Design, synthesis and the effect of 1,2,3-triazole sialylmimetic neoglycoconjugates on Trypanosoma cruzi and its cell surface trans-sialidase

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 1, 2012, Pages 145-156

  Campo, Vanessa L ^a   Sesti Costa, Renata ^a   Carneiro, Zumira A ^a   Silva, João S ^a   Schenkman, Sergio ^b   Carvalho, Ivone ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Click chemistry; Sialylmimetics; trans Sialidase; Triazole; Trypanosoma cruzi

Indexed keywords

1,2,3 TRIAZOLE SIALYLMIMETIC NEOGLYCOCONJUGATE DERIVATIVE; 1,2,4,6 TETRA O ACETYL 3 AZIDO 3 DEOXY ALPHA,BETA DEXTRO GLUCOPYRANOSE; 1,2,4,6 TETRA O ACETYL 3 AZIDO 3 DEOXY ALPHA,BETA DEXTRO GULOPYRANOSE; 2 PROPYNYL 5 ACETAMIDO 3,5 DIDEOXI 4,7,8,9 TETRA O ACETYL DEXTRO GLYCEROL ALPHA DEXTRO GALACTO NON 2 ULOPYRANOSIDE METHYL ESTER; 3 AZIDO 3 DEOXY 1:2,5:6 DI O ISOPROPYLIDENE ALPHA DEXTRO GULOFURANOSE; 5 ACETAMIDO 3,5 DIDEOXY 2 OXYMETHYL [1 (ALPHA DEXTRO GALACTOPYRANOSID 6 YL) 1H 1,2,3 TRIAZOL 4 YL] DEXTRO GLYCEROL ALPHA DEXTRO GALACTO NON 2 ULOPYRANOSIDIC ACID; 5 ACETAMIDO 3,5 DIDEOXY 2 OXYMETHYL [1 (ALPHA DEXTRO GLUCOPYRANOSID 3 YL) 1H 1,2,3 TRIAZOL 4 YL] DEXTRO GLYCEROL ALPHA DEXTRO GALACTO NON 2 ULOPYRANOSIDIC ACID; 5 ACETAMIDO 3,5 DIDEOXY 2 OXYMETHYL [1 (BETA DEXTRO GALACTOPYRANOSYL) 1H 1,2,3 TRIAZOL 4 YL] DEXTRO GLYCEROL ALPHA DEXTRO GALACTO NON 2 ULOPYRANOSIDIC ACID; ANTITRYPANOSOMAL AGENT; AZIDO LEVO THREONINE BENZYL ESTER; BENZNIDAZOLE; METHYL 2,4,6 TRI O ACETYL 3 PROP 2 YNYL ALPHA DEXTRO GALACTOPYRANOSIDE; METHYL 3 PROP 2 YNYL ALPHA DEXTRO GALACTOPYRANOSIDE; METHYL [5 ACETAMIDO 3,5 DIDEOXY 4,7,8,9 TETRA O ACETYL 2 OXYMETHYL [1 (1,2,3,4 TETRA O ACETYL ALPHA DEXTRO GALACTOPYRANOSID 6 YL) 1H 1,2,3 TRIAZOL 4 YL] DEXTRO GLYCEROL ALPHA DEXTRO GALACTO NON 2 ULOPYRANOSIDE]ONATE; METHYL [5 ACETAMIDO 3,5 DIDEOXY 4,7,8,9 TETRA O ACETYL 2 OXYMETHYL [1 (1,2,4,6 TETRA O ACETYL ALPHA DEXTRO GLUCOPYRANOSID 3 YL) 1H 1,2,3 TRIAZOL 4 YL] DEXTRO GLYCEROL ALPHA DEXTRO GALACTO NON 2 ULOPYRANOSIDE]ONATE; METHYL [5 ACETAMIDO 3,5 DIDEOXY 4,7,8,9 TETRA O ACETYL 2 OXYMETHYL [1 (1,2,4,6 TETRA O ACETYL BETA DEXTRO GULOPYRANOSID 3 YL) 1H 1,2,3 TRIAZOL 4 YL] DEXTRO GLYCEROL ALPHA DEXTRO GALACTO NON 2 ULOPYRANOSIDE]ONATE; METHYL [5 ACETAMIDO 3,5 DIDEOXY 4,7,8,9 TETRA O ACETYL 2 OXYMETHYL [1 (2,3,4,6 TETRA O ACETYL BETA DEXTRO GALACTOPYRANOSYL) 1H 1,2,3 TRIAZOL 4 YL] DEXTRO GLYCEROL ALPHA DEXTRO GALACTO NON 2 ULOPYRASONIDE]ONATE; SIALIDASE; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; CATALYSIS; CELL SURFACE; COLUMN CHROMATOGRAPHY; CONTROLLED STUDY; CYCLOADDITION; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG PURIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; GLYCOSYLATION; HYDROGEN BOND; HYDROPHOBICITY; MINIMUM INHIBITORY CONCENTRATION; MOLECULAR DOCKING; NONHUMAN; TRYPANOSOMA CRUZI;

ALKYNES; ANTIPARASITIC AGENTS; AZIDES; CATALYSIS; CLICK CHEMISTRY; COPPER; DRUG DESIGN; ENZYME INHIBITORS; GLYCOCONJUGATES; GLYCOPROTEINS; NEURAMINIDASE; SIALIC ACIDS; TRIAZOLES; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 84855202039     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2011.11.022     Document Type: Article

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