BRI2 as a central protein involved in neurodegeneration

Biotechnology Journal

Volumn 3, Issue 12, 2008, Pages 1548-1554

  Tsachaki, Maria ^a   Ghiso, Jorge ^b   Efthimiopoulos, Spiros ^a  

^a UNIVERSITY OF ATHENS   (Greece)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Alzheimer's disease; Familial British dementia; Familial Danish dementia; Neurodegeneration

Indexed keywords

ALZHEIMER'S DISEASE; AMYLOID PRECURSOR PROTEINS; CELL SURFACES; FAMILIAL BRITISH DEMENTIA; FAMILIAL DANISH DEMENTIA; HOMODIMER; IN CELLS; MOLECULAR MECHANISMS; MOUSE MODELS; NEURODEGENERATION;

AMINES; CELL MEMBRANES; GLYCOPROTEINS; PROTEINS; PUMPING PLANTS;

CELL CULTURE;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BRI2 PROTEIN; HOMODIMER; MEMBRANE PROTEIN; PEPTIDE; RECEPTOR; UNCLASSIFIED DRUG; ITM2B PROTEIN, MOUSE;

ALZHEIMER DISEASE; BIOACCUMULATION; BRAIN TISSUE; CELL CULTURE; CELL SURFACE; DEMENTIA; DENMARK; DISEASE MODEL; FAMILIAL DISEASE; GENE MUTATION; HUMAN; NERVE DEGENERATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; REVIEW; SIGNAL TRANSDUCTION; UNITED KINGDOM; ANIMAL; BRAIN; DEGENERATIVE DISEASE; GENETIC PREDISPOSITION; GENETICS; METABOLISM; MUTATION;

ANIMALS; BRAIN; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MEMBRANE PROTEINS; MUTATION; NEURODEGENERATIVE DISEASES; SIGNAL TRANSDUCTION;

EID: 59049098098     PISSN: 18606768     EISSN: 18607314     Source Type: Journal    
DOI: 10.1002/biot.200800247     Document Type: Review

References (36)

1. Deleersnijder, W., Hong, G., Cortvrindt, R., Poirier, C. et al., Isolation of markers for chondro-osteogenic differentiation using cDNA library subtraction. Molecular cloning and characterization of a gene belonging to a novel multigene family of integral membrane proteins. J. Biol. Chem. 1996, 271, 19475-19482.
2. Vidal, R., Calero, M., Revesz, T., Plant, G. et al., Sequence, genomic structure and tissue expression of Human BRI3, a member of the BRI gene family. Gene 2001, 266, 95-102.
3. Sanchez-Pulido, L., Devos, D., Valencia, A., BRICHOS: A conserved domain in proteins associated with dementia, respiratory distress and cancer. Trends Biochem. Sci. 2002, 27, 329-332.
4. Pittois, K., Deleersnijder, W., Merregaert, J., cDNA sequence analysis, chromosomal assignment and expression pattern of the gene coding for integral membrane protein 2B. Gene 1998, 217, 141-149.
5. Pickford, F., Onstead, L., Camacho-Prihar, C., Hardy, J. et al., Expression of mBRI2 in mice. Neurosci. Lett. 2003, 338, 95-98.
6. Vidal, R., Frangione, B., Rostagno, A., Mead, S. et al., A stop-codon mutation in the BRI gene associated with familial British dementia. Nature. 1999, 399, 776-781.
7. Vidal, R., Revesz, T., Rostagno, A., Kim, E. et al. A decamer duplication in the 3′ region of the BRI gene originates an amyloid peptide that is associated with dementia in a Danish kindred. Proc. Natl. Acad. Sci. USA 2000, 97, 4920-4925.
8. Kim, S. H., Wang, R., Gordon, D. J., Bass, J. et al. Furin mediates enhanced production of fibrillogenic ABri peptides in familial British dementia. Nat. Neurosci. 1999, 2, 984-988.
9. Choi, S. I., Vidal, R., Frangione, B., Levy, E., Axonal transport of British and Danish amyloid peptides via secretory vesicles. FASEB J. 2004, 18, 373-375.
10. Kim, S. H., Creemers, J. W., Chu, S., Thinakaran, G. et al., Proteolytic processing of familial British dementia-associated BRI variants: Evidence for enhanced intracellular accumulation of amyloidogenic peptides. J. Biol. Chem. 2002, 277, 1872-1877.
11. Martin, L., Fluhrer, R., Reiss, K., Kremmer, E. et al., Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. J. Biol. Chem. 2008, 283, 1644-1652.
12. Pan, D., Rubin, G. M., Kuzbanian controls proteolytic processing of Notch and mediates lateral inhibition during Drosophila and vertebrate neurogenesis. Cell 1997, 90, 271-280.
13. Reiss, K., Maretzky, T., Ludwig, A., Tousseyn, T. et al., ADAM10 cleavage of N-cadherin and regulation of cell-cell adhesion and beta-catenin nuclear signalling. EMBO J. 2005, 24, 742-752.
14. Maretzky, T., Reiss, K., Ludwig, A., Buchholz, J. et al., ADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation. Proc. Natl. Acad. Sci. USA 2005, 102, 9182-9187.
15. Artavanis-Tsakonas, S., Rand, M. D., Lake, R. J., Notch signaling: Cell fate control and signal integration in development. Science 1999, 284, 770-776.
16. Tomidokoro, Y., Lashley, T., Rostagno, A., Neubert, T. A. et al., Familial Danish dementia: Co-existence of Danish and Alzheimer amyloid subunits (ADan and Abeta) in the absence of compact plaques. J. Biol. Chem. 2005, 280, 36883-36894.
17. Holton, J. L., Ghiso, J., Lashley, T., Rostagno, A. et al., Regional distribution of amyloid-Bri deposition and its association with neurofibrillary degeneration in familial British dementia. Am. J. Pathol. 2001, 158, 515-526.
18. Ghiso, J. A., Holton, J., Miravalle, L., Calero, M. et al., Systemic amyloid deposits in familial British dementia. J. Biol. Chem. 2001, 276, 43909-43914.
19. El-Agnaf, O. M., Sheridan, J. M., Sidera, C., Siligardi, G. et al., Effect of the disulfide bridge and the C-terminal extension on the oligomerization of the amyloid peptide ABri implicated in familial British dementia. Biochemistry 2001, 40, 3449-3457.
20. Gibson, G., Gunasekera, N., Lee, M., Lelyveld, V. et al., Oligomerization and neurotoxicity of the amyloid ADan peptide implicated in familial Danish dementia. J. Neurochem. 2004, 88, 281-290.
21. Quist, A., Doudevski, I., Lin, H., Azimova, R. et al., Amyloid ion channels: A common structural link for protein-misfolding disease. Proc. Natl. Acad. Sci. USA 2005, 102, 10427-10432.
22. Akiyama, H., Kondo, H., Arai, T., Ikeda, K. et al., Expression of BRI, the normal precursor of the amyloid protein of familial British dementia, in human brain. Acta Neuropathol. (Berl.) 2004, 107, 53-58.
23. Latil, A., Chene, L., Mangin, P., Fournier, G. et al., Extensive analysis of the 13q14 region in human prostate tumors: DNA analysis and quantitative expression of genes lying in the interval of deletion. Prostate 2003, 57, 39-50.
24. Fleischer, A., Ayllon, V., Dumoutier, L., Renauld, J. C. et al., Proapoptotic activity of ITM2B(s), a BH3-only protein induced upon IL-2-deprivation which interacts with Bcl-2. Oncogene 2002, 21, 3181-3189.
25. Tsachaki, M., Ghiso, J., Rostagno, A., Efthimiopoulos, S., BRI2 homodimerizes with the involvement of intermolecular disulfide bonds. Neurobiol. Aging DOI: 10.1016/ j.neuro-biolaging.2008.03.004.█update█
26. Senes, A., Engel, D. E., DeGrado, W. F., Folding of helical membrane proteins: The role of polar, GxxxG-like and proline motifs. Curr. Opin. Struct. Biol. 2004, 14, 465-479.
27. Pickford, F., Coomaraswamy, J., Jucker, M., McGowan, E., Modeling familial British dementia in transgenic mice. Brain Pathol. 2006, 16, 80-85.
28. Vidal, R., Barbeito, A. G., Miravalle, L., Ghetti, B., Cerebral amyloid angiopathy and parenchymal amyloid deposition in transgenic mice expressing the Danish mutant form of human BRI(2). Brain Pathol. DOI: 10.1111/j.1750-3639.2008.00164.x.█update█
29. Delacourte, A., Tauopathies: Recent insights into old diseases. Folia Neuropathol. 2005, 43, 244-257.
30. Holton, J. L., Lashley, T., Ghiso, J., Braendgaard, H. et al., Familial Danish dementia: A novel form of cerebral amyloidosis associated with deposition of both amyloid-Dan and amyloid-beta. J. Neuropathol. Exp. Neurol. 2002, 61, 254-267.
31. Rostagno, A., Revesz, T., Lashley, T., Tomidokoro, Y. et al., Complement activation in chromosome 13 dementias. Similarities with Alzheimer's disease. J. Biol. Chem. 2002, 277, 49782-49790.
32. Tsachaki, M., Fotinopoulou, A., Vlavaki, M., Rostagno, A. et al., Neurodegenerative diseases: Similarities in pathology suggest common molecular mechanisms leading to neuronal death, in: Ruzdijic, S., Rakic, L. (Eds.), Neurobiological studies-from genes to behaviour, Research Singpost, Trivandrum 2006, pp. 109-122.
33. Fotinopoulou, A., Tsachaki, M., Vlavaki, M., Poulopoulos, A. et al., BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. J. Biol. Chem. 2005, 280, 30768-30772.
34. Matsuda, S., Giliberto, L., Matsuda, Y., Davies, P. et al., The familial dementia BRI2 gene binds the Alzheimer gene amyloid-beta precursor protein and inhibits amyloid-beta production. J. Biol. Chem. 2005, 280, 28912-28916.
35. Matsuda, S., Giliberto, L., Matsuda, Y., McGowan, E. M. et al., BRI2 inhibits amyloid beta-peptide precursor protein processing by interfering with the docking of secretases to the substrate. J. Neurosci. 2008, 28, 8668-8676.
36. Kim, J., Miller, V. M., Levites, Y., West, K. J. et al., BRI2 (ITM2b) inhibits Abeta deposition in vivo. J. Neurosci. 2008, 28, 6030-6036.