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Volumn 14, Issue 16, 2013, Pages 2023-2034

Not so pseudo anymore: Pseudogenes as therapeutic targets

Author keywords

epigenetics; lncRNAs; long noncoding RNAs; microRNA; miRNA; pseudogenes; therapeutics

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; APTAMER; LONG UNTRANSLATED RNA; MESSENGER RNA; SMALL INTERFERING RNA;

EID: 84888992963     PISSN: 14622416     EISSN: 17448042     Source Type: Journal    
DOI: 10.2217/pgs.13.172     Document Type: Review
Times cited : (33)

References (95)
  • 1
    • 0022293979 scopus 로고
    • Processed pseudogenes: Characteristics and evolution
    • Vanin EF. Processed pseudogenes: characteristics and evolution. Annu. Rev. Genet. 19, 253-272 (1985).
    • (1985) Annu. Rev. Genet. , vol.19 , pp. 253-272
    • Vanin, E.F.1
  • 3
    • 0017693139 scopus 로고
    • A pseudogene structure in 5S DNA of Xenopus laevis
    • Jacq C, Miller JR, Brownlee GG. A pseudogene structure in 5S DNA of Xenopus laevis. Cell 12(1), 109-120 (1977).
    • (1977) Cell , vol.12 , Issue.1 , pp. 109-120
    • Jacq, C.1    Miller, J.R.2    Brownlee, G.G.3
  • 4
    • 1542682570 scopus 로고    scopus 로고
    • Whole-genome screening indicates a possible burst of formation of processed pseudogenes and Alu repeats by particular L1 subfamilies in ancestral primates
    • Ohshima K, Hattori M, Yada T, Gojobori T, Sakaki Y, Okada N. Whole-genome screening indicates a possible burst of formation of processed pseudogenes and Alu repeats by particular L1 subfamilies in ancestral primates. Genome Biol. 4(11), R74 (2003).
    • (2003) Genome Biol. , vol.4 , Issue.11
    • Ohshima, K.1    Hattori, M.2    Yada, T.3    Gojobori, T.4    Sakaki, Y.5    Okada, N.6
  • 5
    • 0036180936 scopus 로고    scopus 로고
    • Molecular fossils in the human genome: Identification and analysis of the pseudogenes in chromosomes 21 and 22
    • Harrison PM, Hegyi H, Balasubramanian S et al. Molecular fossils in the human genome: identification and analysis of the pseudogenes in chromosomes 21 and 22. Genome Res. 12(2), 272-280 (2002).
    • (2002) Genome Res. , vol.12 , Issue.2 , pp. 272-280
    • Harrison, P.M.1    Hegyi, H.2    Balasubramanian, S.3
  • 6
    • 0342858851 scopus 로고    scopus 로고
    • Nature and structure of human genes that generate retropseudogenes
    • Gonçalves I, Duret L, Mouchiroud D. Nature and structure of human genes that generate retropseudogenes. Genome Res. 10(5), 672-678 (2000).
    • (2000) Genome Res. , vol.10 , Issue.5 , pp. 672-678
    • Gonçalves, I.1    Duret, L.2    Mouchiroud, D.3
  • 7
    • 0015271630 scopus 로고
    • So much 'junk' DNA in our genome
    • Ohno S. So much 'junk' DNA in our genome. Brookhaven Symp. Biol. 23, 366-370 (1972).
    • (1972) Brookhaven Symp. Biol. , vol.23 , pp. 366-370
    • Ohno, S.1
  • 8
    • 0035895505 scopus 로고    scopus 로고
    • The sequence of the human genome
    • Venter JC, Adams MD, Myers EW et al. The sequence of the human genome. Science 291(5507), 1304-1351 (2001).
    • (2001) Science , vol.291 , Issue.5507 , pp. 1304-1351
    • Venter, J.C.1    Adams, M.D.2    Myers, E.W.3
  • 9
    • 2042437650 scopus 로고    scopus 로고
    • Initial sequencing and analysis of the human genome
    • Lander ES, Linton LM, Birren B et al. Initial sequencing and analysis of the human genome. Nature 409(6822), 860-921 (2001).
    • (2001) Nature , vol.409 , Issue.6822 , pp. 860-921
    • Lander, E.S.1    Linton, L.M.2    Birren, B.3
  • 10
    • 0014690698 scopus 로고
    • Gene regulation for higher cells: A theory
    • Britten RJ, Davidson EH. Gene regulation for higher cells: a theory. Science 165(3891), 349-357 (1969).
    • (1969) Science , vol.165 , Issue.3891 , pp. 349-357
    • Britten, R.J.1    Davidson, E.H.2
  • 11
    • 0015070886 scopus 로고
    • Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty
    • Britten RJ, Davidson EH. Repetitive and non-repetitive DNA sequences and a speculation on the origins of evolutionary novelty. Q. Rev. Biol. 46(2), 111-138 (1971).
    • (1971) Q. Rev. Biol. , vol.46 , Issue.2 , pp. 111-138
    • Britten, R.J.1    Davidson, E.H.2
  • 12
    • 40249098860 scopus 로고    scopus 로고
    • Extensive gains and losses of olfactory receptor genes in mammalian evolution
    • Niimura Y, Nei M. Extensive gains and losses of olfactory receptor genes in mammalian evolution. PLoS ONE 2(8), e708 (2007).
    • (2007) PLoS ONE , vol.2 , Issue.8
    • Niimura, Y.1    Nei, M.2
  • 15
    • 33745125901 scopus 로고    scopus 로고
    • The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene
    • Duret L, Chureau C, Samain S, Weissenbach J, Avner P. The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene. Science 312(5780), 1653-1655 (2006).
    • (2006) Science , vol.312 , Issue.5780 , pp. 1653-1655
    • Duret, L.1    Chureau, C.2    Samain, S.3    Weissenbach, J.4    Avner, P.5
  • 16
    • 77952694676 scopus 로고    scopus 로고
    • Identification and analysis of unitary pseudogenes: Historic and contemporary gene losses in humans and other primates
    • Zhang ZD, Frankish A, Hunt T, Harrow J, Gerstein M. Identification and analysis of unitary pseudogenes: historic and contemporary gene losses in humans and other primates. Genome Biol. 11(3), R26 (2010).
    • (2010) Genome Biol. , vol.11 , Issue.3
    • Zhang, Z.D.1    Frankish, A.2    Hunt, T.3    Harrow, J.4    Gerstein, M.5
  • 17
    • 0025885658 scopus 로고
    • Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis
    • Nishikimi M, Yagi K. Molecular basis for the deficiency in humans of gulonolactone oxidase, a key enzyme for ascorbic acid biosynthesis. Am. J. Clin. Nutr. 54(6 Suppl.), 1203S-1208S (1991).
    • (1991) Am. J. Clin. Nutr. , vol.54 , Issue.6 SUPPL.
    • Nishikimi, M.1    Yagi, K.2
  • 18
    • 77954743785 scopus 로고    scopus 로고
    • Mutational effects and the evolution of new protein functions
    • Soskine M, Tawfik DS. Mutational effects and the evolution of new protein functions. Nat. Rev. Genet. 11(8), 572-582 (2010).
    • (2010) Nat. Rev. Genet. , vol.11 , Issue.8 , pp. 572-582
    • Soskine, M.1    Tawfik, D.S.2
  • 19
    • 0022221496 scopus 로고
    • Recombination within the human embryonic xi-globin locus: A common xi-xi chromosome produced by gene conversion of the psi xi gene
    • Hill AV, Nicholls RD, Thein SL, Higgs DR. Recombination within the human embryonic xi-globin locus: a common xi-xi chromosome produced by gene conversion of the psi xi gene. Cell 42(3), 809-819 (1985).
    • (1985) Cell , vol.42 , Issue.3 , pp. 809-819
    • Hill, A.V.1    Nicholls, R.D.2    Thein, S.L.3    Higgs, D.R.4
  • 20
    • 0034079713 scopus 로고    scopus 로고
    • Human LINE retrotransposons generate processed pseudogenes
    • Esnault C, Maestre J, Heidmann T. Human LINE retrotransposons generate processed pseudogenes. Nat. Genet. 24(4), 363-367 (2000).
    • (2000) Nat. Genet. , vol.24 , Issue.4 , pp. 363-367
    • Esnault, C.1    Maestre, J.2    Heidmann, T.3
  • 21
    • 33644777605 scopus 로고    scopus 로고
    • Evolutionary fate of retroposed gene copies in the human genome
    • Vinckenbosch N, Dupanloup I, Kaessmann H. Evolutionary fate of retroposed gene copies in the human genome. Proc. Natl Acad. Sci. USA 103(9), 3220-3225 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.9 , pp. 3220-3225
    • Vinckenbosch, N.1    Dupanloup, I.2    Kaessmann, H.3
  • 22
    • 0031055331 scopus 로고    scopus 로고
    • Sequence patterns indicate an enzymatic involvement in integration of mammalian retroposons
    • Jurka J. Sequence patterns indicate an enzymatic involvement in integration of mammalian retroposons. Proc. Natl Acad. Sci. USA 94(5), 1872-1877 (1997).
    • (1997) Proc. Natl Acad. Sci. USA , vol.94 , Issue.5 , pp. 1872-1877
    • Jurka, J.1
  • 23
    • 34250377325 scopus 로고    scopus 로고
    • Pseudogenes in the ENCODE regions: Consensus annotation, analysis of transcription, and evolution
    • Zheng D, Frankish A, Baertsch R et al. Pseudogenes in the ENCODE regions: consensus annotation, analysis of transcription, and evolution. Genome Res. 17(6), 839-851 (2007).
    • (2007) Genome Res. , vol.17 , Issue.6 , pp. 839-851
    • Zheng, D.1    Frankish, A.2    Baertsch, R.3
  • 24
    • 0036796620 scopus 로고    scopus 로고
    • Identification and analysis of over 2000 ribosomal protein pseudogenes in the human genome
    • Zhang Z, Harrison P, Gerstein M. Identification and analysis of over 2000 ribosomal protein pseudogenes in the human genome. Genome Res. 12(10), 1466-1482 (2002).
    • (2002) Genome Res. , vol.12 , Issue.10 , pp. 1466-1482
    • Zhang, Z.1    Harrison, P.2    Gerstein, M.3
  • 25
    • 84857219241 scopus 로고    scopus 로고
    • The abundance of processed pseudogenes derived from glycolytic genes is correlated with their expression level
    • McDonell L, Drouin G. The abundance of processed pseudogenes derived from glycolytic genes is correlated with their expression level. Genome 55(2), 147-151 (2012).
    • (2012) Genome , vol.55 , Issue.2 , pp. 147-151
    • McDonell, L.1    Drouin, G.2
  • 26
    • 33646468946 scopus 로고    scopus 로고
    • Pseudo-messenger RNA: Phantoms of the transcriptome
    • Frith MC, Wilming LG, Forrest A et al. Pseudo-messenger RNA: phantoms of the transcriptome. PLoS Genet. 2(4), e23 (2006).
    • (2006) PLoS Genet. , vol.2 , Issue.4
    • Frith, M.C.1    Wilming, L.G.2    Forrest, A.3
  • 27
    • 17844396017 scopus 로고    scopus 로고
    • Transcribed processed pseudogenes in the human genome: An intermediate form of expressed retrosequence lacking protein-coding ability
    • Harrison PM, Zheng D, Zhang Z, Carriero N, Gerstein M. Transcribed processed pseudogenes in the human genome: an intermediate form of expressed retrosequence lacking protein-coding ability. Nucleic Acids Res. 33(8), 2374-2383 (2005).
    • (2005) Nucleic Acids Res. , vol.33 , Issue.8 , pp. 2374-2383
    • Harrison, P.M.1    Zheng, D.2    Zhang, Z.3    Carriero, N.4    Gerstein, M.5
  • 28
    • 79952255050 scopus 로고    scopus 로고
    • Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5
    • Hawkins PG, Morris KV. Transcriptional regulation of Oct4 by a long non-coding RNA antisense to Oct4-pseudogene 5. Transcription 1(3), 165-175 (2010).
    • (2010) Transcription , vol.1 , Issue.3 , pp. 165-175
    • Hawkins, P.G.1    Morris, K.V.2
  • 29
    • 0033568856 scopus 로고    scopus 로고
    • Neuronal expression of neural nitric oxide synthase (nNOS) protein is suppressed by an antisense RNA transcribed from an NOS pseudogene
    • Korneev SA, Park JH, O'Shea M. Neuronal expression of neural nitric oxide synthase (nNOS) protein is suppressed by an antisense RNA transcribed from an NOS pseudogene. J. Neurosci. 19(18), 7711-7720 (1999).
    • (1999) J. Neurosci. , vol.19 , Issue.18 , pp. 7711-7720
    • Korneev, S.A.1    Park, J.H.2    O'Shea, M.3
  • 30
    • 84876177255 scopus 로고    scopus 로고
    • A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells
    • Johnsson P, Ackley A, Vidarsdottir L et al. A pseudogene long-noncoding-RNA network regulates PTEN transcription and translation in human cells. Nat. Struct. Mol. Biol. 20(4), 440-446 (2013).
    • (2013) Nat. Struct. Mol. Biol. , vol.20 , Issue.4 , pp. 440-446
    • Johnsson, P.1    Ackley, A.2    Vidarsdottir, L.3
  • 31
    • 79960911703 scopus 로고    scopus 로고
    • The reality of pervasive transcription
    • discussion e1001102
    • Clark MB, Amaral PP, Schlesinger FJ et al. The reality of pervasive transcription. PLoS Biol. 9(7), e1000625; discussion e1001102 (2011).
    • (2011) PLoS Biol. , vol.9 , Issue.7
    • Clark, M.B.1    Amaral, P.P.2    Schlesinger, F.J.3
  • 32
    • 34250330777 scopus 로고    scopus 로고
    • What is a gene, post-ENCODE? History and updated definition
    • Gerstein MB, Bruce C, Rozowsky JS et al. What is a gene, post-ENCODE? history and updated definition. Genome Res. 17(6), 669-681 (2007).
    • (2007) Genome Res. , vol.17 , Issue.6 , pp. 669-681
    • Gerstein, M.B.1    Bruce, C.2    Rozowsky, J.S.3
  • 33
    • 84865757142 scopus 로고    scopus 로고
    • Landscape of transcription in human cells
    • Djebali S, Davis CA, Merkel A et al. Landscape of transcription in human cells. Nature 489(7414), 101-108 (2012).
    • (2012) Nature , vol.489 , Issue.7414 , pp. 101-108
    • Djebali, S.1    Davis, C.A.2    Merkel, A.3
  • 34
    • 84875275808 scopus 로고    scopus 로고
    • On the immortality of television sets: 'Function' in the human genome according to the evolution-free gospel of ENCODE
    • Graur D, Zheng Y, Price N, Azevedo RBR, Zufall RA, Elhaik E. On the immortality of television sets: 'function' in the human genome according to the evolution-free gospel of ENCODE. Genome Biol. Evol. 5(3), 578-590 (2013).
    • (2013) Genome Biol. Evol. , vol.5 , Issue.3 , pp. 578-590
    • Graur, D.1    Zheng, Y.2    Price, N.3    Rbr, A.4    Zufall, R.A.5    Elhaik, E.6
  • 35
    • 70349741137 scopus 로고    scopus 로고
    • Assessing the genomic evidence for conserved transcribed pseudogenes under selection
    • Khachane AN, Harrison PM. Assessing the genomic evidence for conserved transcribed pseudogenes under selection. BMC Genomics 10, 435 (2009).
    • (2009) BMC Genomics , vol.10 , pp. 435
    • Khachane, A.N.1    Harrison, P.M.2
  • 36
    • 8444232039 scopus 로고    scopus 로고
    • Nonneutral evolution of the transcribed pseudogene Makorin1-p1 in mice
    • Podlaha O, Zhang J. Nonneutral evolution of the transcribed pseudogene Makorin1-p1 in mice. Mol. Biol. Evol. 21(12), 2202-2209 (2004).
    • (2004) Mol. Biol. Evol. , vol.21 , Issue.12 , pp. 2202-2209
    • Podlaha, O.1    Zhang, J.2
  • 37
    • 33646941894 scopus 로고    scopus 로고
    • Genome-wide survey for biologically functional pseudogenes
    • Svensson O, Arvestad L, Lagergren J. Genome-wide survey for biologically functional pseudogenes. PLoS Comput. Biol. 2(5), e46 (2006).
    • (2006) PLoS Comput. Biol. , vol.2 , Issue.5
    • Svensson, O.1    Arvestad, L.2    Lagergren, J.3
  • 38
    • 84865726286 scopus 로고    scopus 로고
    • The GENCODE pseudogene resource
    • Pei B, Sisu C, Frankish A et al. The GENCODE pseudogene resource. Genome Biol. 13(9), R51 (2012).
    • (2012) Genome Biol. , vol.13 , Issue.9
    • Pei, B.1    Sisu, C.2    Frankish, A.3
  • 39
    • 2442699825 scopus 로고    scopus 로고
    • Increasing biological complexity is positively correlated with the relative genome-wide expansion of non-protein-coding DNA sequences
    • Taft RJ, Mattick JS. Increasing biological complexity is positively correlated with the relative genome-wide expansion of non-protein-coding DNA sequences. Genome Biol. 5(1), P1 (2003).
    • (2003) Genome Biol. , vol.5 , Issue.1
    • Taft, R.J.1    Mattick, J.S.2
  • 40
    • 0035865397 scopus 로고    scopus 로고
    • Our genome unveiled
    • Baltimore D. Our genome unveiled. Nature 409(6822), 814-816 (2001).
    • (2001) Nature , vol.409 , Issue.6822 , pp. 814-816
    • Baltimore, D.1
  • 41
    • 84862195751 scopus 로고    scopus 로고
    • Structural architecture of the human long non-coding RNA, steroid receptor RNA activator
    • Novikova IV, Hennelly SP, Sanbonmatsu KY. Structural architecture of the human long non-coding RNA, steroid receptor RNA activator. Nucleic Acids Res. 40(11), 5034-5051 (2012).
    • (2012) Nucleic Acids Res. , vol.40 , Issue.11 , pp. 5034-5051
    • Novikova, I.V.1    Hennelly, S.P.2    Sanbonmatsu, K.Y.3
  • 42
    • 0031691569 scopus 로고    scopus 로고
    • The mouse gene encoding the testis-specific isoform of poly(A) binding protein (Pabp2) is an expressed retroposon: Intimations that gene expression in spermatogenic cells facilitates the creation of new genes
    • Kleene KC, Mulligan E, Steiger D, Donohue K, Mastrangelo MA. The mouse gene encoding the testis-specific isoform of poly(A) binding protein (Pabp2) is an expressed retroposon: intimations that gene expression in spermatogenic cells facilitates the creation of new genes. J. Mol. Evol. 47(3), 275-281 (1998).
    • (1998) J. Mol. Evol. , vol.47 , Issue.3 , pp. 275-281
    • Kleene, K.C.1    Mulligan, E.2    Steiger, D.3    Donohue, K.4    Mastrangelo, M.A.5
  • 43
    • 84862695743 scopus 로고    scopus 로고
    • Expressed pseudogenes in the transcriptional landscape of human cancers
    • Kalyana-Sundaram S, Kumar-Sinha C, Shankar S et al. Expressed pseudogenes in the transcriptional landscape of human cancers. Cell 149(7), 1622-1634 (2012).
    • (2012) Cell , vol.149 , Issue.7 , pp. 1622-1634
    • Kalyana-Sundaram, S.1    Kumar-Sinha, C.2    Shankar, S.3
  • 44
    • 0033521873 scopus 로고    scopus 로고
    • Cloning, mRNA localization and evolutionary conservation of a human 5-HT7 receptor pseudogene
    • Olsen MA, Schechter LE. Cloning, mRNA localization and evolutionary conservation of a human 5-HT7 receptor pseudogene. Gene 227(1), 63-69 (1999).
    • (1999) Gene , vol.227 , Issue.1 , pp. 63-69
    • Olsen, M.A.1    Schechter, L.E.2
  • 45
    • 33644868889 scopus 로고    scopus 로고
    • Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin
    • Elliman SJ, Wu I, Kemp DM. Adult tissue-specific expression of a Dppa3-derived retrogene represents a postnatal transcript of pluripotent cell origin. J. Biol. Chem. 281(1), 16-19 (2006).
    • (2006) J. Biol. Chem. , vol.281 , Issue.1 , pp. 16-19
    • Elliman, S.J.1    Wu, I.2    Kemp, D.M.3
  • 46
    • 80052536392 scopus 로고    scopus 로고
    • RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders
    • Lin M, Pedrosa E, Shah A et al. RNA-Seq of human neurons derived from iPS cells reveals candidate long non-coding RNAs involved in neurogenesis and neuropsychiatric disorders. PLoS ONE 6(9), e23356 (2011).
    • (2011) PLoS ONE , vol.6 , Issue.9
    • Lin, M.1    Pedrosa, E.2    Shah, A.3
  • 47
    • 79960191759 scopus 로고    scopus 로고
    • A transcribed pseudogene of MYLK promotes cell proliferation
    • Han YJ, Ma SF, Yourek G, Park YD, Garcia JGN. A transcribed pseudogene of MYLK promotes cell proliferation. FASEB J. 25(7), 2305-2312 (2011).
    • (2011) FASEB J. , vol.25 , Issue.7 , pp. 2305-2312
    • Han, Y.J.1    Ma, S.F.2    Yourek, G.3    Park, Y.D.4    Garcia, J.G.N.5
  • 48
    • 27144549266 scopus 로고    scopus 로고
    • Oct4 pseudogenes are transcribed in cancers
    • Suo G, Han J, Wang X et al. Oct4 pseudogenes are transcribed in cancers. Biochem. Biophys. Res. Commun. 337(4), 1047-1051 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.337 , Issue.4 , pp. 1047-1051
    • Suo, G.1    Han, J.2    Wang, X.3
  • 50
    • 58249116121 scopus 로고    scopus 로고
    • Oncogenic activation of MAP kinase by BRAF pseudogene in thyroid tumors
    • Zou M, Baitei EY, Alzahrani AS et al. Oncogenic activation of MAP kinase by BRAF pseudogene in thyroid tumors. Neoplasia 11(1), 57-65 (2009).
    • (2009) Neoplasia , vol.11 , Issue.1 , pp. 57-65
    • Zou, M.1    Baitei, E.Y.2    Alzahrani, A.S.3
  • 51
    • 0033991343 scopus 로고    scopus 로고
    • Detection of a putative HLA-A 31012 processed (intronless) pseudogene in a laryngeal squamous cell carcinoma
    • Feenstra M, Bakema J, Verdaasdonk M et al. Detection of a putative HLA-A 31012 processed (intronless) pseudogene in a laryngeal squamous cell carcinoma. Genes Chromosomes Cancer 27(1), 26-34 (2000).
    • (2000) Genes Chromosomes Cancer , vol.27 , Issue.1 , pp. 26-34
    • Feenstra, M.1    Bakema, J.2    Verdaasdonk, M.3
  • 52
    • 0033522145 scopus 로고    scopus 로고
    • Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN
    • Fujii GH, Morimoto AM, Berson AE, Bolen JB. Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN. Oncogene 18(9), 1765-1769 (1999).
    • (1999) Oncogene , vol.18 , Issue.9 , pp. 1765-1769
    • Fujii, G.H.1    Morimoto, A.M.2    Berson, A.E.3    Bolen, J.B.4
  • 53
    • 84455191835 scopus 로고    scopus 로고
    • Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma
    • Tsitsiou E, Williams AE, Moschos SA et al. Transcriptome analysis shows activation of circulating CD8+ T cells in patients with severe asthma. J. Allergy Clin. Immunol. 129(1), 95-103 (2012).
    • (2012) J. Allergy Clin. Immunol. , vol.129 , Issue.1 , pp. 95-103
    • Tsitsiou, E.1    Williams, A.E.2    Moschos, S.A.3
  • 54
    • 84855911746 scopus 로고    scopus 로고
    • Next-generation sequencing reveals HIV-1-mediated suppression of T cell activation and RNA processing and regulation of noncoding RNA expression in a CD4+ T cell line
    • Chang ST, Sova P, Peng X et al. Next-generation sequencing reveals HIV-1-mediated suppression of T cell activation and RNA processing and regulation of noncoding RNA expression in a CD4+ T cell line. MBio 2(5), pii: e00134-11 (2011).
    • (2011) MBio , vol.2 , Issue.5
    • Chang, S.T.1    Sova, P.2    Peng, X.3
  • 55
    • 84856793694 scopus 로고    scopus 로고
    • Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and Type 2 diabetes
    • Chiefari E, Iiritano S, Paonessa F et al. Pseudogene-mediated posttranscriptional silencing of HMGA1 can result in insulin resistance and Type 2 diabetes. Nat. Commun. 1, 40 (2010).
    • (2010) Nat. Commun. , vol.1 , Issue.40
    • Chiefari, E.1    Iiritano, S.2    Paonessa, F.3
  • 56
    • 0038414560 scopus 로고    scopus 로고
    • An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene
    • Hirotsune S, Yoshida N, Chen A et al. An expressed pseudogene regulates the messenger-RNA stability of its homologous coding gene. Nature 423(6935), 91-96 (2003).
    • (2003) Nature , vol.423 , Issue.6935 , pp. 91-96
    • Hirotsune, S.1    Yoshida, N.2    Chen, A.3
  • 57
    • 33747066408 scopus 로고    scopus 로고
    • The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans
    • Gray TA, Wilson A, Fortin PJ, Nicholls RD. The putatively functional Mkrn1-p1 pseudogene is neither expressed nor imprinted, nor does it regulate its source gene in trans. Proc. Natl Acad. Sci. USA 103(32), 12039-12044 (2006).
    • (2006) Proc. Natl Acad. Sci. USA , vol.103 , Issue.32 , pp. 12039-12044
    • Gray, T.A.1    Wilson, A.2    Fortin, P.J.3    Nicholls, R.D.4
  • 59
    • 8144225486 scopus 로고    scopus 로고
    • MicroRNA genes are transcribed by RNA polymerase II
    • Lee Y, Kim M, Han J et al. MicroRNA genes are transcribed by RNA polymerase II. EMBO J. 23(20), 4051-4060 (2004).
    • (2004) EMBO J. , vol.23 , Issue.20 , pp. 4051-4060
    • Lee, Y.1    Kim, M.2    Han, J.3
  • 60
    • 0141843656 scopus 로고    scopus 로고
    • The nuclear RNase III Drosha initiates microRNA processing
    • Lee Y, Ahn C, Han J et al. The nuclear RNase III Drosha initiates microRNA processing. Nature 425(6956), 415-419 (2003).
    • (2003) Nature , vol.425 , Issue.6956 , pp. 415-419
    • Lee, Y.1    Ahn, C.2    Han, J.3
  • 61
    • 0035905766 scopus 로고    scopus 로고
    • Role for a bidentate ribonuclease in the initiation step of RNA interference
    • Bernstein E, Caudy AA, Hammond SM, Hannon GJ. Role for a bidentate ribonuclease in the initiation step of RNA interference. Nature 409(6818), 363-366 (2001).
    • (2001) Nature , vol.409 , Issue.6818 , pp. 363-366
    • Bernstein, E.1    Caudy, A.A.2    Hammond, S.M.3    Hannon, G.J.4
  • 62
    • 4444368187 scopus 로고    scopus 로고
    • Argonaute2 is the catalytic engine of mammalian RNAi
    • Liu J, Carmell MA, Rivas FV et al. Argonaute2 is the catalytic engine of mammalian RNAi. Science 305(5689), 1437-1441 (2004).
    • (2004) Science , vol.305 , Issue.5689 , pp. 1437-1441
    • Liu, J.1    Carmell, M.A.2    Rivas, F.V.3
  • 63
    • 0041691111 scopus 로고    scopus 로고
    • MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms
    • Zeng Y, Yi R, Cullen BR. MicroRNAs and small interfering RNAs can inhibit mRNA expression by similar mechanisms. Proc. Natl Acad. Sci. USA 100(17), 9779-9784 (2003).
    • (2003) Proc. Natl Acad. Sci. USA , vol.100 , Issue.17 , pp. 9779-9784
    • Zeng, Y.1    Yi, R.2    Cullen, B.R.3
  • 64
    • 77955644289 scopus 로고    scopus 로고
    • Mammalian microRNAs predominantly act to decrease target mRNA levels
    • Guo H, Ingolia NT, Weissman JS, Bartel DP. Mammalian microRNAs predominantly act to decrease target mRNA levels. Nature 466(7308), 835-840 (2010).
    • (2010) Nature , vol.466 , Issue.7308 , pp. 835-840
    • Guo, H.1    Ingolia, N.T.2    Weissman, J.S.3    Bartel, D.P.4
  • 65
    • 84876935138 scopus 로고    scopus 로고
    • Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding
    • Helwak A, Kudla G, Dudnakova T, Tollervey D. Mapping the human miRNA interactome by CLASH reveals frequent noncanonical binding. Cell 153(3), 654-665 (2013).
    • (2013) Cell , vol.153 , Issue.3 , pp. 654-665
    • Helwak, A.1    Kudla, G.2    Dudnakova, T.3    Tollervey, D.4
  • 66
    • 33748363713 scopus 로고    scopus 로고
    • L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells
    • Yang N, Kazazian HH. L1 retrotransposition is suppressed by endogenously encoded small interfering RNAs in human cultured cells. Nat. Struct. Mol. Biol. 13(9), 763-771 (2006).
    • (2006) Nat. Struct. Mol. Biol. , vol.13 , Issue.9 , pp. 763-771
    • Yang, N.1    Kazazian, H.H.2
  • 68
    • 44349130233 scopus 로고    scopus 로고
    • Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes
    • Watanabe T, Totoki Y, Toyoda A et al. Endogenous siRNAs from naturally formed dsRNAs regulate transcripts in mouse oocytes. Nature 453(7194), 539-543 (2008).
    • (2008) Nature , vol.453 , Issue.7194 , pp. 539-543
    • Watanabe, T.1    Totoki, Y.2    Toyoda, A.3
  • 69
    • 44349159416 scopus 로고    scopus 로고
    • Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes
    • Tam OH, Aravin AA, Stein P et al. Pseudogene-derived small interfering RNAs regulate gene expression in mouse oocytes. Nature 453(7194), 534-538 (2008).
    • (2008) Nature , vol.453 , Issue.7194 , pp. 534-538
    • Tam, O.H.1    Aravin, A.A.2    Stein, P.3
  • 70
    • 84876028103 scopus 로고    scopus 로고
    • Transcribed pseudogene yPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma
    • Chan WL, Yuo CY, Yang WK et al. Transcribed pseudogene yPPM1K generates endogenous siRNA to suppress oncogenic cell growth in hepatocellular carcinoma. Nucleic Acids Res. 41(6), 3734-3747 (2013).
    • (2013) Nucleic Acids Res. , vol.41 , Issue.6 , pp. 3734-3747
    • Chan, W.L.1    Yuo, C.Y.2    Yang, W.K.3
  • 71
    • 52049098967 scopus 로고    scopus 로고
    • Bourc'his D et al. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice
    • Aravin AA, Sachidanandam R, Bourc'his D et al. A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice. Mol. Cell 31(6), 785-799 (2008).
    • (2008) Mol. Cell , vol.31 , Issue.6 , pp. 785-799
    • Aravin, A.A.1    Sachidanandam, R.2
  • 72
    • 34248160438 scopus 로고    scopus 로고
    • Developmentally regulated piRNA clusters implicate MILI in transposon control
    • Aravin AA, Sachidanandam R, Girard A, Fejes-Toth K, Hannon GJ. Developmentally regulated piRNA clusters implicate MILI in transposon control. Science 316(5825), 744-747 (2007).
    • (2007) Science , vol.316 , Issue.5825 , pp. 744-747
    • Aravin, A.A.1    Sachidanandam, R.2    Girard, A.3    Fejes-Toth, K.4    Hannon, G.J.5
  • 73
    • 33947720638 scopus 로고    scopus 로고
    • MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline
    • Carmell MA, Girard A, van de Kant HJG et al. MIWI2 is essential for spermatogenesis and repression of transposons in the mouse male germline. Dev. Cell 12(4), 503-514 (2007).
    • (2007) Dev. Cell , vol.12 , Issue.4 , pp. 503-514
    • Carmell, M.A.1    Girard, A.2    Van De Kant, H.J.G.3
  • 74
    • 34547497309 scopus 로고    scopus 로고
    • Target mimicry provides a new mechanism for regulation of microRNA activity
    • Franco-Zorrilla JM, Valli A, Todesco M et al. Target mimicry provides a new mechanism for regulation of microRNA activity. Nat. Genet. 39(8), 1033-1037 (2007).
    • (2007) Nat. Genet. , vol.39 , Issue.8 , pp. 1033-1037
    • Franco-Zorrilla, J.M.1    Valli, A.2    Todesco, M.3
  • 75
    • 79961170994 scopus 로고    scopus 로고
    • A ceRNA hypothesis: The Rosetta stone of a hidden RNA language
    • Salmena L, Poliseno L, Tay Y, Kats L, Pandolfi PP. A ceRNA hypothesis: the Rosetta stone of a hidden RNA language? Cell 146(3), 353-358 (2011).
    • (2011) Cell , vol.146 , Issue.3 , pp. 353-358
    • Salmena, L.1    Poliseno, L.2    Tay, Y.3    Kats, L.4    Pandolfi, P.P.5
  • 76
    • 77953957633 scopus 로고    scopus 로고
    • A coding-independent function of gene and pseudogene mRNAs regulates tumour biology
    • Poliseno L, Salmena L, Zhang J, Carver B, Haveman WJ, Pandolfi PP. A coding-independent function of gene and pseudogene mRNAs regulates tumour biology. Nature 465(7301), 1033-1038 (2010).
    • (2010) Nature , vol.465 , Issue.7301 , pp. 1033-1038
    • Poliseno, L.1    Salmena, L.2    Zhang, J.3    Carver, B.4    Haveman, W.J.5    Pandolfi, P.P.6
  • 77
    • 80054700538 scopus 로고    scopus 로고
    • Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs
    • Tay Y, Kats L, Salmena L et al. Coding-independent regulation of the tumor suppressor PTEN by competing endogenous mRNAs. Cell 147(2), 344-357 (2011).
    • (2011) Cell , vol.147 , Issue.2 , pp. 344-357
    • Tay, Y.1    Kats, L.2    Salmena, L.3
  • 78
    • 80054689794 scopus 로고    scopus 로고
    • An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma
    • Sumazin P, Yang X, Chiu HS et al. An extensive microRNA-mediated network of RNA-RNA interactions regulates established oncogenic pathways in glioblastoma. Cell 147(2), 370-381 (2011).
    • (2011) Cell , vol.147 , Issue.2 , pp. 370-381
    • Sumazin, P.1    Yang, X.2    Chiu, H.S.3
  • 79
    • 80054681545 scopus 로고    scopus 로고
    • In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma
    • Karreth FA, Tay Y, Perna D et al. In vivo identification of tumor-suppressive PTEN ceRNAs in an oncogenic BRAF-induced mouse model of melanoma. Cell 147(2), 382-395 (2011).
    • (2011) Cell , vol.147 , Issue.2 , pp. 382-395
    • Karreth, F.A.1    Tay, Y.2    Perna, D.3
  • 80
    • 4243110417 scopus 로고    scopus 로고
    • Pten dose dictates cancer progression in the prostate
    • Trotman LC, Niki M, Dotan ZA et al. Pten dose dictates cancer progression in the prostate. PLoS Biol. 1(3), E59 (2003).
    • (2003) PLoS Biol. , vol.1 , Issue.3
    • Trotman, L.C.1    Niki, M.2    Dotan, Z.A.3
  • 81
    • 77951765345 scopus 로고    scopus 로고
    • Subtle variations in Pten dose determine cancer susceptibility
    • Alimonti A, Carracedo A, Clohessy JG et al. Subtle variations in Pten dose determine cancer susceptibility. Nat. Genet. 42(5), 454-458 (2010).
    • (2010) Nat. Genet. , vol.42 , Issue.5 , pp. 454-458
    • Alimonti, A.1    Carracedo, A.2    Clohessy, J.G.3
  • 82
    • 80855130832 scopus 로고    scopus 로고
    • Deletion of PTENP1 pseudogene in human melanoma
    • Poliseno L, Haimovic A, Christos PJ et al. Deletion of PTENP1 pseudogene in human melanoma. J. Invest. Dermatol. 131(12), 2497-2500 (2011).
    • (2011) J. Invest. Dermatol. , vol.131 , Issue.12 , pp. 2497-2500
    • Poliseno, L.1    Haimovic, A.2    Christos, P.J.3
  • 83
    • 67650921949 scopus 로고    scopus 로고
    • Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression
    • Khalil AM, Guttman M, Huarte M et al. Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression. Proc. Natl Acad. Sci. USA 106(28), 11667-11672 (2009).
    • (2009) Proc. Natl Acad. Sci. USA , vol.106 , Issue.28 , pp. 11667-11672
    • Khalil, A.M.1    Guttman, M.2    Huarte, M.3
  • 84
    • 77951118936 scopus 로고    scopus 로고
    • Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
    • Gupta RA, Shah N, Wang KC et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis. Nature 464(7291), 1071-1076 (2010).
    • (2010) Nature , vol.464 , Issue.7291 , pp. 1071-1076
    • Gupta, R.A.1    Shah, N.2    Wang, K.C.3
  • 85
    • 33646147563 scopus 로고    scopus 로고
    • Intergenic transcripts regulate the epigenetic state of rRNA genes
    • Mayer C, Schmitz KM, Li J, Grummt I, Santoro R. Intergenic transcripts regulate the epigenetic state of rRNA genes. Mol. Cell 22(3), 351-361 (2006).
    • (2006) Mol. Cell , vol.22 , Issue.3 , pp. 351-361
    • Mayer, C.1    Schmitz, K.M.2    Li, J.3    Grummt, I.4    Santoro, R.5
  • 86
    • 38049155825 scopus 로고    scopus 로고
    • Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA
    • Yu W, Gius D, Onyango P et al. Epigenetic silencing of tumour suppressor gene p15 by its antisense RNA. Nature 451(7175), 202-206 (2008).
    • (2008) Nature , vol.451 , Issue.7175 , pp. 202-206
    • Yu, W.1    Gius, D.2    Onyango, P.3
  • 87
    • 84879166632 scopus 로고    scopus 로고
    • Therapeutic targeting of non-coding RNAs
    • Roberts TC, Wood MJA. Therapeutic targeting of non-coding RNAs. Essays Biochem. 54(1), 127-145 (2013).
    • (2013) Essays Biochem. , vol.54 , Issue.1 , pp. 127-145
    • Roberts, T.C.1    Wood, M.J.A.2
  • 88
    • 84880923165 scopus 로고    scopus 로고
    • Safety and pharmacokinetics of the antisense oligonucleotide (ASO) LY2181308 as a single-agent or in combination with idarubicin and cytarabine in patients with refractory or relapsed acute myeloid leukemia (AML)
    • Erba HP, Sayar H, Juckett M et al. Safety and pharmacokinetics of the antisense oligonucleotide (ASO) LY2181308 as a single-agent or in combination with idarubicin and cytarabine in patients with refractory or relapsed acute myeloid leukemia (AML). Invest. New Drugs 31(4), 1023-1034 (2013).
    • (2013) Invest. New Drugs , vol.31 , Issue.4 , pp. 1023-1034
    • Erba, H.P.1    Sayar, H.2    Juckett, M.3
  • 89
    • 84860353437 scopus 로고    scopus 로고
    • Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation
    • Modarresi F, Faghihi MA, Lopez-Toledano MA et al. Inhibition of natural antisense transcripts in vivo results in gene-specific transcriptional upregulation. Nat. Biotechnol. 30(5), 453-459 (2012).
    • (2012) Nat. Biotechnol. , vol.30 , Issue.5 , pp. 453-459
    • Modarresi, F.1    Faghihi, M.A.2    Lopez-Toledano, M.A.3
  • 91
    • 34247540352 scopus 로고    scopus 로고
    • Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity
    • Ivanova G, Reigadas S, Ittig D et al. Tricyclo-DNA containing oligonucleotides as steric block inhibitors of human immunodeficiency virus type 1 tat-dependent trans-activation and HIV-1 infectivity. Oligonucleotides 17(1), 54-65 (2007).
    • (2007) Oligonucleotides , vol.17 , Issue.1 , pp. 54-65
    • Ivanova, G.1    Reigadas, S.2    Ittig, D.3
  • 92
    • 78651390167 scopus 로고    scopus 로고
    • Long intergenic noncoding RNAs: New links in cancer progression
    • Tsai MC, Spitale RC, Chang HY. Long intergenic noncoding RNAs: new links in cancer progression. Cancer Res. 71(1), 3-7 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.1 , pp. 3-7
    • Tsai, M.C.1    Spitale, R.C.2    Chang, H.Y.3
  • 94
    • 84857784900 scopus 로고    scopus 로고
    • Progress toward in vivo use of siRNAs-II
    • Rettig GR, Behlke MA. Progress toward in vivo use of siRNAs-II. Mol. Ther. 20(3), 483-512 (2012).
    • (2012) Mol. Ther. , vol.20 , Issue.3 , pp. 483-512
    • Rettig, G.R.1    Behlke, M.A.2
  • 95
    • 33644620908 scopus 로고    scopus 로고
    • Chemical modification of siRNAs to improve serum stability without loss of efficacy
    • Choung S, Kim YJ, Kim S, Park HO, Choi YC. Chemical modification of siRNAs to improve serum stability without loss of efficacy. Biochem. Biophys. Res. Commun. 342(3), 919-927 (2006).
    • (2006) Biochem. Biophys. Res. Commun. , vol.342 , Issue.3 , pp. 919-927
    • Choung, S.1    Kim, Y.J.2    Kim, S.3    Park, H.O.4    Choi, Y.C.5


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