Thrombomodulin: An overview and potential implications in vascular disorders

Lupus

Volumn 7, Issue SUPPL. 2, 1998, Pages

  Boffa, M C ^a   Karmochkine, M ^a  

^a SAINT LOUIS HOSPITAL   (France)

Author keywords

Endothelial damage; Endothelium; Thrombin receptor

Indexed keywords

ACTIVATED PROTEIN C; ANTICOAGULANT AGENT; MARKER; PROCOAGULANT; PROTEIN C; THROMBIN; THROMBIN RECEPTOR; THROMBOMODULIN;

BLOOD LEVEL; CELL DAMAGE; CELL MEMBRANE; CONFERENCE PAPER; DIABETIC MICROANGIOPATHY; DISEASE ACTIVITY; DISSEMINATED INTRAVASCULAR CLOTTING; ENDOTHELIUM CELL; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; INFLAMMATORY DISEASE; KERATINOCYTE; MACROPHAGE; MALARIA; MATERNAL HYPERTENSION; OSTEOBLAST; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; RICKETTSIOSIS; URINE LEVEL; VASCULAR DISEASE;

EID: 0031730635     PISSN: 09612033     EISSN: None     Source Type: Journal    
DOI: 10.1177/096120339800700227     Document Type: Conference Paper

References (67)

1. Esmon CT Thrombomodulin as a model of molecular mechanisms that modulate protease specificity and function at the vessel surface. FASEB J 1995, 9. 946-955.
2. Bourin MC, Lundgren-Akerlund E, Lindahl U. Isolation and characterization of the glycosaminoglycan component of rabbit thrombomodulin proteoglycan. J Biol Chem 1990; 265: 15424-15431.
3. Wen DZ et al. Human thrombomodulin complete cDNA sequence and chromosome localization of the gene Biochemistry 1987; 26: 4350-4357.
4. Conway Ed, Pollefeyt S, Collen D, Mosonyi MS. The amino-terminal lectin-like domain of thrombomodulin is required for constitutive endocytosis. Blood 1997; 89 652-661
5. Gysin J et al. Chondroitin sulfate of thrombomodulin is an adhesion receptor for Plasmodium falciparum-infected erythrocytes. Mol Biochem Parasitology 1997; 88: 267-271.
6. Esmon CT, Owen WG Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc Natl Acad Sci USA 1981, 78: 2249-2252.
7. Bajzar L, Manuel R, Nesheim M. Purification and characterization of TAFI, a thrombin-activatable fibrinolysis inhibitor J Biol Chem 1995, 270. 14477-14484
8. Grey ST, Hancock WW. A physiologic anti-inflammatory pathway based on thrombomodulin expression and generation of activated protein C by human mononuclear phagocytes. J Immunol 1996; 156: 2256-2263
9. Esmon CT, Fudukome K. Cellular regulation of the protein C pathway. Semin Cell Biol 1995; 6: 259-268.
10. Boehme MWJ et al. Release of thrombomodulin from endothelial cells by concerted action of TNF-alpha and neutrophils: in vivo and in vitro studies Immunology 1996; 87: 134-140.
11. Imada S et al Identification of fetomodulin, a surface marker protein of fetal development, as thrombomodulin by gene cloning and functional assays. Dev Biol 1990; 140. 113-122.
12. Raife TJ et al. Thrombomodulin expression by human keratinocytes Induction of cofactor activity during epidermal differentiation. J Clin Invest 1994, 93: 1846-1851.
13. Senet P et al. Thrombomodulin, a functional surface protein on human keratinocytes, is regulated by retinoic acid. Arch Dermatol 1997: 289: 151-157.
14. Boffa MC. Considering cellular thrombomodulin distribution and its modulating factors can facilitate the use of plasma thrombomodulin as a reliable endothelial marker Haemostasis 1996; 26 (Suppl 4). 233-243.
15. Maruyama I, Bell CE, Majerus PW Thrombomodulin is found on endothelium of arteries, veins, capillaries, and lymphatics, and on syncytiotrophoblast of human placenta. J Cell Biol 1985, 101 363-371.
16. Boffa MC et al. Thrombomodulin in the central nervous system Nouv Rev Fr Hematol 1991, 33. 423-429.
17. Boffa MC, Burke B, Haudenschild CC. Preservation of thrombomodulin antigen on vascular and extravascular surfaces. J Histochem Cytochem 1987; 35: 1267-1276.
18. Pruna A, Peyri N, Berard M, Boffa MC. Thrombomodulin is synthesized by human mesangial cells Kidney Int 1997; 51: 687-693
19. McCachren SS, Diggs J, Weinberg JB, Dittman WA. Thrombomodulin expression by human blood monocytes and by human synovial tissue lining macrophages Blood 1991; 78: 3128-3132
20. Conway EM, Nowakowski B, Steiner-Mosonyi M. Human neutrophils synthesize thrombomodulin that does not promote thrombin-dependent protein C activation. Blood 1992; 80: 1254-1263.
21. Maillaid C et al. Thrombomodulin is synthesized by osteoblasts, stimulated by 1,25-(OH)2D3 and activates protein C at their cell membrane. Endocrinology 1993; 133: 668-674
22. Pindon A, Hantai D, Jandrot-Perrus M, Festoff BW. Novel expression and localization of active thrombomodulin on the surface of mouse brain astrocytes. Glia 1997; 19: 259-268
23. Calnek DS, Grinnell BW. Thrombomodulin-dependent anticoagulant activity is regulated by vascular endothelial growth factor. Exp Cel Res 1998, 238: 294-298.
24. Ishii H, Majerus PW. Thrombomodulin is present in human plasma and urine. J Clin Invest 1985; 76: 2178-2181.
25. Ishii H, Uchiyama H, Kazama M. Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb Haemost 1991, 65: 618-623.
26. Abe H et al Granulocyte proteases and hydrogen peroxide synergistically inactivate thrombomodulin of endothelial cells in vitro. J Lab Clin Med 1994; 123 874-881
27. Takano S, Kimura S, Ohdama S, Aoki N. Plasma thrombomodulin in health and diseases. Blood 1990; 76: 2024-2029
28. Kodama S et al One-step sandwich enzyme immunoassay for soluble human thrombomodulin using monoclonal antibodies Clin Chim Acta 1990; 192: 91-99.
29. Ishii H et al. Establishment of enzyme immunoassay of human thrombomodulin in plasma and urine using monoclonal antibodies. Thromb Haemost 1990; 63: 157-162
30. Amiral J et al. Design and validation of a new immunoassay for soluble forms of thrombomodulin and studies on plasma. Hybridoma 1994; 13: 205-213
31. Boffa MC et al. Variations of plasma thrombomodulin level due to sex and age. Blood (Abstract) 1991; 78: S1, 221.
32. Blann AD, Daly RJ, Amiral J. The influence of age, gender and ABO blood groups on soluble endothelial cell markers and adhesion molecules. Br J Haem 1996; 92. 498-500.
33. De Moerloose P, Mermillod N, Amiral J, Reber G. Thrombomodulin levels during normal pregnancy at delivery and in post-partum: comparison with tissue-type plasminogen activator and plasminogen activator inhibitor. Thromb Haemost 1998; 79: 554-556.
34. Boffa MC et al Predictive value of plasma thrombomodulin in prceclampsia and gestational hypertension. Thromb Haemost 1998; 79 1092-1095.
35. Cacoub P et al. Plasma levels of thrombomodulin in pulmonary hypertension. Am J Med 1996; 101: 160-164.
36. Quehenberger P et al. Increased level of activated factor VII and decreased plasma protein S activity and circulating thrombomodulin during use of oral contraceptives. Thromb Haemost 1996; 76 729-734
37. Hemmer CJ et al Elevated thrombomodulin plasma levels as a result of endothelial involvement in Plasmoduim falciparum malaria. Thromb Haemost 1994; 72: 457-464.
38. George F et al. Demonstration of Rickettsia conor-induced endothelial injury in vivo by measuring circulating endothelial cells, thrombomodulin, and von Willebrand factor in patients with Mediterranean spotted fever. Blood 1993; 82: 2109-2116.
39. Tanaka A et al. Increased thrombomodulin values in plasma of diabetic men with microangiopathy. Clin Chem 1991; 37: 269-272.
40. Reverter JL et al. Thrombomodulin and induced tissue factor expression on monocytes are markers of diabetic microangiopathy: a prospective study on haemostasis and lipoproteins in insulin-dependent diabetes mellitus. Am J Hematol 1997; 56: 93-99
41. Asakura H et al. Plasma levels of soluble thrombomodulin increase in cases of disseminated intravascular coagulation with organ failure. Am J Hematol 1991; 38: 281-287.
42. Gando S, Kameue T, Nanzaki S, Nakanishi Y Cytokines, soluble thrombomodulin and disseminated intravascular coagulation in patients with systemic inflammatory response syndrome. Thromb Res 1995; 80: 519-526.
43. Takahashi H et al. Circulating thrombomodulin in thrombotic thrombocytopenic purpura Am J Hematol 1991; 38: 174-177.
44. Wada H et al Plasma thrombomodulin as a marker of vascular disorders in thrombotic thrombocytopenic purpura and disseminated intravascular coagulation. Am J Hematol 1992; 39: 20-24.
45. Bontis J et al. Maternal plasma level of thrombomodulin is increased in mild preeclampsia Eur J Obstet Gynecol 1995, 60: 139-141.
46. Hsu CD, Copel JA, Hong SF, Chan DW. Thrombomodulin levels in preeclampsia, gestational hypertension, and chronic hypertension. Obstet Gynecol 1995; 86. 897-899
47. Boldt J et al. Endothelial-related coagulation in cardiac surgery. Br J Anaesth 1995; 74: 174-179.
48. Hoshi K et al Plasma thrombomodulin levels in coronary sinus blood in patients with coronary artery disease. Blood Coagul Fibrinolysis 1995; 6 129-132.
49. Seigneur M et al. Levels of plasma thrombomodulin are increased in atheromatous arterial disease. Thromb Res 1993: 71. 423-431
50. Blann AD et al. Circulating endothelial cell markers in peripheral vascular disease: relationship to the location and extent of atherosclerotic disease. Eur J Clin Invest 1997; 27: 916-921.
51. Seigneur M et al. Circulating endothelial markers and ischemic status in peripheral occlusive arterial disease. Nouv Rev Fr Hematol 1995; 37: 171-173
52. Karlheinz P et al Circulating vascular cell adhesion molecule-1 correlates with the extent of human atherosclerosis in contrast to circulating intercellular adhesion molecule-1, E-selectin, P-selectin and thrombomodulin. Arteriosc Thromb Vasc Biol 1997, 17: 505-512.
53. De Caterina R et al. Soluble vascular adhesion molecule-1 as a biohumoral correlate of atherosclerosis. Arteriosc Thromb Vasc Biol 1997; 17: 2646-2654.
54. Jansson JH, Boman K, Brannstromm M, Nilsson TK. High concentrations of thrombomodulin in plasma is associated with hemorrhage prospectively studied in patients on long-term anti-coagulant treatment. Circulation 1997; 96. 2938-2943
55. Jansson JH, Boman K, Brannstromm M, Nilsson TK. Increased levels of plasma thrombomodulin are associated with vascular and all-cause mortality in patients on long-term anticoagulant. Eur Heart J 1996; 17. 1503-1505.
56. Takaya M et al. Serum thrombomodulin and anticardiolipin antibodies in patients with systemic lupus erythematosus Clin Exp Rheumatol 1991; 9: 495-499.
57. Karmochkine M et al. Increase in plasma thrombomodulin in lupus erythematosus with antiphospholipid antibodies letter. Blood 1992; 79: 837-838
58. Kawakami M et al. Plasma thrombomodulin and α2-plasmin inhibitor-plasmin complex are elevated in active systemic lupus erythematosus J Rheumatol 1992; 19: 1704-1709.
59. Odhama S et al. Plasma thrombomodulin as a marker of vascular injuries in collagen vascular diseases. Am J Clin Pathol 1994; 101: 109-113.
60. Odhama S, Yoshizawa Y, Kubota T, Aoki N Plasma thrombomodulin as an indicator of thromboembolic disease in systemic lupus erythematosus. Int J Cardiol 1994; 47: S1-S6.
61. Boehme MWJ et al. Serum thrombomodulin a novel marker of disease activity in systemic lupus erythematosus. Arthritis Rheum 1994; 27: 572-577.
62. Matsuda J et al. Clinical significance of the venous occlusion test on systemic lupus erythematosus patients with a focus on changes in blood levels of tissue plasminogen activator, von Willebrand factor antigen, and thrombomodulin. Acta Haematol 1992; 88: 22-26.
63. Alessi MC et al Venous occlusion does not induce the release of thrombomodulin from endothelial cells in patients with thromboembolic disease. Thromb Haemostas 1992, 68: 483-484.
64. Kotajima L, Aotsuka S, Sato T Clinical significance of serum thrombomodulin levels in patients with systemic rheumatic diseases. Clin Exp Rheumatol 1997; 15: 59-65.
65. Mercié P, Seigneur M, Couri C Plasma marker of vascular damage in systemic sclerosis J Rheumatol 1995, 22 1444-1445
66. Odhama S, Matsubara O, Aoki N Plasma thrombomodulin in Wegener's granulomatosis as an indicator of vascular injuries. Chest 1994; 106: 666-671.
67. Boehme MWJ et al. Relevance of elevated serum thrombomodulin and soluble E-selectin in patients with Wegener's granulomatosis and other systemic vasculitides. Am J Med 1996, 101: 387-394.