Leptin upregulates telomerase activity and transcription of human telomerase reverse transcriptase in MCF-7 breast cancer cells

Biochemical and Biophysical Research Communications

Volumn 394, Issue 1, 2010, Pages 59-63

  Ren, He ^a   Zhao, Tiansuo ^a   Wang, Xiuchao ^a   Gao, Chuntao ^a   Wang, Jian ^a   Yu, Ming ^a   Hao, Jihui ^a  

^a TIANJIN MEDICAL UNIVERSITY   (China)

Author keywords

hTERT; Leptin; STAT3; Telomerase

Indexed keywords

LEPTIN; MESSENGER RNA; STAT3 PROTEIN; TELOMERASE; TELOMERASE REVERSE TRANSCRIPTASE;

ARTICLE; BREAST CANCER; CELL PROLIFERATION; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; DISEASE ASSOCIATION; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; OBESITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BINDING; PROTEIN EXPRESSION; UPREGULATION;

BREAST NEOPLASMS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LEPTIN; MALE; OBESITY; STAT3 TRANSCRIPTION FACTOR; TELOMERASE; TRANSCRIPTION, GENETIC;

EID: 77949875577     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2010.02.093     Document Type: Article

References (31)

1. Lorincz A.M., and Sukumar S. Molecular links between obesity and breast cancer. Endocr. Relat. Cancer 13 (2006) 279-292
2. Considine R.V., Sinha M.K., Heiman M.L., Kriauciunas A., Stephens T.W., Nyce M.R., Ohannesian J.P., Marco C.C., McKee L.J., and Bauer T.L. Serum immunoreactive-leptin concentrations in normal-weight and obese humans. N. Engl. J. Med. 334 (1996) 292-295
3. Perera C.N., Chin H.G., Duru N., and Camarillo I.G. Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression. J. Endocrinol. 199 (2008) 221-233
4. Keith W.N., and Cairney C.J. Telomerase redefined: integrated regulation of hTR and hTERT for telomere maintenance and telomerase activity. Biochimie 90 (2008) 13-23
5. Shay J.W., and Bacchetti S. A survey of telomerase activity in human cancer. Eur. J. Cancer 33 (1997) 787-791
6. Schepelmann S., Ogilvie L.M., Hedley D., Friedlos F., Martin J., Scanlon I., Chen P., Marais R., and Springer C.J. Suicide gene therapy of human colon carcinoma xenografts using an armed oncolytic adenovirus expressing carboxypeptidase G2. Cancer Res. 67 (2007) 4949-4955
7. Konnikova L., Simeone M.C., Kruger M.M., Kotecki M., and Cochran B.H. Transducer and activator of transcription 3 (STAT3) regulates human telomerase reverse transcriptase (hTERT) expression in human cancer and primary cells. Cancer Res. 65 (2005) 6516-6520
8. Frank D.A. STAT3 as a central mediator of neoplastic cellular transformation. Cancer Lett. 251 (2007) 199-210
9. Yin N., Wang D., Zhang H., Yi X., Sun X., Shi B., Wu H., Wu G., Wang X., and Shang Y. Molecular mechanisms involved in the growth stimulation of breast cancer cells by leptin. Cancer Res. 64 (2004) 5870-5875
10. Saxena N.K., Vertino P.M., Anania F.A., and Sharma D. Leptin-induced growth stimulation of breast cancer cells involves recruitment of histone acetyltransferases and mediator complex to CYCLIN D1 promoter via activation of Stat3. J. Biol. Chem. 282 (2007) 13316-13325
11. Kato K., Nomoto M., Izumi H., Ise T., Nakano S., Niho Y., and Kohno K. Structure and functional analysis of the human STAT3 gene promoter: alteration of chromatin structure as a possible mechanism for the upregulation in cisplatin-resistant cells. Biochim. Biophys. Acta 1493 (2000) 91-100
12. Calle E.E., Rodriguez C., Walker-Thurmond K., and Thun M.J. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of US adults. N. Engl. J. Med. 348 (2003) 1625-1638
13. Rene Gonzalez R., Watters A., Xu Y., Singh U.P., Mann D.R., Rueda B.R., and Penichet M.L. Leptin-signaling inhibition results in efficient anti-tumor activity in estrogen receptor positive or negative breast cancer. Breast Cancer Res. 11 (2009) R36
14. Jardé T., Caldefie-Chézet F., Goncalves-Mendes N., Mishellany F., Buechler C., Penault-Llorca F., and Vasson M.P. Involvement of adiponectin and leptin in breast cancer: clinical and in vitro studies. Endocr. Relat. Cancer 16 (2009) 1197-1210
15. Perera C.N., Chin H.G., Duru N., and Camarilloa I.G. Leptin-regulated gene expression in MCF-7 breast cancer cells: mechanistic insights into leptin-regulated mammary tumor growth and progression. J. Endocrinol. 199 (2008) 221-233
16. Zhu Y., Wang A., Liu M.C., Zwart A., Lee R.Y., Gallagher A., Wang Y., Miller W.R., Dixon J.M., and Clarke R. Estrogen receptor alpha positive breast tumors and breast cancer cell lines share similarities in their transcriptome data structures. Int. J. Oncol. 29 (2006) 1581-1589
17. Chen C., Chang Y.C., Liu C.L., Liu T.P., Chang K.J., and Guo I.C. Leptin induces proliferation and anti-apoptosis in human hepatocarcinoma cells by up-regulating cyclin D1 and down-regulating Bax via a Janus kinase 2-linked pathway. Endocr. Relat. Cancer 14 (2007) 513-529
18. Somasundar P., Yu A.K., Vona-Davis L., and McFadden D.W. Differential effects of leptin on cancer in vitro. J. Surg. Res. 113 (2003) 50-55
19. Wetterau L.A., Francis M.J., Ma L., and Cohen P. Insulin-like growth factor I stimulates telomerase activity in prostate cancer cells. J. Clin. Endocrinol. Metab. 88 (2003) 3354-3359
20. Chau M.N., El Touny L.H., Jagadeesh S., and Banerjee P.P. Physiologically achievable concentrations of genistein enhance telomerase activity in prostate cancer cells via the activation of STAT3. Carcinogenesis 28 (2007) 2282-2290
21. Hu X., Juneja S.C., Maihle N.J., and Cleary M.P. Leptin - A growth factor in normal and malignant breast cells and for normal mammary gland development. J. Natl. Cancer Inst. 94 (2002) 1704-1711
22. Clark G.M., Osborne C.K., Levitt D., Wu F., and Kim N.W. Telomerase activity and survival of patients with node-positive breast cancer. J. Natl. Cancer Inst. 89 (1997) 1874-1881
23. Lautenbach A., Budde A., Wrann C.D., Teichmann B., Vieten G., Karl T., and Nave H. Obesity and the associated mediators leptin, estrogen and IGF-I enhance the cell proliferation and early tumorigenesis of breast cancer cells. Nutr. Cancer 61 (2009) 484-491
24. Kyo S., Takakura M., Kanaya T., Zhuo W., Fujimoto K., Nishio Y., Orimo A., and Inoue M. Estrogen activates telomerase. Cancer Res. 59 (1999) 5917-5921
25. Lee J., Sung Y.H., Cheong C., Choi Y.S., Jeon H.K., Sun W., Hahn W.C., Ishikawa F., and Lee H.W. TERT promotes cellular and organismal survival independently of telomerase activity. Oncogene 27 (2008) 3754-3760
26. Jagadeesh S., Kyo S., and Banerjee P.P. Genistein represses telomerase activity via both transcriptional and posttranslational mechanisms in human prostate cancer cells. Cancer Res. 66 (2006) 2107-2115
27. Jing N., and Tweardy D.J. Targeting Stat3 in cancer therapy. Anticancer Drugs 16 (2005) 601-607
28. Meydan N., Grunberger T., Dadi H., Shahar M., Arpaia E., Lapidot Z., Leeder J.S., Freedman M., Cohen A., Gazit A., Levitzki A., and Roifman C.M. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor. Nature 379 (1996) 645-648
29. Song H., Wang R., and Wang S. Low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc. Natl. Acad. Sci. USA 102 (2005) 4700-4705
30. Gao Q., Mezei G., Nie Y., Rao Y., Choi C.S., Bechmann I., Leranth C., Toran-Allerand D., Priest C.A., Roberts J.L., Gao X.B., Mobbs C., Shulman G.I., Diano S., and Horvath T.L. Anorectic estrogen mimics leptin's effect on the rewiring of melanocortin cells, Stat3 signaling in obese animals. Nat. Med. 13 (2007) 89-94
31. Binai N.A., Damert A., Carra G., Steckelbroeck S., Löwer J., Löwer R., and Wessler S. Expression of estrogen receptor alpha increases leptin-induced STAT3 activity in breast cancer cells. Int. J. Cancer (2009) (Epub ahead of print)