메뉴 건너뛰기




Volumn 11, Issue , 2011, Pages

Pitavastatin suppresses diethylnitrosamine-induced liver preneoplasms in male C57BL/KsJ-db/db obese mice

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; AMP ACTIVATED KINASE ALPHA; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; DIETHYLNITROSAMINE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INTERLEUKIN 6; PITAVASTATIN; PROTEIN BAD; PROTEIN BCL 2; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; ADIPONECTIN; ADIPONECTIN, MOUSE; AMPK ALPHA1 SUBUNIT, MOUSE; BAD PROTEIN, MOUSE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LEPTIN; LIPID; QUINOLINE DERIVATIVE;

EID: 79959591727     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-11-281     Document Type: Article
Times cited : (48)

References (43)
  • 1
    • 34250020201 scopus 로고    scopus 로고
    • Hepatocellular carcinoma: epidemiology and molecular carcinogenesis
    • 10.1053/j.gastro.2007.04.061, 17570226
    • El-Serag HB, Rudolph KL. Hepatocellular carcinoma: epidemiology and molecular carcinogenesis. Gastroenterology 2007, 132:2557-2576. 10.1053/j.gastro.2007.04.061, 17570226.
    • (2007) Gastroenterology , vol.132 , pp. 2557-2576
    • El-Serag, H.B.1    Rudolph, K.L.2
  • 2
    • 0842321807 scopus 로고    scopus 로고
    • Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma
    • 10.1053/j.gastro.2003.10.065, 14762783
    • El-Serag HB, Tran T, Everhart JE. Diabetes increases the risk of chronic liver disease and hepatocellular carcinoma. Gastroenterology 2004, 126:460-468. 10.1053/j.gastro.2003.10.065, 14762783.
    • (2004) Gastroenterology , vol.126 , pp. 460-468
    • El-Serag, H.B.1    Tran, T.2    Everhart, J.E.3
  • 3
    • 33745727871 scopus 로고    scopus 로고
    • Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis
    • for the Long-Term Survival Study (LOTUS) Group
    • Muto Y, Sato S, Watanabe A, Moriwaki H, Suzuki K, Kato A, Kato M, Nakamura T, Higuchi K, Nishiguchi S, Kumada H, Ohashi Y, . for the Long-Term Survival Study (LOTUS) Group Overweight and obesity increase the risk for liver cancer in patients with liver cirrhosis and long-term oral supplementation with branched-chain amino acid granules inhibits liver carcinogenesis in heavier patients with liver cirrhosis. Hepatol Res 2006, 35:204-214. for the Long-Term Survival Study (LOTUS) Group.
    • (2006) Hepatol Res , vol.35 , pp. 204-214
    • Muto, Y.1    Sato, S.2    Watanabe, A.3    Moriwaki, H.4    Suzuki, K.5    Kato, A.6    Kato, M.7    Nakamura, T.8    Higuchi, K.9    Nishiguchi, S.10    Kumada, H.11    Ohashi, Y.12
  • 4
    • 77954360465 scopus 로고    scopus 로고
    • Insulin resistance raises the risk for recurrence of stage I hepatocellular carcinoma after curative radiofrequency ablation in hepatitis C virus-positive patients: A prospective, case series study
    • 10.1111/j.1872-034X.2009.00616.x, 20236359
    • Imai K, Takai K, Nishigaki Y, Shimizu S, Naiki T, Hayashi H, Uematsu T, Sugihara J, Tomita E, Shimizu M, Nagaki M, Moriwaki H. Insulin resistance raises the risk for recurrence of stage I hepatocellular carcinoma after curative radiofrequency ablation in hepatitis C virus-positive patients: A prospective, case series study. Hepatol Res 2010, 40:376-382. 10.1111/j.1872-034X.2009.00616.x, 20236359.
    • (2010) Hepatol Res , vol.40 , pp. 376-382
    • Imai, K.1    Takai, K.2    Nishigaki, Y.3    Shimizu, S.4    Naiki, T.5    Hayashi, H.6    Uematsu, T.7    Sugihara, J.8    Tomita, E.9    Shimizu, M.10    Nagaki, M.11    Moriwaki, H.12
  • 6
    • 73149120271 scopus 로고    scopus 로고
    • Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link
    • 10.1002/cncr.24687, 19834957
    • Siegel AB, Zhu AX. Metabolic syndrome and hepatocellular carcinoma: two growing epidemics with a potential link. Cancer 2009, 115:5651-5661. 10.1002/cncr.24687, 19834957.
    • (2009) Cancer , vol.115 , pp. 5651-5661
    • Siegel, A.B.1    Zhu, A.X.2
  • 7
    • 74549167737 scopus 로고    scopus 로고
    • Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression
    • 10.1016/j.cell.2009.12.052, 2836922, 20141834
    • Park EJ, Lee JH, Yu GY, He G, Ali SR, Holzer RG, Osterreicher CH, Takahashi H, Karin M. Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression. Cell 2010, 140:197-208. 10.1016/j.cell.2009.12.052, 2836922, 20141834.
    • (2010) Cell , vol.140 , pp. 197-208
    • Park, E.J.1    Lee, J.H.2    Yu, G.Y.3    He, G.4    Ali, S.R.5    Holzer, R.G.6    Osterreicher, C.H.7    Takahashi, H.8    Karin, M.9
  • 9
    • 77951456114 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection
    • 10.1002/hep.23594, 20432259
    • Starley BQ, Calcagno CJ, Harrison SA. Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology 2010, 51:1820-1832. 10.1002/hep.23594, 20432259.
    • (2010) Hepatology , vol.51 , pp. 1820-1832
    • Starley, B.Q.1    Calcagno, C.J.2    Harrison, S.A.3
  • 10
    • 58949094415 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management
    • 10.1002/hep.22603, 2766096, 19065650
    • Vuppalanchi R, Chalasani N. Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis: Selected practical issues in their evaluation and management. Hepatology 2009, 49:306-317. 10.1002/hep.22603, 2766096, 19065650.
    • (2009) Hepatology , vol.49 , pp. 306-317
    • Vuppalanchi, R.1    Chalasani, N.2
  • 11
    • 26244432388 scopus 로고    scopus 로고
    • Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins
    • Cholesterol Treatment Trialists' (CTT) Collaborators
    • Baigent C, Keech A, Kearney PM, Blackwell L, Buck G, Pollicino C, Kirby A, Sourjina T, Peto R, Collins R, Simes R, . Cholesterol Treatment Trialists' (CTT) Collaborators Efficacy and safety of cholesterol-lowering treatment: prospective meta-analysis of data from 90,056 participants in 14 randomised trials of statins. Lancet 2005, 366:1267-1278. Cholesterol Treatment Trialists' (CTT) Collaborators.
    • (2005) Lancet , vol.366 , pp. 1267-1278
    • Baigent, C.1    Keech, A.2    Kearney, P.M.3    Blackwell, L.4    Buck, G.5    Pollicino, C.6    Kirby, A.7    Sourjina, T.8    Peto, R.9    Collins, R.10    Simes, R.11
  • 12
    • 35348845091 scopus 로고    scopus 로고
    • Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: an open question
    • 10.1016/j.numecd.2007.01.007, 17560098
    • Loria P, Lonardo A, Bellentani S, Day CP, Marchesini G, Carulli N. Non-alcoholic fatty liver disease (NAFLD) and cardiovascular disease: an open question. Nutr Metab Cardiovasc Dis 2007, 17:684-698. 10.1016/j.numecd.2007.01.007, 17560098.
    • (2007) Nutr Metab Cardiovasc Dis , vol.17 , pp. 684-698
    • Loria, P.1    Lonardo, A.2    Bellentani, S.3    Day, C.P.4    Marchesini, G.5    Carulli, N.6
  • 13
    • 55649083505 scopus 로고    scopus 로고
    • Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia
    • 10.1016/j.metabol.2008.07.030, 19013295
    • Hyogo H, Tazuma S, Arihiro K, Iwamoto K, Nabeshima Y, Inoue M, Ishitobi T, Nonaka M, Chayama K. Efficacy of atorvastatin for the treatment of nonalcoholic steatohepatitis with dyslipidemia. Metabolism 2008, 57:1711-1718. 10.1016/j.metabol.2008.07.030, 19013295.
    • (2008) Metabolism , vol.57 , pp. 1711-1718
    • Hyogo, H.1    Tazuma, S.2    Arihiro, K.3    Iwamoto, K.4    Nabeshima, Y.5    Inoue, M.6    Ishitobi, T.7    Nonaka, M.8    Chayama, K.9
  • 14
    • 34249342305 scopus 로고    scopus 로고
    • Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study
    • 10.1016/j.jhep.2007.02.013, 17400325
    • Ekstedt M, Franzen LE, Mathiesen UL, Holmqvist M, Bodemar G, Kechagias S. Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: a histopathological follow-up study. J Hepatol 2007, 47:135-141. 10.1016/j.jhep.2007.02.013, 17400325.
    • (2007) J Hepatol , vol.47 , pp. 135-141
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3    Holmqvist, M.4    Bodemar, G.5    Kechagias, S.6
  • 15
    • 10744219760 scopus 로고    scopus 로고
    • Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice
    • 10.1007/s11745-003-1093-x, 12880107
    • Egawa T, Toda K, Nemoto Y, Ono M, Akisaw N, Saibara T, Hayashi Y, Hiroi M, Enzan H, Onishi S. Pitavastatin ameliorates severe hepatic steatosis in aromatase-deficient (Ar-/-) mice. Lipids 2003, 38:519-523. 10.1007/s11745-003-1093-x, 12880107.
    • (2003) Lipids , vol.38 , pp. 519-523
    • Egawa, T.1    Toda, K.2    Nemoto, Y.3    Ono, M.4    Akisaw, N.5    Saibara, T.6    Hayashi, Y.7    Hiroi, M.8    Enzan, H.9    Onishi, S.10
  • 17
    • 66149091493 scopus 로고    scopus 로고
    • Statins, stem cells, and cancer
    • 10.1002/jcb.22092, 19224538
    • Gauthaman K, Fong CY, Bongso A. Statins, stem cells, and cancer. J Cell Biochem 2009, 106:975-983. 10.1002/jcb.22092, 19224538.
    • (2009) J Cell Biochem , vol.106 , pp. 975-983
    • Gauthaman, K.1    Fong, C.Y.2    Bongso, A.3
  • 18
    • 65249190240 scopus 로고    scopus 로고
    • Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes
    • 10.1053/j.gastro.2009.01.053, 2677134, 19208359
    • El-Serag HB, Johnson ML, Hachem C, Morgana RO. Statins are associated with a reduced risk of hepatocellular carcinoma in a large cohort of patients with diabetes. Gastroenterology 2009, 136:1601-1608. 10.1053/j.gastro.2009.01.053, 2677134, 19208359.
    • (2009) Gastroenterology , vol.136 , pp. 1601-1608
    • El-Serag, H.B.1    Johnson, M.L.2    Hachem, C.3    Morgana, R.O.4
  • 19
    • 26244457184 scopus 로고    scopus 로고
    • Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor
    • 10.1016/j.jhep.2005.04.010, 16083991
    • Sutter AP, Maaser K, Hopfner M, Huether A, Schuppan D, Scherubl H. Cell cycle arrest and apoptosis induction in hepatocellular carcinoma cells by HMG-CoA reductase inhibitors. Synergistic antiproliferative action with ligands of the peripheral benzodiazepine receptor. J Hepatol 2005, 43:808-816. 10.1016/j.jhep.2005.04.010, 16083991.
    • (2005) J Hepatol , vol.43 , pp. 808-816
    • Sutter, A.P.1    Maaser, K.2    Hopfner, M.3    Huether, A.4    Schuppan, D.5    Scherubl, H.6
  • 20
    • 33645537284 scopus 로고    scopus 로고
    • Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells
    • 10.1248/bpb.29.634, 16595893
    • Wang J, Tokoro T, Higa S, Kitajima I. Anti-inflammatory effect of pitavastatin on NF-kappaB activated by TNF-alpha in hepatocellular carcinoma cells. Biol Pharm Bull 2006, 29:634-639. 10.1248/bpb.29.634, 16595893.
    • (2006) Biol Pharm Bull , vol.29 , pp. 634-639
    • Wang, J.1    Tokoro, T.2    Higa, S.3    Kitajima, I.4
  • 21
    • 77954645899 scopus 로고    scopus 로고
    • Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice
    • 10.1111/j.1349-7006.2010.01579.x, 20398056
    • Yasuda Y, Shimizu M, Shirakami Y, Sakai H, Kubota M, Hata K, Hirose Y, Tsurumi H, Tanaka T, Moriwaki H. Pitavastatin inhibits azoxymethane-induced colonic preneoplastic lesions in C57BL/KsJ-db/db obese mice. Cancer Sci 2010, 101:1701-1707. 10.1111/j.1349-7006.2010.01579.x, 20398056.
    • (2010) Cancer Sci , vol.101 , pp. 1701-1707
    • Yasuda, Y.1    Shimizu, M.2    Shirakami, Y.3    Sakai, H.4    Kubota, M.5    Hata, K.6    Hirose, Y.7    Tsurumi, H.8    Tanaka, T.9    Moriwaki, H.10
  • 22
    • 75649149159 scopus 로고    scopus 로고
    • Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice
    • 10.1111/j.1349-7006.2009.01402.x, 19906067
    • Iwasa J, Shimizu M, Shiraki M, Shirakami Y, Sakai H, Terakura Y, Takai K, Tsurumi H, Tanaka T, Moriwaki H. Dietary supplementation with branched-chain amino acids suppresses diethylnitrosamine-induced liver tumorigenesis in obese and diabetic C57BL/KsJ-db/db mice. Cancer Sci 2010, 101:460-467. 10.1111/j.1349-7006.2009.01402.x, 19906067.
    • (2010) Cancer Sci , vol.101 , pp. 460-467
    • Iwasa, J.1    Shimizu, M.2    Shiraki, M.3    Shirakami, Y.4    Sakai, H.5    Terakura, Y.6    Takai, K.7    Tsurumi, H.8    Tanaka, T.9    Moriwaki, H.10
  • 24
    • 0034645632 scopus 로고    scopus 로고
    • Gene expression in the mouse retina: the effect of damaging light
    • Grimm C, Wenzel A, Hafezi F, Reme CE. Gene expression in the mouse retina: the effect of damaging light. Mol Vis 2000, 6:252-260.
    • (2000) Mol Vis , vol.6 , pp. 252-260
    • Grimm, C.1    Wenzel, A.2    Hafezi, F.3    Reme, C.E.4
  • 25
    • 70449158340 scopus 로고
    • A simple method for the isolation and purification of total lipides from animal tissues
    • Folch J, Lees M, Sloane Stanley GH. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem 1957, 226:497-509.
    • (1957) J Biol Chem , vol.226 , pp. 497-509
    • Folch, J.1    Lees, M.2    Sloane Stanley, G.H.3
  • 26
    • 34648828532 scopus 로고    scopus 로고
    • AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy
    • 10.1038/nrm2249, 17712357
    • Hardie DG. AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy. Nat Rev Mol Cell Biol 2007, 8:774-785. 10.1038/nrm2249, 17712357.
    • (2007) Nat Rev Mol Cell Biol , vol.8 , pp. 774-785
    • Hardie, D.G.1
  • 27
    • 67749111502 scopus 로고    scopus 로고
    • The LKB1-AMPK pathway: metabolism and growth control in tumour suppression
    • 10.1038/nrc2676, 2756045, 19629071
    • Shackelford DB, Shaw RJ. The LKB1-AMPK pathway: metabolism and growth control in tumour suppression. Nat Rev Cancer 2009, 9:563-575. 10.1038/nrc2676, 2756045, 19629071.
    • (2009) Nat Rev Cancer , vol.9 , pp. 563-575
    • Shackelford, D.B.1    Shaw, R.J.2
  • 28
    • 70349649506 scopus 로고    scopus 로고
    • EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells
    • 10.1002/mnfr.200800592, 19662644
    • Huang CH, Tsai SJ, Wang YJ, Pan MH, Kao JY, Way TD. EGCG inhibits protein synthesis, lipogenesis, and cell cycle progression through activation of AMPK in p53 positive and negative human hepatoma cells. Mol Nutr Food Res 2009, 53:1156-1165. 10.1002/mnfr.200800592, 19662644.
    • (2009) Mol Nutr Food Res , vol.53 , pp. 1156-1165
    • Huang, C.H.1    Tsai, S.J.2    Wang, Y.J.3    Pan, M.H.4    Kao, J.Y.5    Way, T.D.6
  • 31
    • 2542443477 scopus 로고    scopus 로고
    • Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis
    • 10.1161/01.HYP.0000126186.29571.41, 15166180
    • Sata M, Nishimatsu H, Osuga J, Tanaka K, Ishizaka N, Ishibashi S, Hirata Y, Nagai R. Statins augment collateral growth in response to ischemia but they do not promote cancer and atherosclerosis. Hypertension 2004, 43:1214-1220. 10.1161/01.HYP.0000126186.29571.41, 15166180.
    • (2004) Hypertension , vol.43 , pp. 1214-1220
    • Sata, M.1    Nishimatsu, H.2    Osuga, J.3    Tanaka, K.4    Ishizaka, N.5    Ishibashi, S.6    Hirata, Y.7    Nagai, R.8
  • 32
    • 0019140920 scopus 로고
    • Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase
    • 10.1172/JCI109938, 371547, 6903572
    • Kita T, Brown MS, Goldstein JL. Feedback regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase in livers of mice treated with mevinolin, a competitive inhibitor of the reductase. J Clin Invest 1980, 66:1094-1100. 10.1172/JCI109938, 371547, 6903572.
    • (1980) J Clin Invest , vol.66 , pp. 1094-1100
    • Kita, T.1    Brown, M.S.2    Goldstein, J.L.3
  • 33
    • 35348842802 scopus 로고    scopus 로고
    • A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis
    • 10.1002/ijc.22976, 17657716
    • Yasui Y, Suzuki R, Miyamoto S, Tsukamoto T, Sugie S, Kohno H, Tanaka T. A lipophilic statin, pitavastatin, suppresses inflammation-associated mouse colon carcinogenesis. Int J Cancer 2007, 121:2331-2339. 10.1002/ijc.22976, 17657716.
    • (2007) Int J Cancer , vol.121 , pp. 2331-2339
    • Yasui, Y.1    Suzuki, R.2    Miyamoto, S.3    Tsukamoto, T.4    Sugie, S.5    Kohno, H.6    Tanaka, T.7
  • 35
    • 0036084889 scopus 로고    scopus 로고
    • Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha
    • Finck BN, Johnson RW. Anti-inflammatory agents inhibit the induction of leptin by tumor necrosis factor-alpha. Am J Physiol Regul Integr Comp Physiol 2002, 282:R1429-1435.
    • (2002) Am J Physiol Regul Integr Comp Physiol , vol.282
    • Finck, B.N.1    Johnson, R.W.2
  • 36
    • 33947627537 scopus 로고    scopus 로고
    • Adiponectin as an anti-inflammatory factor
    • 10.1016/j.cca.2007.01.026, 2755046, 17343838
    • Ouchi N, Walsh K. Adiponectin as an anti-inflammatory factor. Clin Chim Acta 2007, 380:24-30. 10.1016/j.cca.2007.01.026, 2755046, 17343838.
    • (2007) Clin Chim Acta , vol.380 , pp. 24-30
    • Ouchi, N.1    Walsh, K.2
  • 37
    • 0041302377 scopus 로고    scopus 로고
    • The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice
    • 162288, 12840063
    • Xu A, Wang Y, Keshaw H, Xu LY, Lam KS, Cooper GJ. The fat-derived hormone adiponectin alleviates alcoholic and nonalcoholic fatty liver diseases in mice. J Clin Invest 2003, 112:91-100. 162288, 12840063.
    • (2003) J Clin Invest , vol.112 , pp. 91-100
    • Xu, A.1    Wang, Y.2    Keshaw, H.3    Xu, L.Y.4    Lam, K.S.5    Cooper, G.J.6
  • 39
    • 78049478003 scopus 로고    scopus 로고
    • Adiponectin Modulates C-Jun N-Terminal Kinase and Mammalian Target of Rapamycin and inhibits hepatocellular carcinoma
    • 10.1053/j.gastro.2010.07.001, 2967590, 20637208
    • Saxena NK, Fu PP, Nagalingam A, Wang J, Handy J, Cohen C, Tighiouart M, Sharma D, Anania FA. Adiponectin Modulates C-Jun N-Terminal Kinase and Mammalian Target of Rapamycin and inhibits hepatocellular carcinoma. Gastroenterology 2010, 139:1762-1773. 10.1053/j.gastro.2010.07.001, 2967590, 20637208.
    • (2010) Gastroenterology , vol.139 , pp. 1762-1773
    • Saxena, N.K.1    Fu, P.P.2    Nagalingam, A.3    Wang, J.4    Handy, J.5    Cohen, C.6    Tighiouart, M.7    Sharma, D.8    Anania, F.A.9
  • 40
    • 49649106710 scopus 로고    scopus 로고
    • Statins in liver disease: a molehill, an iceberg, or neither?
    • 10.1002/hep.22402, 18666246
    • Argo CK, Loria P, Caldwell SH, Lonardo A. Statins in liver disease: a molehill, an iceberg, or neither?. Hepatology 2008, 48:662-669. 10.1002/hep.22402, 18666246.
    • (2008) Hepatology , vol.48 , pp. 662-669
    • Argo, C.K.1    Loria, P.2    Caldwell, S.H.3    Lonardo, A.4
  • 41
    • 34247636128 scopus 로고    scopus 로고
    • Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C
    • 10.1016/j.jhep.2007.01.021, 17335930
    • Targher G, Bertolini L, Padovani R, Rodella S, Arcaro G, Day C. Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C. J Hepatol 2007, 46:1126-1132. 10.1016/j.jhep.2007.01.021, 17335930.
    • (2007) J Hepatol , vol.46 , pp. 1126-1132
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Arcaro, G.5    Day, C.6
  • 42
    • 5844370499 scopus 로고    scopus 로고
    • Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group
    • 10.1056/NEJM199606133342402, 8628336
    • Muto Y, Moriwaki H, Ninomiya M, Adachi S, Saito A, Takasaki KT, Tanaka T, Tsurumi K, Okuno M, Tomita E, Nakamura T, Kojima T. Prevention of second primary tumors by an acyclic retinoid, polyprenoic acid, in patients with hepatocellular carcinoma. Hepatoma Prevention Study Group. N Engl J Med 1996, 334:1561-1567. 10.1056/NEJM199606133342402, 8628336.
    • (1996) N Engl J Med , vol.334 , pp. 1561-1567
    • Muto, Y.1    Moriwaki, H.2    Ninomiya, M.3    Adachi, S.4    Saito, A.5    Takasaki, K.T.6    Tanaka, T.7    Tsurumi, K.8    Okuno, M.9    Tomita, E.10    Nakamura, T.11    Kojima, T.12


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.