Natural loss-of-function mutation of myeloid differentiation protein 88 disrupts its ability to form myddosomes

Journal of Biological Chemistry

Volumn 286, Issue 13, 2011, Pages 11875-11882

  Nagpal, Kamalpreet ^a   Plantinga, Theo S ^b   Sirois, Cherilyn M ^a   Monks, Brian G ^a   Latz, Eicke ^a,c   Netea, Mihai G ^b   Golenbock, Douglas T ^a  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTER PROTEINS; CELLULAR LOCALIZATION; DEATH DOMAIN; KNOCKOUT MICE; MACROPHAGE-LIKE CELLS; MYELOID DIFFERENTIATION; REPORTER ASSAY; TOLL-LIKE RECEPTORS; WILD TYPES;

CELL CULTURE; SIGNALING;

PROTEINS;

INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 4; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR;

ARTICLE; CELL ORGANELLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOPLASM; GENE DISRUPTION; GENE FUNCTION; GENE LOCATION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; LIGAND BINDING; LOSS OF FUNCTION MUTATION; MACROPHAGE; MYDDOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; SIGNAL TRANSDUCTION; WILD TYPE;

AMINO ACID SUBSTITUTION; ANIMALS; CYTOPLASM; HEK293 CELLS; HUMANS; MICE; MUTATION, MISSENSE; MYELOID DIFFERENTIATION FACTOR 88; PROTEIN TRANSPORT; TOLL-LIKE RECEPTORS;

MUS;

EID: 79953180063     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.199653     Document Type: Article

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