메뉴 건너뛰기




Volumn 51, Issue 1, 2002, Pages 87-97

Phosphatidylinositol 3-kinase suppresses glucose-stimulated insulin secretion by affecting post-cytosolic [Ca2+] elevation signals

Author keywords

[No Author keywords available]

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; CALCIUM; DIAZOXIDE; GLUCOSE; INSULIN; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHLORIDE; PROTEIN P85; WORTMANNIN;

EID: 0036097594     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.1.87     Document Type: Article
Times cited : (64)

References (73)
  • 2
    • 0033515429 scopus 로고    scopus 로고
    • Deconstructing type 2 diabetes
    • (1999) Cell , vol.97 , pp. 9-12
    • Taylor, S.I.1
  • 7
    • 0030067124 scopus 로고    scopus 로고
    • A lesson in metabolic regulation inspired by the glucokinase glucose sensor paradigm
    • (1996) Diabetes , vol.45 , pp. 223-241
    • Matschinsky, F.M.1
  • 13
    • 0033760442 scopus 로고    scopus 로고
    • Triggering and amplifying pathways of regulation of insulin secretion by glucose
    • (2000) Diabetes , vol.49 , pp. 1751-1760
    • Henquin, J.-C.1
  • 15
    • 0031712798 scopus 로고    scopus 로고
    • +-ATP channel-independent pathway of regulation of insulin secretion by glucose: In search of the underlying mechanism
    • (1998) Diabetes , vol.47 , pp. 1713-1721
    • Sato, Y.1    Henquin, J.C.2
  • 16
    • 85047678584 scopus 로고    scopus 로고
    • 2+-independent pathways in stimulus-coupling to insulin secretion can be distinguished by their guanosine triphosphate requirements: Studies on rat pancreatic islets
    • (1998) Endocrinology , vol.139 , pp. 1172-1183
    • Komatsu, M.1    Noda, M.2    Sharp, G.W.3
  • 17
    • 0030029605 scopus 로고    scopus 로고
    • Are the β-cell signaling molecules malonyl-CoA and cytosolic long-chain acyl-CoA implicated in multiple tissue defects of obesity and NIDDM?
    • (1996) Diabetes , vol.45 , pp. 273-283
    • Prentki, M.1    Corkey, B.E.2
  • 33
    • 0030030660 scopus 로고    scopus 로고
    • A wortmannin-sensitive signal transduction pathway is involved in the stimulation of insulin release by vasoactive intestinal polypeptide and pituitary adenylate cyclase-activating polypeptide
    • (1996) J Biol Chem , vol.271 , pp. 1660-1668
    • Straub, S.G.1    Sharp, G.W.G.2
  • 35
    • 0034457274 scopus 로고    scopus 로고
    • A link between insulin resistance and hyper-insulinemia, inhibitors of phosphatidylinositol 3-kinase augment glucose-induced insulin secretion from islets of lean but not obese rats
    • (2000) Endocrinology , vol.141 , pp. 3287-3295
    • Zawalich, W.1    Zawalich, K.2
  • 45
    • 0032969115 scopus 로고    scopus 로고
    • Regulation of ob gene expression and leptin secretion by insulin and dexamethasone in rat adipocytes
    • (1999) Diabetes , vol.48 , pp. 272-278
    • Bradley, R.L.1    Cheatham, B.2
  • 47
    • 0033607647 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/p7O ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85α regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells
    • (1999) J Biol Chem , vol.274 , pp. 34005-34010
    • Roques, M.1    Vidal, H.2
  • 56
    • 0032504211 scopus 로고    scopus 로고
    • Insulin-like growth factor I (IGF-I)-stimulated pancreatic β-cell growth is glucose-dependent: Synergistic activation of insulin receptor substrate-mediated signal transduction pathways by glucose and IGF-I in INS-1 cells
    • (1998) J Biol Chem , vol.273 , pp. 17771-17779
    • Hugl, S.R.1    White, M.F.2    Rhodes, C.J.3
  • 69
    • 0028802726 scopus 로고
    • Cyclic nucleotide phosphodiesterases: Functional implications of multiple isoforms
    • (1995) Physiol Rev , vol.75 , pp. 725-748
    • Beavo, J.A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.