A combined Hansch/Free-Wilson approach as predictive tool in QSAR studies on propafenone-type modulators of multidrug resistance

Archiv der Pharmazie

Volumn 331, Issue 7-8, 1998, Pages 233-240

  Tmej, Claudia ^a   Chiba, Peter ^a   Huber, Mario ^a   Richter, Elisabeth ^a   Hitzler, Manuela ^a   Schaper, Klaus Jürgen ^b   Ecker, Gerhard ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b RESEARCH CENTER BORSTEL   (Germany)

Author keywords

Free Wilson analysis; Multidrug resistance; P glycoprotein; Propafenone; QSAR

Indexed keywords

DAUNORUBICIN; GLYCOPROTEIN P; PROPAFENONE; PROPANOLAMINE DERIVATIVE; PROPIOPHENONE DERIVATIVE;

ARTICLE; CELL LINE; COMPUTER PROGRAM; CONTROLLED STUDY; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN; HUMAN CELL; IN VITRO STUDY; LIPOPHILICITY; METHODOLOGY; MULTIDRUG RESISTANCE; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; STATISTICAL ANALYSIS;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE; DAUNORUBICIN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; HUMANS; P-GLYCOPROTEIN; PROPAFENONE; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0031822348     PISSN: 03656233     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1521-4184(199807)331:7/8<233::AID-ARDP233>3.0.CO;2-2     Document Type: Article

References (25)

1. Part VII of the series: Studies on Propafenone-type Modulators of Multidrug-Resistance.
2. I. Bosch, J. Croop, Biochim. Biophys. Acta 1996, 1288, F37-F54.
3. M. Raderer, W. Scheithauer, Cancer 1993, 72, 3553-3563.
4. G. Ecker, P. Chiba, Wien. Klin. Wochenschr. 1995, 107, 681-686.
5. I. Pajeva, M. Wiese, Quant. Struct.-Act. Relat. 1997, 16, 1-10.
6. G. Klopman, L. M. Shi, A. Ramu, Mol. Pharmacol. 1997, 52, 323-334.
7. P. Chiba, S. Burghofer, E. Richter, B. Tell, A. Moser, G. Ecker, J. Med. Chem. 1995, 38, 2789-2793.
8. G. Ecker, P. Chiba, M. Hitzler, D. Schmid, K. Visser, H. P. Cordes, J. Csöllei, J. K. Seydel, K.-J. Schaper, J. Med. Chem. 1996, 39, 4767-4774.
9. P. Chiba, G. Ecker, D. Schmid, J. Drach, B. Tell, V. Gekeler, Mol. Pharmacol. 1996, 49, 1122-1130.
10. V. Gekeler, G. Freese, A. Noller, R. Handgretinger, A. Wilisch, H. Schmidt, D. Muller, R. Dopfer, T. Klingbiel, H. Probst, D. Niethammer, Br. J. Cancer 1992, 66, 507-517
11. A. K. Ghose, A. Pritchett, G. M. Crippen, J. Comput. Chem. 1988, 9, 80-90.
12. P. Baricic, M. Mackov, distributed by Milan Hudecek, P. Horova 18, 841 07 Bratislava, Slowakia.
13. S. Prets, A. Jungreithmair, P. Chiba, G. Ecker, Sci. Pharm. 1996, 64, 627-636
14. F. Fujita, T. Ban, J. Med. Chem. 1971, 14, 148-152.
15. P. Chiba, B. Tell, W. Jäger, E. Richter, M. Hitzler, G Ecker, Arch. Pharm. Pharm. Med. Chem. 1997, 330, 343-347.
16. W. Holzer, E. Richter, G. Ecker, P. Chiba, M. Hitzler, G. Bechmann, M. Landau, W. Fleischhacker, Sci. Pharm. 1997, 65, S 90; full paper submitted.
17. H. Kubinyi in QSAR: Hansch Analysis and Related Approaches, VCH, Weinheim - New York - Basel - Cambridge - Tokyo, 1993, chapter 3.4.
18. W. Konings, lecture presented at the FEBS Advanced Lecture Course "ATP Binding (ABC) Transporters: From Multidrug Resistance to Genetic Disease", Gosau, Austria, 1997.
19. P. Chiba, M. Hitzler, E. Richter, M. Huber, C. Tmej, E. Giovagnoni, G. Ecker, Quant. Struct.-Act. Relat. 1997, 16, 361-366.
20. G. Petrik, K. Schubert (Helopharm W. Petrik G.m.b.H.und Co. K.-G.). Ger. Offen. DE 4000213. 1991 [Chem. Abstr. 1991, 115. P158755c]
21. G. Petrik, K. Schubert (Helopharm W. Petrik G.m.b.H.und Co. K.-G.). Ger. Offen. DE 4000213. 1991 [Chem. Abstr. 1991, 115. P158755c]
22. S. N. Rastogi, N. Anand, P. P. Gupta, J. N. Sharma, J. Med. Chem. 1973, 16, 797-804
23. V. Gekeler, S. Weger, H. Probst, Biochem. Biophys. Res. Commun. 1990, 169, 796-802.
24. W. Petrik, R. Sachse, (Helopharm W. Petrik G.m.b.H.und Co. K.-G.). DE 2001431. 1970 [Chem. Abstr. 1971, 75. 151538f].
25. W. Petrik, R. Sachse, (Helopharm W. Petrik G.m.b.H.und Co. K.-G.). DE 2001431. 1970 [Chem. Abstr. 1971, 75. 151538f].