Structure-activity relationships of a series of tariquidar analogs as multidrug resistance modulators

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 5, 2006, Pages 1588-1598

  Globisch, Christoph ^a   Pajeva, Ilza K ^a,b   Wiese, Michael ^a  

^a UNIVERSITY OF BONN   (Germany)

^b CENTRE OF BIOMEDICAL ENGINEERING   (Bulgaria)

Author keywords

Comparative molecular field analysis; Comparative molecular similarity indices analysis; Multidrug resistance; P glycoprotein

Indexed keywords

2 (5 METHYLPYRAZINYL); 2 AMINOBENZAMIDE; 2 FURANYL; 2 PYRAZINYL; 2 PYRIDYL; 2 QUINOLINYL; 2 QUINOXALINYL; 3 (6 METHYLPYRIDYL); 3 FURANYL; 3 ISOQUINOLINYL; 3 PYRIDYL; 3 QUINOLINYL; 3 THIOPHENYL; 4 CYCLOHEXYLPHENYL; 4 DIMETHYLAMINOBENZYL; 4 I PROPYLPHENYL; TARIQUIDAR; UNCLASSIFIED DRUG;

ARTICLE; COMPARATIVE MOLECULAR FIELD ANALYSIS; COMPARATIVE MOLECULAR SIMILARITY INDICES ANALYSIS; DRUG EFFECT; DRUG INHIBITION; DRUG MECHANISM; DRUG STRUCTURE; HYDROPHOBICITY; MULTIDRUG RESISTANCE; PHARMACOPHORE; PREDICTION; STRUCTURE ACTIVITY RELATION;

BINDING SITES; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HYDROPHOBICITY; MODELS, CHEMICAL; P-GLYCOPROTEIN; PRINCIPAL COMPONENT ANALYSIS; QUANTITATIVE STRUCTURE-ACTIVITY RELATIONSHIP; QUINOLINES;

EID: 31044448979     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2005.10.058     Document Type: Article

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