Endothelial Cell Biology

Angiogenesis Assays: A Critical Appraisal of Current Techniques

Volumn , Issue , 2007, Pages 1-38

  Hillen, Femke ^a   Melotte, Veerle ^a   Van Beijnum, Judy R ^a   Griffioen, Arjan W ^a  

^a MAASTRICHT UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Adherens junctions; Coagulation and haemostasis; Endothelial cell adhesion and interactions; Endothelial cell biology; Endothelial cell heterogeneity and organ specificity; Endothelial cell matrix interactions; Endothelial progenitor cells (EPCs); Pericyte morphology and tissue specific functions

Indexed keywords

EID: 84889368806     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470029350.ch1     Document Type: Chapter

References (177)

1. Abe, M. and Sato, Y. (2001) 'cDNA microarray analysis of the gene expression profile of VEGF-activated human umbilical vein endothelial cells', Angiogenesis, 4 (4), pp. 289-298
2. Acevedo, L., Yu, J., Erdjument-Bromage, H., Miao, R. Q. et al. (2004) 'A new role for Nogo as a regulator of vascular remodeling', Nat. Med., 10(4), pp. 382-388.
3. Aird, W. C. (2003) 'Endothelial cell heterogeneity', Crit. Care Med., 31(4) (Suppl), pp. S221-S230.
4. Aird, W. C. (2004) 'Endothelial cell heterogeity: a case for nature and nurture', Blood, 103(11), pp. 3994-3995.
5. Aitkenhead, M., Wang, S. J., Nakatsu, M. N., Mestas, J. et al. (2002) 'Identification of endothelial cell genes expressed in an in vitro model of angiogenesis: induction of ESM-1, (beta)ig-h3, and NrCAM', Microvasc. Res., 63(2), pp. 159-171.
6. Al-Rawi, M. A., Mansel, R. E. and Jiang,W. G. (2005) 'Molecular and cellular mechanisms of lymphangiogenesis', Eur. J. Surg. Oncol., 31(2), pp. 117-121.
7. Alitalo, K. and Carmeliet, P. (2002) 'Molecular mechanisms of lymphangiogenesis in health and disease', Cancer Cell, 1(3), pp. 219-227.
8. Anitua, E., Andia, I., Ardanza, B., Nurden, P. and Nurden, A. T. (2004) 'Autologous platelets as a source of proteins for healing and tissue regeneration', Thromb. Haemost., 91(1), pp. 4-15.
9. Autiero, M., Luttun, A., Tjwa, M. and Carmeliet, P. (2003) 'Placental growth factor and its receptor, vascular endothelial growth factor receptor-1: novel targets for stimulation of ischaemic tissue revascularization and inhibition of angiogenic and inflammatory disorders', J. Thromb. Haemost., 1(7), pp. 1356-1370.
10. Banerji, S., Ni, J., Wang, S. X., Clasper, S. et al. (1999) 'LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan', J. Cell Biol., 144(4), pp. 789-801.
11. Bardin, N., Anfosso, F., Masse, J. M., Cramer, E. et al. (2001) 'Identification of CD146 as a component of the endothelial junction involved in the control of cell-cell cohesion', Blood, 98(13), pp. 3677-3684.
12. Bazzoni, G. and Dejana, E. (2004) 'Endothelial cell-to-cell junctions: molecular organization and role in vascular homeostasis', Physiol. Rev., 84(3), pp. 869-901.
13. Bell, S. E., Mavila, A., Salazar, R., Bayless, K. J. et al. (2001) 'Differential gene expression during capillary morphogenesis in 3D collagen matrices: regulated expression of genes involved in basement membrane matrix assembly, cell cycle progression, cellular differentiation and G-protein signaling', J. Cell Sci., 114(15), pp. 2755-2773.
14. Bevilacqua, M. P. (1993) 'Endothelial-leukocyte adhesion molecules', Annu. Rev. Immunol., 11, pp. 767-804.
15. Bissell, M. J. (1999) 'Tumour plasticity allows vasculogenic mimicry, a novel form of angiogenic switch. A rose by any other name?', Am. J. Pathol., 155(3), pp. 675- 679.
16. Bodolay, E., Koch, A. E., Kim, J., Szegedi, G. and Szekanecz, Z. (2002) 'Angiogenesis and chemokines in rheumatoid arthritis and other systemic inflammatory rheumatic diseases', J. Cell Mol. Med., 6(3), pp. 357-376.
17. Boffa, M. C. and Karmochkine, M. (1998) 'Thrombomodulin: an overview and potential implications in vascular disorders', Lupus, 7 (Suppl. 2), pp. S120-S125.
18. Bohnsack, B. L., Lai, L., Dolle, P. and Hirschi, K. K. (2004) 'Signaling hierarchy downstream of retinoic acid that independently regulates vascular remodeling and endothelial cell proliferation', Genes Dev., 18(11), pp. 1345-1358.
19. Botta, M., Manetti, F. and Corelli, F. (2000) 'Fibroblast growth factors and their inhibitors', Curr. Pharm. Des, 6(18), pp. 1897-1924.
20. Bouis, D., Hospers, G. A., Meijer, C., Molema, G. and Mulder, N. H. (2001) 'Endothelium in vitro: a review of human vascular endothelial cell lines for blood vessel-related research', Angiogenesis, 4(2), pp. 91-102.
21. Breiteneder-Geleff, S., Soleiman, A., Kowalski, H., Horvat, R. et al. (1999) 'Angiosarcomas express mixed endothelial phenotypes of blood and lymphatic capillaries: podoplanin as a specific marker for lymphatic endothelium', Am. J. Pathol., 154(2), pp. 385-394.
22. Brooks, P. C., Stromblad, S., Sanders, L. C., von Schalscha, T. L. et al. (1996) 'Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta', Cell, 85(5), pp. 683-693.
23. Burri, P. H., Hlushchuk, R. and Djonov, V. (2004) 'Intussusceptive angiogenesis: its emergence, its characteristics, and its significance', Dev. Dyn., 231(3), pp. 474-488.
24. Bussolati, B., Deambrosis, I., Russo, S., Deregibus, M. C. and Camussi, G. (2003) 'Altered angiogenesis and survival in human tumour-derived endothelial cells', FASEB J., 17(9), pp. 1159-1161.
25. Cao, Y., Hong, A., Schulten, H. and Post, M. J. (2005) 'Update on therapeutic neovascularization', Cardiovasc. Res., 65(3), pp. 639-648.
26. Carmeliet, P. (2003) 'Angiogenesis in health and disease', Nat. Med., 9(6), pp. 653-660.
27. Carson-Walter, E. B., Watkins, D. N., Nanda, A., Vogelstein, B. et al. (2001) 'Cell surface tumour endothelial markers are conserved in mice and humans', Cancer Res., 61(18), pp. 6649-6655.
28. Chi, J. T., Chang, H. Y., Haraldsen, G., Jahnsen, F. L. et al. (2003) 'Endothelial cell diversity revealed by global expression profiling', Proc. Natl. Acad. Sci. USA, 100(19), pp. 10623- 10628.
29. Chung-Welch, N., Shepro, D., Dunham, B. and Hechtman, H. B. (1988) 'Prostacyclin and prostaglandin E2 secretions by bovine pulmonary microvessel endothelial cells are altered by changes in culture conditions', J. Cell Physiol., 135(2), pp. 224-234.
30. Cines, D. B., Pollak, E. S., Buck, C. A., Loscalzo, J. et al. (1998) 'Endothelial cells in physiology and in the pathophysiology of vascular disorders', Blood, 91(10), pp. 3527-3561.
31. Cleaver, O. and Melton, D. A. (2003) 'Endothelial signaling during development', Nat. Med., 9(6), pp. 661-668.
32. Dejana, E. (2004) 'Endothelial cell-cell junctions: happy together', Nat. Rev. Mol. Cell Biol., 5(4), pp. 261-270.
33. Demeule, M., Labelle, M., Regina, A., Berthelet, F. and Beliveau, R. (2001) 'Isolation of endothelial cells from brain, lung, and kidney: expression of the multidrug resistance P-glycoprotein isoforms', Biochem. Biophys. Res. Commun., 281(3), pp. 827-834.
34. Dvorak, A. M. and Feng, D. (2001) 'The vesiculo-vacuolar organelle (VVO). A new endothelial cell permeability organelle', J. Histochem. Cytochem., 49(4), pp. 419-432.
35. Dvorak, H. F. (2000) 'VPF/VEGF and the angiogenic response', Semin. Perinatol., 24(1), pp. 75-78.
36. Ebnet, K., Suzuki, A., Ohno, S. and Vestweber, D. (2004) 'Junctional adhesion molecules (JAMs): more molecules with dual functions?', J. Cell Sci., 117(1), pp. 19-29.
37. Elangbam, C. S., Qualls, C. W., Jr and Dahlgren, R. R. (1997) 'Cell adhesion molecules- update', Vet. Pathol., 34(1), pp. 61-73.
38. Engelhardt, B. and Wolburg, H. (2004) 'Mini-review: Transendothelial migration of leukocytes: through the front door or around the side of the house?', Eur. J. Immunol., 34(11), pp. 2955-2963.
39. Favre, C. J., Mancuso, M., Maas, K., McLean, J. W. et al. (2003) 'Expression of genes involved in vascular development and angiogenesis in endothelial cells of adult lung', Am. J. Physiol. Heart Circ. Physiol., 285(5), pp. H1917-H1938.
40. Fawcett, J., Harris, A. L. and Bicknell, R. (1991) 'Isolation and properties in culture of human adrenal capillary endothelial cells', Biochem. Biophys. Res. Commun., 174(2), pp. 903-908.
41. Feng, D., Nagy, J. A., Hipp, J., Dvorak, H. F. and Dvorak, A. M. (1996) 'Vesiculo-vacuolar organelles and the regulation of venule permeability to macromolecules by vascular permeability factor, histamine, and serotonin', J. Exp. Med., 183(5), pp. 1981-1986.
42. Feng, D., Nagy, J. A., Dvorak, H. F. and Dvorak, A. M. (2002) 'Ultrastructural studies define soluble macromolecular, particulate, and cellular transendothelial cell pathways in venules, lymphatic vessels, and tumour-associated microvessels in man and animals', Microsc. Res. Tech., 57(5), pp. 289-326.
43. Ferrara, N. (2004) 'Vascular endothelial growth factor: basic science and clinical progress', Endocr. Rev., 25(4), pp. 581-611.
44. Ferrara, N., Gerber, H. P. and LeCouter, J. (2003) 'The biology of VEGF and its receptors', Nat. Med., 9(6), pp. 669-676.
45. Folkman, J. (1971) 'Tumour angiogenesis: therapeutic implications', N. Engl. J. Med., 285(21), pp. 1182-1186.
46. Folkman, J. (1995) 'Angiogenesis in cancer, vascular, rheumatoid and other disease', Nat. Med., 1(1), pp. 27-31.
47. Folkman, J., Haudenschild, C. C. and Zetter, B. R. (1979) 'Long-term culture of capillary endothelial cells', Proc. Natl. Acad. Sci. USA, 76(10), pp. 5217-5221.
48. Folkman, J. and Shing, Y. (1992) 'Angiogenesis', J. Biol. Chem., 267(16), pp. 10931- 10934.
49. Freedman, R. B., Hirst, T. R. and Tuite, M. F. (1994) 'Protein disulphide isomerase: building bridges in protein folding', Trends Biochem. Sci., 19(8), pp. 331-336.
50. Gallagher P. J. (2005) 'Blood vessels', in Histology for Pathologists, 2nd edn, Stephan S. and Sternberg M. D., eds., pp. 763-786.
51. Gallo, R., Kim, C., Kokenyesi, R., Adzick, N. S. and Bernfield, M. (1996) 'Syndecans-1 and -4 are induced during wound repair of neonatal but not fetal skin', J. Invest. Dermatol., 107(5), pp. 676-683.
52. Geng, J. G. (2003) 'Interaction of vascular endothelial cells with leukocytes, platelets and cancer cells in inflammation, thrombosis and cancer growth and metastasis', Acta Pharmacol. Sin., 24(12), pp. 1297-1300.
53. Gerhardt, H. and Betsholtz, C. (2003) 'Endothelial-pericyte interactions in angiogenesis', Cell Tissue Res., 314(1), pp. 15-23.
54. Gerritsen, M. E., Shen, C. P., McHugh, M. C., Atkinson, W. J. et al. (1995) 'Activationdependent isolation and culture of murine pulmonary microvascular endothelium', Microcirculation, 2(2), pp. 151-163.
55. Gerritsen, M. E., Soriano, R., Yang, S., Zlot, C. et al. (2003a) 'Branching out: a molecular fingerprint of endothelial differentiation into tube-like structures generated by Affymetrix oligonucleotide arrays', Microcirculation, 10(1), pp. 63-81.
56. Gerritsen, M. E., Tomlinson, J. E., Zlot, C., Ziman, M. and Hwang, S. (2003b) 'Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells', Br. J. Pharmacol., 140(4), pp. 595-610.
57. Ghitescu, L. and Robert, M. (2002) 'Diversity in unity: the biochemical composition of the endothelial cell surface varies between the vascular beds', Microsc. Res. Tech., 57(5), pp. 381-389.
58. Giordano, F. and Mitola, S. (2000) 'Characterization of endothelial cells isolated by human meningiomas', J. Neurosurg. Sci., 44(4), pp. 177-185.
59. Glienke, J., Schmitt, A. O., Pilarsky, C., Hinzmann, B. et al. (2000) 'Differential gene expression by endothelial cells in distinct angiogenic states', Eur. J. Biochem., 267(9), pp. 2820-2830.
60. Gonlugur, U. and Efeoglu, T. (2004) 'Vascular adhesion and transendothelial migration of eosinophil leukocytes', Cell Tissue Res., 318(3), pp. 473-482.
61. Good, D. J., Polverini, P. J., Rastinejad, F., Le Beau, M. M. et al. (1990) 'A tumour suppressor-dependent inhibitor of angiogenesis is immunologically and functionally indistinguishable from a fragment of thrombospondin', Proc. Natl. Acad. Sci. USA, 87(17), pp. 6624-6628.
62. Griffioen, A. W. (1997) 'Phenotype of the tumour vasculature; cell adhesion as a target for tumour therapy', Cancer Journal, 10(5), pp. 249-255.
63. Grimwood, J., Bicknell, R. and Rees, M. C. (1995) 'The isolation, characterization and culture of human decidual endothelium', Hum. Reprod., 10(8), pp. 2142-2148.
64. Grossfeld, G. D., Ginsberg, D. A., Stein, J. P., Bochner, B. H. et al. (1997) 'Thrombospondin-1 expression in bladder cancer: association with p53 alterations, tumour angiogenesis, and tumour progression', J. Natl. Cancer Inst., 89(3), pp. 219-227.
65. Gupta, S. K., Hassel, T. and Singh, J. P. (1995) 'A potent inhibitor of endothelial cell proliferation is generated by proteolytic cleavage of the chemokine platelet factor 4', Proc. Natl. Acad. Sci. USA, 92(17), pp. 7799-7803.
66. Gussin, H. A., Sharma, A. K. and Elias, S. (2004) 'Culture of endothelial cells isolated from maternal blood using anti-CD105 and CD133', Prenat. Diagn., 24(3), pp. 189-193.
67. Guyton, A. C. and Hall, J. E. (2005) 'Hemostasis and blood coagulation', in Textbook of Medical Physiology, W. B. Saunders Company, pp. 419-429.
68. Harvey, N. L. and Oliver, G. (2004) 'Choose your fate: artery, vein or lymphatic vessel?', Curr. Opin. Genet. Dev., 14(5), pp. 499-505.
69. Hewett, P.W. and Murray, J. C. (1993) 'Human lung microvessel endothelial cells: isolation, culture, and characterization', Microvasc. Res., 46(1), pp. 89-102.
70. Hirata, K., Ishida, T., Penta, K., Rezaee, M. et al. (2001) 'Cloning of an immunoglobulin family adhesion molecule selectively expressed by endothelial cells', J. Biol. Chem., 276(19), pp. 16223-16231.
71. Ho, M., Yang, E., Matcuk, G., Deng, D. et al. (2003) 'Identification of endothelial cell genes by combined database mining and microarray analysis', Physiol Genomics, 13(3), pp. 249-262.
72. Hristov, M. and Weber, C. (2004) 'Endothelial progenitor cells: characterization, pathophysiology, and possible clinical relevance', J. Cell Mol. Med., 8(4), pp. 498-508.
73. Huminiecki, L. and Bicknell, R. (2000) 'In silico cloning of novel endothelial-specific genes', Genome Res., 10(11), pp. 1796-1806.
74. Huminiecki, L., Gorn, M., Suchting, S., Poulsom, R. and Bicknell, R. (2002) 'Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis', Genomics, 79(4), pp. 547-552.
75. Iivanainen, E., Kahari, V. M., Heino, J. and Elenius, K. (2003) 'Endothelial cell-matrix interactions', Microsc. Res. Tech., 60(1), pp. 13-22.
76. Jackson, D. E. (2003) 'The unfolding tale of PECAM-1', FEBS Lett., 540(1-3), pp. 7-14.
77. Jaffe, E. A., Nachman, R. L., Becker, C. G. and Minick, C. R. (1973) 'Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria', J. Clin. Invest, 52(11), pp. 2745-2756.
78. Jeltsch, M., Kaipainen, A., Joukov, V., Meng, X. et al. (1997) 'Hyperplasia of lymphatic vessels in VEGF-C transgenic mice', Science, 276(5317), pp. 1423-1425.
79. Jih, Y. J., Lien,W. H., Tsai,W. C., Yang, G.W. et al. (2001) 'Distinct regulation of genes by bFGF and VEGF-A in endothelial cells', Angiogenesis, 4(4), pp. 313-321.
80. Jones, P. F. (2003) 'Not just angiogenesis-wider roles for the angiopoietins', J. Pathol., 201(4), pp. 515-527.
81. Jung, Y. D., Ahmad, S. A., Liu, W., Reinmuth, N. et al. (2002) 'The role of the microenvironment and intercellular cross-talk in tumour angiogenesis', Semin. Cancer Biol., 12(2), pp. 105-112.
82. Kahn, J., Mehraban, F., Ingle, G., Xin, X. et al. (2000) 'Gene expression profiling in an in vitro model of angiogenesis', Am. J. Pathol., 156(6), pp. 1887-1900.
83. Kaila, N. and Thomas, B. E. (2002) 'Design and synthesis of sialyl Lewis(x) mimics as Eand P-selectin inhibitors', Med. Res. Rev., 22(6), pp. 566-601.
84. Kakkar, A. K. and Lefer, D. J. (2004) 'Leukocyte and endothelial adhesion molecule studies in knockout mice', Curr. Opin. Pharmacol., 4(2), pp. 154-158.
85. Kallmann, B. A., Wagner, S., Hummel, V., Buttmann, M. et al. (2002) 'Characteristic gene expression profile of primary human cerebral endothelial cells', FASEB J., 16(6), pp. 589- 591.
86. Kalluri, R. (2003) 'Basement membranes: structure, assembly and role in tumour angiogenesis', Nat. Rev. Cancer, 3(6), pp. 422-433.
87. Kaneko, T., Fujii, S., Matsumoto, A., Goto, D. et al. (2003) 'Induction of tissue factor expression in endothelial cells by basic fibroblast growth factor and its modulation by fenofibric acid', Thromb. J., 1(1), p. 6.
88. Keiper, T., Santoso, S., Nawroth, P. P., Orlova, V. and Chavakis, T. (2005) 'The role of junctional adhesion molecules in cell-cell interactions', Histol. Histopathol., 20(1), pp. 197-203.
89. Kerbel, R. S. (2000) 'Tumour angiogenesis: past, present and the near future', Carcinogenesis, 21(3), pp. 505-515.
90. Koch, A. E. (2000) 'Angiogenesis as a target in rheumatoid arthritis', Ann. Rheum. Dis., 62(Suppl 2), pp. ii60-ii67.
91. Koivunen, E., Arap, W., Valtanen, H., Rainisalo, A. et al. (1999) 'Tumour targeting with a selective gelatinase inhibitor', Nat. Biotechnol., 17(8), pp. 768-774.
92. Kolber, D. L., Knisely, T. L. and Maione, T. E. (1995) 'Inhibition of development of murine melanoma lung metastases by systemic administration of recombinant platelet factor 4', J. Natl. Cancer Inst., 87(4), pp. 304-309.
93. Lai, L., Bohnsack, B. L., Niederreither, K. and Hirschi, K. K. (2003) 'Retinoic acid regulates endothelial cell proliferation during vasculogenesis', Development, 130(26), pp. 6465- 6474.
94. Lawson, N. D. and Weinstein, B. M. (2002) 'Arteries and veins: making a difference with zebrafish', Nat. Rev. Genet., 3(9), pp. 674-682.
95. Lawson, N. D., Scheer, N., Pham, V. N., Kim, C. H. et al. (2001) 'Notch signaling is required for arterial-venous differentiation during embryonic vascular development', Development, 128(19), pp. 3675-3683.
96. Lawson, N. D., Vogel, A. M. and Weinstein, B. M. (2002) 'Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation', Dev. Cell, 3(1), pp. 127-136.
97. LeCouter, J., Kowalski, J., Foster, J., Hass, P. et al. (2001) 'Identification of an angiogenic mitogen selective for endocrine gland endothelium', Nature, 412(6850), pp. 877-884.
98. Li, J., Zhang, Y. P. and Kirsner, R. S. (2003) 'Angiogenesis in wound repair: angiogenic growth factors and the extracellular matrix', Microsc. Res. Tech., 60(1), pp. 107-114.
99. Lu, X., Le, N. F., Yuan, L., Jiang, Q. et al. (2004) 'The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular system', Nature, 432(7014), pp. 179-186.
100. Luster, A. D., Greenberg, S. M. and Leder, P. (1995) 'The IP-10 chemokine binds to a specific cell surface heparan sulfate site shared with platelet factor 4 and inhibits endothelial cell proliferation', J. Exp. Med., 182(1), pp. 219-231.
101. Madden, S. L., Cook, B. P., Nacht, M.,Weber,W. D. et al. (2004) 'Vascular gene expression in nonneoplastic and malignant brain', Am. J. Pathol., 165(2), pp. 601-608.
102. Makinen, T., Veikkola, T., Mustjoki, S., Karpanen, T. et al. (2001) 'Isolated lymphatic endothelial cells transduce growth, survival and migratory signals via the VEGF-C/D receptor VEGFR-3', EMBO J., 20(17), pp. 4762-4773.
103. Manconi, F., Markham, R. and Fraser, I. S. (2000) 'Culturing endothelial cells of microvascular origin', Methods Cell Sci., 22(2-3), pp. 89-99.
104. Maniotis, A. J., Folberg, R., Hess, A., Seftor, E. A. et al. (1999) 'Vascular channel formation by human melanoma cells in vivo and in vitro: vasculogenic mimicry', Am. J. Pathol., 155(3), pp. 739-752.
105. Marelli-Berg, F. M., Peek, E., Lidington, E. A., Stauss, H. J. and Lechler, R. I. (2000) 'Isolation of endothelial cells from murine tissue', J. Immunol. Methods, 244(1-2), pp. 205-215.
106. Martin, A., Komada, M. R. and Sane, D. C. (2003) 'Abnormal angiogenesis in diabetes mellitus', Med. Res. Rev., 23(2), pp. 117-145.
107. McCarthy, S. A., Kuzu, I., Gatter, K. C. and Bicknell, R. (1991) 'Heterogeneity of the endothelial cell and its role in organ preference of tumour metastasis', Trends Pharmacol. Sci., 12(12), pp. 462-467.
108. McColl, B. K., Stacker, S. A. and Achen, M. G. (2004) 'Molecular regulation of the VEGF family -inducers of angiogenesis and lymphangiogenesis', APMIS, 112(7-8), pp. 463-480.
109. McDonald, D. M. and Foss, A. J. (2000) 'Endothelial cells of tumour vessels: abnormal but not absent', Cancer Metastasis Rev., 19(1-2), pp. 109-120.
110. McDonald, D. M., Munn, L. and Jain, R. K. (2000) 'Vasculogenic mimicry: how convincing, how novel, and how significant?', Am. J. Pathol., 156(2), pp. 383-388.
111. McGinn, S., Poronnik, P., Gallery, E. D. and Pollock, C. A. (2004) 'A method for the isolation of glomerular and tubulointerstitial endothelial cells and a comparison of characteristics with the human umbilical vein endothelial cell model', Nephrology (Carlton), 9(4), pp. 229-237.
112. Meno, C., Shimono, A., Saijoh, Y., Yashiro, K. et al. (1998) 'lefty-1 is required for left-right determination as a regulator of lefty-2 and nodal', Cell, 94(3), pp. 287-297.
113. Muller, A. M., Hermanns, M. I., Cronen, C. and Kirkpatrick, C. J. (2002) 'Comparative study of adhesion molecule expression in cultured human macro- and microvascular endothelial cells', Exp. Mol. Pathol., 73(3), pp. 171-180.
114. Muller, A. W. (2003) 'Finding extraterrestrial organisms living on thermosynthesis', Astrobiology., 3(3), pp. 555-564.
115. Mummert, M. E., Mohamadzadeh, M., Mummert, D. I., Mizumoto, N. and Takashima, A. (2000) 'Development of a peptide inhibitor of hyaluronan-mediated leukocyte trafficking', J. Exp. Med., 192(6), pp. 769-779.
116. Nilius, B. and Droogmans, G. (2001) 'Ion channels and their functional role in vascular endothelium', Physiol Rev., 81(4), pp. 1415-1459.
117. Nourshargh, S. and Marelli-Berg, F. M. (2005) 'Transmigration through venular walls: a key regulator of leukocyte phenotype and function', Trends Immunol., 26(3), pp. 157-165.
118. O'Reilly, M. S., Boehm, T., Shing, Y., Fukai, N. et al. (1997) 'Endostatin: an endogenous inhibitor of angiogenesis and tumour growth', Cell, 88(2), pp. 277-285.
119. O'Reilly, M. S., Holmgren, L., Shing, Y., Chen, C. et al. (1994) 'Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma', Cell, 79(2), pp. 315-328.
120. Okada-Ban, M., Thiery, J. P. and Jouanneau, J. (2000) 'Fibroblast growth factor-2', Int. J. Biochem. Cell Biol., 32(3), pp. 263-267.
121. Parker, B. S., Argani, P., Cook, B. P., Liangfeng, H. et al. (2004) 'Alterations in vascular gene expression in invasive breast carcinoma', Cancer Res., 64(21), pp. 7857-7866.
122. Pasqualini, R., Koivunen, E. and Ruoslahti, E. (1997) 'Alpha v integrins as receptors for tumour targeting by circulating ligands', Nat. Biotechnol., 15(6), pp. 542-546.
123. Pasqualini, R., Koivunen, E., Kain, R., Lahdenranta, J. et al. (2000) 'Aminopeptidase N is a receptor for tumour-homing peptides and a target for inhibiting angiogenesis', Cancer Res., 60(3), pp. 722-727.
124. Pasqualini, R., Arap,W. and McDonald, D. M. (2002) 'Probing the structural and molecular diversity of tumour vasculature', Trends Mol. Med., 8(12), pp. 563-571.
125. Patan, S. (2000) 'Vasculogenesis and angiogenesis as mechanisms of vascular network formation, growth and remodeling 1', J. Neurooncol., 50(1-2), pp. 1-15.
126. Patel, V. A., Logan, A., Watkinson, J. C., Uz-Zaman, S. et al. (2003) 'Isolation and characterization of human thyroid endothelial cells', Am. J. Physiol Endocrinol. Metab, 284(1), pp. E168-E176.
127. Price, G. C., Thompson, S. A. and Kam, P. C. (2004) 'Tissue factor and tissue factor pathway inhibitor', Anaesthesia, 59(5), pp. 483-492.
128. Rajotte, D., Arap, W., Hagedorn, M., Koivunen, E. et al. (1998) 'Molecular heterogeneity of the vascular endothelium revealed by in vivo phage display', J. Clin. Invest, 102(2), pp. 430-437.
129. Rastinejad, F., Polverini, P. J. and Bouck, N. P. (1989) 'Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene', Cell, 56(3), pp. 345-355.
130. Relou, I. A., Damen, C. A., van der Schaft, D. W., Groenewegen, G. and Griffioen, A. W. (1998) 'Effect of culture conditions on endothelial cell growth and responsiveness', Tissue Cell, 30(5), pp. 525-530.
131. Renkin E. M. (1988) 'Transport pathways and processes', in Endothelial Cell Biology in Health and Disease, N. Simionescu and M. Simionescu, eds, Plenum Press, pp. 51-68.
132. Reuss, B. and von Bohlen und, H. O. (2003) 'Fibroblast growth factors and their receptors in the central nervous system', Cell Tissue Res., 313(2), pp. 139-157.
133. Rhee, J. S., Black, M., Schubert, U., Fischer, S. et al. (2004) 'The functional role of blood platelet components in angiogenesis', Thromb. Haemost., 92(2), pp. 394-402.
134. Ribatti, D. (2004) 'The involvement of endothelial progenitor cells in tumour angiogenesis', J. Cell Mol. Med., 8(3), pp. 294-300.
135. Ribatti, D., Nico, B., Vacca, A., Roncali, L. and Dammacco, F. (2002) 'Endothelial cell heterogeneity and organ specificity', J. Hematother. Stem Cell Res., 11(1), pp. 81-90.
136. Richard, L., Velasco, P. and Detmar, M. (1998) 'A simple immunomagnetic protocol for the selective isolation and long-term culture of human dermal microvascular endothelial cells', Exp. Cell Res., 240(1), pp. 1-6.
137. Sadler, J. E. (1997) 'Thrombomodulin structure and function', Thromb. Haemost., vol. 78, no. 1, pp. 392-395.
138. Saharinen, P. and Petrova, T. V. (2004) 'Molecular regulation of lymphangiogenesis', Ann. NY Acad. Sci., 1014, pp. 76-87.
139. Saharinen, P., Tammela, T., Karkkainen, M. J. and Alitalo, K. (2004) 'Lymphatic vasculature: development, molecular regulation and role in tumour metastasis and inflammation', Trends Immunol., 25(7), pp. 387-395.
140. Sato, T. N. (2003) 'Emerging concept in angiogenesis: specification of arterial and venous endothelial cells', Br. J. Pharmacol., 140(4), pp. 611-613.
141. Schneeberger, E. E. and Lynch, R. D. (2004) 'The tight junction: a multifunctional complex', Am. J. Physiol Cell Physiol, 286(6), pp. C1213-C1228.
142. Schneider, M., Othman-Hassan, K., Christ, B. and Wilting, J. (1999) 'Lymphangioblasts in the avian wing bud', Dev. Dyn., 216(4-5), pp. 311-319.
143. Scott, P. A. and Bicknell, R. (1993) 'The isolation and culture of microvascular endothelium', J. Cell Sci., 105(2), pp. 269-273.
144. Shubik, P. and Warren, B. A. (2000) 'Additional literature on ''vasculogenic mimicry'' not cited, Am. J. Pathol., 156(2), p. 736.
145. Simionescu, M., Gafencu, A. and Antohe, F. (2002) 'Transcytosis of plasma macromolecules in endothelial cells: a cell biological survey', Microsc. Res. Tech., 57(5), pp. 269-288.
146. Simionescu, M., Simionescu, N. and Palade, G. E. (1975) 'Segmental differentiations of cell junctions in the vascular endothelium. The microvasculature', J. Cell Biol., 67(3), pp. 863-885.
147. Sottile, J. (2004) 'Regulation of angiogenesis by extracellular matrix', Biochim. Biophys. Acta, 1654(1), pp. 13-22.
148. St Croix, B., Rago, C., Velculescu, V., Traverso, G. et al. (2000) 'Genes expressed in human tumour endothelium', Science, 289(5482), pp. 1197-1202.
149. Stan, R. V. (2002) 'Structure and function of endothelial caveolae', Microsc. Res. Tech., 57(5), pp. 350-364.
150. Stupack, D. G. and Cheresh, D. A. (2004) 'Integrins and angiogenesis', Curr. Top. Dev. Biol., 64, pp. 207-238.
151. Sullivan, D. C., Huminiecki, L., Moore, J. W., Boyle, J. J. et al. (2003) 'EndoPDI, a novel protein-disulfide isomerase-like protein that is preferentially expressed in endothelial cells acts as a stress survival factor', J. Biol. Chem., 278(47), pp. 47079-47088.
152. Sumpio, B. E., Riley, J. T. and Dardik, A. (2002) 'Cells in focus: endothelial cell', Int. J. Biochem. Cell Biol., 34(12), pp. 1508-1512.
153. Sun, L. (2004) 'Tumour-suppressive and promoting function of transforming growth factor beta', Front Biosci., 9, pp. 1925-1935.
154. Takai, Y. and Nakanishi, H. (2003) 'Nectin and afadin: novel organizers of intercellular junctions', J. Cell Sci., 116(1), pp. 17-27
155. Terramani, T. T., Eton, D., Bui, P. A., Wang, Y. et al. (2000) 'Human macrovascular endothelial cells: optimization of culture conditions', In Vitro Cell Dev. Biol. Anim, 36(2), pp. 125-132.
156. Thilo-Korner D. G. S and Heinrich D (1983) 'Historical development of endothelial cell research', in The Endothelial Cell - a Pluripotent Control Cell of the Vessel Wall, Thilo-Korner D. G. S and Freshney R. I, eds, Karger, pp. 1-12.
157. Thurston, G. (2003) 'Role of Angiopoietins and Tie receptor tyrosine kinases in angiogenesis and lymphangiogenesis 3', Cell Tissue Res., 314(1), pp. 61-68.
158. Torres-Vazquez, J., Gitler, A. D., Fraser, S. D., Berk, J. D. et al. (2004) 'Semaphorin-plexin signaling guides patterning of the developing vasculature', Dev. Cell, 7(1), pp. 117-123.
159. van Beijnum, J. R. and Griffioen, A.W. (2005) 'In silico analysis of angiogenesis associated gene expression identifies angiogenic stage related profiles', Biochim. Biophys. Acta, Jul 25; 1755(2), pp. 121-134.
160. van Buul, J. D. and Hordijk, P. L. (2004) 'Signaling in leukocyte transendothelial migration', Arterioscler. Thromb. Vasc. Biol., 24(5), pp. 824-833.
161. van der Schaft, D. W., Wagstaff, J., Mayo, K. H. and Griffioen, A. W. (2002) 'The antiangiogenic properties of bactericidal/permeability-increasing protein (BPI)', Ann. Med., 34(1), pp. 19-27.
162. Verheul, H. M., Jorna, A. S., Hoekman, K., Broxterman, H. J. et al. (2000) 'Vascular endothelial growth factor-stimulated endothelial cells promote adhesion and activation of platelets', Blood, 96(13), pp. 4216-4221.
163. Vincent, P. A., Xiao, K., Buckley, K. M. and Kowalczyk, A. P. (2004) 'VE-cadherin: adhesion at arm's length', Am. J. Physiol Cell Physiol, 286(5), pp. C987-C997.
164. Wang, H. U., Chen, Z. F. and Anderson, D. J. (1998) 'Molecular distinction and angiogenic interaction between embryonic arteries and veins revealed by ephrin-B2 and its receptor Eph-B4', Cell, 93(5), pp. 741-753.
165. Wang, J. L., Liu, Y. H., Lee, M. C., Nguyen, T. M. et al. (2000) 'Identification of tumour angiogenesis-related genes by subtractive hybridization', Microvasc. Res., 59(3), pp. 394- 397.
166. Wary, K. K., Thakker, G. D., Humtsoe, J. O. and Yang, J. (2003) 'Analysis of VEGF-responsive genes involved in the activation of endothelial cells', Mol. Cancer, 2(1), p. 25.
167. Weinstein, B. M., Stemple, D. L., Driever, W. and Fishman, M. C. (1995) 'Gridlock, a localized heritable vascular patterning defect in the zebrafish', Nat. Med., 1(11), pp. 1143- 1147.
168. Wigle, J. T., Harvey, N., Detmar, M., Lagutina, I. et al. (2002) 'An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype', EMBO J., 21(7), pp. 1505- 1513.
169. Wilting, J., Papoutsi, M., Christ, B., Nicolaides, K. H., et al. (2002) 'The transcription factor Prox1 is a marker for lymphatic endothelial cells in normal and diseased human tissues', FASEB J., 16(10), pp. 1271-1273.
170. Xu, Q.,Wang, Y., Dabdoub, A., Smallwood, P. M. et al. (2004) 'Vascular development in the retina and inner ear: control by Norrin and Frizzled-4, a high-affinity ligand-receptor pair 1', Cell, 116(6), pp. 883-895.
171. Yadav, R., Larbi, K. Y., Young, R. E. and Nourshargh, S. (2003) 'Migration of leukocytes through the vessel wall and beyond', Thromb. Haemost., 90(4), pp. 598-606.
172. Yuan, L., Moyon, D., Pardanaud, L., Breant, C. et al. (2002) 'Abnormal lymphatic vessel development in neuropilin 2 mutant mice', Development, 129(20), pp. 4797-4806.
173. Zetter B. R. (1988) 'Endothelial heterogeneity: Influence of vessel size, organ localizaton, and species specificity on the properties of cultured endothelial cells', in Endothelial Cells, vol. 2, Ryan U.S., Ed., CRC Press, pp. 64-79.
174. Zhang, H. T., Gorn, M., Smith, K., Graham, A. P. et al. (1999) 'Transcriptional profiling of human microvascular endothelial cells in the proliferative and quiescent state using cDNA arrays', Angiogenesis, 3(3), pp. 211-219.
175. Zhang, Y., Deng, Y., Luther, T., Muller, M. et al. (1994) 'Tissue factor controls the balance of angiogenic and antiangiogenic properties of tumour cells in mice', J. Clin. Invest, 94(3), pp. 1320-1327.
176. Zhong, T. P., Rosenberg, M., Mohideen, M. A., Weinstein, B. and Fishman, M. C. (2000) 'gridlock, an HLH gene required for assembly of the aorta in zebrafish', Science, 287(5459), pp. 1820-1824.
177. Zhu, D. Z., Cheng, C. F. and Pauli, B. U. (1991) 'Mediation of lung metastasis of murine melanomas by a lung-specific endothelial cell adhesion molecule', Proc. Natl. Acad. Sci. USA, 88(21), pp. 9568-9572.