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Volumn 8, Issue 4, 2013, Pages 333-339

Hematopoietic transplants for disease suppression and cure in type 1 diabetes

Author keywords

Activation induced cell death; Autoimmunity; Fas cross linking; Inflammation; Regulatory T cells

Indexed keywords

C PEPTIDE; CYCLOPHOSPHAMIDE; GLYCOSYLATED HEMOGLOBIN; GUANOSINE TRIPHOSPHATASE; THYMOCYTE ANTIBODY;

EID: 84888097082     PISSN: 1574888X     EISSN: None     Source Type: Journal    
DOI: 10.2174/1574888X113089990001     Document Type: Article
Times cited : (7)

References (111)
  • 2
    • 38349186477 scopus 로고    scopus 로고
    • Diabetes mellitus: A potential target for stem cell therapy
    • Burns CJ, Persaud SJ, Jones PM. Diabetes mellitus: a potential target for stem cell therapy. Curr Stem Cell Res Ther 2006; 1: 255-66.
    • (2006) Curr Stem Cell Res Ther , vol.1 , pp. 255-266
    • Burns, C.J.1    Persaud, S.J.2    Jones, P.M.3
  • 3
    • 79551671049 scopus 로고    scopus 로고
    • Stem cell-based therapies and immunomodulatory approaches in newly diagnosed type 1 diabetes
    • Couri CE, Voltarelli JC. Stem cell-based therapies and immunomodulatory approaches in newly diagnosed type 1 diabetes. Curr Stem Cell Res Ther 2011; 6: 10-5.
    • (2011) Curr Stem Cell Res Ther , vol.6 , pp. 10-15
    • Couri, C.E.1    Voltarelli, J.C.2
  • 4
    • 79551655241 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for the treatment of autoimmunity in type 1 diabetes
    • LoCascio SA, Spinelli J, Kurtz J. Hematopoietic stem cell transplantation for the treatment of autoimmunity in type 1 diabetes. Curr Stem Cell Res Ther 2011; 6: 29-37.
    • (2011) Curr Stem Cell Res Ther , vol.6 , pp. 29-37
    • Locascio, S.A.1    Spinelli, J.2    Kurtz, J.3
  • 5
    • 65449139849 scopus 로고    scopus 로고
    • Intensive immunosuppression with high dose cyclophosphamide but without stem cell rescue for severe autoimmunity: Advantages and disadvantages
    • Brodsky RA, Jones RJ. Intensive immunosuppression with high dose cyclophosphamide but without stem cell rescue for severe autoimmunity: advantages and disadvantages. Autoimmunity 2008; 41: 596-600.
    • (2008) Autoimmunity , vol.41 , pp. 596-600
    • Brodsky, R.A.1    Jones, R.J.2
  • 7
    • 0031423760 scopus 로고    scopus 로고
    • The nonobese diabetic mouse as a model of autoimmune diabetes: Immune dysregulation gets the NOD
    • Delovitch TL, Singh B. The nonobese diabetic mouse as a model of autoimmune diabetes: immune dysregulation gets the NOD. Immunity 1997; 7: 727-38.
    • (1997) Immunity , vol.7 , pp. 727-738
    • Delovitch, T.L.1    Singh, B.2
  • 8
    • 17644361955 scopus 로고    scopus 로고
    • The NOD mouse: A model of immune dysregulation
    • Anderson MS, Bluestone JA. The NOD mouse: a model of immune dysregulation. Annu Rev Immunol 2005; 23: 447-85.
    • (2005) Annu Rev Immunol , vol.23 , pp. 447-485
    • Anderson, M.S.1    Bluestone, J.A.2
  • 9
    • 79251621206 scopus 로고    scopus 로고
    • Mouse models for the study of autoimmune type 1 diabetes: A NOD to similarities and differences to human disease
    • Driver JP, Serreze DV, Chen YG. Mouse models for the study of autoimmune type 1 diabetes: a NOD to similarities and differences to human disease. Semin Immunopathol 2011; 33: 67-87.
    • (2011) Semin Immunopathol , vol.33 , pp. 67-87
    • Driver, J.P.1    Serreze, D.V.2    Chen, Y.G.3
  • 10
    • 0021236967 scopus 로고
    • Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat
    • Rossini AA, Slavin S, Woda BA, Geisberg M, Like AA, Mordes JP. Total lymphoid irradiation prevents diabetes mellitus in the Bio-Breeding/Worcester (BB/W) rat. Diabetes 1984; 33: 543-7.
    • (1984) Diabetes , vol.33 , pp. 543-547
    • Rossini, A.A.1    Slavin, S.2    Woda, B.A.3    Geisberg, M.4    Like, A.A.5    Mordes, J.P.6
  • 11
    • 45449123146 scopus 로고
    • Cellular mechanisms in immune tolerance and treatment of autoimmune disease: Studies using total lymphoid irradiation (TLI)
    • Strober S, Fariñas MC. Cellular mechanisms in immune tolerance and treatment of autoimmune disease: Studies using total lymphoid irradiation (TLI). J Autoimmun 1988; 1: 693-702.
    • (1988) J Autoimmun , vol.1 , pp. 693-702
    • Strober, S.1    Fariñas, M.C.2
  • 12
    • 0037219227 scopus 로고    scopus 로고
    • Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice
    • Beilhack GF, Scheffold YC, Weissman IL, et al. Purified allogeneic hematopoietic stem cell transplantation blocks diabetes pathogenesis in NOD mice. Diabetes 2003; 52: 59-68.
    • (2003) Diabetes , vol.52 , pp. 59-68
    • Beilhack, G.F.1    Scheffold, Y.C.2    Weissman, I.L.3
  • 13
    • 68249109933 scopus 로고    scopus 로고
    • Low levels of allogeneic but not syngeneic hematopoietic chimerism reverse autoimmune insulitis in prediabetic NOD mice
    • Kaminitz A, Mizrahi K, Yaniv I, Farkas DL, Stein J, Askenasy N. Low levels of allogeneic but not syngeneic hematopoietic chimerism reverse autoimmune insulitis in prediabetic NOD mice. J Autoimmun 2009; 33: 83-91.
    • (2009) J Autoimmun , vol.33 , pp. 83-91
    • Kaminitz, A.1    Mizrahi, K.2    Yaniv, I.3    Farkas, D.L.4    Stein, J.5    Askenasy, N.6
  • 14
    • 0036851361 scopus 로고    scopus 로고
    • T cells mediate resistance to genetically modified bone marrow in lethally irradiated recipients
    • Bagley J, Tian C, Sachs DH, Iacomini J. T cells mediate resistance to genetically modified bone marrow in lethally irradiated recipients. Transplantation 2002; 74: 1454-60.
    • (2002) Transplantation , vol.74 , pp. 1454-1460
    • Bagley, J.1    Tian, C.2    Sachs, D.H.3    Iacomini, J.4
  • 15
    • 0029996020 scopus 로고    scopus 로고
    • Programmed cell death in the pathogenesis of murine IDDM: Resistance to apoptosis induced in lymphocytes by cyclophosphamide
    • Colucci F, Cilio CM, Lejon K, Goncalves CP, Bergman ML, Holmberg D. Programmed cell death in the pathogenesis of murine IDDM: resistance to apoptosis induced in lymphocytes by cyclophosphamide. J Autoimmun 1996; 9: 271-6.
    • (1996) J Autoimmun , vol.9 , pp. 271-276
    • Colucci, F.1    Cilio, C.M.2    Lejon, K.3    Goncalves, C.P.4    Bergman, M.L.5    Holmberg, D.6
  • 16
    • 1342265870 scopus 로고    scopus 로고
    • Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation
    • Steptoe RJ, Stankovic S, Lopaticki S, Jones LK, Harrison LC, Morahan G. Persistence of recipient lymphocytes in NOD mice after irradiation and bone marrow transplantation. J Autoimmun 2004; 22: 131-8.
    • (2004) J Autoimmun , vol.22 , pp. 131-138
    • Steptoe, R.J.1    Stankovic, S.2    Lopaticki, S.3    Jones, L.K.4    Harrison, L.C.5    Morahan, G.6
  • 17
    • 0035937587 scopus 로고    scopus 로고
    • Preferential localization of effector memory cells in nonlymphoid tissue
    • Masopust D, Vezys V, Marzo AL, Lefrancois L. Preferential localization of effector memory cells in nonlymphoid tissue. Science. 2001; 291: 2413-7.
    • (2001) Science , vol.291 , pp. 2413-2417
    • Masopust, D.1    Vezys, V.2    Marzo, A.L.3    Lefrancois, L.4
  • 18
    • 1542308572 scopus 로고    scopus 로고
    • Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin
    • Masopust D, Vezys V, Usherwood EJ, et al. Activated primary and memory CD8 T cells migrate to nonlymphoid tissues regardless of site of activation or tissue of origin. J Immunol 2004; 172: 4875-82.
    • (2004) J Immunol , vol.172 , pp. 4875-4882
    • Masopust, D.1    Vezys, V.2    Usherwood, E.J.3
  • 19
    • 34250877389 scopus 로고    scopus 로고
    • Cutting edge: Migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells
    • Marzo AL, Yagita H, Lefrançois L. Cutting edge: migration to nonlymphoid tissues results in functional conversion of central to effector memory CD8 T cells. J Immunol 2007; 179: 36-40.
    • (2007) J Immunol , vol.179 , pp. 36-40
    • Marzo, A.L.1    Yagita, H.2    Lefrançois, L.3
  • 20
    • 33947149074 scopus 로고    scopus 로고
    • A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model
    • Franke DD, Yolcu ES, Alard P, Kosiewicz MM, Shirwan H. A novel multimeric form of FasL modulates the ability of diabetogenic T cells to mediate type 1 diabetes in an adoptive transfer model. Mol Immunol 2007; 44: 2884-92.
    • (2007) Mol Immunol , vol.44 , pp. 2884-2892
    • Franke, D.D.1    Yolcu, E.S.2    Alard, P.3    Kosiewicz, M.M.4    Shirwan, H.5
  • 21
    • 79959609103 scopus 로고    scopus 로고
    • Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice
    • Kaminitz A, Yolcu ES, Askenasy EM, et al. Effector and naturally occurring regulatory T cells display no abnormalities in activation induced cell death in NOD mice. PLOS One 2011; 6: e21630.
    • (2011) PLOS One , vol.6
    • Kaminitz, A.1    Yolcu, E.S.2    Askenasy, E.M.3
  • 22
    • 0037562908 scopus 로고    scopus 로고
    • Deficient activation and resistance to activation-induced apoptosis of CD8+ T cells is associated with defective peripheral tolerance in nonobese diabetic mice
    • Arreaza G, Salojin K, Yang W, et al. Deficient activation and resistance to activation-induced apoptosis of CD8+ T cells is associated with defective peripheral tolerance in nonobese diabetic mice. Clin Immunol 2003; 107: 103-15
    • (2003) Clin Immunol , vol.107 , pp. 103-115
    • Arreaza, G.1    Salojin, K.2    Yang, W.3
  • 23
    • 0038062649 scopus 로고    scopus 로고
    • Defect in activation induced cell death in non-obese diabetic (NOD) T lymphocytes
    • Decallonne B, van Etten E, Giulietti A, et al. Defect in activation induced cell death in non-obese diabetic (NOD) T lymphocytes. J Autoimmun 2003; 20: 219-26.
    • (2003) J Autoimmun , vol.20 , pp. 219-226
    • Decallonne, B.1    van Etten, E.2    Giulietti, A.3
  • 24
    • 4644333954 scopus 로고    scopus 로고
    • Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice
    • Yang W, Hussain S, Mi QS, Santamaria P, Delovitch TL. Perturbed homeostasis of peripheral T cells elicits decreased susceptibility to anti-CD3-induced apoptosis in prediabetic nonobese diabetic mice. J Immunol 2004; 173: 4407-16.
    • (2004) J Immunol , vol.173 , pp. 4407-4416
    • Yang, W.1    Hussain, S.2    Mi, Q.S.3    Santamaria, P.4    Delovitch, T.L.5
  • 25
    • 77949276812 scopus 로고    scopus 로고
    • Targeting of IL-2 receptor with a caspase fusion protein disrupts autoimmunity in prediabetic and diabetic NOD mice
    • Yarkoni S, Kaminitz A, Sagiv Y, Askenasy N. Targeting of IL-2 receptor with a caspase fusion protein disrupts autoimmunity in prediabetic and diabetic NOD mice. Diabetologia 2010; 53: 356-68.
    • (2010) Diabetologia , vol.53 , pp. 356-368
    • Yarkoni, S.1    Kaminitz, A.2    Sagiv, Y.3    Askenasy, N.4
  • 27
    • 0020527178 scopus 로고
    • Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat
    • Elder ME, Maclaren NK. Identification of profound peripheral T lymphocyte immunodeficiencies in the spontaneously diabetic BB rat. J Immunol 1983; 130: 1723-31.
    • (1983) J Immunol , vol.130 , pp. 1723-1731
    • Elder, M.E.1    Maclaren, N.K.2
  • 28
    • 0020533745 scopus 로고
    • Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration
    • Guttmann RD, Colle E, Michel F, Seemayer T. Spontaneous diabetes mellitus syndrome in the rat. II. T lymphopenia and its association with clinical disease and pancreatic lymphocytic infiltration. J Immunol 1983; 130: 1732-5.
    • (1983) J Immunol , vol.130 , pp. 1732-1735
    • Guttmann, R.D.1    Colle, E.2    Michel, F.3    Seemayer, T.4
  • 29
    • 27844588475 scopus 로고    scopus 로고
    • DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats
    • Hawkins T, Fuller J, Olson K, Speros S, Lernmark A. DR.lyp/lyp bone marrow maintains lymphopenia and promotes diabetes in lyp/lyp but not in +/+ recipient DR.lyp BB rats. J Autoimmun 2005; 25: 251-7.
    • (2005) J Autoimmun , vol.25 , pp. 251-257
    • Hawkins, T.1    Fuller, J.2    Olson, K.3    Speros, S.4    Lernmark, A.5
  • 30
    • 0032992530 scopus 로고    scopus 로고
    • The lymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes
    • Hernández-Hoyos G, Joseph S, Miller NG, Butcher GW. The lymphopenia mutation of the BB rat causes inappropriate apoptosis of mature thymocytes. Eur J Immunol 1999; 29: 1832-41.
    • (1999) Eur J Immunol , vol.29 , pp. 1832-1841
    • Hernández-Hoyos, G.1    Joseph, S.2    Miller, N.G.3    Butcher, G.W.4
  • 31
    • 0033407136 scopus 로고    scopus 로고
    • Elevated apoptosis of peripheral T lymphocytes in diabetic BB rats
    • Jung CG, Kamiyama T, Agui T. Elevated apoptosis of peripheral T lymphocytes in diabetic BB rats. Immunology 1999; 98: 590-4.
    • (1999) Immunology , vol.98 , pp. 590-594
    • Jung, C.G.1    Kamiyama, T.2    Agui, T.3
  • 32
    • 0036263450 scopus 로고    scopus 로고
    • The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1
    • Hornum L, Rømer J, Markholst H. The diabetes-prone BB rat carries a frameshift mutation in Ian4, a positional candidate of Iddm1. Diabetes 2002; 51: 1972-9.
    • (2002) Diabetes , vol.51 , pp. 1972-1979
    • Hornum, L.1    Rømer, J.2    Markholst, H.3
  • 33
    • 67650322087 scopus 로고    scopus 로고
    • Sequence variation and expression of the Gimap gene family in the BB rat
    • Rutledge EA, Fuller JM, Van Yserloo B, et al. Sequence variation and expression of the Gimap gene family in the BB rat. Exp Diabetes Res 2009; 2009: 835650.
    • (2009) Exp Diabetes Res , vol.2009 , pp. 835650
    • Rutledge, E.A.1    Fuller, J.M.2    van Yserloo, B.3
  • 34
    • 0033136735 scopus 로고    scopus 로고
    • T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes
    • Ramanathan S, Poussier P. T cell reconstitution of BB/W rats after the initiation of insulitis precipitates the onset of diabetes. J Immunol 1999; 162: 5134-42.
    • (1999) J Immunol , vol.162 , pp. 5134-5142
    • Ramanathan, S.1    Poussier, P.2
  • 35
    • 1942453326 scopus 로고    scopus 로고
    • Homeostatic expansion of T cells during immune insufficiency generates autoimmunity
    • King C, Ilic A, Koelsch K, Sarvetnick N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 2004; 117: 265-77.
    • (2004) Cell , vol.117 , pp. 265-277
    • King, C.1    Ilic, A.2    Koelsch, K.3    Sarvetnick, N.4
  • 37
    • 44849087807 scopus 로고    scopus 로고
    • Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice
    • Zou L, Mendez F, Martin-Orozco N, Peterson EJ. Defective positive selection results in T cell lymphopenia and increased autoimmune diabetes in ADAP-deficient BDC2.5-C57BL/6 mice. Eur J Immunol 2008; 38: 986-94.
    • (2008) Eur J Immunol , vol.38 , pp. 986-994
    • Zou, L.1    Mendez, F.2    Martin-Orozco, N.3    Peterson, E.J.4
  • 38
    • 77954104659 scopus 로고    scopus 로고
    • Autoimmunity during thymectomy-induced lymphopenia: Role of thymus ablation and initial effector T cell activation timing in nonobese diabetic mice
    • Gagnerault MC, Lanvin O, Pasquier V, et al. Autoimmunity during thymectomy-induced lymphopenia: role of thymus ablation and initial effector T cell activation timing in nonobese diabetic mice. J Immunol 2009; 183: 4913-20.
    • (2009) J Immunol , vol.183 , pp. 4913-4920
    • Gagnerault, M.C.1    Lanvin, O.2    Pasquier, V.3
  • 40
    • 11144221749 scopus 로고    scopus 로고
    • The new paradigm of T-cell homeostatic proliferation-induced autoimmunity
    • Baccala R, Theofilopoulos AN. The new paradigm of T-cell homeostatic proliferation-induced autoimmunity. Trends Immunol 2005; 26: 5-8.
    • (2005) Trends Immunol , vol.26 , pp. 5-8
    • Baccala, R.1    Theofilopoulos, A.N.2
  • 41
    • 34247598749 scopus 로고    scopus 로고
    • Balancing autoaggressive and protective T cell responses
    • Abbas AK, Lohr J, Knoechel B. Balancing autoaggressive and protective T cell responses. J Autoimmun 2007; 28: 59-61.
    • (2007) J Autoimmun , vol.28 , pp. 59-61
    • Abbas, A.K.1    Lohr, J.2    Knoechel, B.3
  • 42
    • 0033136945 scopus 로고    scopus 로고
    • Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: Effector function is linked to proliferative capacity
    • Gudmundsdottir H, Wells AD, Turka LA. Dynamics and requirements of T cell clonal expansion in vivo at the single-cell level: effector function is linked to proliferative capacity. J Immunol 1999; 162: 5212-23.
    • (1999) J Immunol , vol.162 , pp. 5212-5223
    • Gudmundsdottir, H.1    Wells, A.D.2    Turka, L.A.3
  • 43
    • 0034698931 scopus 로고    scopus 로고
    • Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation
    • Goldrath AW, Bogatzki LY, Bevan MJ. Naive T cells transiently acquire a memory-like phenotype during homeostasis-driven proliferation. J Exp Med 2000; 192: 557-64.
    • (2000) J Exp Med , vol.192 , pp. 557-564
    • Goldrath, A.W.1    Bogatzki, L.Y.2    Bevan, M.J.3
  • 44
    • 18644376988 scopus 로고    scopus 로고
    • Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms
    • Min B, Yamane H, Hu-Li J, Paul WE. Spontaneous and homeostatic proliferation of CD4 T cells are regulated by different mechanisms. J Immunol 2005; 174: 6039-44
    • (2005) J Immunol , vol.174 , pp. 6039-6044
    • Min, B.1    Yamane, H.2    Hu-Li, J.3    Paul, W.E.4
  • 45
    • 0034529395 scopus 로고    scopus 로고
    • Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire
    • La Gruta NL, Driel IR, Gleeson PA. Peripheral T cell expansion in lymphopenic mice results in a restricted T cell repertoire. Eur J Immunol 2000; 30: 3380-6.
    • (2000) Eur J Immunol , vol.30 , pp. 3380-3386
    • la Gruta, N.L.1    Driel, I.R.2    Gleeson, P.A.3
  • 46
    • 0037450727 scopus 로고    scopus 로고
    • T cell regulation as a side effect of homeostasis and competition
    • Barthlott T, Kassiotis G, Stockinger B. T cell regulation as a side effect of homeostasis and competition. J Exp Med 2003; 197: 451-60.
    • (2003) J Exp Med , vol.197 , pp. 451-460
    • Barthlott, T.1    Kassiotis, G.2    Stockinger, B.3
  • 47
    • 0037438341 scopus 로고    scopus 로고
    • Cutting edge: Homeostatic proliferation of peripheral T lymphocytes is regulated by clonal competition
    • Troy AE, Shen H. Cutting edge: homeostatic proliferation of peripheral T lymphocytes is regulated by clonal competition. J Immunol 2003; 170: 672-6.
    • (2003) J Immunol , vol.170 , pp. 672-676
    • Troy, A.E.1    Shen, H.2
  • 48
    • 0037120052 scopus 로고    scopus 로고
    • The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering
    • Schrum AG, Turka LA. The proliferative capacity of individual naive CD4(+) T cells is amplified by prolonged T cell antigen receptor triggering. J Exp Med 2002; 196: 793-803.
    • (2002) J Exp Med , vol.196 , pp. 793-803
    • Schrum, A.G.1    Turka, L.A.2
  • 49
    • 0034698825 scopus 로고    scopus 로고
    • Homeostatic T cell proliferation: How far can T cells be activated to self-ligands?
    • Surh CD, Sprent J. Homeostatic T cell proliferation: how far can T cells be activated to self-ligands? J Exp Med 2000; 21: F9-F14.
    • (2000) J Exp Med , vol.21
    • Surh, C.D.1    Sprent, J.2
  • 50
    • 33845434853 scopus 로고    scopus 로고
    • Severely impaired clonal deletion of CD4+ T cells in low-dose irradiated mice: Role of T cell antigen receptor and IL-7 receptor signal
    • Shklovskaya E, Fazekas de St. Groth B. Severely impaired clonal deletion of CD4+ T cells in low-dose irradiated mice: role of T cell antigen receptor and IL-7 receptor signals. J Immunol 2006; 177: 8320-30.
    • (2006) J Immuno , vol.17 , pp. 8320-8323
    • Shklovskaya, E.1    Groth, B.2
  • 51
    • 70349249991 scopus 로고    scopus 로고
    • Lymphopeniainduced spontaneous T-cell proliferation as a cofactor for autoimmune disease development
    • Le Campion A, Gagnerault MC, Auffray C, et al. Lymphopeniainduced spontaneous T-cell proliferation as a cofactor for autoimmune disease development. Blood 2009; 114: 1784-93.
    • (2009) Blood , vol.114 , pp. 1784-1793
    • Le, C.A.1    Gagnerault, M.C.2    Auffray, C.3
  • 53
    • 0035459382 scopus 로고    scopus 로고
    • Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool
    • Serreze DV, Johnson EA, Chapman HD, et al. Autoreactive diabetogenic T-cells in NOD mice can efficiently expand from a greatly reduced precursor pool. Diabetes 2001; 50: 1992-2000.
    • (2001) Diabetes , vol.50 , pp. 1992-2000
    • Serreze, D.V.1    Johnson, E.A.2    Chapman, H.D.3
  • 54
    • 71649085278 scopus 로고    scopus 로고
    • Consideration of strategies for hematopoietic cell transplantation
    • Yaniv I, Ash S, Farkas DL, Askenasy N, Stein J. Consideration of strategies for hematopoietic cell transplantation. J Autoimmun 2009; 33: 255-9.
    • (2009) J Autoimmun , vol.33 , pp. 255-259
    • Yaniv, I.1    Ash, S.2    Farkas, D.L.3    Askenasy, N.4    Stein, J.5
  • 55
    • 77955235892 scopus 로고    scopus 로고
    • Does lymphopenia preclude restoration of immune homeostasis? The particular case of type 1 diabetes
    • Askenasy EM, Askenasy N, Askenasy JJ. Does lymphopenia preclude restoration of immune homeostasis? The particular case of type 1 diabetes. Autoimmun Rev 2010; 9: 687-90.
    • (2010) Autoimmun Rev , vol.9 , pp. 687-690
    • Askenasy, E.M.1    Askenasy, N.2    Askenasy, J.J.3
  • 56
    • 28444480230 scopus 로고    scopus 로고
    • Genetic prediction of autoimmunity: Initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes
    • Aly TA, Ide A, Humphrey K, et al. Genetic prediction of autoimmunity: initial oligogenic prediction of anti-islet autoimmunity amongst DR3/DR4-DQ8 relatives of patients with type 1A diabetes. J Autoimmun 2005; 25: 40-5.
    • (2005) J Autoimmun , vol.25 , pp. 40-45
    • Aly, T.A.1    Ide, A.2    Humphrey, K.3
  • 57
    • 33646681230 scopus 로고    scopus 로고
    • Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus
    • Anaya JM, Castiblanco J, Tobon GJ, et al. Familial clustering of autoimmune diseases in patients with type 1 diabetes mellitus. J Autoimmun 2006; 26: 208-14.
    • (2006) J Autoimmun , vol.26 , pp. 208-214
    • Anaya, J.M.1    Castiblanco, J.2    Tobon, G.J.3
  • 58
    • 33845982534 scopus 로고    scopus 로고
    • A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease
    • Awdeh ZL, Yunis EJ, Audeh MJ, et al. A genetic explanation for the rising incidence of type 1 diabetes, a polygenic disease. J Autoimmun 2006; 27: 174-81.
    • (2006) J Autoimmun , vol.27 , pp. 174-181
    • Awdeh, Z.L.1    Yunis, E.J.2    Audeh, M.J.3
  • 59
    • 42249115212 scopus 로고    scopus 로고
    • Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese
    • Shimada A, Kanazawa Y, Motohashi Y, et al. Evidence for association between vitamin D receptor BsmI polymorphism and type 1 diabetes in Japanese. J Autoimmun 2008; 30: 207-11.
    • (2008) J Autoimmun , vol.30 , pp. 207-211
    • Shimada, A.1    Kanazawa, Y.2    Motohashi, Y.3
  • 60
    • 50549104496 scopus 로고    scopus 로고
    • Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their firstdegree relatives
    • Neuhausen SL, Steele L, Ryan S, et al. Co-occurrence of celiac disease and other autoimmune diseases in celiacs and their firstdegree relatives. J Autoimmun 2008; 31: 160-5.
    • (2008) J Autoimmun , vol.31 , pp. 160-165
    • Neuhausen, S.L.1    Steele, L.2    Ryan, S.3
  • 61
    • 56749133320 scopus 로고    scopus 로고
    • The autoimmunologist: Geoepidemiology, a new center of gravity, and prime time for autoimmunity
    • Shoenfeld Y, Selmi C, Zimlichman E, Gershwin ME. The autoimmunologist: geoepidemiology, a new center of gravity, and prime time for autoimmunity. J Autoimmun 2008; 31: 325-30.
    • (2008) J Autoimmun , vol.31 , pp. 325-330
    • Shoenfeld, Y.1    Selmi, C.2    Zimlichman, E.3    Gershwin, M.E.4
  • 62
    • 28444494764 scopus 로고    scopus 로고
    • Infections and autoimmune diseases
    • Bach JF. Infections and autoimmune diseases. J Autoimmun 2005; 25(Suppl.): 74-80
    • (2005) J Autoimmun , vol.25 , Issue.SUPPL. , pp. 74-80
    • Bach, J.F.1
  • 63
    • 67349236051 scopus 로고    scopus 로고
    • The genetics and epigenetics of autoimmune diseases
    • Hewagama A, Richardson B. The genetics and epigenetics of autoimmune diseases. J Autoimmun 2009; 33: 3-11.
    • (2009) J Autoimmun , vol.33 , pp. 3-11
    • Hewagama, A.1    Richardson, B.2
  • 65
    • 84870482851 scopus 로고    scopus 로고
    • Extrathymic development of murine T cells after bone marrow transplantation
    • Holland AM, Zakrzewski JL, Tsai JJ, et al. Extrathymic development of murine T cells after bone marrow transplantation. J Clin Invest 2012; 122: 4716-26.
    • (2012) J Clin Invest , vol.122 , pp. 4716-4726
    • Holland, A.M.1    Zakrzewski, J.L.2    Tsai, J.J.3
  • 66
    • 0037094015 scopus 로고    scopus 로고
    • Conversion of naive T cells to a memory-like phenotype in lymphopenic hosts is not related to a homeostatic mechanism that fills the peripheral naive T cell pool
    • Tanchot C, Le Campion A, Martin B, Léaument S, Dautigny N, Lucas B. Conversion of naive T cells to a memory-like phenotype in lymphopenic hosts is not related to a homeostatic mechanism that fills the peripheral naive T cell pool. J Immunol 2002; 168: 5042-6.
    • (2002) J Immunol , vol.168 , pp. 5042-5046
    • Tanchot, C.1    Le Campion, A.2    Martin, B.3    Léaument, S.4    Dautigny, N.5    Lucas, B.6
  • 67
    • 0043244867 scopus 로고    scopus 로고
    • Antigen-dependent proliferation of CD4+CD25+ regulatory T cells in vivo
    • Walker LSK, Chodos A, Eggena M, Dooms H, Abbas AK. Antigen-dependent proliferation of CD4+CD25+ regulatory T cells in vivo. J Exp Med 2003; 198: 249-58
    • (2003) J Exp Med , vol.198 , pp. 249-258
    • Walker, L.S.K.1    Chodos, A.2    Eggena, M.3    Dooms, H.4    Abbas, A.K.5
  • 68
    • 28444444122 scopus 로고    scopus 로고
    • CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity
    • Stephens LA, Gray D, Anderton SM. CD4+CD25+ regulatory T cells limit the risk of autoimmune disease arising from T cell receptor crossreactivity. Proc Natl Acad Sci USA 2005; 102: 17418-23.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 17418-17423
    • Stephens, L.A.1    Gray, D.2    Anderton, S.M.3
  • 69
    • 58149280846 scopus 로고    scopus 로고
    • Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo
    • Tonkin DR, He J, Barbour G, Haskins K. Regulatory T cells prevent transfer of type 1 diabetes in NOD mice only when their antigen is present in vivo. J Immunol 2008; 181: 4516-22.
    • (2008) J Immunol , vol.181 , pp. 4516-4522
    • Tonkin, D.R.1    He, J.2    Barbour, G.3    Haskins, K.4
  • 70
    • 77955924797 scopus 로고    scopus 로고
    • Immunosuppressive therapy exacerbates autoimmunity in NOD mice and diminishes the protective activity of regulatory T cells
    • Kaminitz A, Mizrahi K, Yaniv I, Stein J, Askenasy N. Immunosuppressive therapy exacerbates autoimmunity in NOD mice and diminishes the protective activity of regulatory T cells. J Autoimmun 2010; 35: 145-52.
    • (2010) J Autoimmun , vol.35 , pp. 145-152
    • Kaminitz, A.1    Mizrahi, K.2    Yaniv, I.3    Stein, J.4    Askenasy, N.5
  • 71
    • 84880590239 scopus 로고    scopus 로고
    • Killer regulatory T cells attenuate inflammatory insulitis in diabetic NOD mice through local and systemic immunomodulat
    • in press
    • Kaminitz A, Yolcu ES, Mizrahi K, Shirwan H, Askenasy N. Killer regulatory T cells attenuate inflammatory insulitis in diabetic NOD mice through local and systemic immunomodulation. Int Immunol 2013; in press
    • (2013) N. Int Immunol
    • Kaminitz, A.1    Yolcu, E.S.2    Mizrahi, K.3    Shirwan, H.4    Askenasy, N.5
  • 72
    • 56549127254 scopus 로고    scopus 로고
    • Presence of donor-derived thymic epithelial cells in [B6/MRL/lpr] mice after allogeneic intrabone marrow-bone marrow transplantation (IBM-BMT)
    • Takaki T, Hosaka N, Miyake T, et al. Presence of donor-derived thymic epithelial cells in [B6/MRL/lpr] mice after allogeneic intrabone marrow-bone marrow transplantation (IBM-BMT). J Autoimmun 2008; 31: 408-15.
    • (2008) J Autoimmun , vol.31 , pp. 408-415
    • Takaki, T.1    Hosaka, N.2    Miyake, T.3
  • 73
    • 20144386375 scopus 로고    scopus 로고
    • Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients
    • Muraro PA, Douek DC, Packer A, et al. Thymic output generates a new and diverse TCR repertoire after autologous stem cell transplantation in multiple sclerosis patients. J Exp Med 2005; 201: 805-16.
    • (2005) J Exp Med , vol.201 , pp. 805-816
    • Muraro, P.A.1    Douek, D.C.2    Packer, A.3
  • 74
    • 30744458573 scopus 로고    scopus 로고
    • Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells
    • Zhang H, Chua KS, Guimond M, et al. Lymphopenia and interleukin-2 therapy alter homeostasis of CD4+CD25+ regulatory T cells. Nat Med 2005; 11: 1238-43.
    • (2005) Nat Med , vol.11 , pp. 1238-1243
    • Zhang, H.1    Chua, K.S.2    Guimond, M.3
  • 75
    • 34247154341 scopus 로고    scopus 로고
    • Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
    • Voltarelli JC, Couri CE, Stracieri AB, et al. Autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 2007; 297: 1568-76.
    • (2007) JAMA , vol.297 , pp. 1568-1576
    • Voltarelli, J.C.1    Couri, C.E.2    Stracieri, A.B.3
  • 76
    • 64749084427 scopus 로고    scopus 로고
    • C-Peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus
    • Couri CE, Oliveira MC, Stracieri AB, et al. C-Peptide levels and insulin independence following autologous nonmyeloablative hematopoietic stem cell transplantation in newly diagnosed type 1 diabetes mellitus. JAMA 2009; 301: 1573-9.
    • (2009) JAMA , vol.301 , pp. 1573-1579
    • Couri, C.E.1    Oliveira, M.C.2    Stracieri, A.B.3
  • 77
    • 79953710866 scopus 로고    scopus 로고
    • Independence of exogenous insulin following immunoablation and stem cell reconstitution in newly diagnosed diabetes type I
    • Snarski E, Milczarczyk A, Torosian T, et al. Independence of exogenous insulin following immunoablation and stem cell reconstitution in newly diagnosed diabetes type I. Bone Marrow Transplant 2011; 46: 562-6.
    • (2011) Bone Marrow Transplant , vol.46 , pp. 562-566
    • Snarski, E.1    Milczarczyk, A.2    Torosian, T.3
  • 78
    • 84863155487 scopus 로고    scopus 로고
    • Acute response of peripheral blood cell to autologous hematopoietic stem cell transplantation in type 1 diabetic patient
    • Zhang X, Ye L, Hu J, et al. Acute response of peripheral blood cell to autologous hematopoietic stem cell transplantation in type 1 diabetic patient. PLoS One 2012; 7: e31887.
    • (2012) PLoS One , vol.7
    • Zhang, X.1    Ye, L.2    Hu, J.3
  • 79
    • 84862835868 scopus 로고    scopus 로고
    • Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes
    • Gu W, Hu J, Wang W, et al. Diabetic ketoacidosis at diagnosis influences complete remission after treatment with hematopoietic stem cell transplantation in adolescents with type 1 diabetes. Diabetes Care 2012; 35: 1413-9.
    • (2012) Diabetes Care , vol.35 , pp. 1413-1419
    • Gu, W.1    Hu, J.2    Wang, W.3
  • 80
    • 84860786267 scopus 로고    scopus 로고
    • Autologous hematopoietic stem cell transplantation modulates immunocompetent cells and improves β-cell function in Chinese patients with new onset of type 1 diabetes
    • Li L, Shen S, Ouyang J, Hu Y, et al. Autologous hematopoietic stem cell transplantation modulates immunocompetent cells and improves β-cell function in Chinese patients with new onset of type 1 diabetes. J Clin Endocrinol Metab 2012; 97: 1729-36.
    • (2012) Clin Endocrinol Metab , vol.97 , pp. 729-736
    • Li, L.1    Shen, S.2    Ouyang, J.3    Hu, Y.4
  • 81
    • 0038110577 scopus 로고    scopus 로고
    • Recovery of the endogenous ß cell function in the NOD model of autoimmune diabetes
    • Zorina TD, Subbotin VM, Bertera S, et al. Recovery of the endogenous ß cell function in the NOD model of autoimmune diabetes. Stem Cells 2003; 21: 377-88.
    • (2003) Stem Cells , vol.21 , pp. 377-388
    • Zorina, T.D.1    Subbotin, V.M.2    Bertera, S.3
  • 82
    • 19444384955 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established
    • Kang EM, Zickler PP, Burns S, et al. Hematopoietic stem cell transplantation prevents diabetes in NOD mice but does not contribute to significant islet cell regeneration once disease is established. Exp Hematol 2005; 33: 699-705.
    • (2005) Exp Hematol , vol.33 , pp. 699-705
    • Kang, E.M.1    Zickler, P.P.2    Burns, S.3
  • 83
    • 38449092694 scopus 로고    scopus 로고
    • Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy
    • Tian C, Ansari MJ, Paez-Cortez J, et al. Induction of robust diabetes resistance and prevention of recurrent type 1 diabetes following islet transplantation by gene therapy. J Immunol 2007; 179: 6762-9.
    • (2007) J Immunol , vol.179 , pp. 6762-6769
    • Tian, C.1    Ansari, M.J.2    Paez-Cortez, J.3
  • 84
    • 84875248649 scopus 로고    scopus 로고
    • Is autoimmune diabetes caused by aberrant immune activity or defective suppression of physiological self-reactivity?
    • Askenasy EM, Askenasy N. Is autoimmune diabetes caused by aberrant immune activity or defective suppression of physiological self-reactivity? Autoimmun Rev 2013; 12: 633-7.
    • (2013) Autoimmun Rev , vol.12 , pp. 633-637
    • Askenasy, E.M.1    Askenasy, N.2
  • 85
    • 38349116204 scopus 로고    scopus 로고
    • Participation of adult bone marrow-derived stem cells in pancreatic regeneration: Neogenesis versus endogenesis
    • Iskovich S, Kaminitz A, Pearl-Yafe M, et al. Participation of adult bone marrow-derived stem cells in pancreatic regeneration: neogenesis versus endogenesis. Curr Stem Cell Res Ther 2007; 2: 272-9.
    • (2007) Curr Stem Cell Res Ther , vol.2 , pp. 272-279
    • Iskovich, S.1    Kaminitz, A.2    Pearl-Yafe, M.3
  • 87
    • 67249159743 scopus 로고    scopus 로고
    • Time point is important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice
    • Wen Y, Ouyang J, Li W, et al. Time point is important for effects of syngeneic bone marrow transplantation for type 1 diabetes in mice. Transplant Proc 2009; 41: 1801-7.
    • (2009) Transplant Proc , vol.41 , pp. 1801-1807
    • Wen, Y.1    Ouyang, J.2    Li, W.3
  • 88
    • 0028932630 scopus 로고    scopus 로고
    • Pancreatic islet beta-cells drive T-cell immune responses in the nonobese diabetic mouse model
    • Larger E, Becourt C, Bach JF, Boitard C. Pancreatic islet beta-cells drive T-cell immune responses in the nonobese diabetic mouse model. J Exp Med 1996; 181: 1635-42.
    • (1996) J Exp Med , vol.181 , pp. 1635-1642
    • Larger, E.1    Becourt, C.2    Bach, J.F.3    Boitard, C.4
  • 89
    • 36849089218 scopus 로고    scopus 로고
    • The vicious cycle of apoptotic B cell death in type 1 diabetes
    • Kaminitz A, Stein J, Yaniv I, Askenasy N. The vicious cycle of apoptotic B cell death in type 1 diabetes. Immunol Cell Biol 2007; 85: 582-9.
    • (2007) Immunol Cell Biol , vol.85 , pp. 582-589
    • Kaminitz, A.1    Stein, J.2    Yaniv, I.3    Askenasy, N.4
  • 90
    • 33644559971 scopus 로고    scopus 로고
    • The dual role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation
    • Pearl-Yafe M, Yolcu ES, Yaniv I, Stein J, Shirwan H, Askenasy N. The dual role of Fas-ligand as an injury effector and defense strategy in diabetes and islet transplantation. Bioessays 2006; 28: 211-22.
    • (2006) Bioessays , vol.28 , pp. 211-222
    • Pearl-Yafe, M.1    Yolcu, E.S.2    Yaniv, I.3    Stein, J.4    Shirwan, H.5    Askenasy, N.6
  • 91
    • 0344338626 scopus 로고
    • Prevention of type I diabetes in nonobese diabetic mice by allogeneic bone marrow transplantation
    • Ikehara S, Ohtsuki H, Good RA, et al. Prevention of type I diabetes in nonobese diabetic mice by allogeneic bone marrow transplantation. Proc Natl Acad Sci USA 1985; 82: 7743-7.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 7743-7747
    • Ikehara, S.1    Ohtsuki, H.2    Good, R.A.3
  • 92
    • 0030265655 scopus 로고    scopus 로고
    • Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach
    • Colson YL, Li H, Boggs SS, Patrene KD, Johnson PC, Ildstad ST. Durable mixed allogeneic chimerism and tolerance by a nonlethal radiation-based cytoreductive approach. J Immunol 1996; 157: 2820-9.
    • (1996) J Immunol , vol.157 , pp. 2820-2829
    • Colson, Y.L.1    Li, H.2    Boggs, S.S.3    Patrene, K.D.4    Johnson, P.C.5    Ildstad, S.T.6
  • 93
    • 0029671326 scopus 로고    scopus 로고
    • Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice
    • Li H, Kaufman CL, Boggs SS, Johnson PC, Patrene KD, Ildstad ST. Mixed allogeneic chimerism induced by a sublethal approach prevents autoimmune diabetes and reverses insulitis in nonobese diabetic (NOD) mice. J Immunol 1996; 156: 380-8.
    • (1996) J Immunol , vol.156 , pp. 380-388
    • Li, H.1    Kaufman, C.L.2    Boggs, S.S.3    Johnson, P.C.4    Patrene, K.D.5    Ildstad, S.T.6
  • 94
    • 0031091740 scopus 로고    scopus 로고
    • Patterns of hemopoietic reconstitution in nonobese diabetic mice: Dichotomy of allogeneic resistance versus competitive advantage of disease-resistant marrow
    • Kaufman CL, Li H, Ildstad ST. Patterns of hemopoietic reconstitution in nonobese diabetic mice: dichotomy of allogeneic resistance versus competitive advantage of disease-resistant marrow. J Immunol 1997; 158: 2435-42.
    • (1997) J Immunol , vol.158 , pp. 2435-2442
    • Kaufman, C.L.1    Li, H.2    Ildstad, S.T.3
  • 95
    • 0842310011 scopus 로고    scopus 로고
    • Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity
    • Nikolic B, Takeuchi Y, Leykin I, Fudaba Y, Smith RN, Sykes M. Mixed hematopoietic chimerism allows cure of autoimmune diabetes through allogeneic tolerance and reversal of autoimmunity. Diabetes 2004; 53: 376-83.
    • (2004) Diabetes , vol.53 , pp. 376-383
    • Nikolic, B.1    Takeuchi, Y.2    Leykin, I.3    Fudaba, Y.4    Smith, R.N.5    Sykes, M.6
  • 96
    • 2942532439 scopus 로고    scopus 로고
    • Prevention of diabetes in nonobese diabetic mice by nonmyeloablative allogeneic bone marrow transplantation
    • Elkin G, Prigozhina TB, Slavin S. Prevention of diabetes in nonobese diabetic mice by nonmyeloablative allogeneic bone marrow transplantation. Exp Hematol 2004; 32: 579-84.
    • (2004) Exp Hematol , vol.32 , pp. 579-584
    • Elkin, G.1    Prigozhina, T.B.2    Slavin, S.3
  • 97
    • 15244339538 scopus 로고    scopus 로고
    • Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of alpha beta-TCR? And CD4? cells negates the effect
    • Ildstad ST, Chilton PM, Xu H, Domenick MA, Ray MB. Preconditioning of NOD mice with anti-CD8 mAb and costimulatory blockade enhances chimerism and tolerance and prevents diabetes, while depletion of alpha beta-TCR? And CD4? cells negates the effect. Blood 2004; 105: 2577-84.
    • (2004) Blood , vol.105 , pp. 2577-2584
    • Ildstad, S.T.1    Chilton, P.M.2    Xu, H.3    Domenick, M.A.4    Ray, M.B.5
  • 98
    • 33847775017 scopus 로고    scopus 로고
    • Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice
    • Zhang C, Todorov I, Lin CL, et al. Elimination of insulitis and augmentation of islet beta cell regeneration via induction of chimerism in overtly diabetic NOD mice. Proc Natl Acad Sci USA 2007; 104: 2337-42.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 2337-2342
    • Zhang, C.1    Todorov, I.2    Lin, C.L.3
  • 99
    • 40949088116 scopus 로고    scopus 로고
    • Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD mice
    • Verda L, Kim DA, Ikehara S, et al. Hematopoietic mixed chimerism derived from allogeneic embryonic stem cells prevents autoimmune diabetes mellitus in NOD mice. Stem Cells 2008; 26: 381-6
    • (2008) Stem Cells , vol.26 , pp. 381-386
    • Verda, L.1    Kim, D.A.2    Ikehara, S.3
  • 100
    • 0034662933 scopus 로고    scopus 로고
    • Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection
    • Shizuru JA, Weissman IL, Kernoff R, Masek M, Scheffold YC. Purified hematopoietic stem cell grafts induce tolerance to alloantigens and can mediate positive and negative T cell selection. Proc Natl Acad Sci USA 2000; 97: 9555-60.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 9555-9560
    • Shizuru, J.A.1    Weissman, I.L.2    Kernoff, R.3    Masek, M.4    Scheffold, Y.C.5
  • 101
    • 0035175577 scopus 로고    scopus 로고
    • A defect in central tolerance in NOD mice
    • Kishimoto H, Sprent J. A defect in central tolerance in NOD mice. Nat Immunol 2001; 2: 1025-31.
    • (2001) Nat Immunol , vol.2 , pp. 1025-1031
    • Kishimoto, H.1    Sprent, J.2
  • 103
    • 0031058466 scopus 로고    scopus 로고
    • Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo
    • Brocker T, Riedinger M, Karjalainen K. Targeted expression of major histocompatibility complex (MHC) class II molecules demonstrates that dendritic cells can induce negative but not positive selection of thymocytes in vivo. J Exp Med 1997; 185: 541-50.
    • (1997) J Exp Med , vol.185 , pp. 541-550
    • Brocker, T.1    Riedinger, M.2    Karjalainen, K.3
  • 104
    • 0030982123 scopus 로고    scopus 로고
    • Pre-existing autoimmune disease in patients with long-term survival after allogeneic bone marrow transplantation
    • Nelson JL, Torrez R, Louie FM, Choe OS, Storb R, Sullivan KM. Pre-existing autoimmune disease in patients with long-term survival after allogeneic bone marrow transplantation. J Rheumatol Suppl 1997; 48: 23-9.
    • (1997) J Rheumatol Suppl , vol.48 , pp. 23-29
    • Nelson, J.L.1    Torrez, R.2    Louie, F.M.3    Choe, O.S.4    Storb, R.5    Sullivan, K.M.6
  • 105
    • 39149111229 scopus 로고    scopus 로고
    • Hematopoietic stem cell transplantation for autoimmune diseases: What have we learned?
    • Burt RK, Testori A, Craig R, Cohen B, Suffit R, Barr W. Hematopoietic stem cell transplantation for autoimmune diseases: what have we learned? J Autoimmun 2008; 30: 116-20.
    • (2008) J Autoimmun , vol.30 , pp. 116-120
    • Burt, R.K.1    Testori, A.2    Craig, R.3    Cohen, B.4    Suffit, R.5    Barr, W.6
  • 106
    • 39149118881 scopus 로고    scopus 로고
    • On reversing the persistence of memory: Hematopoietic stem cell transplant for autoimmune disease in the first ten years
    • Deane S, Meyers FJ, Gershwin ME. On reversing the persistence of memory: hematopoietic stem cell transplant for autoimmune disease in the first ten years. J Autoimmun 2008; 30: 180-96.
    • (2008) J Autoimmun , vol.30 , pp. 180-196
    • Deane, S.1    Meyers, F.J.2    Gershwin, M.E.3
  • 107
    • 39149112225 scopus 로고    scopus 로고
    • Will hematopoietic stem cell transplantation cure human autoimmune diseases?
    • Marmont AM. Will hematopoietic stem cell transplantation cure human autoimmune diseases? J Autoimmun 2008; 30: 145-50.
    • (2008) J Autoimmun , vol.30 , pp. 145-150
    • Marmont, A.M.1
  • 108
    • 0035401164 scopus 로고    scopus 로고
    • Recurrent autoimmunity accelerates destruction of minor and major histoincompatible islet grafts in nonobese diabetic (NOD) mice
    • Okitsu T, Bartlett ST, Hadley GA, Drachenberg CB, Farney AC. Recurrent autoimmunity accelerates destruction of minor and major histoincompatible islet grafts in nonobese diabetic (NOD) mice. Am J Transplant 2001; 1: 138-45.
    • (2001) Am J Transplant , vol.1 , pp. 138-145
    • Okitsu, T.1    Bartlett, S.T.2    Hadley, G.A.3    Drachenberg, C.B.4    Farney, A.C.5
  • 109
    • 0036830461 scopus 로고    scopus 로고
    • The role of autoimmunity in islet allograft destruction: Major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade
    • Makhlouf L, Kishimoto K, Smith RN, et al. The role of autoimmunity in islet allograft destruction: major histocompatibility complex class II matching is necessary for autoimmune destruction of allogeneic islet transplants after T-cell costimulatory blockade. Diabetes 2002; 51: 3202-10.
    • (2002) Diabetes , vol.51 , pp. 3202-3210
    • Makhlouf, L.1    Kishimoto, K.2    Smith, R.N.3
  • 110
    • 23444442762 scopus 로고    scopus 로고
    • MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo
    • Kupfer TM, Crawford ML, Pham K, Gill RG. MHC-mismatched islet allografts are vulnerable to autoimmune recognition in vivo. J Immunol 2005; 175: 2309-16.
    • (2005) J Immunol , vol.175 , pp. 2309-2316
    • Kupfer, T.M.1    Crawford, M.L.2    Pham, K.3    Gill, R.G.4
  • 111
    • 77951168859 scopus 로고    scopus 로고
    • Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells
    • Vendrame F, Pileggi A, Laughlin E, et al. Recurrence of type 1 diabetes after simultaneous pancreas-kidney transplantation, despite immunosuppression, is associated with autoantibodies and pathogenic autoreactive CD4 T-cells. Diabetes 2010; 59: 947-57.
    • (2010) Diabetes , vol.59 , pp. 947-957
    • Vendrame, F.1    Pileggi, A.2    Laughlin, E.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.