Balancing autoaggressive and protective T cell responses

Journal of Autoimmunity

Volumn 28, Issue 2-3, 2007, Pages 59-61

  Abbas, Abul K ^a   Lohr, Jens ^a   Knoechel, Birgit ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Autoimmunity; Cognate antigens; Tolerance; Tregs

Indexed keywords

ANTIGEN; INTERLEUKIN 2; VACCINE;

ACCURACY; AUTOIMMUNE DISEASE; CANCER IMMUNOTHERAPY; CELL MATURATION; CELLULAR IMMUNITY; DRUG EFFICACY; EFFECTOR CELL; HUMAN; IMMUNE RESPONSE; IMMUNE SYSTEM; IN VIVO STUDY; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTOPENIA; MICROORGANISM; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; REGULATORY T LYMPHOCYTE; REVIEW; SIGNAL TRANSDUCTION; STIMULUS RESPONSE; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; TRANSGENIC MOUSE;

ANIMALS; AUTOANTIGENS; AUTOIMMUNITY; CD4-POSITIVE T-LYMPHOCYTES; IMMUNE TOLERANCE; INFLAMMATION; INTERLEUKIN-2; LYMPHOCYTE ACTIVATION; LYMPHOPENIA; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; RECEPTORS, ANTIGEN, T-CELL; T-LYMPHOCYTES, REGULATORY;

EID: 34247598749     PISSN: 08968411     EISSN: 10959157     Source Type: Journal    
DOI: 10.1016/j.jaut.2007.02.002     Document Type: Review

References (12)

1. Lohr J., Knoechel B., Kahn E., and Abbas A.K. The role of B7 in T cell tolerance. J Immunol 173 (2004) 5028-5035
2. Kearney E.R., Pape K.A., Loh D.Y., and Jenkins M.K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1 (1994) 327-339
3. Perez V.L., Van Parijs L., Biuckians A., Zheng X.X., Strom T.B., and Abbas A.K. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity 6 (1997) 411-417
4. Singh N.J., and Schwartz R.H. The strength of persistent antigenic stimulation modulates adaptive tolerance in peripheral CD4+ T cells. J Exp Med 198 (2003) 1107-1117
5. Knoechel B., Lohr J., Zhu S., Wong L., Hu D., Ausubel L., et al. Functional and molecular comparison of anergic and regulatory T lymphocytes. J Immunol 176 (2006) 6473-6483
6. Etzioni A. Immune deficiency and autoimmunity. Autoimmun Rev 2 (2003) 364-369
7. Knoechel B., Lohr J., Kahn E., Bluestone J.A., and Abbas A.K. Sequential development of interleukin 2-dependent effector and regulatory T cells in response to endogenous systemic antigen. J Exp Med 202 (2005) 1375-1386
8. Knoechel B., Lohr J., Kahn E., and Abbas A.K. The link between lymphocyte deficiency and autoimmunity: roles of endogenous T and B lymphocytes in tolerance. J Immunol 175 (2005) 21-26
9. Lohr J., Knoechel B., Wang J.J., Villarino A., and Abbas A.K. Roles of IL-17 and regulatory T cells in a systemic inflammatory disease. J Exp Med 203 (2006) 2785-2791
10. Weaver C.T., Harrington L.E., Mangan P.R., Gavrieli M., and Murphy K.M. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity 24 (2006) 677-688
11. Malek T.R., and Bayer A.L. Tolerance, not immunity, crucially depends on IL-2. Nat Rev Immunol 4 (2004) 665-674
12. Ahmadzadeh M., and Rosenberg S.A. IL-2 administration increases CD4+ CD25(hi) Foxp3+ regulatory T cells in cancer patients. Blood 107 (2006) 2409-2414