메뉴 건너뛰기




Volumn 4, Issue 1, 2010, Pages 48-56

Type 2 diabetes mellitus - Its global prevalence and therapeutic strategies

Author keywords

GLP 1; IKKB; PPAR; Type 2 diabetes

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ACARBOSE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; BIGUANIDE DERIVATIVE; CARBAMAZEPINE; CHLORPROPAMIDE; DIPEPTIDYL PEPTIDASE IV INHIBITOR; DISULFIRAM; ERYTHROMYCIN; GEMFIBROZIL; GLIBENCLAMIDE; GLICLAZIDE; GLIMEPIRIDE; GLIPIZIDE; GLITAZONE DERIVATIVE; KETOCONAZOLE; METFORMIN; NATEGLINIDE; PIOGLITAZONE; REPAGLINIDE; RIFAMPICIN; ROSIGLITAZONE; SALICYLIC ACID DERIVATIVE; SULFONAMIDE; SULFONYLUREA; TIPRANAVIR; TOLAZAMIDE; TOLBUTAMIDE; TROGLITAZONE; UNINDEXED DRUG;

EID: 79551592855     PISSN: 18714021     EISSN: 18780334     Source Type: Journal    
DOI: 10.1016/j.dsx.2008.04.011     Document Type: Review
Times cited : (82)

References (92)
  • 2
    • 0035516047 scopus 로고    scopus 로고
    • Projection of diabetes burden through 2050: Impact of changing demography and disease prevalence in the U.S
    • Boyle JP, Honeycutt AA, Narayan KM, Hoerger TJ, Geiss LS, Chen H, et al. Projection of diabetes burden through 2050: impact of changing demography and disease prevalence in the U.S. Diabetes Care 2001;24:1936-40. (Pubitemid 33716504)
    • (2001) Diabetes Care , vol.24 , Issue.11 , pp. 1936-1940
    • Boyle, J.P.1    Honeycutt, A.A.2    Narayan, K.M.V.3    Hoerger, T.J.4    Geiss, L.S.5    Chen, H.6    Thompson, T.J.7
  • 3
    • 0037027299 scopus 로고    scopus 로고
    • Preclinical developments in type II diabetes
    • Lenhard JM, Gottschalk WK. Preclinical developments in type II diabetes. Adv Drug Deliv Rev 2002;54:1199-212.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1199-1212
    • Lenhard, J.M.1    Gottschalk, W.K.2
  • 4
    • 0029035963 scopus 로고
    • Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM 5-year follow-up of initially nondiabetic Japanese-American men
    • Chen KW, Boyko EJ, Bergstrom RW, Leonetti DL, Newell-Morris L, Wahl PW, et al. Earlier appearance of impaired insulin secretion than of visceral adiposity in the pathogenesis of NIDDM 5-Year follow-up of initially nondiabetic Japanese-American men. Diabetes Care 1995;18:747-53.
    • (1995) Diabetes Care , vol.18 , pp. 747-753
    • Chen, K.W.1    Boyko, E.J.2    Bergstrom, R.W.3    Leonetti, D.L.4    Newell-Morris, L.5    Wahl, P.W.6
  • 5
    • 0028848244 scopus 로고
    • Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of type 2 DM in Mexican-Americans
    • Haffner SM, Miettinin H, Gaskill SP, Stern MP. Decreased insulin secretion and increased insulin resistance are independently related to the 7-year risk of type 2 DM in Mexican-Americans. Diabetes 1995;44:1386-91.
    • (1995) Diabetes , vol.44 , pp. 1386-1391
    • Haffner, S.M.1    Miettinin, H.2    Gaskill, S.P.3    Stern, M.P.4
  • 6
    • 37849039167 scopus 로고    scopus 로고
    • Diabetes Atlas Press Release, Cape Town, South Africa, 4 December
    • Diabetes Atlas. International Diabetes Federation, Press Release, Cape Town, South Africa, 4 December; 2006.
    • (2006) International Diabetes Federation
  • 7
    • 0031897103 scopus 로고    scopus 로고
    • Prevalence of diabetes, impaired fasting glucose, and impaired glucose tolerance in U.S. adults: The Third National Health and Nutrition Examination Survey, 1988-1994
    • DOI 10.2337/diacare.21.4.518
    • Harris MI, Flegal KM, Cowie CC, Eberhardt MS, Goldstein DE, Little RR, et al. Prevalence of diabetes, impaired fasting glucose and impaired glucose tolerance in US adults, the third National health and Nutrition examination survey, 1988-1994. Diabetes Care 1998;21:518-24. (Pubitemid 28172927)
    • (1998) Diabetes Care , vol.21 , Issue.4 , pp. 518-524
    • Harris, M.I.1    Flegal, K.M.2    Cowie, C.C.3    Eberhardt, M.S.4    Goldstein, D.E.5    Little, R.R.6    Wiedmeyer, H.-M.7    Byrd-Holt, D.D.8
  • 8
    • 0027532914 scopus 로고
    • Global estimates for prevalence of diabetes mellitus and impaired glucose tolerance in adults
    • King H, Rewers M. Global estimates for prevalence of diabetes and impaired glucose tolerance in adults. Diabetes Care 1993;16:157-77. (Pubitemid 23013841)
    • (1993) Diabetes Care , vol.16 , Issue.1 , pp. 157-177
    • King, H.1    Rewers, M.2
  • 9
    • 36549007517 scopus 로고    scopus 로고
    • The burden and costs of chronic diseases in low-income and middle-income countries
    • DOI 10.1016/S0140-6736(07)61696-1, PII S0140673607616961
    • Abegunde DO, Mathers CD, Adam T, Ortegon M, Strong K. The burden and costs of chronic diseases in low-income and middle-income countries. Lancet 2007;8:1929-38. (Pubitemid 350192633)
    • (2007) Lancet , vol.370 , Issue.9603 , pp. 1929-1938
    • Abegunde, D.O.1    Mathers, C.D.2    Adam, T.3    Ortegon, M.4    Strong, K.5
  • 10
    • 37849045156 scopus 로고    scopus 로고
    • Targeting obesity to reduce the risk for type 2 diabetes and other co-morbidities in African American youth: A review of the literature and recommendations for prevention
    • Nwobu CO, Johnson CC. Targeting obesity to reduce the risk for type 2 diabetes and other co-morbidities in African American youth: a review of the literature and recommendations for prevention. Diab Vasc Dis Res 2007;4:311-9.
    • (2007) Diab Vasc Dis Res , vol.4 , pp. 311-319
    • Nwobu, C.O.1    Johnson, C.C.2
  • 11
    • 0024592355 scopus 로고
    • Prevalence of diabetes in a predominantly Asian community: Preliminary findings of the Coventry diabetes study
    • Simmons D, Williams DR, Powell MY. Prevalence of diabetes in a predominately Asian community; findings of the Coventry diabetes study. Brit Med J 1989;298:18-21. (Pubitemid 19022881)
    • (1989) British Medical Journal , vol.298 , Issue.6665 , pp. 18-21
    • Simmons, D.1    Williams, D.R.R.2    Powell, M.J.3
  • 12
    • 33750503842 scopus 로고    scopus 로고
    • A better understanding of the pathophysiology of obesity and type 2 diabetes: A clue for new therapeutic approaches
    • DOI 10.1016/j.coph.2006.09.003, PII S147148920600169X, Gastrointestinal/Opinion/Endocrine and Metabolic Diseases
    • Bril A, Ktorza A. A better understanding of the pathophysiology of obesity and type 2 diabetes: a clue for new therapeutic approaches. Curr Opin Pharmacol 2006;6:577-9. (Pubitemid 44660953)
    • (2006) Current Opinion in Pharmacology , vol.6 , Issue.6 , pp. 577-579
    • Bril, A.1    Ktorza, A.2
  • 13
    • 33846952835 scopus 로고    scopus 로고
    • Effect of increased patient-physician contact time and health education in achieving diabetes mellitus management objectives in a resource-poor environment
    • Mshelia DS, Akinosun OM, Abbiyesuku FM. Effect of increased patient-physician contact time and health education in achieving diabetes mellitus management objectives in a resource-poor environment. Singapore Med J 2007;48:74-9. (Pubitemid 351229126)
    • (2007) Singapore Medical Journal , vol.48 , Issue.1 , pp. 74-79
    • Mshelia, D.S.1    Akinosun, O.M.2    Abbiyesuku, F.M.3
  • 14
    • 0037027378 scopus 로고    scopus 로고
    • Epidemiology of diabetes
    • Roger G. Epidemiology of diabetes. Adv Drug Deliv Rev 2002;54:1165-72.
    • (2002) Adv Drug Deliv Rev , vol.54 , pp. 1165-1172
    • Roger, G.1
  • 15
    • 0035885902 scopus 로고    scopus 로고
    • Type 2 diabetes: New drugs, new perspectives
    • Goldfine AB. Type 2 diabetes: new drugs, new perspectives. Hosp Pract 2001;36:29-36.
    • (2001) Hosp Pract , vol.36 , pp. 29-36
    • Goldfine, A.A.1
  • 16
    • 33646053813 scopus 로고    scopus 로고
    • The place of sulfonylureas in the therapy for T2DM mellitus
    • Stefano DP, Pulizzi N. The place of sulfonylureas in the therapy for T2DM mellitus. Metabolism 2006;55(Suppl. 1):S20-7.
    • (2006) Metabolism , vol.55 , Issue.SUPPL. 1
    • Stefano, D.P.1    Pulizzi, N.2
  • 18
    • 33845207048 scopus 로고    scopus 로고
    • Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 anti-diabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability
    • DOI 10.1016/j.bcp.2006.09.013, PII S0006295206005788
    • Youn YS, Chae SY, Lee S, Jeon JE, Shin HG, Lee KC. Evaluation of therapeutic potentials of site-specific PEGylated glucagon-like peptide-1 isomers as a type 2 antidiabetic treatment: Insulinotropic activity, glucose-stabilizing capability, and proteolytic stability. Biochem Pharmacol 2007;73:84-93. (Pubitemid 44853930)
    • (2007) Biochemical Pharmacology , vol.73 , Issue.1 , pp. 84-93
    • Youn, Y.S.1    Chae, S.Y.2    Lee, S.3    Jeon, J.E.4    Shin, H.G.5    Lee, K.C.6
  • 19
    • 20444450632 scopus 로고    scopus 로고
    • Thiazolidinediones, peripheral oedema and congestive heart failure: What is the evidence?
    • Patel C, Wyne KL, McGuire DK. Thiazolidinediones, peripheral oedema and congestive heart failure: whatisthe evidence? Diab Vasc Dis Res 2005;2:61-6. (Pubitemid 40826997)
    • (2005) Diabetes and Vascular Disease Research , vol.2 , Issue.2 , pp. 61-66
    • Patel, C.1    Wyne, K.L.2    McGuire, D.K.3
  • 20
    • 0037027410 scopus 로고    scopus 로고
    • Catching target receptors for drug and vaccine delivery using TOGA gene expression profiling
    • DOI 10.1016/S0169-409X(02)00091-1, PII S0169409X02000911
    • Lo D, Hilbush B, Mah S, Brayden D, Byrne D, Higgins L, et al. Catching target receptors for drug and vaccine delivery using TOGA gene expression profiling. Adv Drug Deliv Rev 2002;54:1213-23. (Pubitemid 35223418)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.9 , pp. 1213-1223
    • Lo, D.1    Hilbush, B.2    Mah, S.3    Brayden, D.4    Byrne, D.5    Higgins, L.6    O'Mahony, D.J.7
  • 21
    • 33645074450 scopus 로고    scopus 로고
    • Etiology of insulin resistance
    • Petersen KF, Shulman GI. Etiology of insulin resistance. Am J Med 2006;119(5 Suppl. 1):10S-6S.
    • (2006) Am J Med , vol.119 , Issue.5 SUPPL. 1
    • Petersen, K.F.1    Shulman, G.I.2
  • 22
    • 0037027390 scopus 로고    scopus 로고
    • Implantable, polymeric systems for modulated drug delivery
    • DOI 10.1016/S0169-409X(02)00090-X, PII S0169409X0200090X
    • Sershen S, West J. Implantable, polymeric systems for modulated drug delivery. Adv Drug Deliv Rev 2002;54:1225-35. (Pubitemid 35223419)
    • (2002) Advanced Drug Delivery Reviews , vol.54 , Issue.9 , pp. 1225-1235
    • Sershen, S.1    West, J.2
  • 23
    • 0029051450 scopus 로고
    • Synthesis of novel hydrolytically degradable hydrogels for controlled drug release
    • Ulbrich K, Subr V, Podperova P, Buresova M. Synthesis of novel hydrolytically degradable hydrogels for controlled drug release. J Control Release 1995;34: 155-65.
    • (1995) J Control Release , vol.34 , pp. 155-165
    • Ulbrich, K.1    Subr, V.2    Podperova, P.3    Buresova, M.4
  • 24
    • 0033992179 scopus 로고    scopus 로고
    • Pulsatile protein release from a laminated device comprising of polyanhydrides and pH-sensitive complexes
    • Jiang HL, Zhu KJ. Pulsatile protein release from a laminated device comprising of polyanhydrides and pH-sensitive complexes. Int J Pharm 2000;194:51-60.
    • (2000) Int J Pharm , vol.194 , pp. 51-60
    • Jiang, H.L.1    Zhu, K.J.2
  • 25
    • 33846593286 scopus 로고    scopus 로고
    • Sulfonylurea therapy is associated with increased NT-proBNP levels in the treatment of type 2 diabetes
    • DOI 10.1016/j.ijcard.2006.03.014, PII S0167527306004025
    • Tildesley HD, Aydin CM, Ignaszewski A, Strelzow JA, Yu E, Bondy G. Sulfonylurea therapyis associated with increased NT-proBNP levelsinthe treatment of type 2 diabetes. Int J Cardiol 2007;115:312-7. (Pubitemid 46185631)
    • (2007) International Journal of Cardiology , vol.115 , Issue.3 , pp. 312-317
    • Tildesley, H.D.1    Aydin, C.M.2    Ignaszewski, A.3    Strelzow, J.A.4    Yu, E.5    Bondy, G.6
  • 26
    • 0023196415 scopus 로고
    • Pharmacokinetics of chlorpropamide in epileptic patients: Effects of enzyme induction and urine pH on chlorpropamide elimination
    • DOI 10.1007/BF00607578
    • Neuvonen PJ, Karkkainen S, Lehtovaara R. Pharmacokinetics of chlorprop-amide in epileptic patients: effects of enzyme induction and urine pH on chlorpropamide elimination. Eur J Clin Pharmacol 1987;32:297-301. (Pubitemid 17069120)
    • (1987) European Journal of Clinical Pharmacology , vol.32 , Issue.3 , pp. 297-301
    • Neuvonen, P.J.1    Karkkainen, S.2    Lehtovaara, R.3
  • 27
    • 9444283277 scopus 로고    scopus 로고
    • Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes: Brief overview
    • DOI 10.2337/diabetes.53.suppl-3.S151
    • Melander A. Kinetics-effect relations of insulin-releasing drugs in patients with type 2 diabetes. Diabetes 2004;53(Suppl. 3):S151-5. (Pubitemid 39564537)
    • (2004) Diabetes , vol.53 , Issue.SUPPL. 3
    • Melander, A.1
  • 28
    • 0002615188 scopus 로고    scopus 로고
    • Sulfonylureas: Basic aspects and clinical uses
    • Alberti KGM, Zimmet P, DeFronzo RA, editors 2nd ed., London: Wiley
    • Lebovitz H, Melander A. Sulfonylureas: basic aspects and clinical uses. In: Alberti KGM, Zimmet P, DeFronzo RA, editors. International textbook of diabetes mellitus. 2nd ed., London: Wiley; 1997. p. 817-40.
    • (1997) International Textbook of Diabetes Mellitus , pp. 817-840
    • Lebovitz, H.1    Melander, A.2
  • 29
    • 0015537697 scopus 로고
    • Mechanism of chlorpropamide-induced antiduretics in man: Evidence for release of ADH and enhancement of peripheral action
    • Moses AM, Numann P, Miller M. Mechanism of chlorpropamide-induced antiduretics in man: evidence for release of ADH and enhancement of peripheral action. Metabolism 1973;22:59-66.
    • (1973) Metabolism , vol.22 , pp. 59-66
    • Moses, A.M.1    Numann, P.2    Miller, M.3
  • 30
    • 3142728651 scopus 로고    scopus 로고
    • The role of sulphonylureas in the management of T2DM
    • Rendell M. The role of sulphonylureas in the management of T2DM. Drugs 2004;64:1339-58.
    • (2004) Drugs , vol.64 , pp. 1339-1358
    • Rendell, M.1
  • 31
    • 0035663656 scopus 로고    scopus 로고
    • The NEPI antidiabetes study (NANSY). 1: Short-term dose-effect relations of glimepiride in subjects with impaired fasting glucose
    • DOI 10.1046/j.1463-1326.2001.00166.x
    • Lindblad U, Lindwall K, Sjöstrand A, Ranstam J, Melander A. The NEPI antidiabetes study (NANSY) 1 short-term dose-effect relations of glimepiride in subjects with impaired fasting glucose. Diabetes Obes Metab 2001;3:443-51. (Pubitemid 34030864)
    • (2001) Diabetes, Obesity and Metabolism , vol.3 , Issue.6 , pp. 443-451
    • Lindblad, U.1    Lindwall, K.2    Sjostrand, A.3    Ranstam, J.4    Melander, A.5
  • 32
    • 0023742758 scopus 로고
    • Influence of glipizide on early insulin release and glucose disposal before and after dietary regulation in diabetic patients with different degrees of hyperglycemia
    • Bitzen PO, Melander A, Schersten B, Wahlin-Boll E. Influence of glipizide on early insulin release and glucose disposal before and after dietary regulation in diabetic patients with different degrees of hyperglycemia. Eur J Clin Pharmacol 1988;35:31-7.
    • (1988) Eur J Clin Pharmacol , vol.35 , pp. 31-37
    • Bitzen, P.O.1    Melander, A.2    Schersten, B.3    Wahlin-Boll, E.4
  • 34
    • 34247144968 scopus 로고    scopus 로고
    • Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes
    • DOI 10.1016/j.diabres.2006.10.021, PII S016882270600492X
    • Zhang H, Liu X, Kuang H, Yi R, Xing H. Association of sulfonylurea receptor 1 genotype with therapeutic response to gliclazide in type 2 diabetes. Diab Res Clin Pract 2007;77:58-61. (Pubitemid 46590477)
    • (2007) Diabetes Research and Clinical Practice , vol.77 , Issue.1 , pp. 58-61
    • Zhang, H.1    Liu, X.2    Kuang, H.3    Yi, R.4    Xing, H.5
  • 35
    • 0036723838 scopus 로고    scopus 로고
    • Differential interactions of nateglinide and repaglinide on the human β-cell sulphonylurea receptor 1
    • Hansen AM, Christensen IT, Hansen IB, Carr RD, Ashcroft FM, Wahl P. Differential interactions of nateglinide and repaglinide on the sulphonylurea receptor 1. Diabetes 2002;51:2789-95. (Pubitemid 34970932)
    • (2002) Diabetes , vol.51 , Issue.9 , pp. 2789-2795
    • Hansen, A.M.K.1    Christensen, I.T.2    Hansen, J.B.3    Carr, R.D.4    Ashcroft, F.M.5    Wahl, P.6
  • 36
    • 0034907620 scopus 로고    scopus 로고
    • Nateglinide - A structurally novel, short-acting, hypoglycemic aqgent
    • Norman P, Rabasseda X. Nateglinide - a structurally novel, short-acting, hypoglycemic aqgent. Drugs Today 2001;37:411-26.
    • (2001) Drugs Today , vol.37 , pp. 411-426
    • Norman, P.1    Rabasseda, X.2
  • 37
    • 0036075924 scopus 로고    scopus 로고
    • Clinical pharmacokinetics and pharmacodynamics of repaglinide
    • Hatorp V. Clinical pharmacokinetics and pharmacodynamics of repaglinide. Clin Pharmacokinet 2002;41:471-83. (Pubitemid 34804160)
    • (2002) Clinical Pharmacokinetics , vol.41 , Issue.7 , pp. 471-483
    • Hatorp, V.1
  • 38
    • 0002275298 scopus 로고    scopus 로고
    • Biguanides: Basic aspects and clinical uses
    • Alberti KGM, Zimmet P, DeFronzo RA, editors 2nd ed., London: Wiley
    • Hermann LS, Melander A. Biguanides: basic aspects and clinical uses. In: Alberti KGM, Zimmet P, DeFronzo RA, editors. International textbook of diabetes mellitus. 2nd ed., London: Wiley; 1997. p. 841-64.
    • (1997) International Textbook of Diabetes Mellitus , pp. 841-864
    • Hermann, L.S.1    Melander, A.2
  • 42
    • 33846656854 scopus 로고    scopus 로고
    • Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide
    • Scheen AJ. Drug-drug and food-drug pharmacokinetic interactions with new insulinotropic agents repaglinide and nateglinide. Clin Pharmacokinet 2007;46:93-108.
    • (2007) Clin Pharmacokinet , vol.46 , pp. 93-108
    • Scheen, A.A.1
  • 43
    • 1442332803 scopus 로고    scopus 로고
    • Clinical pharmacokinetics of nateglinide: A rapidly absorbed, short-acting insulinotropic agent
    • McLeod JF. Clinical pharmacokinetics of nateglinide: a rapidly absorbed, short-acting insulinotropic agent. Clin Pharmacokinet 2004;43:97-120.
    • (2004) Clin Pharmacokinet , vol.43 , pp. 97-120
    • McLeod, J.J.1
  • 44
    • 0024317398 scopus 로고
    • 14C]acarbose to rats and dogs
    • Ahr HJ, Krause HP, Siefert HM, Steinke W, Weber H. Pharmacokinetics of acarbose Part II: Distribution to and elimination from tissues and organs following single or repeated administration of [14C]acarbose to rats and dogs. Arzneimittelforschung 1989;39:1261-7. (Pubitemid 19255302)
    • (1989) Arzneimittel-Forschung/Drug Research , vol.39 , Issue.10 , pp. 1261-1267
    • Ahr, H.J.1    Krause, H.P.2    Siefert, H.M.3    Steinke, W.4    Weber, H.5
  • 45
    • 77956902317 scopus 로고
    • Boyer PD, Krebs EG, editors Miami: Academic Press
    • Brownsey RW, Denton RM. In: Boyer PD, Krebs EG, editors. Acetyl-coenzyme A carboxylase, vol. 18. Miami: Academic Press; 1987. p. 123-46.
    • (1987) Acetyl-coenzyme a Carboxylase , vol.18 , pp. 123-146
    • Brownsey, R.W.1    Denton, R.M.2
  • 46
    • 0024459546 scopus 로고
    • Formation of malonyl coenzyme A in rat heart identification and purification of an isozyme of A carboxylase from rat heart
    • Thampy KG. Formation of malonyl coenzyme A in rat heart Identification and purification of an isozyme of A carboxylase from rat heart. J Biol Chem 1989;264:17631-4.
    • (1989) J Biol Chem , vol.264 , pp. 17631-17634
    • Thampy, K.K.1
  • 49
    • 0031720795 scopus 로고    scopus 로고
    • Is type II diabetes mellitus a disease of the innate immune system?
    • DOI 10.1007/s001250051058
    • Pickup JC, Crook MA. Istype II diabetes mellitusadisease of the innate immune system? Diabetologia 1998;41:1241-8. (Pubitemid 28449093)
    • (1998) Diabetologia , vol.41 , Issue.10 , pp. 1241-1248
    • Pickup, J.C.1    Crook, M.A.2
  • 50
    • 0034604248 scopus 로고    scopus 로고
    • Chronic subclinical inflammation as part of the insulin resistance syndrome: The insulin resistance atherosclerosis study (IRAS)
    • Festa A, Agostino RD, Howard G. Chronic subacute inflammation as part of the insulin resistance syndrome: the insulin resistance atherosclerosis study. Circulation 2000;102:42-7. (Pubitemid 30430551)
    • (2000) Circulation , vol.102 , Issue.1 , pp. 42-47
    • Festa, A.1    D'Agostino Jr., R.2    Howard, G.3    Mykkanen, L.4    Tracy, R.P.5    Haffner, S.M.6
  • 51
    • 0035056003 scopus 로고    scopus 로고
    • Anti-TNFα therapy of rheumatoid arthritis: What have we learned?
    • DOI 10.1146/annurev.immunol.19.1.163
    • Feldmann M, Maini RN. Anti-TNFa therapy ofrheumatoid arthritis: what have we learned. Annu Rev Immunol 2001;19:163-96. (Pubitemid 32368033)
    • (2001) Annual Review of Immunology , vol.19 , pp. 163-196
    • Feldmann, M.1    Maini, R.N.2
  • 52
    • 0027459878 scopus 로고
    • Adipose expression of tumor necrosis factor-α: Direct role in obesity-linked insulin resistance
    • Hotamisligil GS, Shargill NS, Spiegelman BM. Adipose expression of tumor necrosis factor-a: direct role in obesity-linked insulin resistance. Science 1993;259:87-91. (Pubitemid 23036092)
    • (1993) Science , vol.259 , Issue.5091 , pp. 87-91
    • Hotamisligil, G.S.1    Shargill, N.S.2    Spiegelman, B.M.3
  • 53
    • 0342618563 scopus 로고    scopus 로고
    • TNFa and insulin sensitivity in humans: Effectsin vivo of antibody blockadein obese NIDDM patients and invitro upon human cultured myotubes
    • Hurel S, Ofei F, Wells AN, Newkirk J. TNFa and insulin sensitivity in humans: effectsin vivo of antibody blockadein obese NIDDM patients and invitro upon human cultured myotubes. Exp Clin Endrocrinol Diabetes 1996;104(Suppl. 2):59-60.
    • (1996) Exp Clin Endrocrinol Diabetes , vol.104 , Issue.SUPPL. 2 , pp. 59-60
    • Hurel, S.1    Ofei, F.2    Wells, A.N.3    Newkirk, J.4
  • 55
    • 0030458404 scopus 로고    scopus 로고
    • Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the antiadipogenic effects of tumor necrosis factor-α
    • DOI 10.1210/me.10.11.1457
    • Zhang B, Berger J, Hu E, Szalkowski D, White-Carrington S, Spiegelman BM, et al. Negative regulation of peroxisome proliferator-activated receptor-γ gene expression contributes to the antiadipogenic effects of tumor necrosis factor alfa. Mol Endocrinol 1996;10:1457-66. (Pubitemid 26423234)
    • (1996) Molecular Endocrinology , vol.10 , Issue.11 , pp. 1457-1466
    • Zhang, B.1    Berger, J.2    Hu, E.3    Szalkowski, D.4    White-Carrington, S.5    Spiegelman, B.M.6    Moller, D.E.7
  • 56
    • 0028587742 scopus 로고
    • Tumor necrosis factor alpha: A key component of the obesity-diabetes link
    • Hotamisligil GS, Spiegelman BM. Tumor necrosis factor alpha: a key component of the obesity-diabetes link. Diabetes 1994;43:1271-8.
    • (1994) Diabetes , vol.43 , pp. 1271-1278
    • Hotamisligil, G.S.1    Spiegelman, B.M.2
  • 60
    • 33750521829 scopus 로고    scopus 로고
    • GLP-1 and type 2 diabetes: physiology and new clinical advances
    • DOI 10.1016/j.coph.2006.08.003, PII S1471489206001615, Gastrointestinal/Opinion/Endocrine and Metabolic Diseases
    • Combettes MM. GLP-1 and type 2 diabetes - physiology and new clinical advances. Curr Opin Pharmacol 2006;6:598-605. (Pubitemid 44660946)
    • (2006) Current Opinion in Pharmacology , vol.6 , Issue.6 , pp. 598-605
    • Combettes, M.M.1
  • 61
    • 0022617246 scopus 로고
    • Reduced incretin effect in Type 2 (non-insulin-dependent) diabetes
    • DOI 10.1007/BF02427280
    • Nauck M, Stockmann F, Ebert R, Creutzfeldt W. Reduced incretin effect in type 2 (non-insulin dependant) diabetes. Diabetologia 1986;29:46-52. (Pubitemid 16162741)
    • (1986) Diabetologia , vol.29 , Issue.1 , pp. 46-52
    • Nauck, M.1    Stockmann, F.2    Ebert, R.3    Creutzfeldt, W.4
  • 62
    • 0001095690 scopus 로고    scopus 로고
    • Reduced post-prandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients
    • Vilsbøll T, Krarup T, Deacon CF, Madsbad S, Holst JJ. Reduced post-prandial concentrations of intact biologically active glucagon-like peptide 1 in type 2 diabetic patients. Diabetes 2001;50:609-11.
    • (2001) Diabetes , vol.50 , pp. 609-611
    • Vilsbøll, T.1    Krarup, T.2    Deacon, C.F.3    Madsbad, S.4    Holst, J.J.5
  • 63
    • 21744433419 scopus 로고    scopus 로고
    • Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes
    • Gautier JF, Fetita S, Sobngwi E, Martin Cs. Biological actions of the incretins GIP and GLP-1 and therapeutic perspectives in patients with type 2 diabetes. Diabetes Metab 2005;31:233-42. (Pubitemid 40961520)
    • (2005) Diabetes and Metabolism , vol.31 , Issue.3 , pp. 233-242
    • Gautier, J.F.1    Fetita, S.2    Sobngwi, E.3    Salaun-Martin, C.4
  • 64
    • 0027248866 scopus 로고
    • Normalization of fasting hyperglycaemia by exogenous glucagon-like peptide 1 (7-36 amide) in Type 2 (non-insulin-dependent) diabetic patients
    • Nauck MA, Kleine N, Orskov C, Holst JJ, Willms B, Creutzfeldt W. Normalization of fasting hyperglycemia by exogenous glucagons-like peptide 1(7-36) amide in type 2 (non-insulin dependent) diabetic patients. Diabetologia 1993;36: 741-4. (Pubitemid 23218642)
    • (1993) Diabetologia , vol.36 , Issue.8 , pp. 741-744
    • Nauck, M.A.1    Kleine, N.2    Orskov, C.3    Holst, J.J.4    Willms, B.5    Creutzfeldt, W.6
  • 65
    • 0031724691 scopus 로고    scopus 로고
    • Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure
    • DOI 10.2337/diacare.21.11.1925
    • Nauck MA, Sauerwald A, Ritzel R, Holst JJ, Schmiegel W. Influence of glucagon-like peptide 1 on fasting glycemia in type 2 diabetic patients treated with insulin after sulfonylurea secondary failure. Diabetes Care 1998;21: 1925-31. (Pubitemid 28478295)
    • (1998) Diabetes Care , vol.21 , Issue.11 , pp. 1925-1931
    • Nauck, M.A.1    Sauerwald, A.2    Ritzel, R.3    Holst, J.J.4    Schmiegel, W.5
  • 66
  • 67
    • 13344281982 scopus 로고    scopus 로고
    • Enhancement or prolongation of GLP-1 activity as a strategy for treatment of type 2 diabetes
    • DOI 10.1016/j.ddstr.2004.08.001, PII S174067730400004X
    • Ahren B. Enhancement or prolongation of GLP-1 activity as a strategy for treatment of type-2 diabetes. Drug Discov Today 2004;1:207-12. (Pubitemid 40197629)
    • (2004) Drug Discovery Today: Therapeutic Strategies , vol.1 , Issue.2 , pp. 207-212
    • Ahren, B.1
  • 68
    • 12244275009 scopus 로고    scopus 로고
    • GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes
    • DOI 10.1055/s-2004-826178
    • Ahren B, Schimitz O. GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes. Horm Metab Res 2004;36:867-76. (Pubitemid 40115912)
    • (2004) Hormone and Metabolic Research , vol.36 , Issue.11-12 , pp. 867-876
    • Ahren, B.1    Schmitz, O.2
  • 69
    • 0029830703 scopus 로고    scopus 로고
    • Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry. A novel kinetic approach
    • DOI 10.1074/jbc.271.38.23222
    • Pauly RP, Rosche F, Wermann M, McIntosh CH, Pederson RA, Demuth HU. Investigation of glucose-dependent insulinotropic polypeptide-(1-42) and glucagon-like peptide-1-(7-36) degradation in vitro by dipeptidyl peptidase IV using matrix-assisted laser desorption/ionization-time of flight mass spectrometry-A novel kinetic approach. J Biol Chem 1996;271:23222-9. (Pubitemid 26314761)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.38 , pp. 23222-23229
    • Pauly, R.P.1    Rosche, F.2    Wermann, M.3    McIntosh, C.H.S.4    Pederson, R.A.5    Demuth, H.-U.6
  • 71
    • 38449113836 scopus 로고    scopus 로고
    • Dipeptidyl peptidase IV inhibitors and diabetes therapy
    • McIntosh CH. Dipeptidyl peptidase IV inhibitors and diabetes therapy. Front Biosci 2008;13:1753-73.
    • (2008) Front Biosci , vol.13 , pp. 1753-1773
    • McIntosh, C.C.1
  • 72
    • 36649021752 scopus 로고    scopus 로고
    • Dipeptidyl peptidase-IV inhibitors: Fixing type 2 diabetes?
    • McIntyre HF, Grant P. Dipeptidyl peptidase-IV inhibitors: fixing type 2 diabetes? Br J Hosp Med (Lond) 2007;68:599-602. (Pubitemid 350195872)
    • (2007) British Journal of Hospital Medicine , vol.68 , Issue.11 , pp. 599-602
    • McIntyre, H.F.1    Grant, P.2
  • 73
    • 33845478152 scopus 로고    scopus 로고
    • CS-II in type 2 diabetic patients
    • Attali JR. CS-II in type 2 diabetic patients. Diabetes Res Clin Pract 2006;74: S116-8.
    • (2006) Diabetes Res Clin Pract , vol.74
    • Attali, J.J.1
  • 74
    • 33747818266 scopus 로고    scopus 로고
    • Nuclear receptors as drug targets in metabolic diseases: New approaches to therapy
    • James FT, Leonard PF. Nuclear receptors as drug targets in metabolic diseases: new approaches to therapy. Trends Endocrinol Metab 2006;17:284-90.
    • (2006) Trends Endocrinol Metab , vol.17 , pp. 284-290
    • James, F.T.1    Leonard, P.F.2
  • 75
    • 33645112691 scopus 로고    scopus 로고
    • The toxicology of ligands for peroxisome proliferator activated receptors (PPAR)
    • Peraza MA, Burdick AD, Marin HE, Gonzalez FJ, Peters JM. The toxicology of ligands for peroxisome proliferator activated receptors (PPAR). Toxicol Sci 2006;90:269-95.
    • (2006) Toxicol Sci , vol.90 , pp. 269-295
    • Peraza, M.A.1    Burdick, A.D.2    Marin, H.E.3    Gonzalez, F.J.4    Peters, J.M.5
  • 76
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-gamma: Adipogenic regulator and thiazolidinedione receptor
    • Spiegelman BM. PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 1998;47:507-14.
    • (1998) Diabetes , vol.47 , pp. 507-514
    • Spiegelman, B.B.1
  • 77
    • 0033615353 scopus 로고    scopus 로고
    • PPARγ: An essential regulator of adipogenesis and modulator of fat cell function
    • DOI 10.1016/S0092-8674(00)81654-2
    • Lowell BB. PPAR-gamma: an essential regulator of adipogenesis and modulator of fat cell function. Cell 1999;99:239-42. (Pubitemid 29519902)
    • (1999) Cell , vol.99 , Issue.3 , pp. 239-242
    • Lowell, B.B.1
  • 78
    • 0029093852 scopus 로고
    • Molecular characterization of a common binding site for small molecules within the transmembrane domain of gprotein coupled receptors
    • Cascieri MA, Fong TM, Strader CD. Molecular characterization of a common binding site for small molecules within the transmembrane domain of Gprotein coupled receptors. J Pharmacol Toxicol Methods 1995;33:179-85.
    • (1995) J Pharmacol Toxicol Methods , vol.33 , pp. 179-185
    • Cascieri, M.A.1    Fong, T.M.2    Strader, C.D.3
  • 80
    • 0032542247 scopus 로고    scopus 로고
    • Discovery and structure - Activity relationship of the first non- peptide competitive human glucagon receptor antagonists
    • DOI 10.1021/jm9810304
    • Madsen P, Knudsen LB, Wiberg FC, Carr RD. Discovery and structure-activity relationship of the first non-peptide competitive human glucagon receptor antagonists. J Med Chem 1998;41:5150-7. (Pubitemid 29016309)
    • (1998) Journal of Medicinal Chemistry , vol.41 , Issue.26 , pp. 5150-5157
    • Madsen, P.1    Knudsen, L.B.2    Wiberg, F.C.3    Carr, R.D.4
  • 84
    • 0035195977 scopus 로고    scopus 로고
    • Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans
    • DOI 10.1007/s001250100006
    • Petersen KF, Sullivan JT. Effects of a novel glucagon receptor antagonist (Bay 27-9955) on glucagon-stimulated glucose production in humans. Diabetologia 2001;44:2018-24. (Pubitemid 33124047)
    • (2001) Diabetologia , vol.44 , Issue.11 , pp. 2018-2024
    • Petersen, K.F.1    Sullivan, J.T.2
  • 85
    • 0036317545 scopus 로고    scopus 로고
    • Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice
    • Reifsnyder PC, Leiter EH. Deconstructing and reconstructing obesity-induced diabetes (diabesity) in mice. Diabetes 2002;51:825-32. (Pubitemid 34760196)
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 825-832
    • Reifsnyder, P.C.1    Leiter, E.H.2
  • 87
    • 0035340067 scopus 로고    scopus 로고
    • Oral agents in the management of T2DM
    • Luna B, Feinglos MN. Oral agents in the management of T2DM. Am Fam Phys 2001;63:1747-56.
    • (2001) Am Fam Phys , vol.63 , pp. 1747-1756
    • Luna, B.1    Feinglos, M.N.2
  • 89
    • 34648851352 scopus 로고    scopus 로고
    • Combined therapy with ramipril and simvastatin has beneficial additive effects on tissue factor activity and prothrombin fragment 1 + 2 in patients with type 2 diabetes
    • DOI 10.1016/j.atherosclerosis.2006.07.031, PII S0021915006004552
    • Koh KK, Quon MJ, Han SH, Ahn JY, Lee Y, Shin EK. Combined therapy with ramipril and simvastatin has beneficial additive effects on tissue factor activity and prothrombin fragment 1 + 2 in patients with type 2 diabetes. Atherosclerosis 2007;194:230-7. (Pubitemid 47464302)
    • (2007) Atherosclerosis , vol.194 , Issue.1 , pp. 230-237
    • Koh, K.K.1    Quon, M.J.2    Han, S.H.3    Ahn, J.Y.4    Lee, Y.5    Shin, E.K.6
  • 90
    • 0036021081 scopus 로고    scopus 로고
    • Repaglinide versus glibenclamide treatment of Type 2 diabetes during Ramadan fasting
    • DOI 10.1016/S0168-8227(02)00104-3, PII S0168822702001043
    • Mafauzy M. Repaglinide versus glibenclamide treatment of T2DM during Ramadan fasting. Diabetes Res Clin Pract 2002;58:45-53. (Pubitemid 34823624)
    • (2002) Diabetes Research and Clinical Practice , vol.58 , Issue.1 , pp. 45-53
    • Mafauzy, M.1
  • 91
    • 33845668017 scopus 로고    scopus 로고
    • Rosiglitazone: safety and efficacy in combination with insulin in poorly controlled type 2 diabetes mellitus patients treated with insulin alone
    • DOI 10.1016/j.jdiacomp.2005.10.004, PII S1056872705001480
    • Garg R, Gopal J, Jones GR. Rosiglitazone: safety and efficacy in combination with insulin in poorly controlled T2DM patients treated with insulin alone. J Diabetes Complications 2007;21:1-6. (Pubitemid 44960840)
    • (2007) Journal of Diabetes and its Complications , vol.21 , Issue.1 , pp. 1-6
    • Garg, R.1    Gopal, J.2    Jones, G.R.3
  • 92
    • 33745986412 scopus 로고    scopus 로고
    • Effects of 1 Year of Treatment with Pioglitazone or Rosiglitazone Added to Glimepiride on Lipoprotein (a) and Homocysteine Concentrations in Patients with Type 2 Diabetes Mellitus and Metabolic Syndrome: A Multicenter, Randomized, Double-Blind, Controlled Clinical Trial
    • DOI 10.1016/j.clinthera.2006.05.012, PII S0149291806001238
    • Derosa G, Cicero AF, D'Angelo A, Gaddi A, Ciccarelli L, Piccinni MN, et al. Effects of 1 year of treatment with pioglitazone or rosiglitazone added to glimepiride on lipoprotein (a) and homocysteine concentrations in patients with type 2 diabetes mellitus and metabolic syndrome: a multicenter, randomized, double-blind, controlled clinical trial. Clin Ther 2006;28:679-88. (Pubitemid 44067262)
    • (2006) Clinical Therapeutics , vol.28 , Issue.5 , pp. 679-688
    • Derosa, G.1    Cicero, A.F.G.2    D'Angelo, A.3    Gaddi, A.4    Ciccarelli, L.5    Piccinni, M.N.6    Salvadeo, S.A.T.7    Pricolo, F.8    Ferrari, I.9    Gravina, A.10    Ragonesi, P.D.11


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.