Differential gene expression by endothelial cells in distinct angiogenic states

European Journal of Biochemistry

Volumn 267, Issue 9, 2000, Pages 2820-2830

  Glienke, Jens ^a   Schmitt, Armin O ^b   Pilarsky, Christian ^b   Hinzmann, Bernd ^b   Weiß, Bertram ^a   Rosenthal, Andre ^b   Thierauch, Karl Heinz ^a  

^a BAYER PHARMA AG   (Germany)

^b Metagen GmbH   (Germany)

Author keywords

Angiogenesis; Differential gene expression; MVEC; Suppression subtractive hybridization

Indexed keywords

MATRIX METALLOPROTEINASE;

ANGIOGENESIS; ARTICLE; CELL DIFFERENTIATION; CONTROLLED STUDY; DNA HYBRIDIZATION; DNA LIBRARY; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; MICROVASCULATURE; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BASE SEQUENCE; CELLS, CULTURED; DNA PRIMERS; DNA, COMPLEMENTARY; ENDOTHELIUM, VASCULAR; GENE EXPRESSION; HUMANS; NEOVASCULARIZATION, PHYSIOLOGIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SUBTRACTION TECHNIQUE;

EID: 0034068991     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.2000.01325.x     Document Type: Article

References (59)

1. 1. Folkman, J. (1985) Tumor angiogenesis. Adv. Cancer Res. 43, 175-203.
2. 2. Risau, W. (1997) Mechanisms of angiogenesis. Nature 386, 671-674.
3. 3. Sage, E.H. (1997) Pieces of eight: bioactive fragments of extracellular proteins as regulators of angiogenesis. Trends Cell Biol. 7, 182-186.
4. 4. Kubota, Y., Kleinmann, H., Martin, G. & Lawley, T. (1988) Role of laminin and basement membrane in the morphological differentiation of human endothelial cells into capillary-like structures. J. Cell Biol. 107, 1589-1598.
5. 5. Blair, R., Meng, H., Marchese, M., Ren, S., Schwartz, L., Tonnesen, M. & Gruber, B. (1997) Human mast cells stimulate vascular tube formation. J. Clin. Inv. 99, 2691-2700.
6. 6. Diatchenko, L., Lau, Y., Campbell, A., Chenchik, A., Moqadam, F., Huang, B., Lukyanov, K., Gurskaya, N., Sverdlov, E. & Siebert, P. (1996) Suppression subtractive hybridization: a method for generating differentially regulated or tissue-specific cDNA probes and libraries. Proc. Natl Acad. Sci. USA 93, 6025-6030.
7. 7. Piossek, C., Schneider-Mergener, J., Schirner, M., Vakalopoulou, E., Germeroth, L. & Thierauch, K.H. (1999) Vascular endothelial growth factor (VEGF) receptor II-derived peptides inhibit VEGF. J. Biol. Chem. 274, 5612-5619.
8. 8. Sambrook, J., Fritsch, E. & Maniatis, T. (1989) Molecular Cloning: a Laboratory Manual, 2nd edn. Cold Spring Harbour Laboratory Press, Cold Spring Harbour, New York.
9. 9. Bonfield, J.K., Smith, K. & Staden, R. (1995) A new DNA sequence assembly program. Nucleic Acid Res. 23, 4992-4999.
10. 10. Boguski, M., Lowe, T. & Tolstoshev, C. (1993) dbEST - database for expressed sequence tags. Nat. Genet. 4, 332-333.
11. 11. Schmitt, A., Specht, T., Beckmann, G., Dahl, E., Pilarsky, P., Hinzmann, B. & Rosenthal, A. (1999) Exhaustive mining of EST libraries for genes differentially expressed in normal and tumor tissues. Nucleic Acid Res. 27, 4251-4260.
12. 12. Altschul, S., Madden, T., Schaffer, A., Zhang, J., Zhang, Z., Miller, W. & Lipman, D. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acid Res. 25, 3389-3402.
13. 13. Pilarsky, C., Schmidt, U., Eißrich, C., Stade, J., Froschermaier, S., Haase, M., Faller, G., Kirchner, T. & Wirth, M. (1998) Expression of the extracellular matrix signaling molecule Cyr61 is downregulated in prostate cancer. Prostate 36, 85-91.
14. 14. Jaffe, E., Nachman, R., Becker, C. & Minick, C. (1973) Culture of human endothelial cells derived from umbilical veins. Identification by morphologic and immunologic criteria. J. Clin. Invest. 52, 2745-2756.
15. 15. Hewett, P. & Murray, J. (1993) Human lung microvessel endothelial cells: isolation, culture, and characterization. Microvasc. Res. 46, 89-102.
16. 16. Hewett, P. & Murray, J. (1993) Immunomagnetic purification of human microvessel endothelial cells using Dynabeads coated with monoclonal antibodies to PECAM-1. Eur. J. Cell Biol. 62, 451-454.
17. 17. Gress, T., Hoheisel, J., Lennon, G., Zehetner, G. & Lehrach, H. (1992) Hybridization fingerprinting of high-density cDNA-library arrays with cDNA pools derived from whole tissues. Mam. Genome 3, 609-619.
18. 18. Kolesnikowa, T. & Lau, L. (1998) Human CYR61-mediated enhancement of bFGF-induced DNA synthesis in human umbilical vein endothelial cells. Oncogene 16, 747-754.
19. 19. Kireeva, M., Lam, S. & Lau, L. (1998) Adhesion of human umbilical vein endothelial cells to the immediate-early gene product Cyr61 is mediated through integrin αvβ3. J. Biol. Chem. 273, 3090-3096.
20. 20. Shimo, T., Nakanishi, T., Kimura, Y., Nishida, T., Ishizeki, K., Matsumura, T. & Takigawa, M. (1998) Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells. J. Biochem. 124, 130-140.
21. 21. Babic, A., Kireeva, M., Kolesnikova, T. & Lau, L. (1998) CYR61, a product of a growth factor-inducible immediate early gene, promotes angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA 95, 6355-6360.
22. 22. RayChaudhury, A. & D'Amore, P. (1991) Endothelial cell regulation by transforming growth factor beta. J. Cell Biochem. 47, 224-229.
23. 23. Kozian, D., Ziehe, M. & Augustin, H. (1997) The activin-binding protein follistatin regulates autocrine endothelial cell activity and induces angiogenesis. Lab. Invest. 76, 267-276.
24. 24. McCarthy, S. & Bicknell, R. (1993) Inhibition of vascular endothelial cell growth by activin-A. J. Biol. Chem. 268, 23066-23071.
25. 25. Suzuki, A., Chang, C., Yingling, J., Wang, X. & Hemmati-Brivanlou, A. (1997) Smad5 induces ventral fates in Xenopus embryo. Dev. Biol. 184, 402-405.
26. 26. Derynck, R. (1998) SMAD proteins and mammalian anatomy. Nature 393, 737-738.
27. 27. Ebisawa, T., Tada, K., Kitajima, I., Tojo, K., Sampath, T., Kabawata, M., Miyazono, K. & Imamura, T. (1999) Characterization of bone morphogenetic protein-6 signaling pathways in osteoblast differentiation. J. Cell Sci. 112, 3519-3527.
28. 28. Solloway, M., Dudley, A., Bikoff, E., Lyons, K., Hogan, B. & Robertson, E. (1998) Mice lacking Bmp6 function. Dev. Genet. 22, 321-339.
29. 29. Yang, X., Castilla, L., Xu, X., Li, C., Gotay, J., Weinstein, M., Liu, P. & Deng, C.X. (1999) Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5. Development 126, 1571-1580.
30. 30. Polverini, P. (1996) Cellular Adhesion Molecules. Am. J. Pathol. 148, 1023-1029.
31. 31. Griffioen, A., Coenen, M., Damen, C., Hellwig, S., van Weering, D., Vooys, W., Blijham, G. & Groenewegen, G. (1997) CD44 Is involved in tumor angiogenesis; an activation antigen on human endothelial cells. Blood 90, 1150-1159.
32. 32. Neidhart, M., Wehrli, R., Bruhlmann, P., Michel, B., Gay, R. & Gay, S. (1999) Synovial fluid CD146 (MUC18), a marker for synovial membrane angiogenesis in rheumatoid arthritis. Arthritis Rheum. 42, 622-630.
33. 33. DeLisser, H., Christofidou-Solomodou, M., Strieter, R., Burdick, M., Robinson, C., Wexler, R., Kerr, J., Garlanda, C., Merwin, J., Madri, J. & Albelda, S. (1997) Involvement of endothelial PECAM-1/CD31 in angiogenesis. Am. J. Pathol. 151, 671-677.
34. 34. Volkmer, H., Leuschner, R., Zacharias, U. & Rathjen, F. (1996) Neurofascin induces neurites by heterophilic interactions with axonal NrCAM while NrCAM requires F11 on the axonal surface to extend neurites. J. Cell Biol. 135, 1059-1069.
35. 35. Treubert, U. & Brümmendorf, T. (1998) Functional cooperation of ß1-integrins and members of the Ig superfamily in neurite outgrowth induction. J. Neuroscience 18, 1795-1805.
36. 36. Gamble, J., Matthias, L., Meyer, G., Kaur, P., Russ, G., Faull, R., Berndt, M. & Vadas, M. (1993) Regulation of in vitro capillary tube formation by anti-integrin antibodies. J. Cell Biol. 121, 931-943.
37. 37. Klein, S., Giancotti, F., Presta, M., Albelda, S., Buck, C. & Rifkin, D. (1993) Basic fibroblast growth factor modulates integrin expression in microvascular endothelial cells. Mol. Biol. Cell 4, 973-982.
38. 38. Brooks, P., Montgomery, A., Rosenfeld, M., Reisfeld, R., Hu, T., Klier, G. & Cheresh, D. (1994) Integrin αvβ3 antagonists promote tumor regression by inducing apoptosis of angiogenic blood vessels. Cell 79, 1157-1164.
39. 39. Brooks, P., Clark, R. & Cheresh, D. (1994) Requirement of vascular integrin αvβ3 for angiogenesis. Science 264, 569-571.
40. 40. Friedlander, M., Brooks, P., Shaffer, R., Kincaid, C., Varner, J. & Cheresh, D. (1995) Definition of two angiogenic pathways by distinct αv integrins. Science 270, 1500-1502.
41. 41. Ramos, J., Kojima, T., Hughes, P., Fenczik, C. & Ginsberg, M. (1998) The death effector domain of PEA-15 is involved in its regulation of integrin activation. J. Biol. Chem. 273, 33897-33900.
42. 42. Tu, Y., Li, F., Goicoechea, S. & Wu, C. (1999) The LIM-only protein PINCH directly interacts with integrin-linked kinase and is recruited to integrin-rich sites in spreading cells. Mol. Cell. Biol. 19, 2425-2434.
43. 43. Schnittler, H. (1998) Structural and functional aspects of intercellular junctions in vascular endothelium. Basic Res. Cardiol. 93 (Suppl. 3), 30-39.
44. 44. Merwin, J., Anderson, J., Kocher, O., Van Itallie, C. & Madri, J. (1990) Transforming growth factor beta 1 modulates extracellular matrix organization and cell-cell junctional complex formation during in vitro angiogenesis. J. Cell Physiol. 142, 117-128.
45. 45. Furuse, M., Fujita, K., Hiiragi, T., Fujimoto, K. & Tsukita, S. (1998) Claudin-1 and -2: novel integral membrane proteins localizing at tight junctions with no sequence similarity to occludin. J. Cell Biol. 141, 1539-1550.
46. 46. Furuse, M., Sasaki, H., Fujimoto, K. & Tsukita, S. (1998) A single gene product, claudin-1 or -2, reconstitutes tight junction strands and recruits occludin in fibroblasts. J. Cell Biol. 143, 391-401.
47. 47. Morita, K., Furuse, M., Fujimoto, K. & Tsukita, S. (1999) Claudin multigene family encoding four-transmembrane domain protein components of tight junction strands. Proc. Natl Acad. Sci. USA 96, 511-516.
48. 48. Hanahan, D. & Folkman, J. (1996) Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 86, 353-364.
49. 49. Montesano, R., Pepper, M., Möhle-Steinlein, U., Risau, W., Wagner, E. & Orci, L. (1990) Increased proteolytic activity is responsible for the aberrant morphogenetic behaviour of endothelial cells expressing the middle T oncogene. Cell 62, 435-445.
50. 50. Montesano, R. & Orci, L. (1985) Tumor-promoting phorbol esters induce angiogenesis in vitro. Cell 42, 469-477.
51. 51. Bajou, K., Noel, A., Gerard, R., Masson, V., Brunner, N., Holst-Hansen, C., Skobe, M., Fusenig, N., Carmeliet, P., Collen, D. & Foidart, J. (1998) Absence of host plasminogen activator inhibitor 1 prevents cancer invasion and vascularization. Nat. Med. 4, 923-928.
52. 52. Hiraoka, N., Allen, E., Apel. I., Gyetko, M. & Weiss, S. (1998) Matrix metalloproteinases regulate neovascularization by acting as pericellular fibrinolysins. Cell 95, 365-377.
53. 53. Brooks, P., Strömblad, S., Sanders, L., von Schalscha, T., Aimes, R., Stetler-Stevenson, W., Quigley, J. & Cheresh, D. (1996) Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin αvβ3. Cell 85, 683-693.
54. 54. Sato, Y., Okamura, K., Morimoto, A., Hamanaka, R., Hamaguchi, K., Shimada, T., Ono, M., Kohno, K., Sakata, T. & Kuwano, M. (1993) Indispensable role of tissue-type plasminogen activator in growth factor-dependent tube formation of human microvascular endothelial cells in vitro. Exp. Cell Res. 204, 223-229.
55. 55. Mandriota, S. & Pepper, M. (1997) Vascular endothelial growth factor-induced in vitro angiogenesis and plasminogen activator expression are dependent on endogenous basic fibroblast growth factor. J. Cell Sci. 110, 2293-2302.
56. 56. Schnaper, H., Barnathan, E., Mazar, A., Maheshwari, S., Ellis, S., Cortez, S., Barcios, W. & Kleinman, H. (1995) Plasminogen activators augment endothelial cell organization in vitro by two distinct pathways. J. Cell Physiol. 165, 107-118.
57. 57. Kuno, K., Kanada, N., Nakashima, E., Fujiki, F., Ichimura, F. & Matsushima, K. (1997) Molecular Cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. J. Biol. Chem. 272, 556-562.
58. 58. Vazquez, F., Hastings, G., Ortega, M., Lane, T., Oikemus, S., Lombardo, M. & Iruela-Arispe, L. (1999) METH-1, a human ortholog of ADAMTS-1, and METH-2 are members of a new family of proteins with angio-inhibitory activity. J. Biol. Chem. 274, 23349-23357.
59. 59. Tortorella, M., Burn, T., Pratta, M., Hollis, J., Liu, R., Rosenfeld, S., Copeland, R., Deccio, C., Wynn, R., Rockwell, A., Yang, F., Duke, J., Solomon, K., George, H., Bruckner, R., Nagase, H., Itoh, Y, Ellis, D., Ross, H., Wiswall, B., Murphy, K., Hillman, M., Jr., Hollis, G., Newton, R., Magolda, R., Trzaskos, J. & Arner, E. (1999) Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins. Science 284, 1664-1666.