메뉴 건너뛰기




Volumn 24, Issue 6, 2013, Pages 503-513

Role of adipokines and cytokines in obesity-associated breast cancer: Therapeutic targets

Author keywords

Adiponectin; Breast cancer; Cytokines; Leptin; Obesity

Indexed keywords

ADIPOCYTOKINE; ADIPONECTIN; AMFEPRAMONE; BEVACIZUMAB; CYTOKINE; DOCETAXEL; DOXORUBICIN; ERLOTINIB; ESTROGEN; FULVESTRANT; GEFITINIB; INSULIN; INTERLEUKIN 1BETA; INTERLEUKIN 6; LAPATINIB; LEPTIN; LETROZOLE; LORCASERIN; METFORMIN; PHENDIMETRAZINE; PHENTERMINE; PITAVASTATIN; ROSCOVITINE; SEX HORMONE BINDING GLOBULIN; SOMATOMEDIN; TAMOXIFEN; TETRAHYDROLIPSTATIN; TRASTUZUMAB; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG;

EID: 84888305648     PISSN: 13596101     EISSN: 18790305     Source Type: Journal    
DOI: 10.1016/j.cytogfr.2013.10.001     Document Type: Short Survey
Times cited : (125)

References (150)
  • 2
    • 0035961202 scopus 로고    scopus 로고
    • Breast cancer: hormones and other risk factors
    • discussion 13-6
    • Hulka B.S., Moorman P.G. Breast cancer: hormones and other risk factors. Maturitas 2001, 38:103-113. discussion 13-6.
    • (2001) Maturitas , vol.38 , pp. 103-113
    • Hulka, B.S.1    Moorman, P.G.2
  • 3
    • 33745210787 scopus 로고    scopus 로고
    • Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues
    • Key J., Hodgson S., Omar R.Z., Jensen T.K., Thompson S.G., Boobis A.R., et al. Meta-analysis of studies of alcohol and breast cancer with consideration of the methodological issues. Cancer Causes Control 2006, 17:759-770.
    • (2006) Cancer Causes Control , vol.17 , pp. 759-770
    • Key, J.1    Hodgson, S.2    Omar, R.Z.3    Jensen, T.K.4    Thompson, S.G.5    Boobis, A.R.6
  • 6
    • 79952216996 scopus 로고    scopus 로고
    • Biology of obesity: lessons from animal models of obesity
    • Kanasaki K., Koya D. Biology of obesity: lessons from animal models of obesity. J Biomed Biotechnol 2011, 2011:197636.
    • (2011) J Biomed Biotechnol , vol.2011 , pp. 197636
    • Kanasaki, K.1    Koya, D.2
  • 7
    • 0036701556 scopus 로고    scopus 로고
    • Weight control and physical activity in cancer prevention: international evaluation of the evidence
    • Vainio H., Kaaks R., Bianchini F. Weight control and physical activity in cancer prevention: international evaluation of the evidence. Eur J Cancer Prev 2002, 11(Suppl. 2):S94-S100.
    • (2002) Eur J Cancer Prev , vol.11 , Issue.SUPPL. 2
    • Vainio, H.1    Kaaks, R.2    Bianchini, F.3
  • 8
    • 38949108241 scopus 로고    scopus 로고
    • Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies
    • Renehan A.G., Tyson M., Egger M., Heller R.F., Zwahlen M. Body-mass index and incidence of cancer: a systematic review and meta-analysis of prospective observational studies. Lancet 2008, 371:569-578.
    • (2008) Lancet , vol.371 , pp. 569-578
    • Renehan, A.G.1    Tyson, M.2    Egger, M.3    Heller, R.F.4    Zwahlen, M.5
  • 10
    • 27844472511 scopus 로고    scopus 로고
    • (Cancers) CRAcg. Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors
    • Danaei G., Vander Hoorn S., Lopez A.D., Murray C.J., Ezzati M. (Cancers) CRAcg. Causes of cancer in the world: comparative risk assessment of nine behavioural and environmental risk factors. Lancet 2005, 366:1784-1793.
    • (2005) Lancet , vol.366 , pp. 1784-1793
    • Danaei, G.1    Vander Hoorn, S.2    Lopez, A.D.3    Murray, C.J.4    Ezzati, M.5
  • 11
    • 33748755434 scopus 로고    scopus 로고
    • Obesity as a risk factor for development and poor prognosis of breast cancer
    • Carmichael A.R. Obesity as a risk factor for development and poor prognosis of breast cancer. BJOG 2006, 113:1160-1166.
    • (2006) BJOG , vol.113 , pp. 1160-1166
    • Carmichael, A.R.1
  • 14
    • 4444237280 scopus 로고    scopus 로고
    • Obesity and cancer
    • Calle E.E., Thun M.J. Obesity and cancer. Oncogene 2004, 23:6365-6378.
    • (2004) Oncogene , vol.23 , pp. 6365-6378
    • Calle, E.E.1    Thun, M.J.2
  • 15
    • 70350542349 scopus 로고    scopus 로고
    • Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: new therapeutic perspectives
    • Macciò A., Madeddu C., Mantovani G. Adipose tissue as target organ in the treatment of hormone-dependent breast cancer: new therapeutic perspectives. Obes Rev 2009, 10:660-670.
    • (2009) Obes Rev , vol.10 , pp. 660-670
    • Macciò, A.1    Madeddu, C.2    Mantovani, G.3
  • 16
    • 75949102926 scopus 로고    scopus 로고
    • Biological mechanisms linking obesity and cancer risk: new perspectives
    • Roberts D.L., Dive C., Renehan A.G. Biological mechanisms linking obesity and cancer risk: new perspectives. Annu Rev Med 2010, 61:301-316.
    • (2010) Annu Rev Med , vol.61 , pp. 301-316
    • Roberts, D.L.1    Dive, C.2    Renehan, A.G.3
  • 17
    • 0028958031 scopus 로고
    • Insulin-like growth factors and their binding proteins: biological actions
    • Jones J.I., Clemmons D.R. Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 1995, 16:3-34.
    • (1995) Endocr Rev , vol.16 , pp. 3-34
    • Jones, J.I.1    Clemmons, D.R.2
  • 18
    • 0029806068 scopus 로고    scopus 로고
    • Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production
    • Renier G., Clément I., Desfaits A.C., Lambert A. Direct stimulatory effect of insulin-like growth factor-I on monocyte and macrophage tumor necrosis factor-alpha production. Endocrinology 1996, 137:4611-4618.
    • (1996) Endocrinology , vol.137 , pp. 4611-4618
    • Renier, G.1    Clément, I.2    Desfaits, A.C.3    Lambert, A.4
  • 19
    • 0033103098 scopus 로고    scopus 로고
    • Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation
    • Heemskerk V.H., Daemen M.A., Buurman W.A. Insulin-like growth factor-1 (IGF-1) and growth hormone (GH) in immunity and inflammation. Cytokine Growth Factor Rev 1999, 10:5-14.
    • (1999) Cytokine Growth Factor Rev , vol.10 , pp. 5-14
    • Heemskerk, V.H.1    Daemen, M.A.2    Buurman, W.A.3
  • 20
    • 57749089652 scopus 로고    scopus 로고
    • Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival
    • Law J.H., Habibi G., Hu K., Masoudi H., Wang M.Y., Stratford A.L., et al. Phosphorylated insulin-like growth factor-i/insulin receptor is present in all breast cancer subtypes and is related to poor survival. Cancer Res 2008, 68:10238-10246.
    • (2008) Cancer Res , vol.68 , pp. 10238-10246
    • Law, J.H.1    Habibi, G.2    Hu, K.3    Masoudi, H.4    Wang, M.Y.5    Stratford, A.L.6
  • 22
    • 57149139809 scopus 로고    scopus 로고
    • Insulin receptor substrates (IRSs) and breast tumorigenesis
    • Chan B.T., Lee A.V. Insulin receptor substrates (IRSs) and breast tumorigenesis. J Mammary Gland Biol Neoplasia 2008, 13:415-422.
    • (2008) J Mammary Gland Biol Neoplasia , vol.13 , pp. 415-422
    • Chan, B.T.1    Lee, A.V.2
  • 23
    • 0038398622 scopus 로고    scopus 로고
    • The insulin-like growth factor system and cancer
    • LeRoith D., Roberts C.T. The insulin-like growth factor system and cancer. Cancer Lett 2003, 195:127-137.
    • (2003) Cancer Lett , vol.195 , pp. 127-137
    • LeRoith, D.1    Roberts, C.T.2
  • 24
    • 27444437321 scopus 로고    scopus 로고
    • Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans
    • Cinti S., Mitchell G., Barbatelli G., Murano I., Ceresi E., Faloia E., et al. Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans. J Lipid Res 2005, 46:2347-2355.
    • (2005) J Lipid Res , vol.46 , pp. 2347-2355
    • Cinti, S.1    Mitchell, G.2    Barbatelli, G.3    Murano, I.4    Ceresi, E.5    Faloia, E.6
  • 25
    • 50949108719 scopus 로고    scopus 로고
    • Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice
    • Murano I., Barbatelli G., Parisani V., Latini C., Muzzonigro G., Castellucci M., et al. Dead adipocytes, detected as crown-like structures, are prevalent in visceral fat depots of genetically obese mice. J Lipid Res 2008, 49:1562-1568.
    • (2008) J Lipid Res , vol.49 , pp. 1562-1568
    • Murano, I.1    Barbatelli, G.2    Parisani, V.3    Latini, C.4    Muzzonigro, G.5    Castellucci, M.6
  • 27
    • 68849108869 scopus 로고    scopus 로고
    • Inflammation and cancer: how friendly is the relationship for cancer patients?
    • Aggarwal B.B., Gehlot P. Inflammation and cancer: how friendly is the relationship for cancer patients?. Curr Opin Pharmacol 2009, 9:351-369.
    • (2009) Curr Opin Pharmacol , vol.9 , pp. 351-369
    • Aggarwal, B.B.1    Gehlot, P.2
  • 28
    • 79955862214 scopus 로고    scopus 로고
    • Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland
    • Subbaramaiah K., Howe L.R., Bhardwaj P., Du B., Gravaghi C., Yantiss R.K., et al. Obesity is associated with inflammation and elevated aromatase expression in the mouse mammary gland. Cancer Prev Res (Phila) 2011, 4:329-346.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 329-346
    • Subbaramaiah, K.1    Howe, L.R.2    Bhardwaj, P.3    Du, B.4    Gravaghi, C.5    Yantiss, R.K.6
  • 29
    • 79960082421 scopus 로고    scopus 로고
    • Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer
    • Morris P.G., Hudis C.A., Giri D., Morrow M., Falcone D.J., Zhou X.K., et al. Inflammation and increased aromatase expression occur in the breast tissue of obese women with breast cancer. Cancer Prev Res (Phila) 2011, 4:1021-1029.
    • (2011) Cancer Prev Res (Phila) , vol.4 , pp. 1021-1029
    • Morris, P.G.1    Hudis, C.A.2    Giri, D.3    Morrow, M.4    Falcone, D.J.5    Zhou, X.K.6
  • 31
    • 81455143912 scopus 로고    scopus 로고
    • Obesity, inflammation, and postmenopausal breast cancer: therapeutic implications
    • Macciò A., Madeddu C. Obesity, inflammation, and postmenopausal breast cancer: therapeutic implications. ScientificWorldJournal 2011, 11:2020-2036.
    • (2011) ScientificWorldJournal , vol.11 , pp. 2020-2036
    • Macciò, A.1    Madeddu, C.2
  • 32
    • 79960556096 scopus 로고    scopus 로고
    • Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation
    • Grisouard J., Dembinski K., Mayer D., Keller U., Müller B., Christ-Crain M. Targeting AMP-activated protein kinase in adipocytes to modulate obesity-related adipokine production associated with insulin resistance and breast cancer cell proliferation. Diabetol Metab Syndr 2011, 3:16.
    • (2011) Diabetol Metab Syndr , vol.3 , pp. 16
    • Grisouard, J.1    Dembinski, K.2    Mayer, D.3    Keller, U.4    Müller, B.5    Christ-Crain, M.6
  • 33
    • 64549164501 scopus 로고    scopus 로고
    • IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription
    • Zappalà G., Rechler M.M. IGFBP-3, hypoxia and TNF-alpha inhibit adiponectin transcription. Biochem Biophys Res Commun 2009, 382:785-789.
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 785-789
    • Zappalà, G.1    Rechler, M.M.2
  • 34
    • 11144344885 scopus 로고    scopus 로고
    • C-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes
    • Kim K.Y., Kim J.K., Jeon J.H., Yoon S.R., Choi I., Yang Y. c-Jun N-terminal kinase is involved in the suppression of adiponectin expression by TNF-alpha in 3T3-L1 adipocytes. Biochem Biophys Res Commun 2005, 327:460-467.
    • (2005) Biochem Biophys Res Commun , vol.327 , pp. 460-467
    • Kim, K.Y.1    Kim, J.K.2    Jeon, J.H.3    Yoon, S.R.4    Choi, I.5    Yang, Y.6
  • 35
    • 34547741589 scopus 로고    scopus 로고
    • Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression
    • Vona-Davis L., Rose D.P. Adipokines as endocrine, paracrine, and autocrine factors in breast cancer risk and progression. Endocr Relat Cancer 2007, 14:189-206.
    • (2007) Endocr Relat Cancer , vol.14 , pp. 189-206
    • Vona-Davis, L.1    Rose, D.P.2
  • 37
    • 0033977124 scopus 로고    scopus 로고
    • Circulating leptin levels during ovulation induction: relation to adiposity and ovarian morphology
    • Lindheim S.R., Sauer M.V., Carmina E., Chang P.L., Zimmerman R., Lobo R.A. Circulating leptin levels during ovulation induction: relation to adiposity and ovarian morphology. Fertil Steril 2000, 73:493-498.
    • (2000) Fertil Steril , vol.73 , pp. 493-498
    • Lindheim, S.R.1    Sauer, M.V.2    Carmina, E.3    Chang, P.L.4    Zimmerman, R.5    Lobo, R.A.6
  • 38
    • 0029089898 scopus 로고
    • The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7
    • Green E.D., Maffei M., Braden V.V., Proenca R., DeSilva U., Zhang Y., et al. The human obese (OB) gene: RNA expression pattern and mapping on the physical, cytogenetic, and genetic maps of chromosome 7. Genome Res 1995, 5:5-12.
    • (1995) Genome Res , vol.5 , pp. 5-12
    • Green, E.D.1    Maffei, M.2    Braden, V.V.3    Proenca, R.4    DeSilva, U.5    Zhang, Y.6
  • 41
    • 0034988897 scopus 로고    scopus 로고
    • Leptin and its role in lipid metabolism
    • Hynes G.R., Jones P.J. Leptin and its role in lipid metabolism. Curr Opin Lipidol 2001, 12:321-327.
    • (2001) Curr Opin Lipidol , vol.12 , pp. 321-327
    • Hynes, G.R.1    Jones, P.J.2
  • 42
    • 0035794211 scopus 로고    scopus 로고
    • Modulation of circulating leptin levels by its soluble receptor
    • Huang L., Wang Z., Li C. Modulation of circulating leptin levels by its soluble receptor. J Biol Chem 2001, 276:6343-6349.
    • (2001) J Biol Chem , vol.276 , pp. 6343-6349
    • Huang, L.1    Wang, Z.2    Li, C.3
  • 43
    • 0029083859 scopus 로고
    • Increased obese mRNA expression in omental fat cells from massively obese humans
    • Hamilton B.S., Paglia D., Kwan A.Y., Deitel M. Increased obese mRNA expression in omental fat cells from massively obese humans. Nat Med 1995, 1:953-956.
    • (1995) Nat Med , vol.1 , pp. 953-956
    • Hamilton, B.S.1    Paglia, D.2    Kwan, A.Y.3    Deitel, M.4
  • 45
    • 33645066625 scopus 로고    scopus 로고
    • Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli
    • Garofalo C., Koda M., Cascio S., Sulkowska M., Kanczuga-Koda L., Golaszewska J., et al. Increased expression of leptin and the leptin receptor as a marker of breast cancer progression: possible role of obesity-related stimuli. Clin Cancer Res 2006, 12:1447-1453.
    • (2006) Clin Cancer Res , vol.12 , pp. 1447-1453
    • Garofalo, C.1    Koda, M.2    Cascio, S.3    Sulkowska, M.4    Kanczuga-Koda, L.5    Golaszewska, J.6
  • 46
    • 3042817487 scopus 로고    scopus 로고
    • Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer
    • Ishikawa M., Kitayama J., Nagawa H. Enhanced expression of leptin and leptin receptor (OB-R) in human breast cancer. Clin Cancer Res 2004, 10:4325-4331.
    • (2004) Clin Cancer Res , vol.10 , pp. 4325-4331
    • Ishikawa, M.1    Kitayama, J.2    Nagawa, H.3
  • 48
    • 0742287956 scopus 로고    scopus 로고
    • Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors
    • Cleary M.P., Juneja S.C., Phillips F.C., Hu X., Grande J.P., Maihle N.J. Leptin receptor-deficient MMTV-TGF-alpha/Lepr(db)Lepr(db) female mice do not develop oncogene-induced mammary tumors. Exp Biol Med (Maywood) 2004, 229:182-193.
    • (2004) Exp Biol Med (Maywood) , vol.229 , pp. 182-193
    • Cleary, M.P.1    Juneja, S.C.2    Phillips, F.C.3    Hu, X.4    Grande, J.P.5    Maihle, N.J.6
  • 49
    • 0031436148 scopus 로고    scopus 로고
    • Divergent signaling capacities of the long and short isoforms of the leptin receptor
    • Bjørbaek C., Uotani S., da Silva B., Flier J.S. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997, 272:32686-32695.
    • (1997) J Biol Chem , vol.272 , pp. 32686-32695
    • Bjørbaek, C.1    Uotani, S.2    da Silva, B.3    Flier, J.S.4
  • 50
    • 4143118039 scopus 로고    scopus 로고
    • Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin
    • Yin N., Wang D., Zhang H., Yi X., Sun X., Shi B., et al. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res 2004, 64:5870-5875.
    • (2004) Cancer Res , vol.64 , pp. 5870-5875
    • Yin, N.1    Wang, D.2    Zhang, H.3    Yi, X.4    Sun, X.5    Shi, B.6
  • 51
    • 34250315764 scopus 로고    scopus 로고
    • Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3
    • Saxena N.K., Vertino P.M., Anania F.A., Sharma D. leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J Biol Chem 2007, 282:13316-13325.
    • (2007) J Biol Chem , vol.282 , pp. 13316-13325
    • Saxena, N.K.1    Vertino, P.M.2    Anania, F.A.3    Sharma, D.4
  • 52
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjørbaek C., Elmquist J.K., Frantz J.D., Shoelson S.E., Flier J.S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol Cell 1998, 1:619-625.
    • (1998) Mol Cell , vol.1 , pp. 619-625
    • Bjørbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 53
    • 0033569730 scopus 로고    scopus 로고
    • The role of SOCS-3 in leptin signaling and leptin resistance
    • Bjørbaek C., El-Haschimi K., Frantz J.D., Flier J.S. The role of SOCS-3 in leptin signaling and leptin resistance. J Biol Chem 1999, 274:30059-30065.
    • (1999) J Biol Chem , vol.274 , pp. 30059-30065
    • Bjørbaek, C.1    El-Haschimi, K.2    Frantz, J.D.3    Flier, J.S.4
  • 54
    • 78751506524 scopus 로고    scopus 로고
    • The activation of leptin-mediated survivin is limited by the inducible suppressor SOCS-3 in MCF-7 cells
    • Palianopoulou M., Papanikolaou V., Stefanou N., Tsezou A. The activation of leptin-mediated survivin is limited by the inducible suppressor SOCS-3 in MCF-7 cells. Exp Biol Med (Maywood) 2011, 236:70-76.
    • (2011) Exp Biol Med (Maywood) , vol.236 , pp. 70-76
    • Palianopoulou, M.1    Papanikolaou, V.2    Stefanou, N.3    Tsezou, A.4
  • 55
    • 84863709139 scopus 로고    scopus 로고
    • A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice
    • Park H., Kim M., Kwon G.T., Lim D.Y., Yu R., Sung M.K., et al. A high-fat diet increases angiogenesis, solid tumor growth, and lung metastasis of CT26 colon cancer cells in obesity-resistant BALB/c mice. Mol Carcinog 2011.
    • (2011) Mol Carcinog
    • Park, H.1    Kim, M.2    Kwon, G.T.3    Lim, D.Y.4    Yu, R.5    Sung, M.K.6
  • 56
    • 79955136974 scopus 로고    scopus 로고
    • Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells
    • Garonna E., Botham K.M., Birdsey G.M., Randi A.M., Gonzalez-Perez R.R., Wheeler-Jones C.P. Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells. PLoS One 2011, 6:e18823.
    • (2011) PLoS One , vol.6
    • Garonna, E.1    Botham, K.M.2    Birdsey, G.M.3    Randi, A.M.4    Gonzalez-Perez, R.R.5    Wheeler-Jones, C.P.6
  • 57
    • 33748751983 scopus 로고    scopus 로고
    • Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2)
    • Gonzalez R.R., Cherfils S., Escobar M., Yoo J.H., Carino C., Styer A.K., et al. Leptin signaling promotes the growth of mammary tumors and increases the expression of vascular endothelial growth factor (VEGF) and its receptor type two (VEGF-R2). J Biol Chem 2006, 281:26320-26328.
    • (2006) J Biol Chem , vol.281 , pp. 26320-26328
    • Gonzalez, R.R.1    Cherfils, S.2    Escobar, M.3    Yoo, J.H.4    Carino, C.5    Styer, A.K.6
  • 58
    • 0032783093 scopus 로고    scopus 로고
    • Leptin directly stimulates aromatase activity in human luteinized granulosa cells
    • Kitawaki J., Kusuki I., Koshiba H., Tsukamoto K., Honjo H. Leptin directly stimulates aromatase activity in human luteinized granulosa cells. Mol Hum Reprod 1999, 5:708-713.
    • (1999) Mol Hum Reprod , vol.5 , pp. 708-713
    • Kitawaki, J.1    Kusuki, I.2    Koshiba, H.3    Tsukamoto, K.4    Honjo, H.5
  • 59
    • 33745914266 scopus 로고    scopus 로고
    • Interrelationships between serum leptin, IGF-1, IGFBP3, C-peptide and prolactin and breast cancer risk in young women
    • Falk R.T., Brinton L.A., Madigan M.P., Potischman N., Sturgeon S.R., Malone K.E., et al. Interrelationships between serum leptin, IGF-1, IGFBP3, C-peptide and prolactin and breast cancer risk in young women. Breast Cancer Res Treat 2006, 98:157-165.
    • (2006) Breast Cancer Res Treat , vol.98 , pp. 157-165
    • Falk, R.T.1    Brinton, L.A.2    Madigan, M.P.3    Potischman, N.4    Sturgeon, S.R.5    Malone, K.E.6
  • 60
    • 77953582276 scopus 로고    scopus 로고
    • Cellular and molecular crosstalk between leptin receptor and estrogen receptor-{alpha} in breast cancer: molecular basis for a novel therapeutic setting
    • Fusco R., Galgani M., Procaccini C., Franco R., Pirozzi G., Fucci L., et al. Cellular and molecular crosstalk between leptin receptor and estrogen receptor-{alpha} in breast cancer: molecular basis for a novel therapeutic setting. Endocr Relat Cancer 2010, 17:373-382.
    • (2010) Endocr Relat Cancer , vol.17 , pp. 373-382
    • Fusco, R.1    Galgani, M.2    Procaccini, C.3    Franco, R.4    Pirozzi, G.5    Fucci, L.6
  • 61
    • 43849103666 scopus 로고    scopus 로고
    • Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma
    • Jardé T., Caldefie-Chézet F., Damez M., Mishellany F., Penault-Llorca F., Guillot J., et al. Leptin and leptin receptor involvement in cancer development: a study on human primary breast carcinoma. Oncol Rep 2008, 19:905-911.
    • (2008) Oncol Rep , vol.19 , pp. 905-911
    • Jardé, T.1    Caldefie-Chézet, F.2    Damez, M.3    Mishellany, F.4    Penault-Llorca, F.5    Guillot, J.6
  • 62
    • 0034765918 scopus 로고    scopus 로고
    • Effects of tamoxifen on the serum leptin level in patients with breast cancer
    • Ozet A., Arpaci F., Yilmaz M.I., Ayta H., Ozturk B., Komurcu S., et al. Effects of tamoxifen on the serum leptin level in patients with breast cancer. Jpn J Clin Oncol 2001, 31:424-427.
    • (2001) Jpn J Clin Oncol , vol.31 , pp. 424-427
    • Ozet, A.1    Arpaci, F.2    Yilmaz, M.I.3    Ayta, H.4    Ozturk, B.5    Komurcu, S.6
  • 63
    • 2442475308 scopus 로고    scopus 로고
    • Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells
    • Catalano S., Mauro L., Marsico S., Giordano C., Rizza P., Rago V., et al. Leptin induces, via ERK1/ERK2 signal, functional activation of estrogen receptor alpha in MCF-7 cells. J Biol Chem 2004, 279:19908-19915.
    • (2004) J Biol Chem , vol.279 , pp. 19908-19915
    • Catalano, S.1    Mauro, L.2    Marsico, S.3    Giordano, C.4    Rizza, P.5    Rago, V.6
  • 64
    • 5144229540 scopus 로고    scopus 로고
    • Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells
    • Garofalo C., Sisci D., Surmacz E. Leptin interferes with the effects of the antiestrogen ICI 182,780 in MCF-7 breast cancer cells. Clin Cancer Res 2004, 10:6466-6475.
    • (2004) Clin Cancer Res , vol.10 , pp. 6466-6475
    • Garofalo, C.1    Sisci, D.2    Surmacz, E.3
  • 65
    • 4143140907 scopus 로고    scopus 로고
    • Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer
    • Núñez N.P., Jelovac D., Macedo L., Berrigan D., Perkins S.N., Hursting S.D., et al. Effects of the antiestrogen tamoxifen and the aromatase inhibitor letrozole on serum hormones and bone characteristics in a preclinical tumor model for breast cancer. Clin Cancer Res 2004, 10:5375-5380.
    • (2004) Clin Cancer Res , vol.10 , pp. 5375-5380
    • Núñez, N.P.1    Jelovac, D.2    Macedo, L.3    Berrigan, D.4    Perkins, S.N.5    Hursting, S.D.6
  • 66
    • 33750522464 scopus 로고    scopus 로고
    • Changes in bone and lipid metabolism in postmenopausal women with early breast cancer after terminating 2-year treatment with exemestane: a randomised, placebo-controlled study
    • Geisler J., Lønning P.E., Krag L.E., Løkkevik E., Risberg T., Hagen A.I., et al. Changes in bone and lipid metabolism in postmenopausal women with early breast cancer after terminating 2-year treatment with exemestane: a randomised, placebo-controlled study. Eur J Cancer 2006, 42:2968-2975.
    • (2006) Eur J Cancer , vol.42 , pp. 2968-2975
    • Geisler, J.1    Lønning, P.E.2    Krag, L.E.3    Løkkevik, E.4    Risberg, T.5    Hagen, A.I.6
  • 67
    • 57149133679 scopus 로고    scopus 로고
    • Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis
    • Fiorio E., Mercanti A., Terrasi M., Micciolo R., Remo A., Auriemma A., et al. Leptin/HER2 crosstalk in breast cancer: in vitro study and preliminary in vivo analysis. BMC Cancer 2008, 8:305.
    • (2008) BMC Cancer , vol.8 , pp. 305
    • Fiorio, E.1    Mercanti, A.2    Terrasi, M.3    Micciolo, R.4    Remo, A.5    Auriemma, A.6
  • 68
    • 79952974380 scopus 로고    scopus 로고
    • Plasma leptin, hTERT gene expression, and anthropometric measures in obese and non-obese women with breast cancer
    • Rahmati-Yamchi M., Zarghami N., Rahbani M., Montazeri A. Plasma leptin, hTERT gene expression, and anthropometric measures in obese and non-obese women with breast cancer. Breast Cancer (Auckl) 2011, 5:27-35.
    • (2011) Breast Cancer (Auckl) , vol.5 , pp. 27-35
    • Rahmati-Yamchi, M.1    Zarghami, N.2    Rahbani, M.3    Montazeri, A.4
  • 69
    • 77949875577 scopus 로고    scopus 로고
    • Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells
    • Ren H., Zhao T., Wang X., Gao C., Wang J., Yu M., et al. Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells. Biochem Biophys Res Commun 2010, 394:59-63.
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 59-63
    • Ren, H.1    Zhao, T.2    Wang, X.3    Gao, C.4    Wang, J.5    Yu, M.6
  • 70
    • 17744381149 scopus 로고    scopus 로고
    • Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study
    • Chagnon Y.C., Wilmore J.H., Borecki I.B., Gagnon J., Pérusse L., Chagnon M., et al. Associations between the leptin receptor gene and adiposity in middle-aged Caucasian males from the HERITAGE family study. J Clin Endocrinol Metab 2000, 85:29-34.
    • (2000) J Clin Endocrinol Metab , vol.85 , pp. 29-34
    • Chagnon, Y.C.1    Wilmore, J.H.2    Borecki, I.B.3    Gagnon, J.4    Pérusse, L.5    Chagnon, M.6
  • 71
    • 0034527931 scopus 로고    scopus 로고
    • Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight
    • Mammès O., Betoulle D., Aubert R., Herbeth B., Siest G., Fumeron F. Association of the G-2548A polymorphism in the 5' region of the LEP gene with overweight. Ann Hum Genet 2000, 64:391-394.
    • (2000) Ann Hum Genet , vol.64 , pp. 391-394
    • Mammès, O.1    Betoulle, D.2    Aubert, R.3    Herbeth, B.4    Siest, G.5    Fumeron, F.6
  • 72
    • 0034847530 scopus 로고    scopus 로고
    • The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability
    • Yiannakouris N., Yannakoulia M., Melistas L., Chan J.L., Klimis-Zacas D., Mantzoros C.S. The Q223R polymorphism of the leptin receptor gene is significantly associated with obesity and predicts a small percentage of body weight and body composition variability. J Clin Endocrinol Metab 2001, 86:4434-4439.
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4434-4439
    • Yiannakouris, N.1    Yannakoulia, M.2    Melistas, L.3    Chan, J.L.4    Klimis-Zacas, D.5    Mantzoros, C.S.6
  • 73
    • 67650070739 scopus 로고    scopus 로고
    • Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells
    • Terrasi M., Fiorio E., Mercanti A., Koda M., Moncada C.A., Sulkowski S., et al. Functional analysis of the -2548G/A leptin gene polymorphism in breast cancer cells. Int J Cancer 2009, 125:1038-1044.
    • (2009) Int J Cancer , vol.125 , pp. 1038-1044
    • Terrasi, M.1    Fiorio, E.2    Mercanti, A.3    Koda, M.4    Moncada, C.A.5    Sulkowski, S.6
  • 75
    • 18844432308 scopus 로고    scopus 로고
    • Adiponectin and adiponectin receptors
    • Kadowaki T., Yamauchi T. Adiponectin and adiponectin receptors. Endocr Rev 2005, 26:439-451.
    • (2005) Endocr Rev , vol.26 , pp. 439-451
    • Kadowaki, T.1    Yamauchi, T.2
  • 81
    • 56549085580 scopus 로고    scopus 로고
    • Growth-inhibitory effect of adiponectin via adiponectin receptor 1 on human breast cancer cells through inhibition of S-phase entry without inducing apoptosis
    • Nakayama S., Miyoshi Y., Ishihara H., Noguchi S. Growth-inhibitory effect of adiponectin via adiponectin receptor 1 on human breast cancer cells through inhibition of S-phase entry without inducing apoptosis. Breast Cancer Res Treat 2008, 112:405-410.
    • (2008) Breast Cancer Res Treat , vol.112 , pp. 405-410
    • Nakayama, S.1    Miyoshi, Y.2    Ishihara, H.3    Noguchi, S.4
  • 84
    • 33646497663 scopus 로고    scopus 로고
    • Serum adiponectin and leptin levels in Taiwanese breast cancer patients
    • Chen D.C., Chung Y.F., Yeh Y.T., Chaung H.C., Kuo F.C., Fu O.Y., et al. Serum adiponectin and leptin levels in Taiwanese breast cancer patients. Cancer Lett 2006, 237:109-114.
    • (2006) Cancer Lett , vol.237 , pp. 109-114
    • Chen, D.C.1    Chung, Y.F.2    Yeh, Y.T.3    Chaung, H.C.4    Kuo, F.C.5    Fu, O.Y.6
  • 87
    • 33847118950 scopus 로고    scopus 로고
    • Relationship of serum adiponectin and resistin levels with breast cancer risk
    • Kang J.H., Yu B.Y., Youn D.S. Relationship of serum adiponectin and resistin levels with breast cancer risk. J Korean Med Sci 2007, 22:117-121.
    • (2007) J Korean Med Sci , vol.22 , pp. 117-121
    • Kang, J.H.1    Yu, B.Y.2    Youn, D.S.3
  • 88
    • 43249097579 scopus 로고    scopus 로고
    • Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women
    • Miyatani Y., Yasui T., Uemura H., Yamada M., Matsuzaki T., Kuwahara A., et al. Associations of circulating adiponectin with estradiol and monocyte chemotactic protein-1 in postmenopausal women. Menopause 2008, 15:536-541.
    • (2008) Menopause , vol.15 , pp. 536-541
    • Miyatani, Y.1    Yasui, T.2    Uemura, H.3    Yamada, M.4    Matsuzaki, T.5    Kuwahara, A.6
  • 89
    • 0037317488 scopus 로고    scopus 로고
    • Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin
    • Combs T.P., Berg A.H., Rajala M.W., Klebanov S., Iyengar P., Jimenez-Chillaron J.C., et al. Sexual differentiation, pregnancy, calorie restriction, and aging affect the adipocyte-specific secretory protein adiponectin. Diabetes 2003, 52:268-276.
    • (2003) Diabetes , vol.52 , pp. 268-276
    • Combs, T.P.1    Berg, A.H.2    Rajala, M.W.3    Klebanov, S.4    Iyengar, P.5    Jimenez-Chillaron, J.C.6
  • 91
    • 84655175093 scopus 로고    scopus 로고
    • Adiponectin and breast cancer
    • Chen X., Wang Y. Adiponectin and breast cancer. Med Oncol 2011, 28:1288-1295.
    • (2011) Med Oncol , vol.28 , pp. 1288-1295
    • Chen, X.1    Wang, Y.2
  • 92
    • 65949116390 scopus 로고    scopus 로고
    • Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation
    • Kim K.Y., Baek A., Hwang J.E., Choi Y.A., Jeong J., Lee M.S., et al. Adiponectin-activated AMPK stimulates dephosphorylation of AKT through protein phosphatase 2A activation. Cancer Res 2009, 69:4018-4026.
    • (2009) Cancer Res , vol.69 , pp. 4018-4026
    • Kim, K.Y.1    Baek, A.2    Hwang, J.E.3    Choi, Y.A.4    Jeong, J.5    Lee, M.S.6
  • 93
    • 0842332231 scopus 로고    scopus 로고
    • Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL
    • Motoshima H., Wu X., Mahadev K., Goldstein B.J. Adiponectin suppresses proliferation and superoxide generation and enhances eNOS activity in endothelial cells treated with oxidized LDL. Biochem Biophys Res Commun 2004, 315:264-271.
    • (2004) Biochem Biophys Res Commun , vol.315 , pp. 264-271
    • Motoshima, H.1    Wu, X.2    Mahadev, K.3    Goldstein, B.J.4
  • 94
    • 0037129861 scopus 로고    scopus 로고
    • Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell
    • Arita Y., Kihara S., Ouchi N., Maeda K., Kuriyama H., Okamoto Y., et al. Adipocyte-derived plasma protein adiponectin acts as a platelet-derived growth factor-BB-binding protein and regulates growth factor-induced common postreceptor signal in vascular smooth muscle cell. Circulation 2002, 105:2893-2898.
    • (2002) Circulation , vol.105 , pp. 2893-2898
    • Arita, Y.1    Kihara, S.2    Ouchi, N.3    Maeda, K.4    Kuriyama, H.5    Okamoto, Y.6
  • 95
    • 24044538551 scopus 로고    scopus 로고
    • Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner
    • Wang Y., Lam K.S., Xu J.Y., Lu G., Xu L.Y., Cooper G.J., et al. Adiponectin inhibits cell proliferation by interacting with several growth factors in an oligomerization-dependent manner. J Biol Chem 2005, 280:18341-18347.
    • (2005) J Biol Chem , vol.280 , pp. 18341-18347
    • Wang, Y.1    Lam, K.S.2    Xu, J.Y.3    Lu, G.4    Xu, L.Y.5    Cooper, G.J.6
  • 96
    • 33947537241 scopus 로고    scopus 로고
    • Mechanisms of Disease: adipokines and breast cancer-endocrine and paracrine mechanisms that connect adiposity and breast cancer
    • Schäffler A., Schölmerich J., Buechler C. Mechanisms of Disease: adipokines and breast cancer-endocrine and paracrine mechanisms that connect adiposity and breast cancer. Nat Rev Endocrinol 2007, 3:345-354.
    • (2007) Nat Rev Endocrinol , vol.3 , pp. 345-354
    • Schäffler, A.1    Schölmerich, J.2    Buechler, C.3
  • 97
    • 35148854599 scopus 로고    scopus 로고
    • Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice
    • Ye J., Gao Z., Yin J., He Q. Hypoxia is a potential risk factor for chronic inflammation and adiponectin reduction in adipose tissue of ob/ob and dietary obese mice. Am J Physiol Endocrinol Metab 2007, 293:E1118-E1128.
    • (2007) Am J Physiol Endocrinol Metab , vol.293
    • Ye, J.1    Gao, Z.2    Yin, J.3    He, Q.4
  • 98
    • 10644234769 scopus 로고    scopus 로고
    • The role of hypoxia-induced factors in tumor progression
    • Vaupel P. The role of hypoxia-induced factors in tumor progression. Oncologist 2004, 9(Suppl. 5):10-17.
    • (2004) Oncologist , vol.9 , Issue.SUPPL. 5 , pp. 10-17
    • Vaupel, P.1
  • 99
    • 0033566693 scopus 로고    scopus 로고
    • Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2
    • Feldser D., Agani F., Iyer N.V., Pak B., Ferreira G., Semenza G.L. Reciprocal positive regulation of hypoxia-inducible factor 1alpha and insulin-like growth factor 2. Cancer Res 1999, 59:3915-3918.
    • (1999) Cancer Res , vol.59 , pp. 3915-3918
    • Feldser, D.1    Agani, F.2    Iyer, N.V.3    Pak, B.4    Ferreira, G.5    Semenza, G.L.6
  • 100
    • 0037064010 scopus 로고    scopus 로고
    • Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells
    • Fukuda R., Hirota K., Fan F., Jung Y.D., Ellis L.M., Semenza G.L. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem 2002, 277:38205-38211.
    • (2002) J Biol Chem , vol.277 , pp. 38205-38211
    • Fukuda, R.1    Hirota, K.2    Fan, F.3    Jung, Y.D.4    Ellis, L.M.5    Semenza, G.L.6
  • 102
    • 77949655176 scopus 로고    scopus 로고
    • Ectopic expression of hC/EBPs in breast tumor cells induces apoptosis
    • Pal P., Lochab S., Kanaujiya J., Sanyal S., Trivedi A.K. Ectopic expression of hC/EBPs in breast tumor cells induces apoptosis. Mol Cell Biochem 2010, 337:111-118.
    • (2010) Mol Cell Biochem , vol.337 , pp. 111-118
    • Pal, P.1    Lochab, S.2    Kanaujiya, J.3    Sanyal, S.4    Trivedi, A.K.5
  • 103
    • 32944482678 scopus 로고    scopus 로고
    • Fulvestrant ('Faslodex'): extending the reach of endocrine therapy?
    • Johnston S.R. Fulvestrant ('Faslodex'): extending the reach of endocrine therapy?. Breast Cancer Res Treat 2005, 93(Suppl. 1):S1-S2.
    • (2005) Breast Cancer Res Treat , vol.93 , Issue.SUPPL. 1
    • Johnston, S.R.1
  • 104
    • 79960835593 scopus 로고    scopus 로고
    • "Overcoming breast cancer drug resistance with mTOR inhibitors". Could it be a myth or a real possibility in the short-term future?
    • Margariti N., Fox S.B., Bottini A., Generali D. "Overcoming breast cancer drug resistance with mTOR inhibitors". Could it be a myth or a real possibility in the short-term future?. Breast Cancer Res Treat 2011, 128:599-606.
    • (2011) Breast Cancer Res Treat , vol.128 , pp. 599-606
    • Margariti, N.1    Fox, S.B.2    Bottini, A.3    Generali, D.4
  • 105
    • 77149154662 scopus 로고    scopus 로고
    • Phase 2 trial of primary systemic therapy with doxorubicin and docetaxel followed by surgery, radiotherapy, and adjuvant chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil based on clinical and pathologic response in patients with stage IIB to III breast cancer: long-term results from the University of Texas M. D. Anderson Cancer Center Study ID97-099
    • Alvarez R.H., Booser D.J., Cristofanilli M., Sahin A.A., Strom E.A., Guerra L., et al. Phase 2 trial of primary systemic therapy with doxorubicin and docetaxel followed by surgery, radiotherapy, and adjuvant chemotherapy with cyclophosphamide, methotrexate, and 5-fluorouracil based on clinical and pathologic response in patients with stage IIB to III breast cancer: long-term results from the University of Texas M. D. Anderson Cancer Center Study ID97-099. Cancer 2010, 116:1210-1217.
    • (2010) Cancer , vol.116 , pp. 1210-1217
    • Alvarez, R.H.1    Booser, D.J.2    Cristofanilli, M.3    Sahin, A.A.4    Strom, E.A.5    Guerra, L.6
  • 106
    • 34249050833 scopus 로고    scopus 로고
    • Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens
    • Sabnis G., Goloubeva O., Jelovac D., Schayowitz A., Brodie A. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway improves response of long-term estrogen-deprived breast cancer xenografts to antiestrogens. Clin Cancer Res 2007, 13:2751-2757.
    • (2007) Clin Cancer Res , vol.13 , pp. 2751-2757
    • Sabnis, G.1    Goloubeva, O.2    Jelovac, D.3    Schayowitz, A.4    Brodie, A.5
  • 107
    • 20644465808 scopus 로고    scopus 로고
    • Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole
    • Jelovac D., Sabnis G., Long B.J., Macedo L., Goloubeva O.G., Brodie A.M. Activation of mitogen-activated protein kinase in xenografts and cells during prolonged treatment with aromatase inhibitor letrozole. Cancer Res 2005, 65:5380-5389.
    • (2005) Cancer Res , vol.65 , pp. 5380-5389
    • Jelovac, D.1    Sabnis, G.2    Long, B.J.3    Macedo, L.4    Goloubeva, O.G.5    Brodie, A.M.6
  • 108
    • 33745106287 scopus 로고    scopus 로고
    • Molecular links between obesity and breast cancer
    • Lorincz A.M., Sukumar S. Molecular links between obesity and breast cancer. Endocr Relat Cancer 2006, 13:279-292.
    • (2006) Endocr Relat Cancer , vol.13 , pp. 279-292
    • Lorincz, A.M.1    Sukumar, S.2
  • 109
    • 79951807772 scopus 로고    scopus 로고
    • Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells
    • Wisierska-Gadek J., Gritsch D., Zulehner N., Komina O., Maurer M. Roscovitine, a selective CDK inhibitor, reduces the basal and estrogen-induced phosphorylation of ER-α in human ER-positive breast cancer cells. J Cell Biochem 2011, 112:761-772.
    • (2011) J Cell Biochem , vol.112 , pp. 761-772
    • Wisierska-Gadek, J.1    Gritsch, D.2    Zulehner, N.3    Komina, O.4    Maurer, M.5
  • 110
    • 79959591727 scopus 로고    scopus 로고
    • Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice
    • Shimizu M., Yasuda Y., Sakai H., Kubota M., Terakura D., Baba A., et al. Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice. BMC Cancer 2011, 11:281.
    • (2011) BMC Cancer , vol.11 , pp. 281
    • Shimizu, M.1    Yasuda, Y.2    Sakai, H.3    Kubota, M.4    Terakura, D.5    Baba, A.6
  • 111
    • 23044480300 scopus 로고    scopus 로고
    • Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene
    • Menendez J.A., Vellon L., Lupu R. Antitumoral actions of the anti-obesity drug orlistat (XenicalTM) in breast cancer cells: blockade of cell cycle progression, promotion of apoptotic cell death and PEA3-mediated transcriptional repression of Her2/neu (erbB-2) oncogene. Ann Oncol 2005, 16:1253-1267.
    • (2005) Ann Oncol , vol.16 , pp. 1253-1267
    • Menendez, J.A.1    Vellon, L.2    Lupu, R.3
  • 112
    • 84888289653 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00944918%3Fterm=aromatase+inhibitors+phase+3%26rank=3.
  • 113
    • 0028648240 scopus 로고
    • An intensive treatment with mitoxantrone and ifosfamide in second-line therapy of epithelial ovarian cancer
    • Leo A.D., Biganzoli L., Bohm S., Lupi G., Oriana S., Riboldi G., et al. An intensive treatment with mitoxantrone and ifosfamide in second-line therapy of epithelial ovarian cancer. Tumori 1994, 80:443-447.
    • (1994) Tumori , vol.80 , pp. 443-447
    • Leo, A.D.1    Biganzoli, L.2    Bohm, S.3    Lupi, G.4    Oriana, S.5    Riboldi, G.6
  • 114
    • 84888287310 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00241449%3Fterm=fulvestrant+in+postmenopausal+women+phase+3%26rank=14.
  • 115
    • 67649398814 scopus 로고    scopus 로고
    • Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors
    • Chen J.Q., Brown T.R., Russo J. Regulation of energy metabolism pathways by estrogens and estrogenic chemicals and potential implications in obesity associated with increased exposure to endocrine disruptors. Biochim Biophys Acta 2009, 1793:1128-1143.
    • (2009) Biochim Biophys Acta , vol.1793 , pp. 1128-1143
    • Chen, J.Q.1    Brown, T.R.2    Russo, J.3
  • 116
    • 0032792665 scopus 로고    scopus 로고
    • AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes
    • Winder W.W., Hardie D.G. AMP-activated protein kinase, a metabolic master switch: possible roles in type 2 diabetes. Am J Physiol 1999, 277:E1-E10.
    • (1999) Am J Physiol , vol.277
    • Winder, W.W.1    Hardie, D.G.2
  • 118
    • 70349741579 scopus 로고    scopus 로고
    • Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer
    • Rene Gonzalez R., Watters A., Xu Y., Singh U.P., Mann D.R., Rueda B.R., et al. Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res 2009, 11:R36.
    • (2009) Breast Cancer Res , vol.11
    • Rene Gonzalez, R.1    Watters, A.2    Xu, Y.3    Singh, U.P.4    Mann, D.R.5    Rueda, B.R.6
  • 119
    • 80053478017 scopus 로고    scopus 로고
    • Design and development of a peptide-based adiponectin receptor agonist for cancer treatment
    • Otvos L., Haspinger E., La Russa F., Maspero F., Graziano P., Kovalszky I., et al. Design and development of a peptide-based adiponectin receptor agonist for cancer treatment. BMC Biotechnol 2011, 11:90.
    • (2011) BMC Biotechnol , vol.11 , pp. 90
    • Otvos, L.1    Haspinger, E.2    La Russa, F.3    Maspero, F.4    Graziano, P.5    Kovalszky, I.6
  • 120
    • 84888286059 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00201773%3Fterm=celecoxib+phase+2+clinical+trial+in+postmenopausal+women%26rank=2.
  • 121
    • 84888293385 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00933309%3Fterm=exemestane%2C+avandamet%26rank=1.
  • 122
    • 84888304785 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00073073%3Fterm=celecoxib+postmenopausal+breast+cancer+phase+2%26rank=3.
  • 123
    • 84888295730 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00112749%3Fterm=infliximab+breast+cancer+phase+2%26rank=1.
  • 124
    • 84888307078 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT01127867%3Fterm=dha+breast+cancer%26rank=2.
  • 125
    • 84888297192 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00917735%3Fterm=green+tea+extract+breast+cancer%26rank=1.
  • 126
    • 84888299683 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/ct2/show/NCT00516243%3Fterm=green+tea+extract+breast+cancer%26rank=2.
  • 127
    • 33646028804 scopus 로고    scopus 로고
    • Molecular targets of dietary agents for prevention and therapy of cancer
    • Aggarwal B.B., Shishodia S. Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 2006, 71:1397-1421.
    • (2006) Biochem Pharmacol , vol.71 , pp. 1397-1421
    • Aggarwal, B.B.1    Shishodia, S.2
  • 129
    • 84857335865 scopus 로고    scopus 로고
    • Curcumin molecular targets in obesity and obesity-related cancers
    • Shehzad A., Khan S., Sup Lee Y. Curcumin molecular targets in obesity and obesity-related cancers. Future Oncol 2012, 8:179-190.
    • (2012) Future Oncol , vol.8 , pp. 179-190
    • Shehzad, A.1    Khan, S.2    Sup Lee, Y.3
  • 130
    • 77955633792 scopus 로고    scopus 로고
    • Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals
    • Aggarwal B.B. Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals. Annu Rev Nutr 2010, 30:173-199.
    • (2010) Annu Rev Nutr , vol.30 , pp. 173-199
    • Aggarwal, B.B.1
  • 131
    • 77956585215 scopus 로고    scopus 로고
    • An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol
    • Ghanim H., Sia C.L., Abuaysheh S., Korzeniewski K., Patnaik P., Marumganti A., et al. An antiinflammatory and reactive oxygen species suppressive effects of an extract of Polygonum cuspidatum containing resveratrol. J Clin Endocrinol Metab 2010, 95:E1-E8.
    • (2010) J Clin Endocrinol Metab , vol.95
    • Ghanim, H.1    Sia, C.L.2    Abuaysheh, S.3    Korzeniewski, K.4    Patnaik, P.5    Marumganti, A.6
  • 132
    • 79953043473 scopus 로고    scopus 로고
    • Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy
    • Morselli E., Maiuri M.C., Markaki M., Megalou E., Pasparaki A., Palikaras K., et al. Caloric restriction and resveratrol promote longevity through the Sirtuin-1-dependent induction of autophagy. Cell Death Dis 2010, 1:e10.
    • (2010) Cell Death Dis , vol.1
    • Morselli, E.1    Maiuri, M.C.2    Markaki, M.3    Megalou, E.4    Pasparaki, A.5    Palikaras, K.6
  • 133
    • 33645234909 scopus 로고    scopus 로고
    • Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro
    • Lanzilli G., Fuggetta M.P., Tricarico M., Cottarelli A., Serafino A., Falchetti R., et al. Resveratrol down-regulates the growth and telomerase activity of breast cancer cells in vitro. Int J Oncol 2006, 28:641-648.
    • (2006) Int J Oncol , vol.28 , pp. 641-648
    • Lanzilli, G.1    Fuggetta, M.P.2    Tricarico, M.3    Cottarelli, A.4    Serafino, A.5    Falchetti, R.6
  • 134
    • 84865574556 scopus 로고    scopus 로고
    • Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents
    • Zhang X., Chen L.X., Ouyang L., Cheng Y., Liu B. Plant natural compounds: targeting pathways of autophagy as anti-cancer therapeutic agents. Cell Prolif 2012, 45:466-476.
    • (2012) Cell Prolif , vol.45 , pp. 466-476
    • Zhang, X.1    Chen, L.X.2    Ouyang, L.3    Cheng, Y.4    Liu, B.5
  • 136
    • 0029999052 scopus 로고    scopus 로고
    • Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition
    • Ferry D.R., Smith A., Malkhandi J., Fyfe D.W., deTakats P.G., Anderson D., et al. Phase I clinical trial of the flavonoid quercetin: pharmacokinetics and evidence for in vivo tyrosine kinase inhibition. Clin Cancer Res 1996, 2:659-668.
    • (1996) Clin Cancer Res , vol.2 , pp. 659-668
    • Ferry, D.R.1    Smith, A.2    Malkhandi, J.3    Fyfe, D.W.4    deTakats, P.G.5    Anderson, D.6
  • 137
    • 78249242752 scopus 로고    scopus 로고
    • Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer
    • De Angel R.E., Smith S.M., Glickman R.D., Perkins S.N., Hursting S.D. Antitumor effects of ursolic acid in a mouse model of postmenopausal breast cancer. Nutr Cancer 2010, 62:1074-1086.
    • (2010) Nutr Cancer , vol.62 , pp. 1074-1086
    • De Angel, R.E.1    Smith, S.M.2    Glickman, R.D.3    Perkins, S.N.4    Hursting, S.D.5
  • 138
    • 77954203666 scopus 로고    scopus 로고
    • Antiangiogenic activity of ursolic acid
    • Kanjoormana M., Kuttan G. Antiangiogenic activity of ursolic acid. Integr Cancer Ther 2010, 9:224-235.
    • (2010) Integr Cancer Ther , vol.9 , pp. 224-235
    • Kanjoormana, M.1    Kuttan, G.2
  • 139
    • 27744455616 scopus 로고    scopus 로고
    • Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase
    • Hwang J.T., Park I.J., Shin J.I., Lee Y.K., Lee S.K., Baik H.W., et al. Genistein, EGCG, and capsaicin inhibit adipocyte differentiation process via activating AMP-activated protein kinase. Biochem Biophys Res Commun 2005, 338:694-699.
    • (2005) Biochem Biophys Res Commun , vol.338 , pp. 694-699
    • Hwang, J.T.1    Park, I.J.2    Shin, J.I.3    Lee, Y.K.4    Lee, S.K.5    Baik, H.W.6
  • 141
    • 65649118867 scopus 로고    scopus 로고
    • Genistein suppresses adipogenesis of 3T3-L1 cells via multiple signal pathways
    • Zhang M., Ikeda K., Xu J.W., Yamori Y., Gao X.M., Zhang B.L. Genistein suppresses adipogenesis of 3T3-L1 cells via multiple signal pathways. Phytother Res 2009, 23:713-718.
    • (2009) Phytother Res , vol.23 , pp. 713-718
    • Zhang, M.1    Ikeda, K.2    Xu, J.W.3    Yamori, Y.4    Gao, X.M.5    Zhang, B.L.6
  • 142
    • 84868204577 scopus 로고    scopus 로고
    • (-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice
    • Grove K.A., Sae-tan S., Kennett M.J., Lambert J.D. (-)-Epigallocatechin-3-gallate inhibits pancreatic lipase and reduces body weight gain in high fat-fed obese mice. Obesity (Silver Spring) 2012, 20:2311-2313.
    • (2012) Obesity (Silver Spring) , vol.20 , pp. 2311-2313
    • Grove, K.A.1    Sae-tan, S.2    Kennett, M.J.3    Lambert, J.D.4
  • 143
    • 77956925426 scopus 로고    scopus 로고
    • (-)-Epigallocatechin gallate suppresses the differentiation of 3T3-L1 preadipocytes through transcription factors FoxO1 and SREBP1c
    • Kim H., Hiraishi A., Tsuchiya K., Sakamoto K. (-)-Epigallocatechin gallate suppresses the differentiation of 3T3-L1 preadipocytes through transcription factors FoxO1 and SREBP1c. Cytotechnology 2010, 62:245-255.
    • (2010) Cytotechnology , vol.62 , pp. 245-255
    • Kim, H.1    Hiraishi, A.2    Tsuchiya, K.3    Sakamoto, K.4
  • 144
    • 20044383992 scopus 로고    scopus 로고
    • Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation
    • Klaus S., Pültz S., Thöne-Reineke C., Wolfram S. Epigallocatechin gallate attenuates diet-induced obesity in mice by decreasing energy absorption and increasing fat oxidation. Int J Obes (Lond) 2005, 29:615-623.
    • (2005) Int J Obes (Lond) , vol.29 , pp. 615-623
    • Klaus, S.1    Pültz, S.2    Thöne-Reineke, C.3    Wolfram, S.4
  • 145
    • 77957747958 scopus 로고    scopus 로고
    • Evidence for the relationship between diet and cancer
    • Ross S.A. Evidence for the relationship between diet and cancer. Exp Oncol 2010, 32:137-142.
    • (2010) Exp Oncol , vol.32 , pp. 137-142
    • Ross, S.A.1
  • 146
    • 34047241705 scopus 로고    scopus 로고
    • (-)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells
    • Cho S.Y., Park P.J., Shin H.J., Kim Y.K., Shin D.W., Shin E.S., et al. (-)-Catechin suppresses expression of Kruppel-like factor 7 and increases expression and secretion of adiponectin protein in 3T3-L1 cells. Am J Physiol Endocrinol Metab 2007, 292:E1166-E1172.
    • (2007) Am J Physiol Endocrinol Metab , vol.292
    • Cho, S.Y.1    Park, P.J.2    Shin, H.J.3    Kim, Y.K.4    Shin, D.W.5    Shin, E.S.6
  • 147
    • 79958188915 scopus 로고    scopus 로고
    • Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster
    • Si H., Fu Z., Babu P.V., Zhen W., Leroith T., Meaney M.P., et al. Dietary epicatechin promotes survival of obese diabetic mice and Drosophila melanogaster. J Nutr 2011, 141:1095-1100.
    • (2011) J Nutr , vol.141 , pp. 1095-1100
    • Si, H.1    Fu, Z.2    Babu, P.V.3    Zhen, W.4    Leroith, T.5    Meaney, M.P.6
  • 149
    • 80054944137 scopus 로고    scopus 로고
    • Persicaria hydropiper (L.) spach and its flavonoid components, isoquercitrin and isorhamnetin, activate the Wnt/β-catenin pathway and inhibit adipocyte differentiation of 3T3-L1 cells
    • Lee S.H., Kim B., Oh M.J., Yoon J., Kim H.Y., Lee K.J., et al. Persicaria hydropiper (L.) spach and its flavonoid components, isoquercitrin and isorhamnetin, activate the Wnt/β-catenin pathway and inhibit adipocyte differentiation of 3T3-L1 cells. Phytother Res 2011, 25:1629-1635.
    • (2011) Phytother Res , vol.25 , pp. 1629-1635
    • Lee, S.H.1    Kim, B.2    Oh, M.J.3    Yoon, J.4    Kim, H.Y.5    Lee, K.J.6
  • 150
    • 84859760154 scopus 로고    scopus 로고
    • Myricetin increases hepatic peroxisome proliferator-activated receptor α protein expression and decreases plasma lipids and adiposity in rats
    • Chang C.J., Tzeng T.F., Liou S.S., Chang Y.S., Liu I.M. Myricetin increases hepatic peroxisome proliferator-activated receptor α protein expression and decreases plasma lipids and adiposity in rats. Evid Based Complement Alternat Med 2012, 2012:787152.
    • (2012) Evid Based Complement Alternat Med , vol.2012 , pp. 787152
    • Chang, C.J.1    Tzeng, T.F.2    Liou, S.S.3    Chang, Y.S.4    Liu, I.M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.