메뉴 건너뛰기




Volumn 410, Issue 3, 2011, Pages 377-381

Novel protein tyrosine phosphatase 1B inhibitors: Interaction requirements for improved intracellular efficacy in type 2 diabetes mellitus and obesity control

Author keywords

Obesity; PTP1B; Type 2 diabetes mellitus

Indexed keywords

BERBERINE; GLUCOSE; IMIDAZOLE DERIVATIVE; IMIDAZOLINE DERIVATIVE; INSULIN; JT 551; JTT 551; LEPTIN; LGH 00081; LZP 25; LZP 6; N [2 (4 METHOXYPHENYL) ETHYL] ACETAMIDE DERIVATIVE; P 28; PAPAVERINE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE 1B INHIBITOR; SA 18; SA 32; UNCLASSIFIED DRUG; VANADIUM DERIVATIVE;

EID: 79960073235     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.06.009     Document Type: Short Survey
Times cited : (95)

References (46)
  • 1
    • 72249092928 scopus 로고    scopus 로고
    • Recent advances in understanding leptin signaling and leptin resistance
    • Morris D.L., Rui L. Recent advances in understanding leptin signaling and leptin resistance. Am. J. Physiol. Endocrinol. Metab. 2009, 297:E1247-E1259.
    • (2009) Am. J. Physiol. Endocrinol. Metab. , vol.297
    • Morris, D.L.1    Rui, L.2
  • 2
    • 0033525870 scopus 로고    scopus 로고
    • Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene
    • Elchebly M., Payette P., Michaliszyn E., et al. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 1999, 283:1544-1548.
    • (1999) Science , vol.283 , pp. 1544-1548
    • Elchebly, M.1    Payette, P.2    Michaliszyn, E.3
  • 3
    • 0033942614 scopus 로고    scopus 로고
    • Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice
    • Klaman L.D., Boss O., Peroni O.D., et al. Increased energy expenditure, decreased adiposity, and tissue-specific insulin sensitivity in protein-tyrosine phosphatase 1B-deficient mice. Mol. Cell. Biol. 2000, 20:5479-5489.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5479-5489
    • Klaman, L.D.1    Boss, O.2    Peroni, O.D.3
  • 4
    • 72449125227 scopus 로고    scopus 로고
    • Deletion of protein tyrosine phosphatase 1B improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone
    • Ali M.I., Ketsawatsomkron P., Belin de Chantemele E.J., et al. Deletion of protein tyrosine phosphatase 1B improves peripheral insulin resistance and vascular function in obese, leptin-resistant mice via reduced oxidant tone. Circ. Res. 2009, 105:1013-1022.
    • (2009) Circ. Res. , vol.105 , pp. 1013-1022
    • Ali, M.I.1    Ketsawatsomkron, P.2    Belin de Chantemele, E.J.3
  • 5
    • 0036228770 scopus 로고    scopus 로고
    • Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B
    • Cheng A., Uetani N., Simoncic P.D., et al. Attenuation of leptin action and regulation of obesity by protein tyrosine phosphatase 1B. Dev. Cell. 2002, 2:385-387.
    • (2002) Dev. Cell. , vol.2 , pp. 385-387
    • Cheng, A.1    Uetani, N.2    Simoncic, P.D.3
  • 6
    • 65549091169 scopus 로고    scopus 로고
    • Prodrug delivery of novel PTP1B inhibitors to enhance insulin signaling
    • Erbe D.V., Klaman L.D., Wilson D.P., et al. Prodrug delivery of novel PTP1B inhibitors to enhance insulin signaling. Diab. Obes. Metab. 2009, 11:579-588.
    • (2009) Diab. Obes. Metab. , vol.11 , pp. 579-588
    • Erbe, D.V.1    Klaman, L.D.2    Wilson, D.P.3
  • 7
    • 67349173660 scopus 로고    scopus 로고
    • Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors
    • Park H., Bhattarai B.R., Ham S.W., et al. Structure-based virtual screening approach to identify novel classes of PTP1B inhibitors. Eur. J. Med. Chem. 2009, 44:3280-3284.
    • (2009) Eur. J. Med. Chem. , vol.44 , pp. 3280-3284
    • Park, H.1    Bhattarai, B.R.2    Ham, S.W.3
  • 8
    • 67651102915 scopus 로고    scopus 로고
    • Molecular dynamics studies on the interactions of PTP1B with inhibitors: from the first phosphate-binding site to the second one
    • Wang J.F., Gong K., Wei D.Q., et al. Molecular dynamics studies on the interactions of PTP1B with inhibitors: from the first phosphate-binding site to the second one. Protein Eng. Des. Sel. 2009, 22:349-355.
    • (2009) Protein Eng. Des. Sel. , vol.22 , pp. 349-355
    • Wang, J.F.1    Gong, K.2    Wei, D.Q.3
  • 9
    • 34047252001 scopus 로고    scopus 로고
    • The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding
    • Picha K.M., Patel S.S., Mandiyan S., et al. The role of the C-terminal domain of protein tyrosine phosphatase-1B in phosphatase activity and substrate binding. J. Biol. Chem. 2007, 282:2911-2917.
    • (2007) J. Biol. Chem. , vol.282 , pp. 2911-2917
    • Picha, K.M.1    Patel, S.S.2    Mandiyan, S.3
  • 10
    • 77950366124 scopus 로고    scopus 로고
    • Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice
    • González-Rodríguez Á., Mas Gutierrez J.A., Sanz-González S., et al. Inhibition of PTP1B restores IRS1-mediated hepatic insulin signaling in IRS2-deficient mice. Diabetes 2010, 59:588-599.
    • (2010) Diabetes , vol.59 , pp. 588-599
    • González-Rodríguez, Á.1    Mas Gutierrez, J.A.2    Sanz-González, S.3
  • 11
    • 56749112559 scopus 로고    scopus 로고
    • Endoplasmic reticulum stress induces leptin resistance
    • Hosoi T., Sasaki M., Miyahara T., et al. Endoplasmic reticulum stress induces leptin resistance. Mol. Pharmacol. 2008, 74:1610-1619.
    • (2008) Mol. Pharmacol. , vol.74 , pp. 1610-1619
    • Hosoi, T.1    Sasaki, M.2    Miyahara, T.3
  • 12
    • 54049132119 scopus 로고    scopus 로고
    • Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B
    • Venkatesan B., Ghosh-Choudhury N., Das F., et al. Resveratrol inhibits PDGF receptor mitogenic signaling in mesangial cells: role of PTP1B. FASEB J. 2008, 22:3469-3482.
    • (2008) FASEB J. , vol.22 , pp. 3469-3482
    • Venkatesan, B.1    Ghosh-Choudhury, N.2    Das, F.3
  • 13
    • 78651304021 scopus 로고    scopus 로고
    • Suppression of PKG by PDGF or nitric oxide in differentiated aortic smooth muscle cells: obligatory role of protein tyrosine phosphatase 1B
    • Zhuang D., Balani P., Pu Q., et al. Suppression of PKG by PDGF or nitric oxide in differentiated aortic smooth muscle cells: obligatory role of protein tyrosine phosphatase 1B. Am. J. Physiol. Heart Circ. Physiol. 2011, 300:H57-H63.
    • (2011) Am. J. Physiol. Heart Circ. Physiol. , vol.300
    • Zhuang, D.1    Balani, P.2    Pu, Q.3
  • 14
    • 44449160071 scopus 로고    scopus 로고
    • Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling
    • Juarez J.C., Manuia M., Burnett M.E., et al. Superoxide dismutase 1 (SOD1) is essential for H2O2-mediated oxidation and inactivation of phosphatases in growth factor signaling. Proc. Natl. Acad. Sci. USA 2008, 105:7147-7152.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 7147-7152
    • Juarez, J.C.1    Manuia, M.2    Burnett, M.E.3
  • 15
    • 77950890821 scopus 로고    scopus 로고
    • Enhancement of insulin responsiveness by nitric oxide-mediated inactivation of protein-tyrosine phosphatases
    • Hsu M.-F., Meng T.-C. Enhancement of insulin responsiveness by nitric oxide-mediated inactivation of protein-tyrosine phosphatases. J. Biol. Chem. 2010, 285:7919-7928.
    • (2010) J. Biol. Chem. , vol.285 , pp. 7919-7928
    • Hsu, M.-F.1    Meng, T.-C.2
  • 16
    • 77955085828 scopus 로고    scopus 로고
    • Synthesis, characterization, and protein tyrosine phosphatases inhibition activities of oxovanadium(IV) complexes with Schiff base and polypyridyl derivatives
    • Yuan C., Lu L., Wu Y., et al. Synthesis, characterization, and protein tyrosine phosphatases inhibition activities of oxovanadium(IV) complexes with Schiff base and polypyridyl derivatives. J. Inorg. Biochem. 2010, 104:978-986.
    • (2010) J. Inorg. Biochem. , vol.104 , pp. 978-986
    • Yuan, C.1    Lu, L.2    Wu, Y.3
  • 17
    • 77149122716 scopus 로고    scopus 로고
    • Inhibition of acid, alkaline, and tyrosine (PTP1B) phosphatases by novel vanadium complexes
    • McLauchlan C.C., Hooker J.D., Jones M.A., et al. Inhibition of acid, alkaline, and tyrosine (PTP1B) phosphatases by novel vanadium complexes. J. Inorg. Biochem. 2010, 104:274-281.
    • (2010) J. Inorg. Biochem. , vol.104 , pp. 274-281
    • McLauchlan, C.C.1    Hooker, J.D.2    Jones, M.A.3
  • 18
    • 78650212664 scopus 로고    scopus 로고
    • Preparation of triazole-linked glycosylated (α-ketocarboxylic acid derivatives as new PTP1B inhibitors
    • Song Z., He X.P., Li C., et al. Preparation of triazole-linked glycosylated (α-ketocarboxylic acid derivatives as new PTP1B inhibitors. Carbohydr. Res. 2011, 346:140-145.
    • (2011) Carbohydr. Res. , vol.346 , pp. 140-145
    • Song, Z.1    He, X.P.2    Li, C.3
  • 19
    • 41849149691 scopus 로고    scopus 로고
    • PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold
    • Holmes C.P., Li X., Pan Y., et al. PTP1B inhibitors: synthesis and evaluation of difluoro-methylenephosphonate bioisosteres on a sulfonamide scaffold. Bioorg. Med. Chem. Lett. 2008, 18:2719-2724.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 2719-2724
    • Holmes, C.P.1    Li, X.2    Pan, Y.3
  • 20
    • 79960032014 scopus 로고    scopus 로고
    • Antihyperglycemic activity of VMNS2E, a novel biphenyl PTP1B inhibitor and its effect on insulin resistance, diabetes and dyslipidemia
    • Kurundkara S.B., Sachanb N., Kodama K.M., et al. Antihyperglycemic activity of VMNS2E, a novel biphenyl PTP1B inhibitor and its effect on insulin resistance, diabetes and dyslipidemia. Diab. Vasc. Dis. Res. 2011, 8:91.
    • (2011) Diab. Vasc. Dis. Res. , vol.8 , pp. 91
    • Kurundkara, S.B.1    Sachanb, N.2    Kodama, K.M.3
  • 21
    • 56549087210 scopus 로고    scopus 로고
    • Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors
    • Lin L., Shen Q., Chen G.R., et al. Beta-C-glycosiduronic acids and beta-C-glycosyl compounds: new PTP1B inhibitors. Bioorg. Med. Chem. Lett. 2008, 18:6348-6351.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 6348-6351
    • Lin, L.1    Shen, Q.2    Chen, G.R.3
  • 22
    • 77957553514 scopus 로고    scopus 로고
    • Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors
    • Gupta S., Pandey G., Rahuja N., et al. Design, synthesis and docking studies on phenoxy-3-piperazin-1-yl-propan-2-ol derivatives as protein tyrosine phosphatase 1B inhibitors. Bioorg. Med. Chem. Lett. 2010, 20:5732-5734.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 5732-5734
    • Gupta, S.1    Pandey, G.2    Rahuja, N.3
  • 23
    • 63349108728 scopus 로고    scopus 로고
    • Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies
    • Saxena A.K., Pandey G., Gupta S., et al. Synthesis of protein tyrosine phosphatase 1B inhibitors: model validation and docking studies. Bioorg. Med. Chem. Lett. 2009, 19:2320-2323.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 2320-2323
    • Saxena, A.K.1    Pandey, G.2    Gupta, S.3
  • 24
    • 71749083846 scopus 로고    scopus 로고
    • Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects
    • Bhattarai B.R., Kafle B., Hwang J.-S., et al. Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects. Bioorg. Med. Chem. Lett. 2009, 19:6161-6165.
    • (2009) Bioorg. Med. Chem. Lett. , vol.19 , pp. 6161-6165
    • Bhattarai, B.R.1    Kafle, B.2    Hwang, J.-S.3
  • 25
    • 77958039797 scopus 로고    scopus 로고
    • Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-γ activators
    • Bhattarai B.R., Kafle B., Hwang J.S., et al. Novel thiazolidinedione derivatives with anti-obesity effects: dual action as PTP1B inhibitors and PPAR-γ activators. Bioorg. Med. Chem. Lett. 2010, 20:6758-6763.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 6758-6763
    • Bhattarai, B.R.1    Kafle, B.2    Hwang, J.S.3
  • 26
    • 37549060353 scopus 로고    scopus 로고
    • Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines
    • Douty B., Wayland B., Ala P.J., et al. Isothiazolidinone inhibitors of PTP1B containing imidazoles and imidazolines. Bioorg. Med. Chem. Lett. 2008, 18:66-71.
    • (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 66-71
    • Douty, B.1    Wayland, B.2    Ala, P.J.3
  • 27
    • 38749150385 scopus 로고    scopus 로고
    • Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening
    • Shi L., Yu H.P., Zhou Y.Y., et al. Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening. Acta Pharmacol. Sin. 2008, 29:278-284.
    • (2008) Acta Pharmacol. Sin. , vol.29 , pp. 278-284
    • Shi, L.1    Yu, H.P.2    Zhou, Y.Y.3
  • 28
    • 58049206736 scopus 로고    scopus 로고
    • Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors
    • Liu S., Zeng L.F., Wu L., et al. Targeting inactive enzyme conformation: aryl diketoacid derivatives as a new class of PTP1B inhibitors. J. Am. Chem. Soc. 2008, 130:17075-17084.
    • (2008) J. Am. Chem. Soc. , vol.130 , pp. 17075-17084
    • Liu, S.1    Zeng, L.F.2    Wu, L.3
  • 29
    • 56049097649 scopus 로고    scopus 로고
    • Molecular dynamics simulation study of PTP1B with allosteric inhibitor and its application in receptor based pharmacophore modeling
    • Bharatham K., Bharatham N., Kwon Y.J., et al. Molecular dynamics simulation study of PTP1B with allosteric inhibitor and its application in receptor based pharmacophore modeling. J. Comput. Aid. Mol. Des. 2008, 22:925-933.
    • (2008) J. Comput. Aid. Mol. Des. , vol.22 , pp. 925-933
    • Bharatham, K.1    Bharatham, N.2    Kwon, Y.J.3
  • 30
    • 61349110857 scopus 로고    scopus 로고
    • 5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors
    • Ottana R., Maccari R., Ciurleo R., et al. 5-Arylidene-2-phenylimino-4-thiazolidinones as PTP1B and LMW-PTP inhibitors. Bioorg. Med. Chem. Lett. 2009, 17:1928-1937.
    • (2009) Bioorg. Med. Chem. Lett. , vol.17 , pp. 1928-1937
    • Ottana, R.1    Maccari, R.2    Ciurleo, R.3
  • 31
    • 77549086943 scopus 로고    scopus 로고
    • Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity
    • Ye D., Zhang Y., Wang F., et al. Novel thiophene derivatives as PTP1B inhibitors with selectivity and cellular activity. Bioorg. Med. Chem. Lett. 2010, 18:1773-1782.
    • (2010) Bioorg. Med. Chem. Lett. , vol.18 , pp. 1773-1782
    • Ye, D.1    Zhang, Y.2    Wang, F.3
  • 32
    • 77954052098 scopus 로고    scopus 로고
    • Probing interaction requirements in PTP1B inhibitors: a comparative molecular dynamics study
    • Kumar R., Shinde R.N., Ajay D., et al. Probing interaction requirements in PTP1B inhibitors: a comparative molecular dynamics study. J. Chem. Inf. Model. 2010, 50:1147-1158.
    • (2010) J. Chem. Inf. Model. , vol.50 , pp. 1147-1158
    • Kumar, R.1    Shinde, R.N.2    Ajay, D.3
  • 33
    • 56449094179 scopus 로고    scopus 로고
    • Studies of the mechanism of selectivity of protein tyrosine phosphatase 1B (PTP1B) bidentate inhibitors using molecular dynamics simulations and free energy calculations
    • Fang L., Zhang H., Cui W., et al. Studies of the mechanism of selectivity of protein tyrosine phosphatase 1B (PTP1B) bidentate inhibitors using molecular dynamics simulations and free energy calculations. J. Chem. Inf. Model. 2008, 48:2030-2041.
    • (2008) J. Chem. Inf. Model. , vol.48 , pp. 2030-2041
    • Fang, L.1    Zhang, H.2    Cui, W.3
  • 34
    • 77955125921 scopus 로고    scopus 로고
    • An RNA aptamer that selectively inhibits the enzymatic activity of protein tyrosine phosphatase 1B in vitro
    • Townshend B., Aubry I., Marcellus R.C., et al. An RNA aptamer that selectively inhibits the enzymatic activity of protein tyrosine phosphatase 1B in vitro. Chembiochem. 2010, 11:1583-1593.
    • (2010) Chembiochem. , vol.11 , pp. 1583-1593
    • Townshend, B.1    Aubry, I.2    Marcellus, R.C.3
  • 35
    • 77954214500 scopus 로고    scopus 로고
    • Berberine inhibits PTP1B activity and mimics insulin action
    • Chen C., Zhang Y., Huang C. Berberine inhibits PTP1B activity and mimics insulin action. Biochem. Biophys. Res. Commun. 2010, 397:543-547.
    • (2010) Biochem. Biophys. Res. Commun. , vol.397 , pp. 543-547
    • Chen, C.1    Zhang, Y.2    Huang, C.3
  • 36
    • 65249166560 scopus 로고    scopus 로고
    • Docking simulations and in vitro assay unveil potent inhibitory action of Papaverine against protein tyrosine phosphatase 1B
    • Bustanji Y., Taha M.O., Al-Masri I.M., et al. Docking simulations and in vitro assay unveil potent inhibitory action of Papaverine against protein tyrosine phosphatase 1B. Biol. Pharm. Bull. 2009, 32:640-645.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 640-645
    • Bustanji, Y.1    Taha, M.O.2    Al-Masri, I.M.3
  • 37
    • 77955461653 scopus 로고    scopus 로고
    • Discovery of novel PTP1B inhibitors with antihyperglycemic activity
    • Liu Z., Chai Q., Li Y.Y., et al. Discovery of novel PTP1B inhibitors with antihyperglycemic activity. Acta Pharmacol. Sin. 2010, 31:1005-1012.
    • (2010) Acta Pharmacol. Sin. , vol.31 , pp. 1005-1012
    • Liu, Z.1    Chai, Q.2    Li, Y.Y.3
  • 38
    • 77954378714 scopus 로고    scopus 로고
    • Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551
    • Fukuda S., Ohta T., Sakata S., et al. Pharmacological profiles of a novel protein tyrosine phosphatase 1B inhibitor, JTT-551. Diab. Obes. Metab. 2010, 12:299-306.
    • (2010) Diab. Obes. Metab. , vol.12 , pp. 299-306
    • Fukuda, S.1    Ohta, T.2    Sakata, S.3
  • 39
    • 76749093185 scopus 로고    scopus 로고
    • Antihyperglycemic effects of methylenedisalicylic acid
    • Bhattarai B.R., Lee K.-H., Cho H. Antihyperglycemic effects of methylenedisalicylic acid. Bull. Korean Chem. Soc. 2009, 30:2879-2880.
    • (2009) Bull. Korean Chem. Soc. , vol.30 , pp. 2879-2880
    • Bhattarai, B.R.1    Lee, K.-H.2    Cho, H.3
  • 40
    • 74349118714 scopus 로고    scopus 로고
    • Inhibition of IKK-b: a new development in the mechanism of the anti-obesity effects of PTP1B inhibitors SA18 and SA32
    • Bhattarai B.R., Ko J.-H., Shrestha S., et al. Inhibition of IKK-b: a new development in the mechanism of the anti-obesity effects of PTP1B inhibitors SA18 and SA32. Bioorg. Med. Chem. Lett. 2010, 20:1075-1077.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 1075-1077
    • Bhattarai, B.R.1    Ko, J.-H.2    Shrestha, S.3
  • 41
    • 77957256789 scopus 로고    scopus 로고
    • Inhibition of protein tyrosine phosphatase 1B and regulation of insulin signalling markers by caffeoyl derivatives of chicory (Cichorium intybus) salad leaves
    • Muthusamy V.S., Saravanababu C., Ramanathan M., et al. Inhibition of protein tyrosine phosphatase 1B and regulation of insulin signalling markers by caffeoyl derivatives of chicory (Cichorium intybus) salad leaves. Br. J. Nutr. 2010, 104:813-823.
    • (2010) Br. J. Nutr. , vol.104 , pp. 813-823
    • Muthusamy, V.S.1    Saravanababu, C.2    Ramanathan, M.3
  • 42
    • 77951427605 scopus 로고    scopus 로고
    • Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats
    • Li J.M., Li Y.C., Kong L.D., et al. Curcumin inhibits hepatic protein-tyrosine phosphatase 1B and prevents hypertriglyceridemia and hepatic steatosis in fructose-fed rats. Hepatology 2010, 51:1555-1566.
    • (2010) Hepatology , vol.51 , pp. 1555-1566
    • Li, J.M.1    Li, Y.C.2    Kong, L.D.3
  • 43
    • 45849148856 scopus 로고    scopus 로고
    • Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition
    • Muthusamy V.S., Anand S., Sangeetha K.N., et al. Tannins present in Cichorium intybus enhance glucose uptake and inhibit adipogenesis in 3T3-L1 adipocytes through PTP1B inhibition. Chem. Biol. Interact. 2008, 174:69-78.
    • (2008) Chem. Biol. Interact. , vol.174 , pp. 69-78
    • Muthusamy, V.S.1    Anand, S.2    Sangeetha, K.N.3
  • 44
    • 77956747889 scopus 로고    scopus 로고
    • A focused library of protein tyrosine phosphatase inhibitors
    • Comeau A.B., Critton D.A., Page R., et al. A focused library of protein tyrosine phosphatase inhibitors. J. Med. Chem. 2010, 53:6768-6772.
    • (2010) J. Med. Chem. , vol.53 , pp. 6768-6772
    • Comeau, A.B.1    Critton, D.A.2    Page, R.3
  • 45
    • 77953285912 scopus 로고    scopus 로고
    • Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: hologram QSAR for OBA and BBB analogues
    • Cheng Y., Zhou M., Tung C.H., et al. Studies on two types of PTP1B inhibitors for the treatment of type 2 diabetes: hologram QSAR for OBA and BBB analogues. Bioorg. Med. Chem. Lett. 2010, 20:3329-3337.
    • (2010) Bioorg. Med. Chem. Lett. , vol.20 , pp. 3329-3337
    • Cheng, Y.1    Zhou, M.2    Tung, C.H.3
  • 46
    • 77957223996 scopus 로고    scopus 로고
    • Bioactivity-guided isolation of 1,2,3,4,6-penta-O-galloyl-d-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor
    • Baumgartner R.R., Steinmann D., Heiss E.H., et al. Bioactivity-guided isolation of 1,2,3,4,6-penta-O-galloyl-d-glucopyranose from Paeonia lactiflora roots as a PTP1B inhibitor. J. Nat. Prod. 2010, 73:1578-1581.
    • (2010) J. Nat. Prod. , vol.73 , pp. 1578-1581
    • Baumgartner, R.R.1    Steinmann, D.2    Heiss, E.H.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.