The Xist RNA gene evolved in eutherians by pseudogenization of a protein-coding gene

Science

Volumn 312, Issue 5780, 2006, Pages 1653-1655

  Duret, Laurent ^a   Chureau, Corinne ^b   Samain, Sylvie ^c   Weissanbach, Jean ^c   Avner, Philip ^b  

^a UNIVERSITÉ LYON 1   (France)

^b INSTITUT PASTEUR   (France)

^c CENTRE NATIONAL DE SÉQUENÇAGE   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CHROMOSOMES; GENETIC ENGINEERING; PROTEINS;

EUTHERIANS AND MARSUPIALS; PROTEIN-CODING GENE; PROTO-XIST; PSEUDOGENIZATION;

RNA;

PDZ PROTEIN; RNA;

CHROMOSOME; DIVERGENCE; GENE; GENETIC ANALYSIS; MARSUPIAL; PROTEIN; RNA;

ARTICLE; CDX4 GENE; CHIC1 GENE; CHICKEN; CONTROLLED STUDY; EUTHERIAN; EXON; FRAMESHIFT MUTATION; GENE; GENE DOSAGE; HUMAN; MAMMAL; MARSUPIAL; MONOTREMATE; MOUSE; NONHUMAN; PHYLOGENETIC TREE; PRIORITY JOURNAL; PSEUDOGENE; RNA GENE; SEQUENCE HOMOLOGY; X CHROMOSOME INACTIVATION; XENOPUS; XIC GENE; XIST GENE; XPCT GENE;

ANIMALS; CATTLE; CHICKENS; DOGS; EVOLUTION, MOLECULAR; EXONS; FEMALE; HUMANS; MALE; MAMMALS; MICE; MOLECULAR SEQUENCE DATA; OPOSSUMS; PHYLOGENY; PSEUDOGENES; RNA, UNTRANSLATED; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, NUCLEIC ACID; VERTEBRATES; X CHROMOSOME INACTIVATION; XENOPUS;

EUTHERIA; MAMMALIA; METATHERIA;

EID: 33745125901     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1126316     Document Type: Article

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19. This work was supported by the CNRS, the Institut Pasteur, the Genoscope, the European Union Epigenome Network of Excellence, and the Mission de la Recherche et de la Technologie. We thank the Broad Institute for making the opossum sequences publicly available. Sequences have been deposited in EMBL (accession numbers AM230659 and AM230660).