Quinol derivatives as potential trypanocidal agents

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 4, 2012, Pages 1607-1615

  Capes, Amy ^a   Patterson, Stephen ^a   Wyllie, Susan ^a   Hallyburton, Irene ^a   Collie, Iain T ^a   McCarroll, Andrew J ^b   Stevens, Malcolm F G ^c   Frearson, Julie A ^a   Wyatt, Paul G ^a   Fairlamb, Alan H ^a   Gilbert, Ian H ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

^b Pharminox Ltd   (United Kingdom)

^c UNIVERSITY OF NOTTINGHAM   (United Kingdom)

Author keywords

Inhibitors; Medicinal chemistry; P2 transporter; Quinols; Trypanosoma brucei

Indexed keywords

2 (4 ((1 HYDROXY 4 OXOCYCLOHEXA 2,5 DIEN 1 YL)ETHYNYL)PHENYL) N PHENYLPROPANAMIDE; 2 (4 ((1 HYDROXY 4 OXOCYCLOHEXA 2,5 DIEN 1 YL)ETHYNYL)PHENYL)ACETIC ACID; 3 (4 ((2 (1 HYDROXY 4 OXOCYCLOHEXA 2,5 DIEN 1 YL) 1H INDOL 1 YL)SULFONYL)PHENYL)PROPANOIC ACID; 3 (4 (1 HYDROXY 4 OXOCYCLOHEXA 2,5 DIEN 1 YL) 1H 1,2,3 TRIAZOL 1 YL)N PHENYLPROPANAMIDE; 3 (4 (N (2 IODOPHENYL)SULFAMOYL)PHENYL)PROPANOIC ACID; 3 AZIDO N PHENYLPROPANAMIDE; 3 BROMO N PHENYLPROPANAMIDE; 4 AZIDO 1,3,5 TRIAZINE 2,4 DIAMINE; 4 AZIDOBENZIMIDAMIDE SULFATE; 4 ETHYNYL 4 HYDROXYCYCLOHEXA 2,5 DIENONE; 4,4 DIMETHOXYCYCLOHEXA 2,5 DIENONE; ANTITRYPANOSOMAL AGENT; BENZAMIDE DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; CARRIER PROTEIN; DIMINAZENE ACETURATE; INDOLYL DERIVATIVE; MELAMINE; P2 TRANSPORTER PROTEIN; QUINOLE DERIVATIVE; TRIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIPROTOZOAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG IDENTIFICATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG TARGETING; HUMAN; HUMAN CELL; NONHUMAN; PROTEIN FUNCTION; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA BRUCEI;

BENZAMIDINES; CELL LINE; DRUG DELIVERY SYSTEMS; HUMANS; HYDROQUINONES; INHIBITORY CONCENTRATION 50; MODELS, MOLECULAR; MOLECULAR STRUCTURE; TRIAZINES; TRYPANOCIDAL AGENTS; TRYPANOSOMA BRUCEI BRUCEI;

MAMMALIA; TRYPANOSOMA BRUCEI;

EID: 84857033995     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.12.018     Document Type: Article

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