BRI2 interacts with BACE1 and regulates its cellular levels by promoting its degradation and reducing its mRNA levels

Current Alzheimer Research

Volumn 10, Issue 5, 2013, Pages 532-541

  Tsachaki, Maria ^a   Fotinopoulou, Angeliki ^a   Slavi, Nefeli ^a   Zarkou, Vasiliki ^a   Ghiso, Jorge ^b   Efthimiopoulos, Spiros ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; APP; BACE1; BRI2; Familia Danish dementia; Familial British dementia; Neurodegeneration

Indexed keywords

BETA SECRETASE 1; BRI2 PROTEIN; MEMBRANE PROTEIN; MESSENGER RNA; PROTEASOME; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CYTOPLASM; EMBRYO; GENE DELETION; HUMAN; HUMAN CELL; LYSOSOME; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN PROTEIN INTERACTION;

AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ASPARTIC ACID ENDOPEPTIDASES; EXTRACELLULAR FLUID; GENE EXPRESSION REGULATION; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; MEMBRANE GLYCOPROTEINS; MICROSCOPY, CONFOCAL; RNA, MESSENGER; TRANSFECTION;

EID: 84888224030     PISSN: 15672050     EISSN: 18755828     Source Type: Journal    
DOI: 10.2174/1567205011310050009     Document Type: Article

References (36)

1. Vidal R, Frangione B, Rostagno A, Mead S, Revesz T, Plant G, et al. A stop-codon mutation in the BRI gene associated with familial British dementia. Nature 399: 776-781 (1999).
2. Vidal R, Revesz T, Rostagno A, Kim E, Holton JL, Bek T, et al. A decamer duplication in the 3' region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proc Natl Acad Sci U S A 97: 4920-4925 (2000).
3. Kim SH, Creemers JW, Chu S, Thinakaran G, Sisodia SS. Prote-olytic processing of familial British dementia-associated BRI variants: evidence for enhanced intracellular accumulation of amyloi-dogenic peptides. J Biol Chem 277: 1872-1877 (2002).
4. Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Lynn DG, et al. Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nat Neurosci 2: 984-988 (1999).
5. Kim SH, Wang R, Gordon DJ, Bass J, Steiner DF, Thinakaran G, et al. Familial British dementia: expression and metabolism of BRI. Ann N Y Acad Sci 920: 93-99 (2000).
6. Delacourte A. Tauopathies: recent insights into old diseases. Folia Neuropathol 43: 244-257 (2005).
7. Holton JL, Lashley T, Ghiso J, Braendgaard H, Vidal R, Guerin CJ, et al. Familial Danish dementia: a novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta. J Neuropathol Exp Neurol 61: 254-267 (2002).
8. Fotinopoulou A, Tsachaki M, Vlavaki M, Poulopoulos A, Rostagno A, Frangione B, et al. BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. J Biol Chem 280: 30768-30772 (2005).
9. Matsuda S, Giliberto L, Matsuda Y, Davies P, McGowan E, Pickford F, et al. The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. J Biol Chem 280: 28912-28916 (2005).
10. Zhang YW, Thompson R, Zhang H, Xu H. APP processing in Alzheimer's disease. Mol Brain 4: 3 (2011).
11. Barthet G, Georgakopoulos A, Robakis NK. Cellular mechanisms of y-secretase substrate selection, processing and toxicity. Prog Neurobiol. Aug; 98(2):166-75 (2012).
12. Chow VW, Mattson MP, Wong PC, Gleichmann M. An overview of APP processing enzymes and products. Neuromolecular Med 12: 1-12 (2010).
13. Matsuda S, Giliberto L, Matsuda Y, McGowan EM, D'Adamio L. BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J Neurosci 28: 8668-8676 (2008).
14. Kim J, Miller VM, Levites Y, West KJ, Zwizinski CW, Moore BD, et al. BRI2 (ITM2b) inhibits Abeta deposition in vivo. J Neurosci 28: 6030-6036 (2008).
15. Kilger E, Buehler A, Woelfing H, Kumar S, Kaeser SA, Nagarathi-nam A, et al. BRI2 Protein Regulates {beta}-Amyloid Degradation by Increasing Levels of Secreted Insulin-degrading Enzyme (IDE). J Biol Chem 286: 37446-37457 (2011).
16. Matsuda S, Tamayev R, D'Adamio L. Increased AbetaPP Processing in Familial Danish Dementia Patients. J Alzheimers Dis: (2011).
17. Giliberto L, Matsuda S, Vidal R, D'Adamio L. Generation and initial characterization of FDD knock in mice. PLoS One 4: e7900 (2009).
18. Tamayev R, Matsuda S, Giliberto L, Arancio O, D'Adamio L. APP heterozygosity averts memory deficit in knockin mice expressing the Danish dementia BRI2 mutant. Embo J 30: 2501-2509 (2011).
19. Parisiadou L, Bethani I, Michaki V, Krousti K, Rapti G, Efthimio-poulos S. Homer2 and Homer3 interact with amyloid precursor protein and inhibit Abeta production. Neurobiol Dis 30: 353-364 (2008).
20. Gatta LB, Albertini A, Ravid R, Finazzi D. Levels of beta-secretase BACE and alpha-secretase ADAM 10 mRNAs in Alzheimer hippocampus. Neuroreport 13: 2031-2033 (2002).
21. Matsuda S, Matsuda Y, D'Adamio L. BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. J Biol Chem 284: 15815-15825 (2009).
22. Wickham L, Benjannet S, Marcinkiewicz E, Chretien M, Seidah NG. Beta-amyloid protein converting enzyme 1 and brain-specific type II membrane protein BRI3: binding partners processed by furin. J Neurochem 92: 93-102 (2005).
23. Qing H, Zhou W, Christensen MA, Sun X, Tong Y, Song W. Degradation of BACE by the ubiquitin-proteasome pathway. Faseb J 18: 1571-1573 (2004).
24. Koh YH, von Arnim CA, Hyman BT, Tanzi RE, Tesco G. BACE is degraded via the lysosomal pathway. J Biol Chem 280: 32499-32504 (2005).
25. Lublin AL, Gandy S. Amyloid-beta oligomers: possible roles as key neurotoxins in Alzheimer's Disease. Mt Sinai J Med 77: 43-49 (2010).
26. Sakono M, Zako T. Amyloid oligomers: formation and toxicity of Abeta oligomers. Febs J 277: 1348-1358 (2010).
27. Tsachaki M, Ghiso J, Efthimiopoulos S. BRI2 as a central protein involved in neurodegeneration. Biotechnol J 3: 1548-1554 (2008).
28. Rossner S, Sastre M, Bourne K, Lichtenthaler SF. Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease. Prog Neurobiol 79: 95-111 (2006).
29. Tournoy J, Bossuyt X, Snellinx A, Regent M, Garmyn M, Serneels L, et al. Partial loss of presenilins causes seborrheic keratosis and autoimmune disease in mice. Hum Mol Genet 13: 1321-1331 (2004).
30. Imbimbo BP, Panza F, Frisardi V, Solfrizzi V, D'Onofrio G, Logroscino G, et al. Therapeutic intervention for Alzheimer's disease with gamma-secretase inhibitors: still a viable option? Expert Opin Investig Drugs 20: 325-341 (2011).
31. Olsen MK, Roberds SL, Ellerbrock BR, Fleck TJ, McKinley DK, Gurney ME. Disease mechanisms revealed by transcription profil-ing in SOD1-G93A transgenic mouse spinal cord. Ann Neurol 50: 730-740 (2001).
32. Luo Y, Bolon B, Kahn S, Bennett BD, Babu-Khan S, Denis P, et al. Mice deficient in BACE1, the Alzheimer's beta-secretase, have normal phenotype and abolished beta-amyloid generation. Nat Neurosci 4: 231-232 (2001).
33. Harrison SM, Harper AJ, Hawkins J, Duddy G, Grau E, Pugh PL, et al. BACE1 (beta-secretase) transgenic and knockout mice: identification of neurochemical deficits and behavioral changes. Mol Cell Neurosci 24: 646-655 (2003).
34. von Arnim CA, Kinoshita A, Peltan ID, Tangredi MM, Herl L, Lee BM, et al. The low density lipoprotein receptor-related protein (LRP) is a novel beta-secretase (BACE1) substrate. J Biol Chem 280: 17777-17785 (2005).
35. Lichtenthaler SF. Ectodomain shedding of the amyloid precursor protein: cellular control mechanisms and novel modifiers. Neu-rodegener Dis 3: 262-269 (2006).
36. Kitazume S, Tachida Y, Oka R, Shirotani K, Saido TC, Hashimoto Y. Alzheimer's beta-secretase, beta-site amyloid precursor protein-cleaving enzyme, is responsible for cleavage secretion of a Golgi-resident sialyltransferase. Proc Natl Acad Sci U S A 98: 13554-13559 (2001).