Sterol biosynthesis inhibitors: Potential for transition state analogs and mechanism-based inactivators targeted at sterol methyltransferase

Lipids

Volumn 42, Issue 1, 2007, Pages 15-33

  Song, Zhihong ^a   Nes, W David ^a  

^a TEXAS TECH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MECHANISM BASED INACTIVATORS; STEROL BIOSYNTHESIS INHIBITORS (SBI); STEROL METHYLTRANSFERASE; TRANSITION STATE ANALOGS;

BIOSYNTHESIS; DISEASES; DRUG PRODUCTS; ENZYME INHIBITION; ENZYMES; FUNGI;

ALCOHOLS;

24 METHYLENELOPHENOL C METHYLTRANSFERASE; ALKALOID DERIVATIVE; AZASTEROID; AZIRIDINE; BERBERINE; CARBON; CYCLOARTENOL; CYCLOARTENOL 24 METHYLTRANSFERASE; ERGOSTEROL; LANOSTEROL; METHYLTRANSFERASE; NITROGEN; PALMATINE; PLAKINAMINE A; PLAKINAMINE B; PYRROLE DERIVATIVE; SITOSTEROL; SOLACONGESTIDINE; SOLANIDINE; SOLASODINE; STEROL 14ALPHA DEMETHYLASE; STEROL METHYLTRANSFERASE; TOMATIDINE; TRIPARINOL; UNCLASSIFIED DRUG; VERAZINE; ZYMOSTEROL 24 METHYLTRANSFERASE;

ALKYLATION; ANTIBIOTIC RESISTANCE; ANTIFUNGAL ACTIVITY; CATALYSIS; CATALYST; CONFERENCE PAPER; CROP PROTECTION; DRUG STRUCTURE; DRUG USE; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME METABOLISM; ENZYME SUBSTRATE COMPLEX; FUNGUS; HOMEOSTASIS; METHYLATION; MYCOSIS; PROTEIN DOMAIN; PROTEIN EXPRESSION; REACTION ANALYSIS; SIGNAL TRANSDUCTION; STEREOCHEMISTRY; STEREOSPECIFICITY; STEROL ANALYSIS; STEROL SYNTHESIS; STRUCTURE ANALYSIS;

ENZYME INHIBITORS; ERGOSTEROL; METHYLTRANSFERASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33947682816     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-006-3017-1     Document Type: Conference Paper

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