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Volumn 39, Issue 8, 2004, Pages 737-746

Disruption of ergosterol biosynthesis, growth, and the morphological transition in Candida albicans by sterol methyltransferase inhibitors containing sulfur at C-25 in the sterol side chain

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CELLS; ENZYME INHIBITION; ENZYME KINETICS; FUNGUS PROTECTION;

EID: 10044266753     PISSN: 00244201     EISSN: None     Source Type: Journal    
DOI: 10.1007/s11745-004-1290-7     Document Type: Article
Times cited : (23)

References (50)
  • 3
    • 0036178410 scopus 로고    scopus 로고
    • Amphotericin B: Spectrum and Resistance
    • Ellis, D. (2002) Amphotericin B: Spectrum and Resistance, J. Antimicrob. Chemother. 49, 7-10.
    • (2002) J. Antimicrob. Chemother. , vol.49 , pp. 7-10
    • Ellis, D.1
  • 4
    • 0030033020 scopus 로고    scopus 로고
    • Antifungal Agents: Chemotherapeutic Targets and Immunologic Strategies
    • Georgopapadakou, N.K., and Walsh, T.J. (1996) Antifungal Agents: Chemotherapeutic Targets and Immunologic Strategies, Antimicrob. Agents Chemother. 40, 279-291.
    • (1996) Antimicrob. Agents Chemother. , vol.40 , pp. 279-291
    • Georgopapadakou, N.K.1    Walsh, T.J.2
  • 5
    • 0032775156 scopus 로고    scopus 로고
    • Regulatory Networks Controlling Candida albicans morphogenesis
    • Brown, A.J., and Gow, N.A. (1999) Regulatory Networks Controlling Candida albicans morphogenesis, Trends Microbiol. 7, 333-338.
    • (1999) Trends Microbiol. , vol.7 , pp. 333-338
    • Brown, A.J.1    Gow, N.A.2
  • 8
    • 0035836681 scopus 로고    scopus 로고
    • Purification and Characterization of an Autoregulatory Substance Capable of Regulating the Morphological Transition in Candida albicans
    • Oh, K., Miyazawa, H., Naito, T., and Matsuoka, H. (2001) Purification and Characterization of an Autoregulatory Substance Capable of Regulating the Morphological Transition in Candida albicans, Proc. Natl. Acad. Sci. USA 98, 4664-4668.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 4664-4668
    • Oh, K.1    Miyazawa, H.2    Naito, T.3    Matsuoka, H.4
  • 9
    • 0036840116 scopus 로고    scopus 로고
    • Inhibition of Candida albicans Biofilm Formation by Farnesol, a Quorum-Sensing Molecule
    • Ramage, G., Saville, S.P., Wickes, B.L., and Lopez-Ribot, J.L. (2002) Inhibition of Candida albicans Biofilm Formation by Farnesol, a Quorum-Sensing Molecule, Appl. Environ. Microbiol. 68, 5459-5463.
    • (2002) Appl. Environ. Microbiol. , vol.68 , pp. 5459-5463
    • Ramage, G.1    Saville, S.P.2    Wickes, B.L.3    Lopez-Ribot, J.L.4
  • 10
    • 2542454811 scopus 로고    scopus 로고
    • Enhanced Production of Farnesol by Candida albicans treated with Four Azoles
    • Hornby, J.M., and Nickerson, K.W. (2004) Enhanced Production of Farnesol by Candida albicans treated with Four Azoles, Antimicrob. Agents Chemother. 48, 2305-2307.
    • (2004) Antimicrob. Agents Chemother. , vol.48 , pp. 2305-2307
    • Hornby, J.M.1    Nickerson, K.W.2
  • 11
    • 0032942954 scopus 로고    scopus 로고
    • Effects of Azole Antifungal Drugs on the Transition from Yeast Cells to Hyphae in Susceptible and Resistant Isolates of the Pathogenic Yeast Candida albicans
    • Ha, K.C., and White, T.C. (1999) Effects of Azole Antifungal Drugs on the Transition from Yeast Cells to Hyphae in Susceptible and Resistant Isolates of the Pathogenic Yeast Candida albicans, Antimicrob. Agents Chemother. 43, 763-768.
    • (1999) Antimicrob. Agents Chemother. , vol.43 , pp. 763-768
    • Ha, K.C.1    White, T.C.2
  • 12
    • 0001074757 scopus 로고    scopus 로고
    • Mechanisms of Antifungal Resistance
    • Vanden Bossche, H. (1997) Mechanisms of Antifungal Resistance, Rev. Iberoam. Micol. 14, 44-49.
    • (1997) Rev. Iberoam. Micol. , vol.14 , pp. 44-49
    • Vanden Bossche, H.1
  • 13
    • 0001894935 scopus 로고
    • Drug Discovery: A Chemist's Approach
    • Ryley, J.F., ed., Springer, Berlin
    • Boyle, F.T. (1990) Drug Discovery: A Chemist's Approach, in Chemotherapy of Fungal Infections (Ryley, J.F., ed.), pp. 3-30, Springer, Berlin.
    • (1990) Chemotherapy of Fungal Infections , pp. 3-30
    • Boyle, F.T.1
  • 14
    • 0035002003 scopus 로고    scopus 로고
    • HWY-289, a Novel Semi-synthetic Protoberberine Derivative with Multiple Target Sites in Candida albicans
    • Park, K., Kang, K., Kim, K., Jeong, P., Kim, J., Adams, D.J., Kim, J., and Paik, Y. (2001) HWY-289, A Novel Semi-synthetic Protoberberine Derivative with Multiple Target Sites in Candida albicans, J. Antimicrob. Chemother. 47, 513-519.
    • (2001) J. Antimicrob. Chemother. , vol.47 , pp. 513-519
    • Park, K.1    Kang, K.2    Kim, K.3    Jeong, P.4    Kim, J.5    Adams, D.J.6    Kim, J.7    Paik, Y.8
  • 17
    • 51249173864 scopus 로고
    • Sterol Structure and Function
    • Bloch, K.E. (1988) Sterol Structure and Function, J. Am. Oil Chem. Soc. 65, 1763-1766.
    • (1988) J. Am. Oil Chem. Soc. , vol.65 , pp. 1763-1766
    • Bloch, K.E.1
  • 18
    • 0020522411 scopus 로고
    • Stereochemical Specificity for Sterols in Saccharomyces cerevisiae
    • Pinto, W.J., and Nes, W.D. (1983) Stereochemical Specificity for Sterols in Saccharomyces cerevisiae, J. Biol. Chem. 258, 4472-4476.
    • (1983) J. Biol. Chem. , vol.258 , pp. 4472-4476
    • Pinto, W.J.1    Nes, W.D.2
  • 19
    • 0030770249 scopus 로고    scopus 로고
    • Assessment of the Essentiality of ERG6 Genes Late in Ergosterol Biosynthesis in Saccharomyces cerevisiae
    • Palermo, L.M., Leak, F.W., Tove, S., and Parks, L.W. (1997) Assessment of the Essentiality of ERG6 Genes Late in Ergosterol Biosynthesis in Saccharomyces cerevisiae, Curr. Genetics 32, 93-99.
    • (1997) Curr. Genetics , vol.32 , pp. 93-99
    • Palermo, L.M.1    Leak, F.W.2    Tove, S.3    Parks, L.W.4
  • 20
    • 0024348798 scopus 로고
    • The Yeast Gene ERG6 Is Required for Normal Membrane Function but Is Not Essential for Biosynthesis of the Cell-Cycle-Sparking Sterol
    • Gaber, R.F., Copple, D.M., Kennedy, B.K., Vidal, M., and Bard, M. (1989) The Yeast Gene ERG6 Is Required for Normal Membrane Function but Is Not Essential for Biosynthesis of the Cell-Cycle-Sparking Sterol, Mol. Cell. Biol. 9, 3447-3456.
    • (1989) Mol. Cell. Biol. , vol.9 , pp. 3447-3456
    • Gaber, R.F.1    Copple, D.M.2    Kennedy, B.K.3    Vidal, M.4    Bard, M.5
  • 21
    • 0031959699 scopus 로고    scopus 로고
    • Sequencing, Disruption and Characterization of the Candida albicans Sterol Methyltransferase (ERG6) Gene: Drug Susceptibility
    • Jensen-Pergakes, K.L., Kennedy, M.A., Lees, N.D., Barbuch, R., Koegel, C., and Bard, M. (1998) Sequencing, Disruption and Characterization of the Candida albicans Sterol Methyltransferase (ERG6) Gene: Drug Susceptibility, Antimicrob. Agents Chemother. 42, 1160-1167.
    • (1998) Antimicrob. Agents Chemother. , vol.42 , pp. 1160-1167
    • Jensen-Pergakes, K.L.1    Kennedy, M.A.2    Lees, N.D.3    Barbuch, R.4    Koegel, C.5    Bard, M.6
  • 22
    • 0042424651 scopus 로고    scopus 로고
    • Disruption of Ergosterol Biosyntesis Confers Resistance to Amphotericin B in Candida lusitaniae
    • Young, J.Y., Hull, C.M., and Heitman, J. (2003) Disruption of Ergosterol Biosyntesis Confers Resistance to Amphotericin B in Candida lusitaniae, Antimicrob. Agents Chemother. 47, 2717-2724.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 2717-2724
    • Young, J.Y.1    Hull, C.M.2    Heitman, J.3
  • 23
    • 0033807662 scopus 로고    scopus 로고
    • Upregulation of ERC6 Genes in Candida Species by Azoles and Other Biosynthesis Inhibitors
    • Henry, K.W., Nickels, J.T., and Edlind, T.D. (2000) Upregulation of ERC6 Genes in Candida Species by Azoles and Other Biosynthesis Inhibitors, Antimicrob. Agents Chemother. 44, 2693-2700.
    • (2000) Antimicrob. Agents Chemother. , vol.44 , pp. 2693-2700
    • Henry, K.W.1    Nickels, J.T.2    Edlind, T.D.3
  • 24
    • 0042818290 scopus 로고    scopus 로고
    • Genome-wide Expression Profiling of the Response to Polyene, Pyrimidine, Azole and Echinocandin Antifungal Agents in Saccharomyces cerevisiae
    • Agarwal, A.K., Rogers, P.D., Baerson, S.R., Jacob, M.R., Barker, K.S., Cleary, J.D., Walker, L.A., Nagle, D.G., and Clark, A.M. (2003) Genome-wide Expression Profiling of the Response to Polyene, Pyrimidine, Azole and Echinocandin Antifungal Agents in Saccharomyces cerevisiae, J. Biol. Chem. 278, 34998-35015.
    • (2003) J. Biol. Chem. , vol.278 , pp. 34998-35015
    • Agarwal, A.K.1    Rogers, P.D.2    Baerson, S.R.3    Jacob, M.R.4    Barker, K.S.5    Cleary, J.D.6    Walker, L.A.7    Nagle, D.G.8    Clark, A.M.9
  • 25
    • 0034672702 scopus 로고    scopus 로고
    • Sterol Methyltransferase: Enzymology and Inhibition
    • Nes, W.D. (2000) Sterol Methyltransferase: Enzymology and Inhibition, Biochim. Biophys. Acta. 1529, 63-88.
    • (2000) Biochim. Biophys. Acta , vol.1529 , pp. 63-88
    • Nes, W.D.1
  • 27
    • 0026584580 scopus 로고
    • Synthesis, Specificity, and Antifungal Activity of Inhibitors of the Candida albicans Δ24-Sterol Methyltransferase
    • Ator, M.A., Schmidt, S.J., Adams, J.L., Dolle, R.E., Kruse, L.I., Frey, C.L., and Barone, J.M. (1992) Synthesis, Specificity, and Antifungal Activity of Inhibitors of the Candida albicans Δ24-Sterol Methyltransferase, J. Med. Chem. 35, 100-106.
    • (1992) J. Med. Chem. , vol.35 , pp. 100-106
    • Ator, M.A.1    Schmidt, S.J.2    Adams, J.L.3    Dolle, R.E.4    Kruse, L.I.5    Frey, C.L.6    Barone, J.M.7
  • 28
    • 0021213468 scopus 로고
    • Azasterol Inhibition of Δ24-Sterol Methyltransferase in Saccharomyces cerevisiae
    • Oehlschlager, A.C., Angus, R.H., Pierce, A.M., Pierce, H.D., and Srinivasan, R. (1984) Azasterol Inhibition of Δ24-Sterol Methyltransferase in Saccharomyces cerevisiae, Biochemistry 23, 3582-3589.
    • (1984) Biochemistry , vol.23 , pp. 3582-3589
    • Oehlschlager, A.C.1    Angus, R.H.2    Pierce, A.M.3    Pierce, H.D.4    Srinivasan, R.5
  • 30
    • 0031172883 scopus 로고    scopus 로고
    • 24(28)-Sterol Methyltransferase from Saccharomyces cerevisiae
    • 24(28)- Sterol Methyltransferase from Saccharomyces cerevisiae, Arch. Biochem. Biophys. 342, 68-81.
    • (1997) Arch. Biochem. Biophys. , vol.342 , pp. 68-81
    • Nes, W.D.1    Guo, D.2    Zhou, W.3
  • 31
    • 0024720149 scopus 로고
    • Metabolism of 24(R,S), 25-Epiminolanosterol to 25-Aminolanosterol and lanosterol by Gibberella fujikuroi
    • Nes, W.D., Xu, S., and Parish, E.J. (1989) Metabolism of 24(R,S), 25-Epiminolanosterol to 25-Aminolanosterol and lanosterol by Gibberella fujikuroi, Arch. Biochem. Biophys. 272, 323-331.
    • (1989) Arch. Biochem. Biophys. , vol.272 , pp. 323-331
    • Nes, W.D.1    Xu, S.2    Parish, E.J.3
  • 32
    • 0034117077 scopus 로고    scopus 로고
    • Sterol C-Methyl Transferase from Prototheca wickerhamii. Mechanism, Sterol Specificity and Inhibition
    • Mangla, A.T., and Nes, W.D. (1999) Sterol C-Methyl Transferase from Prototheca wickerhamii. Mechanism, Sterol Specificity and Inhibition, Bioorg. Med. Chem. 8, 925-936.
    • (1999) Bioorg. Med. Chem. , vol.8 , pp. 925-936
    • Mangla, A.T.1    Nes, W.D.2
  • 33
    • 0347418210 scopus 로고    scopus 로고
    • 24-Thiacycloartanol, a Potent Mechanism-Based Inactivator of Plant Sterol Methyltransferase
    • Zhou, W., Song, Z., Liu, J., Miller, M.B., and Nes, W.D. (2004) 24-Thiacycloartanol, a Potent Mechanism-Based Inactivator of Plant Sterol Methyltransferase, Tetrahedron Lett. 45, 875-879.
    • (2004) Tetrahedron Lett. , vol.45 , pp. 875-879
    • Zhou, W.1    Song, Z.2    Liu, J.3    Miller, M.B.4    Nes, W.D.5
  • 34
    • 0025233784 scopus 로고
    • Inhibitors of Ergosterol Biosynthesis and Growth of the Trypanosomatid Protozoan Crithidia fasciculata
    • Rahman, M.D., and Pascal, R.A., Jr. (1990) Inhibitors of Ergosterol Biosynthesis and Growth of the Trypanosomatid Protozoan Crithidia fasciculata, J. Biol. Chem. 265, 4989-4996.
    • (1990) J. Biol. Chem. , vol.265 , pp. 4989-4996
    • Rahman, M.D.1    Pascal Jr., R.A.2
  • 35
    • 0141924824 scopus 로고    scopus 로고
    • Sensitive Assay for Antifungal Activity of Glucan Synthase Inhibitors That Uses Germ Tube Formation in Candida albicans as an End Point
    • Brayman, T.G., and Wilks, J.W. (2003) Sensitive Assay for Antifungal Activity of Glucan Synthase Inhibitors That Uses Germ Tube Formation in Candida albicans as an End Point, Antimicrob. Agents Chemother. 47, 3305-3310.
    • (2003) Antimicrob. Agents Chemother. , vol.47 , pp. 3305-3310
    • Brayman, T.G.1    Wilks, J.W.2
  • 37
    • 0001150457 scopus 로고
    • Synthesis of New Epiminoisopentenoids
    • Parish, E.J., and Nes, W.D. (1988) Synthesis of New Epiminoisopentenoids, Synth. Commun. 18, 221-226.
    • (1988) Synth. Commun. , vol.18 , pp. 221-226
    • Parish, E.J.1    Nes, W.D.2
  • 39
    • 0023727547 scopus 로고
    • Comparison of the chromatographic Properties of Sterols, Select Additional Steroids and Triterpenoids: Gravity-Flow Liquid Chromatography, Thin-Layer Chromatography, Gas-Liquid Chromatography, and High-Performance Liquid Chromatography
    • Xu, S., Norton, R.A., Crumley, F.G., and Nes, W.D. (1988) Comparison of the chromatographic Properties of Sterols, Select Additional Steroids and Triterpenoids: Gravity-Flow Liquid Chromatography, Thin-Layer Chromatography, Gas-Liquid Chromatography, and High-Performance Liquid Chromatography, J. Chromatogr. 452, 377-398.
    • (1988) J. Chromatogr. , vol.452 , pp. 377-398
    • Xu, S.1    Norton, R.A.2    Crumley, F.G.3    Nes, W.D.4
  • 40
    • 0017184389 scopus 로고
    • A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding
    • Bradford, M.M. (1976) A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding, Anal Biochem. 72, 248-254.
    • (1976) Anal Biochem. , vol.72 , pp. 248-254
    • Bradford, M.M.1
  • 42
    • 0141780880 scopus 로고    scopus 로고
    • Biosynthesis of Phytosterols: Kinetic Mechanism for the Enzymatic C-Methylation of Sterols
    • Nes, W.D., Song, Z., Dennis, A.L., Zhou, W., Nam, J., and Miller, M. (2003) Biosynthesis of Phytosterols: Kinetic Mechanism for the Enzymatic C-Methylation of Sterols, J. Biol. Chem. 278, 34505-34516.
    • (2003) J. Biol. Chem. , vol.278 , pp. 34505-34516
    • Nes, W.D.1    Song, Z.2    Dennis, A.L.3    Zhou, W.4    Nam, J.5    Miller, M.6
  • 43
    • 0022551949 scopus 로고
    • Dimorphism-Associated Variations in the Lipid Composition of Candida albicans
    • Ghannoum, M.A., Janini, G., Khamis, L., and Radwan, S.S. (1986) Dimorphism-Associated Variations in the Lipid Composition of Candida albicans, J. Gen. Microbiol. 132, 2367-2375.
    • (1986) J. Gen. Microbiol. , vol.132 , pp. 2367-2375
    • Ghannoum, M.A.1    Janini, G.2    Khamis, L.3    Radwan, S.S.4
  • 44
    • 0017226725 scopus 로고
    • Sterol Biosynthesis in Antibiotic Sensitive and Resistant Candida
    • Fryberg, M., Oehlschlager, A.C., and Unrau, A.M. (1975) Sterol Biosynthesis in Antibiotic Sensitive and Resistant Candida, Arch. Biochem. Biophys. 173, 171-177.
    • (1975) Arch. Biochem. Biophys. , vol.173 , pp. 171-177
    • Fryberg, M.1    Oehlschlager, A.C.2    Unrau, A.M.3
  • 45
    • 0017648360 scopus 로고
    • Eburicol, Lichesterol, Ergosterol and Obtusifoliol from Polyene Antibiotic-Resistant Mutants of Candida albicans
    • Subden, R.E., Safe, L., Morris, D.C., and Brown, R.G. (1977) Eburicol, Lichesterol, Ergosterol and Obtusifoliol from Polyene Antibiotic-Resistant Mutants of Candida albicans, Can. J. Microbiol. 23, 751-754.
    • (1977) Can. J. Microbiol. , vol.23 , pp. 751-754
    • Subden, R.E.1    Safe, L.2    Morris, D.C.3    Brown, R.G.4
  • 48
    • 0041821530 scopus 로고    scopus 로고
    • Enzyme Mechanisms for Sterol C-Methylations
    • Nes, W.D. (2003) Enzyme Mechanisms for Sterol C-Methylations, Phytochemistry 64, 75-95.
    • (2003) Phytochemistry , vol.64 , pp. 75-95
    • Nes, W.D.1
  • 49
    • 0022449714 scopus 로고
    • Control of Fungal Sterol C-24 Transalkylation: Importance to Developmental Regulation
    • Nes, W.D., Hanners, P.K., and Parish, E.J. (1986) Control of Fungal Sterol C-24 Transalkylation: Importance to Developmental Regulation, Biochem. Biophys. Res. Commun. 139, 410-415.
    • (1986) Biochem. Biophys. Res. Commun. , vol.139 , pp. 410-415
    • Nes, W.D.1    Hanners, P.K.2    Parish, E.J.3
  • 50
    • 0037044738 scopus 로고    scopus 로고
    • Active Site Mapping and Substrate Channelling in the Sterol Methyltransferase Pathway
    • Nes, W.D., Marshall, J.A., Jia, Z., Jaradat, T.T., Song, Z., and Jayasimha, P. (2002). Active Site Mapping and Substrate Channelling in the Sterol Methyltransferase Pathway, J. Biol. Chem. 277, 42459-42556.
    • (2002) J. Biol. Chem. , vol.277 , pp. 42459-42556
    • Nes, W.D.1    Marshall, J.A.2    Jia, Z.3    Jaradat, T.T.4    Song, Z.5    Jayasimha, P.6


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