Toward an understanding of agonist binding to human orexin-1 and orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis

Biochemistry

Volumn 52, Issue 46, 2013, Pages 8246-8260

  Heifetz, Alexander ^a   Barker, Oliver ^a   Benjamin Morris, G ^c   Law, Richard J ^a   Slack, Mark ^b   Biggin, Philip C ^c  

^a EVOTEC UK LTD   (United Kingdom)

^b EVOTEC AG   (Germany)

^c UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

G PROTEIN COUPLED RECEPTORS; HOMOLOGY MODELING; MOLECULAR DYNAMICS SIMULATIONS; PHYSIOLOGICAL FUNCTIONS; RECEPTOR INTERACTION; SITE DIRECTED MUTAGENESIS; STRUCTURAL ASSESSMENTS; STRUCTURAL INTERPRETATION;

MOLECULAR DYNAMICS; POLYPEPTIDES;

PEPTIDES;

NEUROPEPTIDE; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR;

ARTICLE; MODEL; MOLECULAR DYNAMICS; PRIORITY JOURNAL; SIMULATION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MODELS, CHEMICAL; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; MUTAGENESIS, SITE-DIRECTED; NEUROPEPTIDES; OREXIN RECEPTORS; PROTEIN CONFORMATION; RECEPTORS, G-PROTEIN-COUPLED; SEQUENCE ALIGNMENT;

EID: 84888266137     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi401119m     Document Type: Article

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