Orexin-A is composed of a highly conserved C-terminal and a specific, hydrophilic N-terminal region, revealing the structural basis of specific recognition by the orexin-1 receptor

Journal of Peptide Science

Volumn 12, Issue 7, 2006, Pages 443-454

  Takai, Tomoyo ^a   Takaya, Takao ^b   Nakano, Mutsuko ^b   Akutsu, Hideo ^a   Nakagawa, Atsushi ^a   Aimoto, Saburo ^a   Nagai, Katsuya ^a   Ikegami, Takahisa ^a  

^a OSAKA UNIVERSITY   (Japan)

^b Division of Technology Licensing Organization of Osaka Prefecture   (Japan)

Author keywords

Feeding; GPCR; Narcolepsy; Orexin; Protein structure

Indexed keywords

G PROTEIN COUPLED RECEPTOR; OREXIN 1 RECEPTOR; OREXIN 2 RECEPTOR; OREXIN A; OREXIN B;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CLUSTER ANALYSIS; CONFORMATIONAL TRANSITION; DISULFIDE BOND; ELECTRICITY; FEEDING; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; NARCOLEPSY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; NUCLEAR OVERHAUSER EFFECT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; RESIDUE ANALYSIS; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; BENZOXAZOLES; BINDING SITES; CONSERVED SEQUENCE; HUMANS; HYDROPHOBICITY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MICELLES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; NEUROPEPTIDES; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, NEUROPEPTIDE; UREA;

EID: 33745953546     PISSN: 10752617     EISSN: 10991387     Source Type: Journal    
DOI: 10.1002/psc.747     Document Type: Article

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