Phagocytosis of neuronal debris by microglia is associated with neuronal damage in multiple sclerosis

GLIA

Volumn 60, Issue 3, 2012, Pages 422-431

  Huizinga, Ruth ^a   van der Star, Baukje J ^b   Kipp, Markus ^b,c   Jong, Rosa ^b   Gerritsen, Wouter ^b   Clarner, Tim ^c   Puentes, Fabiola ^d   Dijkstra, Christine D ^b   van der Valk, Paul ^b   Amor, Sandra ^b,d  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

^c RWTH AACHEN UNIVERSITY   (Germany)

^d QUEEN MARY UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Autoimmunity; Axonal damage; Macrophages; Neurodegeneration; Tolerance

Indexed keywords

HLA DR ANTIGEN; LYSOSOME ASSOCIATED MEMBRANE PROTEIN 1; MYELIN; MYELIN BASIC PROTEIN; NEUROFILAMENT PROTEIN;

ADULT; AGED; ANIMAL CELL; ANTIGEN PRESENTING CELL; ARTICLE; CELL LINE; CEREBROSPINAL FLUID; CONFOCAL MICROSCOPY; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GRAY MATTER; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; MACROPHAGE; MALE; MICROGLIA; MOUSE; MULTIPLE SCLEROSIS; NERVE CELL; NERVE CELL LESION; NERVE FIBER; NEUROFILAMENT; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; WHITE MATTER;

ADULT; AGED; AGED, 80 AND OVER; ANIMALS; CATHEPSIN D; CATHEPSINS; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HLA-DR ANTIGENS; HUMANS; MALE; MICE; MICROGLIA; MICROSCOPY, CONFOCAL; MIDDLE AGED; MULTIPLE SCLEROSIS; MYELIN BASIC PROTEIN; NERVE FIBERS, MYELINATED; NEUROFILAMENT PROTEINS; NEURONS; PHAGOCYTOSIS; TIME FACTORS;

EID: 84856227885     PISSN: 08941491     EISSN: 10981136     Source Type: Journal    
DOI: 10.1002/glia.22276     Document Type: Article

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