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Volumn 4, Issue MAY, 2013, Pages

Differential roles of orexin receptors in the regulation of sleep/wakefulness

Author keywords

Arousal; Hypothalamus; Monoamine; Narcolepsy; Orexin; Sleep

Indexed keywords

CHOLINERGIC RECEPTOR; G PROTEIN COUPLED INWARDLY RECTIFYING POTASSIUM CHANNEL; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; SEROTONIN AGONIST;

EID: 84884180617     PISSN: None     EISSN: 16642392     Source Type: Journal    
DOI: 10.3389/fendo.2013.00057     Document Type: Review
Times cited : (43)

References (69)
  • 1
    • 10844253886 scopus 로고    scopus 로고
    • Reduced food anticipatory activity in genetically orexin (hypocretin) neuron -ablated mice
    • Akiyama, M., Yuasa, T., Hayasaka, N., Horikawa, K., Sakurai, T., and Shibata, S. (2004). Reduced food anticipatory activity in genetically orexin (hypocretin) neuron -ablated mice. Eur. J. Neurosci. 20, 3054-3062.
    • (2004) Eur. J. Neurosci. , vol.20 , pp. 3054-3062
    • Akiyama, M.1    Yuasa, T.2    Hayasaka, N.3    Horikawa, K.4    Sakurai, T.5    Shibata, S.6
  • 2
    • 0020067062 scopus 로고
    • Canine model of narcolepsy: genetic and developmental determinants
    • Baker, T. L., Foutz, A. S., McNerney, V., Mitler, M. M., and Dement, W. C. (1982). Canine model of narcolepsy: genetic and developmental determinants. Exp. Neurol. 75, 729-742.
    • (1982) Exp. Neurol. , vol.75 , pp. 729-742
    • Baker, T.L.1    Foutz, A.S.2    McNerney, V.3    Mitler, M.M.4    Dement, W.C.5
  • 4
    • 0034667702 scopus 로고    scopus 로고
    • Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons
    • Bourgin, P., Huitron-Resendiz, S., Spier, A. D., Fabre, V., Morte, B., Criado, J. R., et al. (2000). Hypocretin-1 modulates rapid eye movement sleep through activation of locus coeruleus neurons. J. Neurosci. 20, 7760-7765.
    • (2000) J. Neurosci. , vol.20 , pp. 7760-7765
    • Bourgin, P.1    Huitron-Resendiz, S.2    Spier, A.D.3    Fabre, V.4    Morte, B.5    Criado, J.R.6
  • 6
    • 0035134269 scopus 로고    scopus 로고
    • Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat
    • Brown, R. E., Sergeeva, O., Eriksson, K. S., and Haas, H. L. (2001). Orexin A excites serotonergic neurons in the dorsal raphe nucleus of the rat. Neuropharmacology 40, 457-459.
    • (2001) Neuropharmacology , vol.40 , pp. 457-459
    • Brown, R.E.1    Sergeeva, O.2    Eriksson, K.S.3    Haas, H.L.4
  • 7
    • 0036546690 scopus 로고    scopus 로고
    • Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy
    • Burlet, S., Tyler, C. J., and Leonard, C. S. (2002). Direct and indirect excitation of laterodorsal tegmental neurons by Hypocretin/Orexin peptides: implications for wakefulness and narcolepsy. J. Neurosci. 22, 2862-2872.
    • (2002) J. Neurosci. , vol.22 , pp. 2862-2872
    • Burlet, S.1    Tyler, C.J.2    Leonard, C.S.3
  • 8
    • 69749116172 scopus 로고    scopus 로고
    • Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions
    • Carter, M. E., Adamantidis, A., Ohtsu, H., Deisseroth, K., and de Lecea, L. (2009). Sleep homeostasis modulates hypocretin-mediated sleep-to-wake transitions. J. Neurosci. 29, 10939-10949.
    • (2009) J. Neurosci. , vol.29 , pp. 10939-10949
    • Carter, M.E.1    Adamantidis, A.2    Ohtsu, H.3    Deisseroth, K.4    de Lecea, L.5
  • 10
    • 0033588184 scopus 로고    scopus 로고
    • Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation
    • Chemelli, R. M., Willie, J. T., Sinton, C. M., Elmquist, J. K., Scammell, T., Lee, C., et al. (1999). Narcolepsy in orexin knockout mice: molecular genetics of sleep regulation. Cell 98, 437-451.
    • (1999) Cell , vol.98 , pp. 437-451
    • Chemelli, R.M.1    Willie, J.T.2    Sinton, C.M.3    Elmquist, J.K.4    Scammell, T.5    Lee, C.6
  • 11
    • 41149102361 scopus 로고    scopus 로고
    • Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons
    • Chen, X. W., Mu, Y., Huang, H. P., Guo, N., Zhang, B., Fan, S. Y., et al. (2008). Hypocretin-1 potentiates NMDA receptor-mediated somatodendritic secretion from locus ceruleus neurons. J. Neurosci. 28, 3202-3208.
    • (2008) J. Neurosci. , vol.28 , pp. 3202-3208
    • Chen, X.W.1    Mu, Y.2    Huang, H.P.3    Guo, N.4    Zhang, B.5    Fan, S.Y.6
  • 12
    • 0033582175 scopus 로고    scopus 로고
    • Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems
    • Date, Y., Ueta, Y., Yamashita, H., Yamaguchi, H., Matsukura, S., Kangawa, K., et al. (1999). Orexins, orexigenic hypothalamic peptides, interact with autonomic, neuroendocrine and neuroregulatory systems. Proc. Natl. Acad. Sci. U.S.A. 96, 748-753.
    • (1999) Proc. Natl. Acad. Sci. U.S.A. , vol.96 , pp. 748-753
    • Date, Y.1    Ueta, Y.2    Yamashita, H.3    Yamaguchi, H.4    Matsukura, S.5    Kangawa, K.6
  • 14
    • 67649867893 scopus 로고    scopus 로고
    • Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonisminduced sleep promotion in the rat
    • Dugovic, C., Shelton, J. E., Aluisio, L. E., Fraser, I. C., Jiang, X., Sutton, S. W., et al. (2009). Blockade of orexin-1 receptors attenuates orexin-2 receptor antagonisminduced sleep promotion in the rat. J. Pharmacol. Exp. Ther. 330, 142-151.
    • (2009) J. Pharmacol. Exp. Ther. , vol.330 , pp. 142-151
    • Dugovic, C.1    Shelton, J.E.2    Aluisio, L.E.3    Fraser, I.C.4    Jiang, X.5    Sutton, S.W.6
  • 16
    • 0035576310 scopus 로고    scopus 로고
    • Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus
    • Eriksson, K. S., Sergeeva, O., Brown, R. E., and Haas, H. L. (2001). Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus. J. Neurosci. 21, 9273-9279.
    • (2001) J. Neurosci. , vol.21 , pp. 9273-9279
    • Eriksson, K.S.1    Sergeeva, O.2    Brown, R.E.3    Haas, H.L.4
  • 17
    • 0035977981 scopus 로고    scopus 로고
    • Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats
    • Greco, M. A., and Shiromani, P. J. (2001). Hypocretin receptor protein and mRNA expression in the dorsolateral pons of rats. Brain Res. Mol. Brain Res. 88, 176- 182.
    • (2001) Brain Res. Mol. Brain Res. , vol.88
    • Greco, M.A.1    Shiromani, P.J.2
  • 19
    • 12844284453 scopus 로고    scopus 로고
    • The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling
    • Haj-Dahmane, S., and Shen, R. Y. (2005). The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling. J. Neurosci. 25, 896-905.
    • (2005) J. Neurosci. , vol.25 , pp. 896-905
    • Haj-Dahmane, S.1    Shen, R.Y.2
  • 20
    • 0034992322 scopus 로고    scopus 로고
    • Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity
    • Hara, J., Beuckmann, C. T., Nambu, T., Willie, J. T., Chemelli, R. M., Sinton, C. M., et al. (2001). Genetic ablation of orexin neurons in mice results in narcolepsy, hypophagia, and obesity. Neuron 30, 345-354.
    • (2001) Neuron , vol.30 , pp. 345-354
    • Hara, J.1    Beuckmann, C.T.2    Nambu, T.3    Willie, J.T.4    Chemelli, R.M.5    Sinton, C.M.6
  • 21
    • 25644432796 scopus 로고    scopus 로고
    • A role for lateral hypothalamic orexin neurons in reward seeking
    • Harris, G. C., Wimmer, M., and Aston-Jones, G. (2005). A role for lateral hypothalamic orexin neurons in reward seeking. Nature 437, 556-559.
    • (2005) Nature , vol.437 , pp. 556-559
    • Harris, G.C.1    Wimmer, M.2    Aston-Jones, G.3
  • 22
    • 0035210704 scopus 로고    scopus 로고
    • Orexin A and B evoke noradrenaline release from rat cerebrocortical slices
    • Hirota, K., Kushikata, T., Kudo, M., Kudo, T., Lambert, D. G., and Matsuki, A. (2001). Orexin A and B evoke noradrenaline release from rat cerebrocortical slices. Br. J. Pharmacol. 134, 1461-1466.
    • (2001) Br. J. Pharmacol. , vol.134 , pp. 1461-1466
    • Hirota, K.1    Kushikata, T.2    Kudo, M.3    Kudo, T.4    Lambert, D.G.5    Matsuki, A.6
  • 24
    • 8644284844 scopus 로고    scopus 로고
    • Orexin (hypocretin) effects on constitutively active inward rectifier K+ channels in cultured nucleus basalis neurons
    • Hoang, Q. V., Zhao, P., Nakajima, S., and Nakajima, Y. (2004). Orexin (hypocretin) effects on constitutively active inward rectifier K+ channels in cultured nucleus basalis neurons. J. Neurophysiol. 92, 3183-3191.
    • (2004) J. Neurophysiol. , vol.92 , pp. 3183-3191
    • Hoang, Q.V.1    Zhao, P.2    Nakajima, S.3    Nakajima, Y.4
  • 25
    • 75749126518 scopus 로고    scopus 로고
    • Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states
    • Hondo, M., Nagai, K., Ohno, K., Kisanuki, Y., Willie, J. T., Watanabe, T., et al. (2010). Histamine-1 receptor is not required as a downstream effector of orexin-2 receptor in maintenance of basal sleep/wake states. Acta Physiol (Oxf.) 198, 287-294.
    • (2010) Acta Physiol (Oxf.) , vol.198 , pp. 287-294
    • Hondo, M.1    Nagai, K.2    Ohno, K.3    Kisanuki, Y.4    Willie, J.T.5    Watanabe, T.6
  • 26
    • 0033552658 scopus 로고    scopus 로고
    • Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system
    • Horvath, T. L., Peyron, C., Diano, S., Ivanov, A., Aston-Jones, G., Kilduff, T. S., et al. (1999). Hypocretin (orexin) activation and synaptic innervation of the locus coeruleus noradrenergic system. J. Comp. Neurol. 415, 145-159.
    • (1999) J. Comp. Neurol. , vol.415 , pp. 145-159
    • Horvath, T.L.1    Peyron, C.2    Diano, S.3    Ivanov, A.4    Aston-Jones, G.5    Kilduff, T.S.6
  • 28
    • 58149528050 scopus 로고    scopus 로고
    • Electrophysiological effects of orexins/hypocretins on pedunculopontine tegmental neurons in rats: an in vitro study
    • Kim, J., Nakajima, K., Oomura, Y., Wayner, M. J., and Sasaki, K. (2009a). Electrophysiological effects of orexins/hypocretins on pedunculopontine tegmental neurons in rats: an in vitro study. Peptides 30, 191-209.
    • (2009) Peptides , vol.30 , pp. 191-209
    • Kim, J.1    Nakajima, K.2    Oomura, Y.3    Wayner, M.J.4    Sasaki, K.5
  • 29
    • 67349114404 scopus 로고    scopus 로고
    • Orexin-A and ghrelin depolarize the same pedunculopontine tegmental neurons in rats: an in vitro study
    • Kim, J., Nakajima, K., Oomura, Y., Wayner, M. J., and Sasaki, K. (2009b). Orexin-A and ghrelin depolarize the same pedunculopontine tegmental neurons in rats: an in vitro study. Peptides 30, 1328-1335.
    • (2009) Peptides , vol.30 , pp. 1328-1335
    • Kim, J.1    Nakajima, K.2    Oomura, Y.3    Wayner, M.J.4    Sasaki, K.5
  • 30
    • 3042552335 scopus 로고    scopus 로고
    • Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum
    • Kohlmeier, K. A., Inoue, T., and Leonard, C. S. (2004). Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum. J. Neurophysiol. 92, 221-235.
    • (2004) J. Neurophysiol. , vol.92 , pp. 221-235
    • Kohlmeier, K.A.1    Inoue, T.2    Leonard, C.S.3
  • 31
    • 57349100377 scopus 로고    scopus 로고
    • Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels
    • Kohlmeier, K. A., Watanabe, S., Tyler, C. J., Burlet, S., and Leonard, C. S. (2008). Dual orexin actions on dorsal raphe and laterodorsal tegmentum neurons: noisy cation current activation and selective enhancement of Ca2+ transients mediated by L-type calcium channels. J. Neurophysiol. 100, 2265-2281.
    • (2008) J. Neurophysiol. , vol.100 , pp. 2265-2281
    • Kohlmeier, K.A.1    Watanabe, S.2    Tyler, C.J.3    Burlet, S.4    Leonard, C.S.5
  • 32
    • 0033529520 scopus 로고    scopus 로고
    • The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene
    • Lin, L., Faraco, J., Li, R., Kadotani, H., Rogers, W., Lin, X., et al. (1999). The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 gene. Cell 98, 365-376.
    • (1999) Cell , vol.98 , pp. 365-376
    • Lin, L.1    Faraco, J.2    Li, R.3    Kadotani, H.4    Rogers, W.5    Lin, X.6
  • 33
    • 0036848635 scopus 로고    scopus 로고
    • Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions
    • Liu, R. J., van den Pol, A. N., and Aghajanian, G. K. (2002). Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions. J. Neurosci. 22, 9453-9464.
    • (2002) J. Neurosci. , vol.22 , pp. 9453-9464
    • Liu, R.J.1    van den Pol, A.N.2    Aghajanian, G.K.3
  • 34
    • 0033921449 scopus 로고    scopus 로고
    • Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting
    • Lu, X. Y., Bagnol, D., Burke, S., Akil, H., and Watson, S. J. (2000). Differential distribution and regulation of OX1 and OX2 orexin/hypocretin receptor messenger RNA in the brain upon fasting. Horm. Behav. 37, 335-344.
    • (2000) Horm. Behav. , vol.37 , pp. 335-344
    • Lu, X.Y.1    Bagnol, D.2    Burke, S.3    Akil, H.4    Watson, S.J.5
  • 36
    • 79955777621 scopus 로고    scopus 로고
    • Differential roles of orexin receptor-1 and -2 in the regulation of non- REM and REM sleep
    • Mieda, M., Hasegawa, E., Kisanuki, Y. Y., Sinton, C. M., Yanagisawa, M., and Sakurai, T. (2011). Differential roles of orexin receptor-1 and -2 in the regulation of non- REM and REM sleep. J. Neurosci. 31, 6518-6526.
    • (2011) J. Neurosci. , vol.31 , pp. 6518-6526
    • Mieda, M.1    Hasegawa, E.2    Kisanuki, Y.Y.3    Sinton, C.M.4    Yanagisawa, M.5    Sakurai, T.6
  • 37
    • 84876932335 scopus 로고    scopus 로고
    • Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders
    • Mieda, M., and Sakurai, T. (2013). Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status. CNS Drugs 27, 83-90.
    • (2013) Rationale for development and current status. CNS Drugs , vol.27 , pp. 83-90
    • Mieda, M.1    Sakurai, T.2
  • 38
    • 9244251539 scopus 로고    scopus 로고
    • Orexin neurons function in an efferent pathway of a foodentrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness
    • Mieda, M., Williams, S. C., Sinton, C. M., Richardson, J. A., Sakurai, T., and Yanagisawa, M. (2004). Orexin neurons function in an efferent pathway of a foodentrainable circadian oscillator in eliciting food-anticipatory activity and wakefulness. J. Neurosci. 24, 10493-10501.
    • (2004) J. Neurosci. , vol.24 , pp. 10493-10501
    • Mieda, M.1    Williams, S.C.2    Sinton, C.M.3    Richardson, J.A.4    Sakurai, T.5    Yanagisawa, M.6
  • 39
  • 40
    • 84863614156 scopus 로고    scopus 로고
    • Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone
    • doi:10.1371/journal.pone.0039131
    • Morairty, S. R., Revel, F. G., Malherbe, P., Moreau, J. L., Valladao, D., Wettstein, J. G., et al. (2012). Dual hypocretin receptor antagonism is more effective for sleep promotion than antagonism of either receptor alone. PLoS ONE 7:e39131. doi:10.1371/journal.pone.0039131
    • (2012) PLoS ONE , vol.7
    • Morairty, S.R.1    Revel, F.G.2    Malherbe, P.3    Moreau, J.L.4    Valladao, D.5    Wettstein, J.G.6
  • 41
    • 10444233582 scopus 로고    scopus 로고
    • Orexins cause depolarization via nonselective cationic and K+ channels in isolated locus coeruleus neurons
    • Murai, Y., and Akaike, T. (2005). Orexins cause depolarization via nonselective cationic and K+ channels in isolated locus coeruleus neurons. Neurosci. Res. 51, 55- 65.
    • (2005) Neurosci. Res. , vol.51
    • Murai, Y.1    Akaike, T.2
  • 43
    • 32344453801 scopus 로고    scopus 로고
    • Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine
    • Narita, M., Nagumo, Y., Hashimoto, S., Khotib, J., Miyatake, M., Sakurai, T., et al. (2006). Direct involvement of orexinergic systems in the activation of the mesolimbic dopamine pathway and related behaviors induced by morphine. J. Neurosci. 26, 398-405.
    • (2006) J. Neurosci. , vol.26 , pp. 398-405
    • Narita, M.1    Nagumo, Y.2    Hashimoto, S.3    Khotib, J.4    Miyatake, M.5    Sakurai, T.6
  • 44
    • 0036674614 scopus 로고    scopus 로고
    • The neurobiology of sleep: genetics, cellular physiology and subcortical networks
    • Pace-Schott, E. F., and Hobson, J. A. (2002). The neurobiology of sleep: genetics, cellular physiology and subcortical networks. Nat. Rev. Neurosci. 3, 591-605.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 591-605
    • Pace-Schott, E.F.1    Hobson, J.A.2
  • 45
    • 0033826856 scopus 로고    scopus 로고
    • A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
    • Peyron, C., Faraco, J., Rogers, W., Ripley, B., Overeem, S., Charnay, Y., et al. (2000). A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains. Nat. Med. 6, 991-997.
    • (2000) Nat. Med. , vol.6 , pp. 991-997
    • Peyron, C.1    Faraco, J.2    Rogers, W.3    Ripley, B.4    Overeem, S.5    Charnay, Y.6
  • 47
    • 33847121297 scopus 로고    scopus 로고
    • The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
    • Sakurai, T. (2007). The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nat. Rev. Neurosci. 8, 171-181.
    • (2007) Nat. Rev. Neurosci. , vol.8 , pp. 171-181
    • Sakurai, T.1
  • 48
    • 20244380014 scopus 로고    scopus 로고
    • Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior
    • Sakurai, T., Amemiya, A., Ishii, M., Matsuzaki, I., Chemelli, R. M., Tanaka, H., et al. (1998). Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behavior. Cell 92, 573-585.
    • (1998) Cell , vol.92 , pp. 573-585
    • Sakurai, T.1    Amemiya, A.2    Ishii, M.3    Matsuzaki, I.4    Chemelli, R.M.5    Tanaka, H.6
  • 49
    • 79960942001 scopus 로고    scopus 로고
    • Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal
    • Sakurai, T., and Mieda, M. (2011). Connectomics of orexin-producing neurons: interface of systems of emotion, energy homeostasis and arousal. Trends Pharmacol. Sci. 32, 451-462.
    • (2011) Trends Pharmacol. Sci. , vol.32 , pp. 451-462
    • Sakurai, T.1    Mieda, M.2
  • 50
    • 20244374121 scopus 로고    scopus 로고
    • Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice
    • Sakurai, T., Nagata, R., Yamanaka, A., Kawamura, H., Tsujino, N., Muraki, Y., et al. (2005). Input of orexin/hypocretin neurons revealed by a genetically encoded tracer in mice. Neuron 46, 297-308.
    • (2005) Neuron , vol.46 , pp. 297-308
    • Sakurai, T.1    Nagata, R.2    Yamanaka, A.3    Kawamura, H.4    Tsujino, N.5    Muraki, Y.6
  • 51
    • 79951994324 scopus 로고    scopus 로고
    • Orexin receptors: pharmacology and therapeutic opportunities
    • Scammell, T. E., and Winrow, C. J. (2011). Orexin receptors: pharmacology and therapeutic opportunities. Annu. Rev. Pharmacol. Toxicol. 51, 243-266.
    • (2011) Annu. Rev. Pharmacol. Toxicol. , vol.51 , pp. 243-266
    • Scammell, T.E.1    Winrow, C.J.2
  • 52
    • 84865717083 scopus 로고    scopus 로고
    • Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ
    • Schone, C., Cao, Z. F., Apergis-Schoute, J., Adamantidis, A., Sakurai, T., and Burdakov, D. (2012). Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ. J. Neurosci. 32, 12437-12443.
    • (2012) J. Neurosci. , vol.32 , pp. 12437-12443
    • Schone, C.1    Cao, Z.F.2    Apergis-Schoute, J.3    Adamantidis, A.4    Sakurai, T.5    Burdakov, D.6
  • 54
    • 1942468742 scopus 로고    scopus 로고
    • Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus
    • Soffin, E. M., Gill, C. H., Brough, S. J., Jerman, J. C., and Davies, C. H. (2004). Pharmacological characterisation of the orexin receptor subtype mediating postsynaptic excitation in the rat dorsal raphe nucleus. Neuropharmacology 46, 1168-1176.
    • (2004) Neuropharmacology , vol.46 , pp. 1168-1176
    • Soffin, E.M.1    Gill, C.H.2    Brough, S.J.3    Jerman, J.C.4    Davies, C.H.5
  • 56
    • 11144285981 scopus 로고    scopus 로고
    • State-dependent effects of orexins on the serotonergic dorsal raphe neurons in the rat
    • Takahashi, K., Wang, Q. P., Guan, J. L., Kayama, Y., Shioda, S., and Koyama, Y. (2005). State-dependent effects of orexins on the serotonergic dorsal raphe neurons in the rat. Regul. Pept. 126, 43-47.
    • (2005) Regul. Pept. , vol.126 , pp. 43-47
    • Takahashi, K.1    Wang, Q.P.2    Guan, J.L.3    Kayama, Y.4    Shioda, S.5    Koyama, Y.6
  • 57
    • 27844592708 scopus 로고    scopus 로고
    • Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy
    • Takakusaki, K., Takahashi, K., Saitoh, K., Harada, H., Okumura, T., Kayama, Y., et al. (2005). Orexinergic projections to the cat midbrain mediate alternation of emotional behavioural states from locomotion to cataplexy. J. Physiol. (Lond.) 568, 1003-1020.
    • (2005) J. Physiol. (Lond.) , vol.568 , pp. 1003-1020
    • Takakusaki, K.1    Takahashi, K.2    Saitoh, K.3    Harada, H.4    Okumura, T.5    Kayama, Y.6
  • 60
    • 4444253020 scopus 로고    scopus 로고
    • Orexin-A infusion in the locus ceruleus triggers norepinephrine (NE) release and NE-induced long -term potentiation in the dentate gyrus
    • Walling, S. G., Nutt, D. J., Lalies, M. D., and Harley, C. W. (2004). Orexin-A infusion in the locus ceruleus triggers norepinephrine (NE) release and NE-induced long -term potentiation in the dentate gyrus. J. Neurosci. 24, 7421-7426.
    • (2004) J. Neurosci. , vol.24 , pp. 7421-7426
    • Walling, S.G.1    Nutt, D.J.2    Lalies, M.D.3    Harley, C.W.4
  • 61
    • 11044234757 scopus 로고    scopus 로고
    • The orexinergic synaptic innervation of serotonin- and orexin 1-receptorcontaining neurons in the dorsal raphe nucleus
    • Wang, Q. P., Koyama, Y., Guan, J. L., Takahashi, K., Kayama, Y., and Shioda, S. (2005). The orexinergic synaptic innervation of serotonin- and orexin 1-receptorcontaining neurons in the dorsal raphe nucleus. Regul. Pept. 126, 35-42.
    • (2005) Regul. Pept. , vol.126 , pp. 35-42
    • Wang, Q.P.1    Koyama, Y.2    Guan, J.L.3    Takahashi, K.4    Kayama, Y.5    Shioda, S.6
  • 62
    • 0038724250 scopus 로고    scopus 로고
    • Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes
    • Willie, J. T., Chemelli, R. M., Sinton, C. M., Tokita, S., Williams, S. C., Kisanuki, Y. Y., et al. (2003). Distinct narcolepsy syndromes in Orexin receptor-2 and Orexin null mice: molecular genetic dissection of Non-REM and REM sleep regulatory processes. Neuron 38, 715-730.
    • (2003) Neuron , vol.38 , pp. 715-730
    • Willie, J.T.1    Chemelli, R.M.2    Sinton, C.M.3    Tokita, S.4    Williams, S.C.5    Kisanuki, Y.Y.6
  • 63
    • 1842782809 scopus 로고    scopus 로고
    • Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons
    • Wu, M., Zaborszky, L., Hajszan, T., van den Pol, A. N., and Alreja, M. (2004). Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons. J. Neurosci. 24, 3527-3536.
    • (2004) J. Neurosci. , vol.24 , pp. 3527-3536
    • Wu, M.1    Zaborszky, L.2    Hajszan, T.3    van den Pol, A.N.4    Alreja, M.5
  • 64
    • 0035906548 scopus 로고    scopus 로고
    • Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat
    • Xi, M. C., Morales, F. R., and Chase, M. H. (2001). Effects on sleep and wakefulness of the injection of hypocretin-1 (orexin-A) into the laterodorsal tegmental nucleus of the cat. Brain Res. 901, 259-264.
    • (2001) Brain Res. , vol.901 , pp. 259-264
    • Xi, M.C.1    Morales, F.R.2    Chase, M.H.3
  • 65
    • 0038521277 scopus 로고    scopus 로고
    • Hypothalamic orexin neurons regulate arousal according to energy balance in mice
    • Yamanaka, A., Beuckmann, C. T., Willie, J. T., Hara, J., Tsujino, N., Mieda, M., et al. (2003). Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 38, 701-713.
    • (2003) Neuron , vol.38 , pp. 701-713
    • Yamanaka, A.1    Beuckmann, C.T.2    Willie, J.T.3    Hara, J.4    Tsujino, N.5    Mieda, M.6
  • 68
    • 33745512663 scopus 로고    scopus 로고
    • The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions
    • Zeitzer, J. M., Nishino, S., and Mignot, E. (2006). The neurobiology of hypocretins (orexins), narcolepsy and related therapeutic interventions. Trends Pharmacol. Sci. 27, 368-374.
    • (2006) Trends Pharmacol. Sci. , vol.27 , pp. 368-374
    • Zeitzer, J.M.1    Nishino, S.2    Mignot, E.3
  • 69
    • 0042565939 scopus 로고    scopus 로고
    • Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins
    • Zhu, Y., Miwa, Y., Yamanaka, A., Yada, T., Shibahara, M., Abe, Y., et al. (2003). Orexin receptor type-1 couples exclusively to pertussis toxin-insensitive G-proteins, while orexin receptor type-2 couples to both pertussis toxin-sensitive and -insensitive G-proteins. J. Pharmacol. Sci. 92, 259-266.
    • (2003) J. Pharmacol. Sci. , vol.92 , pp. 259-266
    • Zhu, Y.1    Miwa, Y.2    Yamanaka, A.3    Yada, T.4    Shibahara, M.5    Abe, Y.6


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