance. Arch Pharm (Weinheim) 1998;331:233-40.
-
(1998)
Arch Pharm (Weinheim)
, vol.331
, pp. 233-240
-
-
Tmej, C.1
Chiba, P.2
Huber, M.3
Richter, E.4
Hitzler, M.5
Schaper, K.J.6
Ecker, G.7
-
15
-
-
33846082015
-
Interaction field based and hologram based QSAR analysis of propafenone-type modulators of multidrug resistance
-
Kaiser D, Smiesko M, Kopp S, Chiba P, Ecker GF. Interaction field based and hologram based QSAR analysis of propafenone-type modulators of multidrug resistance. Med Chem 2005;1:431-44.
-
(2005)
Med Chem
, vol.1
, pp. 431-444
-
-
Kaiser, D.1
Smiesko, M.2
Kopp, S.3
Chiba, P.4
Ecker, G.F.5
-
16
-
-
0032610933
-
Artificial neural networks as versatile tools for prediction of MDR-modulatory activity
-
Tmej C, Chiba P, Schaper KJ, Ecker G, Fleischhacker W. Artificial neural networks as versatile tools for prediction of MDR-modulatory activity. Adv Exp Med Biol 1999;457:95-105.
-
(1999)
Adv Exp Med Biol
, vol.457
, pp. 95-105
-
-
Tmej, C.1
Chiba, P.2
Schaper, K.J.3
Ecker, G.4
Fleischhacker, W.5
-
17
-
-
0037499662
-
Similarity based SAR (SIBAR) as tool for early ADME profiling
-
Klein C, Kaiser D, Kopp S, Chiba P, Ecker GF. Similarity based SAR (SIBAR) as tool for early ADME profiling. J Comput Aided Mol Des 2002;16:785-93.
-
(2002)
J Comput Aided Mol Des
, vol.16
, pp. 785-793
-
-
Klein, C.1
Kaiser, D.2
Kopp, S.3
Chiba, P.4
Ecker, G.F.5
-
18
-
-
0030449507
-
Structure-activity relationship studies on benzofurane analogs of propafenone-type modulators of tumor cell multidrug resistance
-
Ecker G, Chiba P, Hitzler M, Schmid D, Visser K, Cordes HP, Csöllei J, Seydel JK, Schaper KJ. Structure-activity relationship studies on benzofurane analogs of propafenone-type modulators of tumor cell multidrug resistance. J Med Chem 1996;39:4767-74.
-
(1996)
J Med Chem
, vol.39
, pp. 4767-4774
-
-
Ecker, G.1
Chiba, P.2
Hitzler, M.3
Schmid, D.4
Visser, K.5
Cordes, H.P.6
Csöllei, J.7
Seydel, J.K.8
Schaper, K.J.9
-
19
-
-
0029898576
-
Structural requirements for activity of propafenone type modulators in PGP-mediated multidrug resistance
-
Chiba P, Ecker G, Schmid D, Drach J, Tell B, Goldenberg S, Gekeler V. Structural requirements for activity of propafenone type modulators in PGP-mediated multidrug resistance. Mol Pharmacol 1996;49:1122-30.
-
(1996)
Mol Pharmacol
, vol.49
, pp. 1122-1130
-
-
Chiba, P.1
Ecker, G.2
Schmid, D.3
Drach, J.4
Tell, B.5
Goldenberg, S.6
Gekeler, V.7
-
20
-
-
0030684024
-
Studies on propafenone-type modulators of multidrug resistance: III. Variations on the nitrogen
-
Chiba P, Hitzler M, Richter E, Huber M, Tmej C, Ecker G. Studies on propafenone-type modulators of multidrug resistance: III. Variations on the nitrogen. Quant Struct-Act Rel 1997;16:361-6.
-
(1997)
Quant Struct-Act Rel
, vol.16
, pp. 361-366
-
-
Chiba, P.1
Hitzler, M.2
Richter, E.3
Huber, M.4
Tmej, C.5
Ecker, G.6
-
21
-
-
0344761958
-
The importance of a nitrogen atom in modulators of multidrug resistance
-
Ecker G, Huber M, Schmid D, Chiba GF. The importance of a nitrogen atom in modulators of multidrug resistance. Mol Pharmacol 1999;56:791-6.
-
(1999)
Mol Pharmacol
, vol.56
, pp. 791-796
-
-
Ecker, G.1
Huber, M.2
Schmid, D.3
Chiba, G.F.4
-
22
-
-
14544269934
-
Inhibitors of multidrug efflux transporters: Their membrane and protein interactions
-
Seelig A, Gatlik-Landwojtowicz E. Inhibitors of multidrug efflux transporters: Their membrane and protein interactions. Minirev Med Chem 2005;5:135-51.
-
(2005)
Minirev Med Chem
, vol.5
, pp. 135-151
-
-
Seelig, A.1
Gatlik-Landwojtowicz, E.2
-
23
-
-
0032554868
-
Molecular modelling of phenothiazines and related drugs as multidrug resistance modifiers: A comparative molecular field analysis study
-
Pajeva IK, Wiese M. Molecular modelling of phenothiazines and related drugs as multidrug resistance modifiers: A comparative molecular field analysis study. J Med Chem 1998;41:1815-26.
-
(1998)
J Med Chem
, vol.41
, pp. 1815-1826
-
-
Pajeva, I.K.1
Wiese, M.2
-
24
-
-
0031664884
-
A comparative molecular field analysis of propafenone-type modulators of cancer multidrug resistance
-
Pajeva IK, Wiese M. A comparative molecular field analysis of propafenone-type modulators of cancer multidrug resistance. Quant Struct-Act Rel 1998;17:301-12.
-
(1998)
Quant Struct-Act Rel
, vol.17
, pp. 301-312
-
-
Pajeva, I.K.1
Wiese, M.2
-
25
-
-
31044448979
-
Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators
-
Globisch C, Pajeva IK, Wiese M. Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators. Bioorg Med Chem 2006; 14:1588-98.
-
(2006)
Bioorg Med Chem
, vol.14
, pp. 1588-1598
-
-
Globisch, C.1
Pajeva, I.K.2
Wiese, M.3
-
26
-
-
22144469590
-
A Volsurf model of propafenone-type inhibitors of P-glycoprotein for in silico screening of the Leadquest compound library
-
Kaiser D, Bohl M, Kopp S, Chiba P, Ecker GF. A Volsurf model of propafenone-type inhibitors of P-glycoprotein for in silico screening of the Leadquest compound library. Drugs Future 2004;29 (Suppl A):119.
-
(2004)
Drugs Future
, vol.29
, Issue.SUPPL. A
, pp. 119
-
-
Kaiser, D.1
Bohl, M.2
Kopp, S.3
Chiba, P.4
Ecker, G.F.5
-
27
-
-
0037137614
-
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: Explanation of structural variety (hypothesis)
-
Pajeva IK, Wiese M. Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: Explanation of structural variety (hypothesis). J Med Chem 2002;45:5671-86.
-
(2002)
J Med Chem
, vol.45
, pp. 5671-5686
-
-
Pajeva, I.K.1
Wiese, M.2
-
28
-
-
0036893219
-
Characterization of two pharmacophores on the multidrug transporter P-glycopro-tein
-
Garrigues A, Loiseau N, Delaforge M, Ferte J, Garrigos M, Andre F, Orlowski S. Characterization of two pharmacophores on the multidrug transporter P-glycopro-tein. Mol Pharmacol 2002;62:1288-98.
-
(2002)
Mol Pharmacol
, vol.62
, pp. 1288-1298
-
-
Garrigues, A.1
Loiseau, N.2
Delaforge, M.3
Ferte, J.4
Garrigos, M.5
Andre, F.6
Orlowski, S.7
-
29
-
-
0037171818
-
A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein
-
Penzotti JE, Lamb ML, Evensen E, Grootenhuis PD. A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein. J Med Chem 2002;45:1737-40.
-
(2002)
J Med Chem
, vol.45
, pp. 1737-1740
-
-
Penzotti, J.E.1
Lamb, M.L.2
Evensen, E.3
Grootenhuis, P.D.4
-
30
-
-
18344364851
-
Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates
-
Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz E, Lan LB, et al. Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates. Mol Pharmacol 2002;61:974-81.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 974-981
-
-
Ekins, S.1
Kim, R.B.2
Leake, B.F.3
Dantzig, A.H.4
Schuetz, E.5
Lan, L.B.6
-
31
-
-
18344390872
-
Threedimensional quantitiative structure-activity relationships of inhibitors of P-glycoprotein
-
Ekins S, Kim RB, Leake BF, Dantzig AH, Schuetz EG, Lan LB, et al. Threedimensional quantitiative structure-activity relationships of inhibitors of P-glycoprotein. Mol Pharmacol 2002;61:964-73.
-
(2002)
Mol Pharmacol
, vol.61
, pp. 964-973
-
-
Ekins, S.1
Kim, R.B.2
Leake, B.F.3
Dantzig, A.H.4
Schuetz, E.G.5
Lan, L.B.6
-
32
-
-
4043109757
-
Lead identification for modulators of multidrug resistance based on in silico screening with a pharma-cophoric feature model
-
Langer T, Eder M, Hoffmann RD, Chiba P, Ecker GF. Lead identification for modulators of multidrug resistance based on in silico screening with a pharma-cophoric feature model. Arch Pharm (Weinheim) 2004;337:317-27.
-
(2004)
Arch Pharm (Weinheim)
, vol.337
, pp. 317-327
-
-
Langer, T.1
Eder, M.2
Hoffmann, R.D.3
Chiba, P.4
Ecker, G.F.5
-
33
-
-
22144463182
-
An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network
-
Wang YH, Li Y, Yang SL, Yang L. An in silico approach for screening flavonoids as P-glycoprotein inhibitors based on a Bayesian-regularized neural network. J Comput Aided Mol Des 2005;19:137-47.
-
(2005)
J Comput Aided Mol Des
, vol.19
, pp. 137-147
-
-
Wang, Y.H.1
Li, Y.2
Yang, S.L.3
Yang, L.4
-
34
-
-
0034732325
-
Artificial neural networks in drug design: II. Influence of learning rate and momentum factor on the predictive ability
-
Kaiser D, Tmej C, Chiba P, Schaper KJ, Ecker G. Artificial neural networks in drug design: II. Influence of learning rate and momentum factor on the predictive ability. Sci Pharm 2000;68:57-64.
-
(2000)
Sci Pharm
, vol.68
, pp. 57-64
-
-
Kaiser, D.1
Tmej, C.2
Chiba, P.3
Schaper, K.J.4
Ecker, G.5
-
35
-
-
84889615836
-
Artificial neural networks for identification of new modulators of multidrug resistance
-
In: Sener E, Yalcin I, editors,, Computer aided Drug Design & Development Society in Turkey, Antrara, Turkey
-
Kaiser D, Terfloth L, Kopp S, Chiba P, Gasteiger J, Ecker GF. Artificial neural networks for identification of new modulators of multidrug resistance. In: Sener E, Yalcin I, editors, QSAR & molecular modelling in rational design of bioactive molecules. Computer aided Drug Design & Development Society in Turkey, Antrara, Turkey, 2006, p. 274-7.
-
(2006)
QSAR & molecular modelling in rational design of bioactive molecules
, pp. 274-277
-
-
Kaiser, D.1
Terfloth, L.2
Kopp, S.3
Chiba, P.4
Gasteiger, J.5
Ecker, G.F.6
-
36
-
-
1842854619
-
Inhibitors of ABC-type drug efflux pumps-An overview on the actual patent situation
-
Chiba P, Ecker GF. Inhibitors of ABC-type drug efflux pumps-An overview on the actual patent situation. Expert Opin Ther Patents 2004;14:499-508.
-
(2004)
Expert Opin Ther Patents
, vol.14
, pp. 499-508
-
-
Chiba, P.1
Ecker, G.F.2
-
37
-
-
0036364467
-
Multidrug resistance in cancer: Role of ATP-dependent transporters
-
Gottesman MM, Fojo T, Bates SE. Multidrug resistance in cancer: Role of ATP-dependent transporters. Nat Rev Canc 2002;2:48-58.
-
(2002)
Nat Rev Canc
, vol.2
, pp. 48-58
-
-
Gottesman, M.M.1
Fojo, T.2
Bates, S.E.3
-
38
-
-
30344444454
-
The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins
-
van Herwaarden AE, Schinkel AH. The function of breast cancer resistance protein in epithelial barriers, stem cells and milk secretion of drugs and xenotoxins. Trends in Pharmacol Sci 2006;27:10-16.
-
(2006)
Trends in Pharmacol Sci
, vol.27
, pp. 10-16
-
-
Van Herwaarden, A.E.1
Schinkel, A.H.2
-
39
-
-
27644480743
-
Role of breast cancer resistance protein (ABCG2) in drug transport
-
Mao Q, Unadkat JD. Role of breast cancer resistance protein (ABCG2) in drug transport. AAPS J 2005;7:E118-33.
-
(2005)
AAPS J
, vol.7
-
-
Mao, Q.1
Unadkat, J.D.2
-
40
-
-
22144481699
-
Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein
-
Zhang S, Yang X, Coburn RA, Morris ME. Structure activity relationships and quantitative structure activity relationships for the flavonoid-mediated inhibition of breast cancer resistance protein. Biochem Pharmacol 2005;70:627-39.
-
(2005)
Biochem Pharmacol
, vol.70
, pp. 627-639
-
-
Zhang, S.1
Yang, X.2
Coburn, R.A.3
Morris, M.E.4
-
41
-
-
28544452258
-
Piperazinobenzopyranones and phenylalkylaminobenzopyranones: Potent inhibitors of breast cancer resistance protein (ABCG2)
-
Boumendjel A, Nicolle E, Moraux T, Gerby B, Blanc M, Ronot X, Boutonnat J. Piperazinobenzopyranones and phenylalkylaminobenzopyranones: Potent inhibitors of breast cancer resistance protein (ABCG2). J Med Chem 2005;48:7275-81.
-
(2005)
J Med Chem
, vol.48
, pp. 7275-7281
-
-
Boumendjel, A.1
Nicolle, E.2
Moraux, T.3
Gerby, B.4
Blanc, M.5
Ronot, X.6
Boutonnat, J.7
-
43
-
-
84889620088
-
Multispecificity of drug transporters: Probing inhibitor selectivity for the human drug efflux transporters ABCB1 and ABCG2
-
Submitted.
-
Cramer J, Kopp S, Bates SE, Chiba P, Ecker GF. Multispecificity of drug transporters: Probing inhibitor selectivity for the human drug efflux transporters ABCB1 and ABCG2. Submitted.
-
-
-
Cramer, J.1
Kopp, S.2
Bates, S.E.3
Chiba, P.4
Ecker, G.F.5
-
44
-
-
0037457802
-
Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview
-
Schinkel AH, Jonker JW. Mammalian drug efflux transporters of the ATP binding cassette (ABC) family: An overview. Adv Drug Deliv Rev 2003;55:3-29.
-
(2003)
Adv Drug Deliv Rev
, vol.55
, pp. 3-29
-
-
Schinkel, A.H.1
Jonker, J.W.2
-
45
-
-
31844455959
-
Substrate recognition and transport by multidrug resistance protein 1 (ABCC1)
-
Deeley RG, Cole SPC. Substrate recognition and transport by multidrug resistance protein 1 (ABCC1). FEBS Lett 2006;580:1103-11.
-
(2006)
FEBS Lett
, vol.580
, pp. 1103-1111
-
-
Deeley, R.G.1
Cole, S.P.C.2
-
46
-
-
21744447836
-
Anticancer multidrug resistance mediated by MRP1: Recent advances in the discovery of reversal agents
-
Boumendjel A, Baubichon-Cortay H, Trompier D, Perrotton T, Di Pietro A. Anticancer multidrug resistance mediated by MRP1: Recent advances in the discovery of reversal agents. Med Res Rev 2005;25:453-72.
-
(2005)
Med Res Rev
, vol.25
, pp. 453-472
-
-
Boumendjel, A.1
Baubichon-Cortay, H.2
Trompier, D.3
Perrotton, T.4
Di Pietro, A.5
-
47
-
-
25844493053
-
Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine
-
Lather V, Madan AK. Topological model for the prediction of MRP1 inhibitory activity of pyrrolopyrimidines and templates derived from pyrrolopyrimidine. Bioorg Med Chem Lett 2005;15:4967-72.
-
(2005)
Bioorg Med Chem Lett
, vol.15
, pp. 4967-4972
-
-
Lather, V.1
Madan, A.K.2
-
49
-
-
12744256734
-
Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2
-
van Zanden JJ, Wortelboer HM, Bijlsma S, Punt A, Usta M, van Bladeren PJ, et al. Quantitative structure activity relationship studies on the flavonoid mediated inhibition of multidrug resistance proteins 1 and 2. Biochem Pharmacol 2005; 69:699-708.
-
(2005)
Biochem Pharmacol
, vol.69
, pp. 699-708
-
-
Van Zanden, J.J.1
Wortelboer, H.M.2
Bijlsma, S.3
Punt, A.4
Usta, M.5
Van Bladeren, P.J.6
-
50
-
-
27644478718
-
Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance-associated protein 2 (rMrp2)
-
Ng C, Xiao YD, Lum BL, Han YH. Quantitative structure-activity relationships of methotrexate and methotrexate analogues transported by the rat multispecific resistance-associated protein 2 (rMrp2). Eur J Pharm Sci 2005;26:405-13.
-
(2005)
Eur J Pharm Sci
, vol.26
, pp. 405-413
-
-
Ng, C.1
Xiao, Y.D.2
Lum, B.L.3
Han, Y.H.4
-
51
-
-
0032818587
-
Estimation of active comformation of drugs by a new molecular superposing procedure
-
Iwase K, Hirono S. Estimation of active comformation of drugs by a new molecular superposing procedure. J Comput Aided Mol Des 1999;13:305-15.
-
(1999)
J Comput Aided Mol Des
, vol.13
, pp. 305-315
-
-
Iwase, K.1
Hirono, S.2
-
52
-
-
16844380011
-
Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance associated protein 2 using ligand-based drug design techniques
-
Hirono S, Nakagome I, Imai R, Maeda K, Kusuhara H, Sugiyama Y. Estimation of the three-dimensional pharmacophore of ligands for rat multidrug-resistance associated protein 2 using ligand-based drug design techniques. Pharm Res 2005; 22:260-9.
-
(2005)
Pharm Res
, vol.22
, pp. 260-269
-
-
Hirono, S.1
Nakagome, I.2
Imai, R.3
Maeda, K.4
Kusuhara, H.5
Sugiyama, Y.6
-
53
-
-
33745786364
-
High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis
-
Hirano H, Kurata A, Onishi Y, Sakurai A, Saito H, Nakagawa H, et al. High-speed screening and QSAR analysis of human ATP-binding cassette transporter ABCB11 (bile salt export pump) to predict drug-induced intrahepatic cholestasis. Mol Pharm 2006;3:252-65.
-
(2006)
Mol Pharm
, vol.3
, pp. 252-265
-
-
Hirano, H.1
Kurata, A.2
Onishi, Y.3
Sakurai, A.4
Saito, H.5
Nakagawa, H.6
-
54
-
-
0242469240
-
Organic anion-transporting polypeptide (OATP) transporter family and drug disposition
-
Kim RB. Organic anion-transporting polypeptide (OATP) transporter family and drug disposition. Eur J Clin Investig 2003;33:1-5.
-
(2003)
Eur J Clin Investig
, vol.33
, pp. 1-5
-
-
Kim, R.B.1
-
55
-
-
22944440991
-
Comparative pharmacophore modelling of organic anion transporting polypeptides: A meta-analysis of rat Oatp1a1 and human OATP1B1
-
Chang C, Pang KS, Swaan PW, Ekins S. Comparative pharmacophore modelling of organic anion transporting polypeptides: A meta-analysis of rat Oatp1a1 and human OATP1B1. J Pharmacol Exp Ther 2005;314:533-41.
-
(2005)
J Pharmacol Exp Ther
, vol.314
, pp. 533-541
-
-
Chang, C.1
Pang, K.S.2
Swaan, P.W.3
Ekins, S.4
-
56
-
-
0346728729
-
The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability
-
Chan LM, Lowes S, Hirst BH. The ABCs of drug transport in intestine and liver: Efflux proteins limiting drug absorption and bioavailability. Eur J Pharm Sci 2004;21:25-51.
-
(2004)
Eur J Pharm Sci
, vol.21
, pp. 25-51
-
-
Chan, L.M.1
Lowes, S.2
Hirst, B.H.3
-
57
-
-
0030787532
-
A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model
-
Delie F, Rubas WA. A human colonic cell line sharing similarities with enterocytes as a model to examine oral absorption: Advantages and limitations of the Caco-2 model. Crit Rev Ther Drug Carrier Sys 1997;14:221-86.
-
(1997)
Crit Rev Ther Drug Carrier Sys
, vol.14
, pp. 221-286
-
-
Delie, F.1
Rubas, W.A.2
-
58
-
-
0032949615
-
MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening
-
Irvine JD, Takahashi L, Lockhart K, Cheong J, Tolan JW, Selick HE, Grove JR. MDCK (Madin-Darby canine kidney) cells: A tool for membrane permeability screening. J Pharm Sci 1999;88:28-33.
-
(1999)
J Pharm Sci
, vol.88
, pp. 28-33
-
-
Irvine, J.D.1
Takahashi, L.2
Lockhart, K.3
Cheong, J.4
Tolan, J.W.5
Selick, H.E.6
Grove, J.R.7
-
59
-
-
0032518454
-
A general pattern for substrate recognition by P-glycoprotein
-
Seelig A. A general pattern for substrate recognition by P-glycoprotein. Eur J Biochem 1998;251:252-61.
-
(1998)
Eur J Biochem
, vol.251
, pp. 252-261
-
-
Seelig, A.1
-
61
-
-
1842586876
-
Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model
-
Gombar VK, Polli JW, Humphreys JE, Wring SA, Serabjit-Singh CS. Predicting P-glycoprotein substrates by a quantitative structure-activity relationship model. J Pharm Sci 2004;93:957-68.
-
(2004)
J Pharm Sci
, vol.93
, pp. 957-968
-
-
Gombar, V.K.1
Polli, J.W.2
Humphreys, J.E.3
Wring, S.A.4
Serabjit-Singh, C.S.5
-
62
-
-
33645357793
-
A topological substructural approach for the prediction of P-glycoprotein substrates
-
Cabrera MA, Gonzalez I, Fernandez C, Navarro C, Bermejo M. A topological substructural approach for the prediction of P-glycoprotein substrates. J Pharm Sci 2006;95:589-606.
-
(2006)
J Pharm Sci
, vol.95
, pp. 589-606
-
-
Cabrera, M.A.1
Gonzalez, I.2
Fernandez, C.3
Navarro, C.4
Bermejo, M.5
-
64
-
-
1842740111
-
A combinatorial QSAR of Ambergris fragrance compounds
-
Kovatcheva A, Golbraikh A, Oloff S, Xiao YD, Zheng W, Wolschann P, et al. A combinatorial QSAR of Ambergris fragrance compounds. J Chem Inf Comput Sci 2004;44:582-95.
-
(2004)
J Chem Inf Comput Sci
, vol.44
, pp. 582-595
-
-
Kovatcheva, A.1
Golbraikh, A.2
Oloff, S.3
Xiao, Y.D.4
Zheng, W.5
Wolschann, P.6
-
65
-
-
33745341752
-
Combinatorial QSAR modeling of P-glycoprotein substrates
-
De Cerqueira Lima P, Golbraikh A, Oloff S, Xiao Y, Tropsha A. Combinatorial QSAR modeling of P-glycoprotein substrates. J Chem Inf Model 2006;46:1245-54.
-
(2006)
J Chem Inf Model
, vol.46
, pp. 1245-1254
-
-
De Cerqueira Lima, P.1
Golbraikh, A.2
Oloff, S.3
Xiao, Y.4
Tropsha, A.5
-
66
-
-
33644674142
-
Computational models for identifying potential P-glycoprotein substrates and inhibitors
-
Crivori P, Reinach B, Pezzetta D, Poggesi I. Computational models for identifying potential P-glycoprotein substrates and inhibitors. Mol Pharm 2006;3:33-44.
-
(2006)
Mol Pharm
, vol.3
, pp. 33-44
-
-
Crivori, P.1
Reinach, B.2
Pezzetta, D.3
Poggesi, I.4
-
67
-
-
17444419056
-
A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR
-
Cianchetta G, Singleton RW, Zhang M, Wildgoose M, Giesing D, Fravolini A, et al. A pharmacophore hypothesis for P-glycoprotein substrate recognition using GRIND-based 3D-QSAR. J Med Chem 2005;48:2927-35.
-
(2005)
J Med Chem
, vol.48
, pp. 2927-2935
-
-
Cianchetta, G.1
Singleton, R.W.2
Zhang, M.3
Wildgoose, M.4
Giesing, D.5
Fravolini, A.6
-
68
-
-
0037171818
-
A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein
-
Penzotti JE, Lamb ML, Evensen E, Grootenhuis PDJ. A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein. J Med Chem 2002;45:1737-40.
-
(2002)
J Med Chem
, vol.45
, pp. 1737-1740
-
-
Penzotti, J.E.1
Lamb, M.L.2
Evensen, E.3
Grootenhuis, P.D.J.4
-
69
-
-
33751525373
-
Rapid identification of P-glycoprotein substrates and inhibitors
-
Chang C, Bahadduri PM, Polli JE, Swaan PW, Ekins S. Rapid identification of P-glycoprotein substrates and inhibitors. Drug Metab Dispos 2006;34:1976-84.
-
(2006)
Drug Metab Dispos
, vol.34
, pp. 1976-1984
-
-
Chang, C.1
Bahadduri, P.M.2
Polli, J.E.3
Swaan, P.W.4
Ekins, S.5
-
70
-
-
20444403742
-
Classification of substrates and inhibitors of P-glycoprotein using unsupervised machine learning approach
-
Wang YH, Li Y, Yang SL, Yang L. Classification of substrates and inhibitors of P-glycoprotein using unsupervised machine learning approach. J Chem Inf Model 2005;45:750-7.
-
(2005)
J Chem Inf Model
, vol.45
, pp. 750-757
-
-
Wang, Y.H.1
Li, Y.2
Yang, S.L.3
Yang, L.4
-
71
-
-
4043091303
-
Prediction of P-glyco-protein substrates by a support vector machine approach
-
Xue Y, Yap CW, Sun LZ, Cao ZW, Wang JF, Chen YZ. Prediction of P-glyco-protein substrates by a support vector machine approach. J Chem Inf Comput Sci 2004;44:1497-505.
-
(2004)
J Chem Inf Comput Sci
, vol.44
, pp. 1497-1505
-
-
Xue, Y.1
Yap, C.W.2
Sun, L.Z.3
Cao, Z.W.4
Wang, J.F.5
Chen, Y.Z.6
-
72
-
-
1542426103
-
Blood-brain barrier permeation models: Discrimination between potential CNS and non-CNS drugs including P-glycoprotein substrates
-
Adenot M, Lahana R. Blood-brain barrier permeation models: Discrimination between potential CNS and non-CNS drugs including P-glycoprotein substrates. J Chem Inf Comput Sci 2004;44:239-48.
-
(2004)
J Chem Inf Comput Sci
, vol.44
, pp. 239-248
-
-
Adenot, M.1
Lahana, R.2
-
73
-
-
33244476755
-
Ensemble of linear models for predicting drug properties
-
Arodz T, Yuen DA, Dudek AZ. Ensemble of linear models for predicting drug properties. J Chem Inf Model 2006;46:416-23.
-
(2006)
J Chem Inf Model
, vol.46
, pp. 416-423
-
-
Arodz, T.1
Yuen, D.A.2
Dudek, A.Z.3
-
74
-
-
0032822237
-
Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements
-
Schmid D, Ecker G, Richter E, Hitzler M, Chiba P. Structure-activity relationship studies of propafenone analogs based on P-glycoprotein ATPase activity measurements. Biochem Pharmacol 1999;58:1447-56.
-
(1999)
Biochem Pharmacol
, vol.58
, pp. 1447-1456
-
-
Schmid, D.1
Ecker, G.2
Richter, E.3
Hitzler, M.4
Chiba, P.5
|