The multiligand receptor RAGE as a progression factor amplifying immune and inflammatory responses

Journal of Clinical Investigation

Volumn 108, Issue 7, 2001, Pages 949-955

  Schmidt, Ann Marie ^a   Yan, Shi Du ^a   Yan, Shi Fang ^a   Stern, David M ^a  

^a Columbia University ^*  (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADVANCED GLYCATION END PRODUCT; CALGRANULIN; CELL SURFACE PROTEIN; CELL SURFACE RECEPTOR; CYTOKINE; DNA BINDING PROTEIN; HIGH MOBILITY GROUP B1 PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NUCLEAR PROTEIN; PROTEIN S 100; UNCLASSIFIED DRUG;

AMYLOIDOSIS; ANGIOGENESIS; ANIMAL MODEL; ATHEROSCLEROSIS; BINDING AFFINITY; CONTROLLED STUDY; DIABETES MELLITUS; HUMAN; IMMUNE RESPONSE; INFLAMMATION; LIGAND BINDING; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW; SIGNAL TRANSDUCTION; STRESS; TUMOR CELL; TUMOR GROWTH;

AMYLOIDOSIS; ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; GLYCOSYLATION END PRODUCTS, ADVANCED; HMGB1 PROTEIN; HUMANS; MEMBRANE PROTEINS; NEOPLASMS; RECEPTORS, IMMUNOLOGIC;

EID: 0034795140     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI200114002     Document Type: Review

References (44)

1. Recognition and plasma clearance of endotoxin by scavenger receptors
2. The serum mannose-binding protein and the macrophage mannose receptor are pattern recognition molecules that link innate and adaptive immunity
3. Innate immunity
4. Advanced glycosylation in diabetes and aging
5. RAGE mediates the interaction of AGE-beta-2-microglobulin with human mononuclear phagocytes via an oxidant-sensitive pathway: Implications for the pathogenesis of dialysis-related amyloidosis
6. The dark side of glucose
7. Isolation and characterization of binding proteins for advanced glycosylation endproducts from lung tissue which are present on the endothelial cell surface
8. Cloning and expression of RAGE: A cell surface receptor for advanced glycosylation end products of proteins
9. RAGE mediates a novel proinflammatory axis: The cell surface receptor for S100/calgranulin polypeptides
10. Blockade of RAGE/amphoterin suppresses tumor growth and metastases
11. Characterization and functional analysis of the promoter of RAGE
12. Sp1 binding elements in the promoter of RAGE are essential for amphoterin-mediated gene expression in cultured neuroblastoma cells
13. RAGE is induced by the glycation products themselves and TNF-alpha through NF-kB and by 17β-estradiol through Sp1 in human vascular endothelial cells
14. N(epsilon)-(carboxymethyl)lysine adducts of proteins are ligands for RAGE that activate cell signaling pathways and modulate gene expression
15. AGE-mediated induction of tissue factor in cultured endothelial cells is dependent on RAGE
16. AGE-driven angiogenesis in vitro. Induction of the growth and tube formation of human microvascular endothelial cells through autocrine vascular endothelial growth factor
17. AGEs inhibit prostacyclin production and induce PAI-1 in human microvascular endothelial cells
18. Receptor-mediated endothelial cell dysfunction in diabetic vasculopathy: Soluble RAGE blocks hyperpermeability
19. RAGE has a central role in vessel wall interactions and gene activation in response to AGEs
20. Advanced glycation endproducts interacting with their endothelial receptor induce expression of VCAM-1 in cultured human endothelial cells and in mice
21. Enhanced cellular oxidant stress by the interaction of AGEs with their receptors/binding proteins
22. Regulation of human mononuclear phagocyte migration by cell surface binding proteins for AGEs
23. Suppression of accelerated diabetic arherosclerosis by soluble receptor for AGE (sRAGE)
24. Accelerated atherosclerosis and vascular inflammation develop in apoE null mice with type 2 diabetes
25. Blockade of RAGE restores effective wound healing in diabetic mice
26. Blockade of RAGE suppresses periodontitis-associated alveolar bone loss in diabetic mice
27. RAGE and amyloid-beta peptide neurotoxicity in Alzheimer's disease
28. Receptor-dependent cell stress and amyloid accumulation in systemic amyloidosis
29. Microglial cells internalize aggregates of the Alzheimer's disease amyloid beta-protein via a scavenger receptor
30. Aβ(1-42)binds to α-7 nicotinic acetylcholine receptor with high affinity
31. Binding of beta-amyloid to the p75 neurotrophin receptor induces apoptosis
32. The HHQK domain of beta-amyloid provides a structural basis for the immunopathology of Alzheimer's disease
33. Familial amyloid polyneuropathy: RAGE-dependent triggering of neuronal inflammatory and apoptotic pathways
34. RAGE is a cellular binding site for amphoterin: Mediation of neurite outgrowth and co-expression of RAGE and amphoterin in the developing nervous system
35. The S100 family of EF-hand calcium-binding proteins: Functions and pathology
36. RAGE-mediated neurite outgrowth and activation of NF-kB require the cytoplasmic domain of the receptor but different downstream signaling pathways
37. V-Ha-ras transgene abrogates the initiation step in mouse skin tumorigenesis: Effects of phorbol esters and retinoic acid
38. B7 and CD28 receptor families
39. Is the class A macrophage scavenger receptor (SR-A) multifunctional? - The mouse's tale
40. Structures and functions of multiligand lipoprotein receptors: Macrophage scavenger receptors and LDL receptor-related protein
41. A family of human receptors structurally related to Drosophila Toll