Azasterols as Inhibitors of Sterol 24-Methyltransferase in Leishmania Species and Trypanosoma cruzi

Journal of Medicinal Chemistry

Volumn 46, Issue 22, 2003, Pages 4714-4727

  Magaraci, Filippo ^a   Jimenez Jimenez, Carmen ^b   Rodrigues, Carlos ^c   Rodrigues, Juliany C F ^d   Vianna Braga, Marina ^d   Yardley, Vanessa ^e   De Luca Fradley, Kate ^e   Croft, Simon L ^e   De Souza, Wanderley ^d   Ruiz Perez, Luis M ^b   Urbina, Julio ^c   Gonzalez Pacanowska, Dolores ^b   Gilbert, Ian H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

^c INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

^d FEDERAL UNIVERSITY OF RIO DE JANEIRO   (Brazil)

^e LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ERGOSTEROL; METHYLTRANSFERASE; METHYLTRANSFERASE INHIBITOR; NITROGEN; RECOMBINANT ENZYME; STEROL 24 METHYLTRANSFERASE; STEROL DERIVATIVE; UNCLASSIFIED DRUG;

ALKALINITY; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG SELECTIVITY; DRUG SYNTHESIS; LEISHMANIA; LEISHMANIA MAJOR; NONHUMAN; PARASITE DEVELOPMENT; PARASITE PREVALENCE; STEREOCHEMISTRY; STEROL SYNTHESIS; STRUCTURE ACTIVITY RELATION; TRYPANOSOMA CRUZI;

ANIMALS; AZA COMPOUNDS; ENZYME INHIBITORS; LEISHMANIA; METHYLTRANSFERASES; PREGNANEDIOL; RECOMBINANT PROTEINS; SPECIES SPECIFICITY; STEROLS; STRUCTURE-ACTIVITY RELATIONSHIP; TRYPANOCIDAL AGENTS; TRYPANOSOMA;

EID: 0142124194     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm021114j     Document Type: Article

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