Organic anion-transporting polypeptide (OATP) transporter family and drug disposition

European Journal of Clinical Investigation, Supplement

Volumn 33, Issue 2, 2003, Pages 1-5

  Kim, R B ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Drug uptake; OATP; Pharmacokinetics; Transport

Indexed keywords

ORGANIC ANION TRANSPORTER; ORGANIC ANION TRANSPORTER 8; ORGANIC ANION TRANSPORTER A; ORGANIC ANION TRANSPORTER B; ORGANIC ANION TRANSPORTER C; ORGANIC ANION TRANSPORTER D; ORGANIC ANION TRANSPORTER E; ORGANIC ANION TRANSPORTER F; UNCLASSIFIED DRUG; DIGOXIN; GLYCOPROTEIN P; MULTIDRUG RESISTANCE PROTEIN 1;

BLOOD BRAIN BARRIER; CELL MEMBRANE TRANSPORT; CLINICAL PHARMACOLOGY; CONFERENCE PAPER; DRUG ABSORPTION; DRUG DISPOSITION; DRUG ELIMINATION; DRUG PENETRATION; DRUG UPTAKE; EXPERIMENTAL RAT; GASTROINTESTINAL TRACT; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE ABSORPTION; KIDNEY PARENCHYMA; LIVER; NONHUMAN; NUCLEOTIDE SEQUENCE; PHARMACOGENETICS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; PROTEIN LOCALIZATION; SEQUENCE HOMOLOGY; SPECIES COMPARISON; STATISTICAL SIGNIFICANCE; CELL MEMBRANE; DRUG TRANSPORT; KIDNEY; PROTEIN TRANSPORT; REVIEW;

EID: 0242469240     PISSN: 0960135X     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1365-2362.33.s2.5.x     Document Type: Conference Paper

References (27)

1. Schinkel AH. The physiological function of drug-transporting P-glycoproteins. Sem Cancer Biol 1997;8:161-70.
2. Kim RB. Transporters and drug disposition. Curr Opin Drug Discovery Dev 2000;3:94-101.
3. Cvetkovic M, Leake B, Fromm MF, Wilkinson GR, Kim RB. OATP and P-glycoprotein transporters mediate the cellular uptake and excretion of fexofenadine. Drug Metab Dispos 1999;27:866-71.
4. Dresser GK, Bailey DG, Leake BF, Schwarz UI, Dawson PA, Freeman DJ et al. Fruit juices inhibit organic anion transporting polypeptide-mediated drug uptake to decrease the oral availability of fexofenadine. Clin Pharm Therapeut 2002;71:11-20.
5. Tirona RG, Kim RB. Pharmacogenomics of drug transporters. In: Licinio J, Wong ML, eds. Pharmacogenomics. The Search of Individualized Therapeutics. Chichester: Wiley, 2002.
6. Tirona RG, Leake BF, Merino G, Kim RB. Polymorphisms in OATP-C. Identification of multiple allelic variants associated with altered transport activity among European-and African-Americans. J Biol Chem 2001;276:35669-75.
7. Jacquemin E, Hagenbuch B, Stieger B, Wolkoff AW, Meier PJ. Expression cloning of a rat liver Na[+]-independent organic anion transporter. Proc Natl Acad Sci USA 1994;91:133-7.
8. Kullak-Ublick GA, Hagenbuch B, Stieger B, Schteingart CD, Hofmann AF, Wolkoff AW et al. Molecular and functional characterization of an organic anion transporting polypeptide cloned from human liver. Gastroenterology 1995;109:1274-82.
9. Kullak-Ublick GA, Glasa J, Boker C, Oswald M, Grutzner U, Hagenbuch B et al. Chlorambucil-taurocholate is transported by bile acid carriers expressed in human hepatocellular carcinomas. Gastroenterology 1997;113:1295-305.
10. Abe T, Kakyo M, Tokui T, Nakagomi R, Nishio T, Nakai D et al. Identification of a novel gene family encoding human liver-specific organic anion transporter LST-1. J Biol Chem 1999;120:17159-63.
11. Kullak-Ublick GA, Fisch T, Oswald M, Hagenbuch B, Meier PJ, Beuers U et al. Dehydroepiandrosterone sulfate [DHEAS]: identification of a carrier protein in human liver and brain. FEBS Lett 1998;424:173-6.
12. Gao B, Hagenbuch B, Kullak-Ublick GA, Benke D, Aguzzi A, Meier PJ. Organic anion-transporting polypeptides mediate transport of opioid peptides across blood-brain barrier. J Pharmacol Exp Ther 2000;294:73-9.
13. Chignard N, Mergey M, Veissiere D, Parc R, Capeau J, Poupon R et al. Bile acid transport and regulating functions in the human biliary epithelium. Hepatology 2001;33:496-503.
14. Walters HC, Craddock AL, Fusegawa H, Willingham MC, Dawson PA. Expression, transport properties, and chromosomal location of organic anion transporter subtype. Am J Physiol Gastrointest. Liver Physiol 2000;279:G1188-G1200.
15. Bossuyt X, Muller M, Meier PJ. Multispecific amphipathic substrate transport by an organic anion transporter of human liver. J Hepatol 1996;25:733-8.
16. van Montfoort JE, Hagenbuch B, Fattinger KE, Muller M, Groothuis GM, Meijer DK et al. Polyspecific organic anion transporting polypeptides mediate hepatic uptake of amphipathic type II organic cations. J Pharmacol Exp Ther 1999;291:147-52.
17. van Montfoort JE, Muller M, Groothuis GM, Meijer DK, Koepsell H, Meier PJ. Comparison of 'type I' and 'type II' organic cation transport by organic cation transporters and organic anion-transporting polypeptides. J Pharmacol Exp Ther 2001;298:110-5.
18. Kullak-Ublick GA, Ismair MG, Stieger B, Landmann L, Huber R, Pizzagalli F et al. Organic anion-transporting polypeptide B [OATP-B] and its functional comparison with three other OATPs of human liver. Gastroenterology 2001;120:525-33.
19. Tamai I, Nezu J, Uchino H, Sai Y, Oku A, Shimane M et al. Molecular identification and characterization of novel members of the human organic anion transporter [OATP] family. Biochemical Biophysical Res Communications 2000;273:251-60.
20. Hsiang B, Zhu Y, Wang Z, Wu Y, Sasseville V, Yang WP et al. A novel human hepatic organic anion transporting polypeptide 2 (OATP2): identification of a liver-specific organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA-reductase inhibitor transporters. J Biol Chem 1999;274:37161-8.
21. Konig J, Cui Y, Nies AT, Keppler D. A novel human organic anion transporting polypeptide localized to the basolateral hepatocyte membrane. Am J Physiol Gastrointest. Liver Physiol 2000;278:G156-G164.
22. Nakai D, Nakagomi R, Furuta Y, Tokui T, Abe T, Ikeda T et al. Human liver-specific organic anion transporter, LST-1, mediates uptake of pravastatin by human hepatocytes. J Pharmacol Exp Ther 2001;297:861-7.
23. Abe T, Unno M, Onogawa T, Tokui T, Kondo TN, Nakagomi R et al. Lst-2, a human liver-specific organic anion transporter, determines methotrexate sensitivity in gastrointestinal cancers. Gastroenterology 2001;274:1689-99.
24. Cui Y, Konig J, Leier I, Buchholz U, Keppler D. Hepatic uptake of bilirubin and its conjugates by the human organic anion transporter SLC21A6. J Biol Chem 2001;276:9626-30.
25. Fujiwara K, Adachi H, Nishio T, Unno M, Tokui T, Okabe M et al. Identification of thyroid hormone transporters in humans: different molecules are involved in a tissue-specific manner. Endocrinology 2001;142:2005-12.
26. Konig J, Cui Y, Nies AT, Keppler D. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide. J Biol Chem 2000;275:23161-8.
27. Pizzagalli F, Hagenbuch B, Stieger B, Klenk U, Folkers G, Meier PJ. Identification of a novel human organic anion transporting polypeptide as a high affinity thyroxine transporter. Mol Endocrinol, 2002;16:2283-96.