Functional assessment of the mutational effects of human IRAK4 and MyD88 genes

Molecular Immunology

Volumn 58, Issue 1, 2014, Pages 66-76

  Yamamoto, Takahiro ^a   Tsutsumi, Naotaka ^b   Tochio, Hidehito ^b   Ohnishi, Hidenori ^a   Kubota, Kazuo ^a   Kato, Zenichiro ^a   Shirakawa, Masahiro ^b,c   Kondo, Naomi ^a,d  

^a GIFU UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

^c JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

^d Heisei College of Health Sciences   (Japan)

Author keywords

Death domain; Immune deficiency; IRAK4; MyD88; Myddosome; TIR domain

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MYELOID DIFFERENTIATION FACTOR 88;

ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; GEL FILTRATION; GENE MUTATION; GENETIC VARIABILITY; HUMAN; HUMAN CELL; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SINGLE NUCLEOTIDE POLYMORPHISM;

DD; DEATH DOMAIN; DEATH DOMAIN AND INTERNAL DOMAIN OF IRAK4; DEATH DOMAIN AND INTERNAL DOMAIN OF MYD88; DEATH DOMAIN OF IRAK4; DEATH DOMAIN OF MYD88; ELISA; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEK; HUMAN EMBRYONIC KIDNEY; ID; IMMUNE-DEFICIENCY; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASE; INTERNAL DOMAIN; IRAK; IRAK4; IRAK4-DD; IRAK4-DD+ID; MAL; MAL-TIR; MYD88; MYD88 ADAPTOR-LIKE; MYD88-DD; MYD88-DD+ID; MYD88-TIR; MYDDOSOME; MYELOID DIFFERENTIATING FACTOR 88; NMR; NUCLEAR MAGNETIC RESONANCE; SINGLE NUCLEOTIDE POLYMORPHISM; SNP; TIR DOMAIN; TIR DOMAIN OF MAL; TIR DOMAIN OF MYD88; TNF RECEPTOR ASSOCIATED FACTOR.; TOLL/INTERLEUKIN-1 RECEPTOR HOMOLOGY DOMAIN; TRAF; WILD TYPE; WT;

CELL LINE; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEK293 CELLS; HUMANS; IMMUNOLOGIC DEFICIENCY SYNDROMES; INTERLEUKIN-1 RECEPTOR-ASSOCIATED KINASES; MUTATION; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

EID: 84889571746     PISSN: 01615890     EISSN: 18729142     Source Type: Journal    
DOI: 10.1016/j.molimm.2013.11.008     Document Type: Article

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