Neuronal expression of neural nitric oxide synthase (nNOS) protein is suppressed by an antisense RNA transcribed from an NOS pseudogene

Journal of Neuroscience

Volumn 19, Issue 18, 1999, Pages 7711-7720

  Korneev, Sergei A ^a   Park, Ji Ho ^a   O'Shea, Michael ^a  

^a UNIVERSITY OF SUSSEX   (United Kingdom)

Author keywords

Antisense; dsRNA; nNOS; Pseudogene; RNA interface; Translational regulation

Indexed keywords

COMPLEMENTARY RNA; NITRIC OXIDE SYNTHASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE DEHYDROGENASE;

ARTICLE; BRAIN GANGLION; DNA LIBRARY; ENZYME ACTIVITY; HISTOCHEMISTRY; LYMNAEA; MOLECULAR CLONING; NERVE CELL; NONHUMAN; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PSEUDOGENE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RIBONUCLEASE PROTECTION ASSAY; SEQUENCE HOMOLOGY; TRANSLATION REGULATION;

LYMNAEA STAGNALIS;

EID: 0033568856     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.19-18-07711.1999     Document Type: Article

References (33)

1. Bredt DS, Snyder SH (1990) Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc Natl Acad Sci USA 87:682-685.
2. Bredt DS, Snyder SH (1992) Nitric oxide, a novel neuronal messenger. Neuron 8:3-11.
3. Bredt DS, Hwang PM, Snyder SH (1990) Localization of nitric oxide synthase indicating a neural role for nitric oxide. Nature 347:768-770.
4. Chomczynski P, Sacchi N (1987) Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162:156-159.
5. Dawson TM, Snyder SH (1994) Gases as biological messengers. Nitric oxide and carbon monoxide in the brain. J Neurosci 14:5147-5159.
6. Dawson TM, Bredt DS, Fotuhi M, Hwang PM, Snyder SH (1991) Nitric oxide synthase and neuronal NADPH-diaphorase are identical in brain and peripheral tissue. Proc Nat Acad Sci USA 88:7797-7801.
7. Elphick MR, Rayne RC, Riveros-Moreno V, Moncada S, O'Shea M (1995) Nitric oxide synthase in locust olfactory interneurons. J Exp Biol 198:821-829.
8. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC (1998) Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 391:806-811.
9. Garthwaite J, Boulton CL (1995) Nitric oxide signaling in the central nervous system. Annu Rev Physiol 57:683-706.
10. Garthwaite J, Charles SL, Chess-Williams R (1988) Edothelium-derived relaxing factor release on activation of NMDA receptors suggests role as intercellular messenger in the brain. Nature 336:385-388.
11. Gillette R, Davis WJ (1977) The role of the metacerebral giant neuron in the feeding behaviour of Pleurobranchaea. J Comp Physiol 116:129-159.
12. Hölscher C (1997) Nitric oxide, the enigmatic neuronal messenger: its role in synaptic plasticity. Trends Neurosci 20:298-303.
13. Hope BT, Michael GJ, Knigge KM, Vincent SR (1991) Neuronal NADPH-diaphorase is a nitric oxide synthase. Proc Natl Acad Sci USA 88:2811-2814.
14. Jacklet JW (1995) Nitric oxide is used as an orthograde cotransmitter at identified histaminergic synapses. J Neurophysiol 74:891-895.
15. Jacklet JW, Gruhn M (1994) Nitric oxide as a putative transmitter in Aplysia: neural circuits and membrane effects. Neth J Zool 44:524-534.
16. Kemenes G, Hiripi L, Benjamin PR (1994) Behavioural and biochemical changes in the feeding system of Lymnaea induced by the dopamine and serotonin neurotoxins 6-hydroxydopamine and 5,6-dihydroxytryptamine. Phil Trans R Soc Lond B Biol Sci 329:243-255.
17. Kennerdell JR, Carthew RW (1998) Use of dsRNA-mediated genetic interference to demonstrate that frizzled and frizzled 2 act in the wingless pathway. Cell 95:1017-1026.
18. Koh H-Y, Jacklet JW (1999) Nitric oxide stimulates cGMP production and mimics synaptic responses in metacerebral neurons of Aplysia. J Neurosci 19:3818-3826.
19. Korneev SA, Piper MR, Picot J, Phillips R, Korneeva EI, O'Shea M (1998) Molecular characterization of NOS in a mollusc: expression in a giant modulatory neuron. J Neurobiol 35:65-76.
20. Kupfermann I, Weiss KR (1982) Activity of an identified serotonergic neuron in free-moving Aplysia correlates with behavioral arousal. Brain Res 241:334-337.
21. Lewin B (1990) Genes IV. New York: Oxford UP.
22. Matsumoto T, Nakane M, Pollock JS, Kuk JE, Forstermann U (1993) A correlation between soluble brain nitric oxide synthase and NADPH-diaphorase is seen only after exposure of the tissue to fixative. Neurosci Lett 155:61-64.
23. Moroz LL, Gillette R (1996) NADPH-diaphorase localization in the CNS and peripheral tissues of the predatory sea-slug Pleurobranchaea californica. J Comp Physiol [A] 367:607-622.
24. Moroz LL, Bulloch AGM, Lukowiak K,Syed NI (1994a) Putative NOs-synthesizing neurons of Lymnaea in vivo and in vitro. Neth J Zool 44:535-549.
25. Moroz LL, Winlow W, Turner RW, Bulloch AGM, Lukowiak K, Syed NI (1994b) Nitric oxide synthase-immunoreactive cells in the CNS and periphery of Lymnaea. NeuroReport 5:1277-1280.
26. Nellen W, Lichtenstein C (1993) What makes an mRNA antisense-itive? Trends Biochem Sci 18:419-423.
27. Park J-H, Straub VA, O'Shea M (1998) Anterograde signaling by nitric oxide: characterization and in vivo reconstitution of an identified nitrergic synapse. J Neurosci 18:5463-5476.
28. Schulz-Aellen M-F, Roulet E, Fischer-Lougheed J, O'Shea M (1989) Synthesis of a heterodimer neurohormone precursor of locust adipokinetic hormone studied by in vitro translation and cDNA cloning. Neuron 2:1369-1373.
29. Shayiq RM (1997) Role of gene overlap in the regulation of mRNA translation for mitochondrial cytochrome P-450c27/25 in the rat. J Biol Chem 272:4050-4057.
30. Vanhe-Brossolleet C, Vaquero C (1998) Do natural antisense transcripts make sense in eukaryotes? Gene 211:1-9.
31. Wagner EG, Simons RW (1994) Antisense RNA control in bacteria, phages and plasmids. Annu Rev Microbiol 48:713-742.
32. Wightman B, Ha I, Ruvkun G (1993) Posttranscriptional regulation of the heterochronic gene lin-14 mediates temporal pattern formation in C. elegans. Cell 75:855-862.
33. Zaphiropoulos PG, Folk WR, Coon MJ (1986) Isolation and characterization of a novel cytochrome P-450-like pseudogene. Biochem Biophys Res Commun 134:499-505.