메뉴 건너뛰기




Volumn 457, Issue , 1999, Pages 95-105

Artificial neural networks as versatile tools for prediction of MDR-modulatory activity

Author keywords

Artificial neural networks; Free Wilson analysis; Modulators of Multidrug resistance; Propafenone; Structure activity relationship

Indexed keywords

ABC TRANSPORTER; ANTINEOPLASTIC AGENT; DAUNORUBICIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN;

EID: 0032610933     PISSN: 00652598     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-4615-4811-9_12     Document Type: Article
Times cited : (4)

References (22)
  • 1
    • 0029821966 scopus 로고    scopus 로고
    • Multidrug resistance of cancer cells
    • Kane, S.E. Multidrug resistance of cancer cells. Adv. Drug Res. 1996, 28, 182-238.
    • (1996) Adv. Drug Res. , vol.28 , pp. 182-238
    • Kane, S.E.1
  • 2
    • 0030952650 scopus 로고    scopus 로고
    • Transport proteins in drug resistance: Detection and prognostic significance in acute myeloid leukemia
    • Broxterman, H.L., Schuurhuis, G.J. Transport proteins in drug resistance: detection and prognostic significance in acute myeloid leukemia. J. Intern. Med. Suppl. 1997, 740, 147-151.
    • (1997) J. Intern. Med. Suppl. , vol.740 , pp. 147-151
    • Broxterman, H.L.1    Schuurhuis, G.J.2
  • 4
    • 0027136660 scopus 로고
    • Clinical trials of agents that reverse multidrug resistance
    • Raderer, M., Scheithauer, W. Clinical trials of agents that reverse multidrug resistance. Cancer 1993, 72, 3553-3563.
    • (1993) Cancer , vol.72 , pp. 3553-3563
    • Raderer, M.1    Scheithauer, W.2
  • 5
    • 0028879438 scopus 로고
    • Structure-activity-relationship studies on modulators of the multidrug transporter P-glycoprotein - An overview
    • Ecker, G., Chiba, P. Structure-activity-relationship studies on modulators of the multidrug transporter P-glycoprotein - an overview. Wien. Klin. Wochenschr. 1995, 107, 681-686.
    • (1995) Wien. Klin. Wochenschr. , vol.107 , pp. 681-686
    • Ecker, G.1    Chiba, P.2
  • 6
    • 0026075594 scopus 로고
    • Applications of neural networks in quantitative structure-activity relationships of dihydrofolate reductase inhibitors
    • Andrea, T.A., Kalayeh, H. Applications of neural networks in quantitative structure-activity relationships of dihydrofolate reductase inhibitors. J. Med. Chem. 1991, 34, 2824-2836.
    • (1991) J. Med. Chem. , vol.34 , pp. 2824-2836
    • Andrea, T.A.1    Kalayeh, H.2
  • 7
    • 0031008762 scopus 로고    scopus 로고
    • Calculation of Octanol/Water Partition Coefficients (logP) using artificial neural networks and connection malices
    • Schaper, K.J., Samitier, M.L.R. Calculation of Octanol/Water Partition Coefficients (logP) using artificial neural networks and connection malices. Quant. Struct. Act. Relat. 1997, 16, 224-230.
    • (1997) Quant. Struct. Act. Relat. , vol.16 , pp. 224-230
    • Schaper, K.J.1    Samitier, M.L.R.2
  • 8
    • 0031822348 scopus 로고    scopus 로고
    • A combined Hansch/Free-Wilson approach as predictive tool in QSAR studies on propafenone-type modulators of multidrug resistance
    • Tmej, C., Chiba, P., Huber, M., Richter, E., Hitzler, M., Schaper, K.J., Ecker, G. A combined Hansch/Free-Wilson approach as predictive tool in QSAR studies on propafenone-type modulators of multidrug resistance. Archiv, der Pharmazie 1998, 331, 233-240.
    • (1998) Archiv, der Pharmazie , vol.331 , pp. 233-240
    • Tmej, C.1    Chiba, P.2    Huber, M.3    Richter, E.4    Hitzler, M.5    Schaper, K.J.6    Ecker, G.7
  • 9
    • 84911792416 scopus 로고
    • Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships III: Modeling hydrophobic interactions
    • Ghose, A.K., Pritchett, A., Grippen, G.M. Atomic physicochemical parameters for three dimensional structure directed quantitative structure-activity relationships III: Modeling hydrophobic interactions. J. Comput. Chem. 1988, 9, 80-90
    • (1988) J. Comput. Chem. , vol.9 , pp. 80-90
    • Ghose, A.K.1    Pritchett, A.2    Grippen, G.M.3
  • 10
    • 27844534634 scopus 로고    scopus 로고
    • Baricic, P., Mackov, M.; distributed by Hudecek, M., P. Horova 18, 841 07 Bratislava, Slowakia
    • Baricic, P., Mackov, M.; distributed by Hudecek, M., P. Horova 18, 841 07 Bratislava, Slowakia
  • 11
    • 0029750205 scopus 로고    scopus 로고
    • Comparison of different methods for estimation of lipophilicity of propafenone-type modulators of multidrug resistance
    • Prets, S., Jungreithmair, A., Chiba, P., Ecker, G. Comparison of different methods for estimation of lipophilicity of propafenone-type modulators of multidrug resistance. Sci. Pharm. 1996, 64, 627-636.
    • (1996) Sci. Pharm. , vol.64 , pp. 627-636
    • Prets, S.1    Jungreithmair, A.2    Chiba, P.3    Ecker, G.4
  • 13
    • 27844539614 scopus 로고    scopus 로고
    • Trajan Software Ltd., Trajan House, Durham, England.
    • TRAJAN V 3.0, Trajan Software Ltd., Trajan House, Durham, England.
    • TRAJAN V 3.0
  • 14
    • 0345670761 scopus 로고
    • An artificial neural networks tutorial: Part 1 - Basics
    • Kama, K.N., Breen, D.M. An artificial neural networks tutorial: Part 1 - basics. Neural Networks 1989, 1, 4-22.
    • (1989) Neural Networks , vol.1 , pp. 4-22
    • Kama, K.N.1    Breen, D.M.2
  • 15
    • 0026738394 scopus 로고
    • Application of neural networks: Quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors
    • So, S.-S., Richards, G. Application of neural networks: Quantitative structure-activity relationships of the derivatives of 2,4-diamino-5-(substituted-benzyl)pyrimidines as DHFR inhibitors. J. Med. Chem. 1992, 35, 3201-3207.
    • (1992) J. Med. Chem. , vol.35 , pp. 3201-3207
    • So, S.-S.1    Richards, G.2
  • 16
    • 0025971792 scopus 로고
    • Obtaining the correlation indices between drug activity and strucutral parameters using a neural network
    • Aoyama, T., Ichikawa, H. Obtaining the correlation indices between drug activity and strucutral parameters using a neural network. Chem. Pharm. Bull. 1991, 39, 372-378.
    • (1991) Chem. Pharm. Bull. , vol.39 , pp. 372-378
    • Aoyama, T.1    Ichikawa, H.2
  • 18
    • 0023751431 scopus 로고
    • Comparative molacular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins
    • Cramer, R.D. III, Patterson, D.E., Bunce, J.D. Comparative molacular field analysis (CoMFA). 1. Effect of shape on binding of steroids to carrier proteins. J. Am. Chem. Soc. 1988, 110, 5959-5967.
    • (1988) J. Am. Chem. Soc. , vol.110 , pp. 5959-5967
    • Cramer III, R.D.1    Patterson, D.E.2    Bunce, J.D.3
  • 19
    • 0015009844 scopus 로고
    • Structure-activity study of phenylethylamines as substrates of biosynthetic enzymes of sympathetic transmitters
    • Fujita, T., Ban, T. Structure-activity study of phenylethylamines as substrates of biosynthetic enzymes of sympathetic transmitters. J. Med. Chem. 1971, 14, 148-152.
    • (1971) J. Med. Chem. , vol.14 , pp. 148-152
    • Fujita, T.1    Ban, T.2
  • 20
    • 0030449507 scopus 로고    scopus 로고
    • Structure-activity relationship studies on benzofurane analogs of propafenone-type modulators of tumor cell multidrug resistance
    • Ecker, G., Chiba, P., Hitzler, M., Schmid, D., Visser, K., Cordes, H.P., Csöllei, J., Seydel, J.K., Schaper, K.J. Structure-activity relationship studies on benzofurane analogs of propafenone-type modulators of tumor cell multidrug resistance. J. Med. Chem. 1996, 39, 4767-4774.
    • (1996) J. Med. Chem. , vol.39 , pp. 4767-4774
    • Ecker, G.1    Chiba, P.2    Hitzler, M.3    Schmid, D.4    Visser, K.5    Cordes, H.P.6    Csöllei, J.7    Seydel, J.K.8    Schaper, K.J.9
  • 21
    • 0029898576 scopus 로고    scopus 로고
    • Structural requirements for activity of propafenone type modulators in PGP-mediated multidrug resistance
    • Chiba, P., Ecker, G., Schmid, D., Drach, J., Tell, B., Goldenberg, S., Gekeler, V. Structural requirements for activity of propafenone type modulators in PGP-mediated multidrug resistance. Mol. Pharmacol. 1996, 49, 1122-1130.
    • (1996) Mol. Pharmacol. , vol.49 , pp. 1122-1130
    • Chiba, P.1    Ecker, G.2    Schmid, D.3    Drach, J.4    Tell, B.5    Goldenberg, S.6    Gekeler, V.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.