Homer2 and Homer3 interact with amyloid precursor protein and inhibit Aβ production

Neurobiology of Disease

Volumn 30, Issue 3, 2008, Pages 353-364

  Parisiadou, Loukia ^a   Bethani, Ioanna ^a   Michaki, Vasiliki ^a   Krousti, Kaliopi ^a   Rapti, Georgia ^a   Efthimiopoulos, Spiros ^a  

^a UNIVERSITY OF ATHENS   (Greece)

Author keywords

Alzheimer; Amyloid; Neurodegeneration; Secretase

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; ISOPROTEIN; PROTEIN HOMER 1; PROTEIN HOMER 2; PROTEIN HOMER 3; PROTEIN SUBUNIT;

ANIMAL TISSUE; ARTICLE; CELL SURFACE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROCESSING; PROTEIN PROTEIN INTERACTION; PROTEIN SECRETION;

AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; ANIMALS; CARRIER PROTEINS; CELL LINE; HUMANS; MICE; MICE, INBRED C57BL;

EID: 43849103683     PISSN: 09699961     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.nbd.2008.02.004     Document Type: Article

References (51)

1. Ango F., Robbe D., Tu J.C., Xiao B., Worley P.F., Pin J.P., Bockaert J., and Fagni L. Homer-dependent cell surface expression of metabotropic glutamate receptor type 5 in neurons. Mol. Cell. Neurosci. 20 (2002) 323-329
2. Beneken J., Tu J.C., Xiao B., Nuriya M., Yuan J.P., Worley P.F., and Leahy D.J. Structure of the Homer EVH1 domain-peptide complex reveals a new twist in polyproline recognition. Neuron 26 (2000) 143-154
3. Bennett B.D., Denis P., Haniu M., Teplow D.B., Kahn S., Louis J.C., Citron M., and Vassar R. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's beta-secretase. J. Biol. Chem. 275 (2000) 37712-37717
4. Brakeman P.R., Lanahan A.A., O'Brien R., Roche K., Barnes C.A., Huganir R.L., and Worley P.F. Homer: a protein that selectively binds metabotropic glutamate receptors. Nature 386 (1997) 284-288
5. Buxbaum J.D., Ruefli A.A., Parker C.A., Cypess A.M., and Greengard P. Calcium regulates processing of the Alzheimer amyloid protein precursor in a protein kinase C-independent manner. Proc. Natl Acad. Sci. USA 91 (1994) 4489-4493
6. Capell A., Steiner H., Willem M., Kaiser H., Meyer C., Walter J., Lammich S., Multhaup G., and Haass C. Maturation and pro-peptide cleavage of beta-secretase. J Biol Chem. 275 (2000) 30849-30854
7. Chyung J.H., Raper D.M., and Selkoe D.J. Gamma-secretase exists on the plasma membrane as an intact complex that accepts substrates and effects intramembrane cleavage. J. Biol. Chem. 280 (2005) 4383-4392
8. Ciruela F., Soloviev M.M., Chan W.Y., and McIlhinney R.A. Homer-1c/Vesl-1L modulates the cell surface targeting of metabotropic glutamate receptor type 1alpha: evidence for an anchoring function. Mol. Cell. Neurosci. 15 (2000) 36-50
9. Ciruela F., Soloviev M.M., and McIlhinney R.A. Co-expression of metabotropic glutamate receptor type 1alpha with homer-1a/Vesl-1S increases the cell surface expression of the receptor. Biochem. J. 341 (1999) 795-803
10. Creemers J.W., Ines Dominguez D., Plets E., Serneels L., Taylor N.A., Multhaup G., Craessaerts K., Annaert W., and De Strooper B. Processing of beta-secretase by furin and other members of the proprotein convertase family. J. Biol. Chem. 276 (2001) 4211-4217
11. de Bartolomeis A., and Iasevoli F. The Homer family and the signal transduction system at glutamatergic postsynaptic density: potential role in behavior and pharmacotherapy. Psychopharmacol. Bull. 37 (Summer 2003) 51-83
12. De Strooper B. Aph-1, Pen-2, and Nicastrin with Presenilin generate an active gamma-secretase complex. Neuron 38 (2003) 9-12
13. De Strooper B., and Annaert W. Proteolytic processing and cell biological functions of the amyloid precursor protein. J Cell Sci. 113 (2000) 1857-1870
14. Dickey C.A., Loring J.F., Montgomery J., Gordon M.N., Eastman P.S., and Morgan D. Selectively reduced expression of synaptic plasticity-related genes in amyloid precursor protein + presenilin-1 transgenic mice. J. Neurosci. 23 (2003) 5219-5226
15. Efthimiopoulos S., Felsenstein K.M., Sambamurti K., Robakis N.K., and Refolo L.M. Study of the phorbol ester effect on Alzheimer amyloid precursor processing: sequence requirements and involvement of a cholera toxin sensitive protein. J. Neurosci. Res. 38 (1994) 81-90
16. Esler W.P., and Wolfe M.S. A portrait of Alzheimer secretases-new features and familiar faces. Science. 293 (2001) 1449-1454
17. Fagni L., Worley P.F., and Ango F. Homer as both a scaffold and transduction molecule. Sci. STKE (2002) RE8
18. Fassa A., Mehta P., and Efthimiopoulos S. Notch 1 interacts with the amyloid precursor protein in a Numb-independent manner. J. Neurosci. Res. 82 (2005) 214-224
19. Fiore F., Zambrano N., Minopoli G., Donini V., Duilio A., and Russo T. The regions of the Fe65 protein homologous to the phosphotyrosine interaction/phosphotyrosine binding domain of Shc bind the intracellular domain of the Alzheimer's amyloid precursor protein. J. Biol. Chem. 270 (1995) 30853-30856
20. Fotinopoulou A., Tsachaki M., Vlavaki M., Poulopoulos A., Rostagno A., Frangione B., Ghiso J., and Efthimiopoulos S. BRI2 interacts with amyloid precursor protein (APP) and regulates amyloid beta (Abeta) production. J. Biol. Chem. 280 (2005) 30768-30772
21. Georgakopoulos A., Marambaud P., Efthimiopoulos S., Shioi J., Cui W., Li H.C., Schutte M., Gordon R., Holstein G.R., Martinelli G., Mehta P., Friedrich Jr. V.L., and Robakis N.K. Presenilin-1 forms complexes with the cadherin/catenin cell-cell adhesion system and is recruited to intercellular and synaptic contacts. Mol. Cell. 4 (1999) 893-902
22. Graeve L., Drickamer K., and Rodriguez-Boulan E. Polarized endocytosis by Madin-Darby canine kidney cells transfected with functional chicken liver glycoprotein receptor. J. Cell Biol. 109 (1989) 2809-2816
23. Haass C., Schlossmacher M.G., Hung A.Y., Vigo-Pelfrey C., Mellon A., Ostaszewski B.L., Lieberburg I., Koo E.H., Schenk D., Teplow D.B., and Selkoe D.J. Amyloid beta-peptide is produced by cultured cells during normal metabolism. Nature 359 (1992) 322-325
24. Homayouni R., Rice D.S., Sheldon M., and Curran T. Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J Neurosci. 19 (1999) 7507-7515
25. King G.D., and Scott Turner R. Adaptor protein interactions: modulators of amyloid precursor protein metabolism and Alzheimer's disease risk?. Exp. Neurol. 185 (2004) 208-219
26. Kreienkamp H.J. Organization of G-protein-coupled receptor signalling complexes by scaffolding proteins. Curr. Opin. Pharmacol. 2 (2002) 581-586
27. Klugmann M., Symes C.W., Leichtlein C.B., Klaussner B.K., Dunning J., Fong D., Young D., and During M.J. AAV-mediated hippocampal expression of short and long Homer 1 proteins differentially affect cognition and seizure activity in adult rats. Mol. Cell. Neurosci. 28 (2005) 347-360
28. Minopoli G., Zambrano N., and Russo T. The cytosolic domain of APP and its possible role in the pathogenesis of Alzheimer's disease. Ital. J. Biochem. 55 (2006) 205-211
29. Nitsch R.M., Wurtman R.J., and Growdon J.H. Regulation of APP processing. Potential for the therapeutical reduction of brain amyloid burden. Ann. N.Y. Acad. 777 (1996) 175-182
30. Ono Y., Kinouchi T., Sorimachi H., Ishiura S., and Suzuki K. Deletion of an endosomal/lysosomal targeting signal promotes the secretion of Alzheimer's disease amyloid precursor protein (APP). J Biochem (Tokyo). 121 (1997) 585-590
31. Pappolla M.A., Sos M., Omar R.A., Bick R.J., Hickson-Bick D.L., Reiter R.J., Efthimiopoulos S., and Robakis N.K. Melatonin prevents death of neuroblastoma cells exposed to the Alzheimer amyloid peptide. J. Neurosci. 17 (1997) 1683-1690
32. Parisiadou L., and Efthimiopoulos S. Expression of mDab1 promotes the stability and processing of amyloid precursor protein and this effect is counteracted by X11alpha. Neurobiol. Aging 28 (2007) 377-388
33. Parisiadou L., Fassa A., Fotinopoulou A., Bethani I., and Efthimiopoulos S. Presenilin 1 and cadherins: stabilization of cell-cell adhesion and proteolysis-dependent regulation of transcription. Neurodegener. Dis. 1 (2004) 184-191
34. Querfurth H.W., and Selkoe D.J. Calcium ionophore increases amyloid peptide production by cultured cells. Biochemistry 33 (1994) 4550-4561
35. Querfurth H.W., Jiang J., Geiger J.D., and Selkoe D.J. Caffeine stimulates amyloid -peptide release from β-amyloid precursor protein-transfected HEK293 cells. J Neurochem. 69 (1997) 1580-1591
36. Roche K.W., Tu J.C., Petralia R.S., Xiao B., Wenthold R.J., and Worley P.F. Homer 1b regulates the trafficking of group I metabotropic glutamate receptors. J. Biol. Chem 274 (1999) 25953-25957
37. Sala C., Roussignol G., Meldolesi J., and Fagni L. Key role of the postsynaptic density scaffold proteins Shank and Homer in the functional architecture of Ca2+ homeostasis at dendritic spines in hippocampal neurons. J. Neurosci 25 (2005) 4587-4592
38. Sastre M., Turner R.S., and Levy E. X11 interaction with beta-amyloid precursor protein modulates its cellular stabilization and reduces amyloid beta-protein secretion. J. Biol. Chem. 273 (1998) 22351-22357
39. Selkoe D.J. Alzheimer's disease: genes, proteins, and therapy. Physiol. Rev. 81 (2001) 741-766
40. Selkoe D.J. Alzheimer's disease is a synaptic failure. Science 298 (2002) 789-791
41. Selkoe D.J., Yamazaki T., Citron M., Podlisny M.B., Koo E.H., Teplow D.B., and Haass C. The role of APP processing and trafficking pathways in the formation of amyloid beta-protein. Ann. N.Y. Acad. Sci. 777 (1996) 57-64
42. Shankar G.M., Bloodgood B.L., Townsend M., Walsh D.M., Selkoe D.J., and Sabatini B.L. Natural oligomers of the Alzheimer amyloid-β protein induce reversible synapse loss by modulating an NMDA-type glutamate receptor-dependent signaling pathway. J. Neurosci. 27 (2007) 2866-2875
43. Szumlinski K.K., Kalivas P.W., and Worley P.F. Homer proteins: implications for neuropsychiatric disorders. Curr. Opin. Neurobiol. 16 (2006) 251-257
44. Szumlinski K.K., Ary A.W., and Lominac K.D. Homers regulate drug-induced neuroplasticity: implications for addiction. Biochem. Pharmacol. 75 (2008) 112-133
45. Takasugi N., Tomita T., Hayashi I., Tsuruoka M., Niimura M., Takahashi Y., Thinakaran G., and Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature 422 (2003) 438-441
46. Tu J.C., Xiao B., Naisbitt S., Yuan J.P., Petralia R.S., Brakeman P., Doan A., Aakalu V.K., Lanahan A.A., Sheng M., and Worley P.F. Coupling of mGluR/Homer and PSD-95 complexes by the Shank family of postsynaptic density proteins. Neuron 23 (1999) 583-592
47. Tu J.C., Xiao B., Yuan J.P., Lanahan A.A., Leoffert K., Li M., Linden D.J., and Worley P.F. Homer binds a novel proline-rich motif and links group 1 metabotropic glutamate receptors with IP3 receptors. Neuron 21 (1998) 717-726
48. Vassar R., Bennett B.D., Babu-Khan S., Kahn S., Mendiaz E.A., Denis P., Teplow D.B., Ross S., Amarante P., Loeloff R., Luo Y., Fisher S., Fuller J., Edenson S., Lile J., Jarosinski M.A., Biere A.L., Curran E., Burgess T., Louis J.C., Collins F., Treanor J., Rogers G., and Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 286 (1999) 735-741
49. Worley P.F., Zeng W., Huang G., Kim J.Y., Shin D.M., Kim M.S., Yuan J.P., Kiselyov K., and Muallem S. Homer proteins in Ca2+ signaling by excitable and non-excitable cells. Cell Calcium 42 (2007) 363-371
50. Xiao B., Tu J.C., Petralia R.S., Yuan J.P., Doan A., Breder C.D., Ruggiero A., Lanahan A.A., Wenthold R.J., and Worley P.F. Homer regulates the association of group 1 metabotropic glutamate receptors with multivalent complexes of homer-related, synaptic proteins. Neuron 21 (1998) 707-716
51. Yuan J.P., Kiselyov K., Shin D.M., Chen J., Shcheynikov N., Kang S.H., Dehoff M.H., Schwarz M.K., Seeburg P.H., Muallem S., and Worley P.F. Homer binds TRPC family channels and is required for gating of TRPC1 by IP3 receptors. Cell 114 (2003) 777-789