Click chemistry decoration of amino sterols as promising strategy to developed new leishmanicidal drugs

Steroids

Volumn 79, Issue , 2014, Pages 28-36

  Porta, Exequiel O J ^a   Carvalho, Paulo B ^b   Avery, Mitchell A ^c   Tekwani, Babu L ^c   Labadie, Guillermo R ^a  

^a Universidad Nacional de Rosario   (Argentina)

^b NOTRE DAME OF MARYLAND UNIVERSITY   (United States)

^c UNIVERSITY OF MISSISSIPPI   (United States)

Author keywords

Antileishmanial; Antimalarial; Click chemistry; Pregnenolone; Reductive amination; Triazolylsterols

Indexed keywords

20 (PROP 2 YN 1 YLAMINO)PREGN 5 EN 3BETA OL; 20 [[(1 BENZYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]AMINO]PREGN 5 EN 3BETA OL; 20 [[(1 OCTYL 1H 1,2,3 TRIAZOL 4 YL)METHYL]AMINO]PREGN 5 EN 3BETA OL; 20 [[[1 (3 PHENYLPROPYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]AMINO]PREGN 5 EN 3BETA OL; 20 [[[1 (3 PHENYLPROPYL) 1H 1,2,3 TRIAZOL 4-YL]METHYL]AMINO]PREGN 5 EN 3BETA OL; 20 [[[1 (3,7 DIMETHYLOCTA 2,6 DIENYL) 1H 1,2,3 TRIAZOL 4 YL]ETHYL]AMINO]PREGN 5 EN 3BETA OL; 20 [[[1 (3,7 DIMETHYLOCTA 2,6 DIENYL) 1H 1,2,3 TRIAZOL 4 YL]METHYL]AMINO]PREGN 5 EN 3BETA OL; ANTILEISHMANIAL AGENT; ETHYL 2 [4 [[[1 [(20 PREGN 5 EN 3BETA YL)EHTYL]AMINO]METHYL] 1H 1,2,3 TRIAZOL 1 YL]ACETATE; STEROL; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CLICK CHEMISTRY; CONTROLLED STUDY; DIASTEREOISOMER; DRUG SYNTHESIS; IC 50; IN VITRO STUDY; LEISHMANIA DONOVANI; NONHUMAN; X RAY CRYSTALLOGRAPHY;

LEISHMANIA DONOVANI;

ANTILEISHMANIAL; ANTIMALARIAL; CLICK CHEMISTRY; PREGNENOLONE; REDUCTIVE AMINATION; TRIAZOLYLSTEROLS;

ANTIPROTOZOAL AGENTS; CHEMISTRY, PHARMACEUTICAL; CLICK CHEMISTRY; CRYSTALLOGRAPHY, X-RAY; INHIBITORY CONCENTRATION 50; LEISHMANIA DONOVANI; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, CHEMICAL; MOLECULAR STRUCTURE; PLASMODIUM FALCIPARUM; STEROLS;

EID: 84888120103     PISSN: 0039128X     EISSN: 18785867     Source Type: Journal    
DOI: 10.1016/j.steroids.2013.10.010     Document Type: Article

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